Research Topics
Genomes and Genes | Edward R SauterSummaryAffiliation: University of North Dakota Country: USA Publications
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Publications
Circulating microRNAs in breast cancer and healthy subjectsWeizhu Zhu
Department of Surgery, University of North Dakota, Grand Forks, ND, USA
BMC Res Notes 2:89. 2009..Screening serum for miRNAs that predict the presence of breast cancer is feasible, and may be useful for breast cancer detection...- Nipple aspirate fluid and ductoscopy to detect breast cancerEdward R Sauter
Department of Surgery, University of North Dakota, Grand Forks, North Dakota 58203, USA
Diagn Cytopathol 38:244-51. 2010..The presence of atypical cells arising from an intraductal papilloma in ductoscopic specimens is a potential source of false positive diagnosis in patients with nipple discharge... - Identification of a beta-casein-like peptide in breast nipple aspirate fluid that is associated with breast cancerEdward R Sauter
Department of Surgery, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Stop 9037, Grand Forks, ND 58201, USA
Biomark Med 3:577-88. 2009..Combining proteomic and clinical information, which are available before surgery, optimizes the prediction of which women have breast cancer... - Skin necrosis in smoking patients receiving partial breast irradiation: two case reportsEdward R Sauter
Departments of Surgery ERS, JT and Radiology SW, Ellis Fischel Cancer Center, Columbia, MO 65212, USA
Cases J 1:230. 2008..Early reports suggest good to excellent cosmesis in the vast majority of subjects. Herein we report two cases of skin necrosis in women with Stage 1 breast cancer who smoked before and after partial breast irradiation... - uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancerWenyi Qin
Department of Surgery, University of North Dakota, Grand Forks, ND, USA
BMC Cancer 8:298. 2008.... 
Biomarkers associated with breast cancer are associated with obesityEdward R Sauter
Department of Surgery, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
Cancer Detect Prev 32:149-55. 2008..It was our hypothesis that proteins associated with breast cancer would be associated with body mass index (BMI)...- Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsyWenyi Qin
Department of Surgery, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Rd, Grand Forks, ND 58202, USA
BMC Cancer 12:52. 2012..The second study assessed if these proteins increased the predictive ability of a carbohydrate (Thomsen Friedenreich, TF) which we previously demonstrated predicted the presence of disease in postmenopausal women requiring surgery... - Celecoxib decreases prostaglandin E2 concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancerEdward R Sauter
Surgery, University of Missouri, Columbia, MO 65212, USA
BMC Cancer 6:248. 2006..The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer... - Celecoxib concentration predicts decrease in prostaglandin E2 concentrations in nipple aspirate fluid from high risk womenEdward R Sauter
Department of Surgery, University of Missouri, Columbia, MO, USA
BMC Cancer 8:49. 2008.... - Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancerWeizhu Zhu
Departments of Surgery and Pathology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
Nutr Cancer 64:393-400. 2012..Because of the limited sample size, our findings should be validated in a larger study... - Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findingsEdward R Sauter
Department of Surgery, Ellis Fischel Cancer Center at the University of Missouri, Columbia, One Hospital Drive, Columbia, MO 65212, United States
Cancer Detect Prev 31:50-8. 2007.... - Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal womenWenyi Qin
Department of Surgery, University of Missouri School of Medicine Columbia, One Hospital Drive, Columbia, MO 65212, USA
Nutr Cancer 61:238-44. 2009..Isoflavones induced dose-specific changes in RARbeta2 and CCND2 gene methylation, which correlated with genistein levels. This work provides novel insights into estrogenic and methylation effects of dietary isoflavones... 
