Research Topics
| Yuri Y SautinSummaryAffiliation: University of Florida Country: USA Publications
| Collaborators
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Detail Information
Publications
The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular diseaseRichard J Johnson
Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
Med Hypotheses 71:22-31. 2008....- Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cellsYuri Y Sautin
Department of Medicine, Division of Nephrology, Box 100224, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0224, USA
Mol Cell Biol 25:575-89. 2005.... 
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stressYuri Y Sautin
Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
Am J Physiol Cell Physiol 293:C584-96. 2007....- Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cellsPietro Cirillo
Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
J Am Soc Nephrol 20:545-53. 2009..Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. In summary, postprandial concentrations of fructose stimulate redox- and urate-dependent inflammatory mediators in proximal tubular cells... - Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?Richard J Johnson
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
J Comp Physiol B 179:67-76. 2009.... - Comparison of free fructose and glucose to sucrose in the ability to cause fatty liverLaura G Sanchez-Lozada
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
Eur J Nutr 49:1-9. 2010.... - Fructose, but not dextrose, accelerates the progression of chronic kidney diseaseMichael S Gersch
Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
Am J Physiol Renal Physiol 293:F1256-61. 2007..In conclusion, consumption of a high-fructose diet greatly accelerates progression of chronic kidney disease in the rat remnant kidney model... - Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblastsTakahiko Nakagawa
Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
J Am Soc Nephrol 16:899-904. 2005..Because TSP-1 is a major antiangiogenic molecule and an activator of TGF-beta1, this provides an important insight to the mechanism by which TGF-beta1 may mediate interstitial fibrosis and progressive renal disease... - Could uric acid have a role in acute renal failure?A Ahsan Ejaz
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Clin J Am Soc Nephrol 2:16-21. 2007..It is suggested that studies are needed to investigate the role of chronic hyperuricemia on renal outcomes after acute tubular injury... - Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndromeWilliam Baldwin
Department of Medicine, University of Florida, Gainesville, Florida, USA
Diabetes 60:1258-69. 2011..Previously, we showed that soluble uric acid directly stimulated the redox-dependent proinflammatory signaling in adipocytes. In this study we demonstrate the role of hyperuricemia in the production of key adipokines... - Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?Richard J Johnson
Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
Endocr Rev 30:96-116. 2009..If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace... - Human vascular smooth muscle cells express a urate transporterKaren L Price
Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, Florida, USA
J Am Soc Nephrol 17:1791-5. 2006..It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease... - The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPaseMing Lu
Department of Medicine, University of California, San Francisco, California 94143, USA
J Biol Chem 279:8732-9. 2004..Taken together, these findings provide functional evidence that the ATP-generating glycolytic pathway is directly coupled to the ATP-hydrolyzing proton pump through physical interaction between aldolase and V-ATPase... - A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acidKyung Mee Kim
Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009..10 to 103.59% and 98.74 to 106.12% for in vivo and in vitro analyses, respectively. This study demonstrates that intracellular levels of UA can be measured using LC-MS/MS with isotope labeled UA as an internal standard... - Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis?Michael S Gersch
University of Florida, 1600 SW Archer Road, PO Box 100224, Gainesville, FL 32610 0224, USA
Nephrol Dial Transplant 21:2938-42. 2006..Thus, an attractive hypothesis could be that THP would bind to uric acid in the distal tubule, and decrease its subsequent reabsorption in the distal nephron... - Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathyTakahiko Nakagawa
Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
J Am Soc Nephrol 17:736-45. 2006..These results may provide new insights into the understanding of the mechanism of diabetic vascular disease... - EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injuryStanislav I Svetlov
Department of Pathology, University of Florida College of Medicine, 1600 Archer Rd, P O Box 100275, Gainesville FL 32610, USA
Biochim Biophys Acta 1582:251-6. 2002..The underlying mechanisms recruited by LPA and S1P in pathogenesis of liver injury remain to be investigated... - Uric acid: the oxidant-antioxidant paradoxYuri Y Sautin
Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
Nucleosides Nucleotides Nucleic Acids 27:608-19. 2008..We suggest that it is the pro-oxidative effects of uric acid that occur in cardiovascular disease and may have a contributory role in the pathogenesis of these conditions... - Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injuryYuri Y Sautin
Department of Pathology, Immunology and Laboratory Medicine, Hepatobiliary Program, University of Florida, Gainesville, FL 32610, USA
J Hematother Stem Cell Res 11:643-9. 2002..As a result, LPA and its analogs may represent critical endogenous mediators, which regulate survival, increase motility, and modulate proliferation and differentiation of hepatocyte progenitors in regenerating liver...