Yuri Y Sautin

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
    Med Hypotheses 71:22-31. 2008
  2. pmc Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells
    Yuri Y Sautin
    Department of Medicine, Division of Nephrology, Box 100224, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0224, USA
    Mol Cell Biol 25:575-89. 2005
  3. ncbi request reprint Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    Yuri Y Sautin
    Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Cell Physiol 293:C584-96. 2007
  4. pmc Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 20:545-53. 2009
  5. pmc Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Comp Physiol B 179:67-76. 2009
  6. pmc Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver
    Laura G Sanchez-Lozada
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 49:1-9. 2010
  7. ncbi request reprint Could uric acid have a role in acute renal failure?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 2:16-21. 2007
  8. ncbi request reprint Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
  9. ncbi request reprint Fructose, but not dextrose, accelerates the progression of chronic kidney disease
    Michael S Gersch
    Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1256-61. 2007
  10. pmc Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, CO 80045, USA
    J Biol Chem 287:40732-44. 2012

Detail Information

Publications20

  1. pmc The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
    Med Hypotheses 71:22-31. 2008
    ....
  2. pmc Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells
    Yuri Y Sautin
    Department of Medicine, Division of Nephrology, Box 100224, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0224, USA
    Mol Cell Biol 25:575-89. 2005
    ....
  3. ncbi request reprint Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    Yuri Y Sautin
    Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Cell Physiol 293:C584-96. 2007
    ....
  4. pmc Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 20:545-53. 2009
    ..Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. In summary, postprandial concentrations of fructose stimulate redox- and urate-dependent inflammatory mediators in proximal tubular cells...
  5. pmc Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Comp Physiol B 179:67-76. 2009
    ....
  6. pmc Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver
    Laura G Sanchez-Lozada
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 49:1-9. 2010
    ....
  7. ncbi request reprint Could uric acid have a role in acute renal failure?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 2:16-21. 2007
    ..It is suggested that studies are needed to investigate the role of chronic hyperuricemia on renal outcomes after acute tubular injury...
  8. ncbi request reprint Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
    ..Because TSP-1 is a major antiangiogenic molecule and an activator of TGF-beta1, this provides an important insight to the mechanism by which TGF-beta1 may mediate interstitial fibrosis and progressive renal disease...
  9. ncbi request reprint Fructose, but not dextrose, accelerates the progression of chronic kidney disease
    Michael S Gersch
    Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1256-61. 2007
    ..In conclusion, consumption of a high-fructose diet greatly accelerates progression of chronic kidney disease in the rat remnant kidney model...
  10. pmc Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, CO 80045, USA
    J Biol Chem 287:40732-44. 2012
    ..Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown...
  11. pmc Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome
    William Baldwin
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Diabetes 60:1258-69. 2011
    ..Previously, we showed that soluble uric acid directly stimulated the redox-dependent proinflammatory signaling in adipocytes. In this study we demonstrate the role of hyperuricemia in the production of key adipokines...
  12. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
    ..If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace...
  13. ncbi request reprint Human vascular smooth muscle cells express a urate transporter
    Karen L Price
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 17:1791-5. 2006
    ..It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease...
  14. ncbi request reprint The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase
    Ming Lu
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 279:8732-9. 2004
    ..Taken together, these findings provide functional evidence that the ATP-generating glycolytic pathway is directly coupled to the ATP-hydrolyzing proton pump through physical interaction between aldolase and V-ATPase...
  15. pmc A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid
    Kyung Mee Kim
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009
    ..10 to 103.59% and 98.74 to 106.12% for in vivo and in vitro analyses, respectively. This study demonstrates that intracellular levels of UA can be measured using LC-MS/MS with isotope labeled UA as an internal standard...
  16. ncbi request reprint Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis?
    Michael S Gersch
    University of Florida, 1600 SW Archer Road, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 21:2938-42. 2006
    ..Thus, an attractive hypothesis could be that THP would bind to uric acid in the distal tubule, and decrease its subsequent reabsorption in the distal nephron...
  17. ncbi request reprint Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
    J Am Soc Nephrol 17:736-45. 2006
    ..These results may provide new insights into the understanding of the mechanism of diabetic vascular disease...
  18. ncbi request reprint EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury
    Stanislav I Svetlov
    Department of Pathology, University of Florida College of Medicine, 1600 Archer Rd, P O Box 100275, Gainesville FL 32610, USA
    Biochim Biophys Acta 1582:251-6. 2002
    ..The underlying mechanisms recruited by LPA and S1P in pathogenesis of liver injury remain to be investigated...
  19. pmc Uric acid: the oxidant-antioxidant paradox
    Yuri Y Sautin
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
    Nucleosides Nucleotides Nucleic Acids 27:608-19. 2008
    ..We suggest that it is the pro-oxidative effects of uric acid that occur in cardiovascular disease and may have a contributory role in the pathogenesis of these conditions...
  20. ncbi request reprint Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury
    Yuri Y Sautin
    Department of Pathology, Immunology and Laboratory Medicine, Hepatobiliary Program, University of Florida, Gainesville, FL 32610, USA
    J Hematother Stem Cell Res 11:643-9. 2002
    ..As a result, LPA and its analogs may represent critical endogenous mediators, which regulate survival, increase motility, and modulate proliferation and differentiation of hepatocyte progenitors in regenerating liver...