Nipple aspirate fluid expression of urokinase-type plasminogen activator, plasminogen activator inhibitor-1, and urokinase-type plasminogen activator receptor predicts breast cancer diagnosis and advanced diseaseWenyi Qin
Department of Surgery, University of Missouri, Columbia, Missouri 65212, USA
Ann Surg Oncol 10:948-53. 2003..CONCLUSIONS: NAF evaluation of uPA, uPAR, and, perhaps, PAI-1 (significant only in univariate analysis) may provide useful breast cancer diagnostic and prognostic information...- Fiberoptic ductoscopy findings in women with and without spontaneous nipple dischargeEdward R Sauter
Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, Columbia, Missouri 65212, USA
Cancer 103:914-21. 2005.... - Prospective multicenter trial to determine the feasibility of collection and predictive ability of breast fluid analysis in postmenopausal women receiving SERMsEdward R Sauter
Department of Surgery, University of Missouri Columbia, One Hospital Drive, Rm N510, Columbia, MO 65212, USA
Breast 16:489-94. 2007..Multiinstitutional clinical trials in postmenopausal women using NAF biomarkers as the primary endpoints are feasible... - Increased expression of the inflammatory protein YKL-40 in precancers of the breastWenyi Qin
Department of Surgery University of Missouri, Columbia, MO 65121, USA
Int J Cancer 121:1536-42. 2007..NAF levels of YKL-40 are significantly higher in women with precancers than healthy subjects, suggesting that measuring YKL-40 in NAF may improve the identification of women at increased breast cancer risk... - Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluidsWeizhu Zhu
Department of Research Affairs, University of North Dakota, Grand Forks, USA
Int J Cancer 126:474-82. 2010.... - Thomsen-Friedenreich and Tn antigens in nipple fluid: carbohydrate biomarkers for breast cancer detectionSenthil R Kumar
Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
Clin Cancer Res 11:6868-71. 2005..In 92% of the cancerous breast NAF samples tested, either TF or Tn was found. CONCLUSIONS: Simultaneous measurement of TF and Tn in NAF may facilitate the noninvasive detection of breast cancer and warrants further study... - Can mitochondrial DNA mutations in circulating white blood cells and serum be used to detect breast cancer?Julian E Losanoff
Department of Surgery, John D Dingell VAMC and Wayne State University, Detroit, MI, USA
Breast 17:540-2. 2008..The method used did not detect mtDNA mutations in the blood of women with breast cancer, but was extremely sensitive in polymorphism detection... - Prostate-specific antigen expression in nipple aspirate fluid is associated with advanced breast cancerEdward R Sauter
Department of Surgery, University of Missouri Columbia, M588 Health Sciences Center, One Hospital Drive, Columbia, MO 65212, USA
Cancer Detect Prev 28:27-31. 2004..009), nodal status (P = 0.005), disease stage (P = 0.004), and distant metastases (P = 0.04). NAF PSA provides useful prognostic information which may assist with breast cancer treatment... - Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancyWenyi Qin
Department of Surgery, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Rd, Grand Forks, ND 58202, USA
BMC Cancer 12:100. 2012..Our hypothesis was that proteins linked to breast cancer would be differentially expressed in human milk collected at three time points during lactation based on age at FFTP... - Carbohydrate antigens in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsySusan L Deutscher
University of Missouri, Department of Biochemistry, One Hospital Drive, Columbia, MO 65212, USA
BMC Cancer 10:519. 2010.... - Ductoscopic cytology and image analysis to detect breast carcinomaEdward R Sauter
Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, 65212, USA
Cancer 101:1283-92. 2004.... - Mitochondrial DNA mutations in breast cancer tissue and in matched nipple aspirate fluidWeizhu Zhu
Ellis Fischel Cancer Center, Department of Surgery, University of Missouri, Columbia, MO 65212, USA
Carcinogenesis 26:145-52. 2005..The high frequency of mtDNA mutations at polymorphic loci requires further investigation. Specific mtDNA mutations can be detected in a subset of NAF samples from women with breast cancer... - α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophagesLaurel A Grisanti
Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202 9037, USA
J Pharmacol Exp Ther 338:648-57. 2011..This study characterizes α(1)-AR subtype expression on both human monocyte and macrophage cells and illustrates a mechanism by which increased IL-1β production can be modulated by α(1)-AR input... - Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluidHannah Alexander
Division of Biological Sciences, and Department of Surgery, University of Missouri, Columbia, Missouri 65212, USA
Clin Cancer Res 10:7500-10. 2004..CONCLUSIONS: Our study revealed that the NAF proteome, as defined by two-dimensional PAGE, consists of a limited number of proteins, and that the expression of AAG and GCDFP-15 correlates with disease presence and stage... - Black cohosh does not exert an estrogenic effect on the breastRachel L Ruhlen
Department of Surgery, University of Missouri Columbia, Columbia, MO 65212, USA
Nutr Cancer 59:269-77. 2007..Triterpene content in commercially available black cohosh preparations varies. BCE standardized to 2.5% triterpenes relieved menopausal symptoms without systemic or breast-specific estrogenic effects... - Proteomic analysis of nipple aspirate fluid using SELDI-TOF-MSEdward R Sauter
Department of Surgery, University of Missouri-Columbia, Columbia, MO 65212, USA
Int J Cancer 114:791-6. 2005.... - Ductoscopic cytology to detect breast cancerEdward R Sauter
Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, Columbia, Missouri 65212, USA
Cancer J 10:33-41; discussion 15-6. 2004.... - Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat modelRachel L Ruhlen
Department of Surgery, University of Missouri Columbia, One Hospital Drive, Rm N510, Columbia, MO 65212, USA
Breast Cancer Res Treat 117:517-24. 2009..ERalpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers... - Nipple aspirate fluid color is associated with breast cancerEdward R Sauter
Department of Surgery, University of Missouri Columbia, N510 Health Sciences Center, One Hospital Drive, Columbia, MO 65212, United States
Cancer Detect Prev 30:322-8. 2006.... - The association of bloody nipple discharge with breast pathologyEdward R Sauter
Department of Surgery, University of Missouri-Columbia/Ellis Fischel Cancer Center, Columbia MO 65212, USA
Surgery 136:780-5. 2004..CONCLUSIONS: Breast cancer can present as unilateral nonbloody SND, indicating the importance of surgical intervention. Papilloma was more common in women with SND than without and most often presented as bloody SND... - Association of kallikrein expression in nipple aspirate fluid with breast cancer riskEdward R Sauter
Department of Surgery, University of Missouri, Columbia, MO 65212, USA
Int J Cancer 108:588-91. 2004..hK2 and PSA, and hK6 and hK10 are highly associated. Higher premenopausal PSA levels suggest the influence of ovarian steroids. PSA shows the most promise in aiding in the early detection of breast cancer... - Analysis of nipple aspirate fluid for diagnosis of breast cancer: an alternative to invasive biopsyEdward R Sauter
University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
Expert Rev Mol Diagn 5:873-81. 2005..Herein, the technology is reviewed as it was, as it is today, and its future potential is discussed... - Large-scale mitochondrial DNA deletion mutations and nuclear genome instability in human breast cancerWeizhu Zhu
Ellis Fischel Cancer Center and Department of Surgery, University of Missouri, M588 One Hospital Drive, Columbia, MO 65212, USA
Cancer Detect Prev 28:119-26. 2004.... - Lack of effect of celecoxib on prostaglandin E2 concentrations in nipple aspirate fluid from women at increased risk of breast cancerEdward R Sauter
Department of Surgery, University of Missouri Columbia, One Hospital Drive, Room M588, Columbia, MO 65212, USA
Cancer Epidemiol Biomarkers Prev 13:1745-50. 2004..Among these, prostaglandin E(2) (PGE(2)) has tumor growth-promoting activity. The COX-2 isoform is the primary enzyme involved in PGE(2) production in cancerous tissue... - Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in womenSusan K Raatz
ARS, USDA, Human Nutrition Research Center, Grand Forks, ND 58203, USA
Nutr Res 32:1-7. 2012.... - Serum Müllerian inhibiting substance levels are lower in premenopausal women with breast precancer and cancerAndrew C McCoy
Department of Surgery, University of North Dakota School of Medicine, Grand Forks, ND, USA
BMC Res Notes 4:152. 2011..abstract:.. - Radionuclide-peptide nucleic acid in diagnosis and treatment of pancreatic cancerEric Wickstrom
Department of Biochemistry, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
Methods Mol Med 106:135-91. 2005 - Association of uPA, PAT-1, and uPAR in nipple aspirate fluid (NAF) with breast cancerWenyi Qin
Department of Surgery, University of Missouri, Columbia, Missouri 65212, USA
Cancer J 9:293-301. 2003..DISCUSSION: Our data suggest that PAI-1, alone or in combination with uPA, may be useful as a noninvasive biologic marker to aid in the detection of breast cancer... - Breast cancer after severe burn injury: coincidence or consequence?Julian E Losanoff
Department of Surgery, John D Dingell VAMC and Wayne State University, Detroit, Michigan, USA
Breast J 14:87-9. 2008..Breast lesions in this or a similar clinical scenario should be considered malignant until proven otherwise, and a tissue diagnosis must be pursued without delay... - Ethnic variation in kallikrein expression in nipple aspirate fluidEdward R Sauter
Department of Surgery, Thomas Jefferson University, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA
Int J Cancer 100:678-82. 2002.... - Breast cancer biomarkers predict weight loss after gastric bypass surgeryEdward R Sauter
Departments of Surgery, University of North Dakota School of Medicine and Health Sciences, 501 N, Columbia Rd, Grand Forks, ND 58202, USA
BMC Res Notes 5:82. 2012..abstract:.. - Primary angiosarcoma of the breast: do enlarged axillary nodes matter?Julian E Losanoff
Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
Breast J 12:371-4. 2006..Pathology found no tumor in the lymph nodes. Based on this experience and data from the literature, we suggest evaluation of the sentinel nodes prior to potentially morbid standard level 1 and 2 axillary lymph node clearance... - Pro-inflammatory responses in human monocytes are beta1-adrenergic receptor subtype dependentLaurel A Grisanti
Department of Pharmacology, Physiology and Therapeutics, The University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202 9037, USA
Mol Immunol 47:1244-54. 2010..These results demonstrate a unique synergistic pro-inflammatory response mediated through a beta(1)-AR cAMP-dependent mechanism in LPS-challenged monocytic cells... - Proteomics of nipple aspirate fluid, breast cyst fluid, milk, and colostrumRachel L Ruhlen
Department of Surgery, University of Missouri, Columbia, MO, USA
Proteomics Clin Appl 1:845-52. 2007..A better understanding of the protein composition of milk and colostrum should improve infant care and nutrition, and lead to alternatives for individuals with milk allergies... - Proteomic analysis of breast tissue and nipple aspirate fluid for breast cancer detectionRachel L Ruhlen
University of Missouri Columbia, Department of Surgery, One Hospital Drive, Room N510, Columbia, MO 65212, USA
Biomark Med 1:251-60. 2007..Proteomic analysis of breast biopsies will allow more detailed characterization of the individual's cancer, with therapy tailored to the disease based on this information... - Circulating testosterone and prostate-specific antigen in nipple aspirate fluid and tissue are associated with breast cancerEdward R Sauter
Department of Surgery, Thomas Jefferson University Hospital, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA
Environ Health Perspect 110:241-6. 2002..NAF and serum PSA levels in postmenopausal women are correlated, suggesting that as laboratory assessment of PSA becomes more sensitive, serum PSA may become useful in identifying women with breast cancer... - Prostate-specific antigen and insulin-like growth factor binding protein-3 in nipple aspirate fluid are associated with breast cancerEdward R Sauter
Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Detect Prev 26:149-57. 2002..001). When considered jointly, only NAF PSA was significant. Therefore, NAF PSA, and to a lesser extent NAF IGFBP-3 and serum PSA, seem to be important predictors of breast cancer... - Proteomic analysis of nipple aspirate fluid to detect biologic markers of breast cancerEdward R Sauter
Department of Surgery, Thomas Jefferson University, 1025 Walnut St, Ste 605, Philadelphia, PA 19107, USA
Br J Cancer 86:1440-3. 2002..These findings suggest that (1) differential expression of nipple aspirate fluid proteins exists between women with normal and diseased breasts, and (2) analysis of these proteins may predict the presence of breast cancer...