E R Sauter

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint Nipple aspirate fluid color is associated with breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, N510 Health Sciences Center, One Hospital Drive, Columbia, MO 65212, United States
    Cancer Detect Prev 30:322-8. 2006
  2. doi request reprint Biomarkers associated with breast cancer are associated with obesity
    Edward R Sauter
    Department of Surgery, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
    Cancer Detect Prev 32:149-55. 2008
  3. pmc Black Cohosh: Insights into its Mechanism(s) of Action
    Rachel L Ruhlen
    Departments of Surgery and
    Integr Med Insights 3:21-32. 2008
  4. ncbi request reprint Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer
    E R Sauter
    Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, MO 65212, USA
    Horm Metab Res 36:336-40. 2004
  5. ncbi request reprint Lack of effect of celecoxib on prostaglandin E2 concentrations in nipple aspirate fluid from women at increased risk of breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, One Hospital Drive, Room M588, Columbia, MO 65212, USA
    Cancer Epidemiol Biomarkers Prev 13:1745-50. 2004
  6. ncbi request reprint Analysis of nipple aspirate fluid for diagnosis of breast cancer: an alternative to invasive biopsy
    Edward R Sauter
    University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
    Expert Rev Mol Diagn 5:873-81. 2005
  7. ncbi request reprint Ductoscopic cytology and image analysis to detect breast carcinoma
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, 65212, USA
    Cancer 101:1283-92. 2004
  8. ncbi request reprint Breast cancer detection using mammary ductoscopy
    Edward Sauter
    University of Missouri, Columbia, MO 65212, USA
    Future Oncol 1:385-93. 2005
  9. pmc Celecoxib decreases prostaglandin E2 concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer
    Edward R Sauter
    Surgery, University of Missouri, Columbia, MO 65212, USA
    BMC Cancer 6:248. 2006
  10. ncbi request reprint Prostate-specific antigen expression in nipple aspirate fluid is associated with advanced breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, M588 Health Sciences Center, One Hospital Drive, Columbia, MO 65212, USA
    Cancer Detect Prev 28:27-31. 2004

Research Grants

  1. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
  2. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
  3. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
  4. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
  5. Epigenetic Effects of Resveratrol
    Edward Sauter; Fiscal Year: 2007

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Nipple aspirate fluid color is associated with breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, N510 Health Sciences Center, One Hospital Drive, Columbia, MO 65212, United States
    Cancer Detect Prev 30:322-8. 2006
    ....
  2. doi request reprint Biomarkers associated with breast cancer are associated with obesity
    Edward R Sauter
    Department of Surgery, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
    Cancer Detect Prev 32:149-55. 2008
    ..It was our hypothesis that proteins associated with breast cancer would be associated with body mass index (BMI)...
  3. pmc Black Cohosh: Insights into its Mechanism(s) of Action
    Rachel L Ruhlen
    Departments of Surgery and
    Integr Med Insights 3:21-32. 2008
    ..A variety of activities have been reported for black cohosh and its compounds, but the absorption and tissue distribution of these compounds is unknown...
  4. ncbi request reprint Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer
    E R Sauter
    Ellis Fischel Cancer Center, University of Missouri Columbia, Columbia, MO 65212, USA
    Horm Metab Res 36:336-40. 2004
    ....
  5. ncbi request reprint Lack of effect of celecoxib on prostaglandin E2 concentrations in nipple aspirate fluid from women at increased risk of breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, One Hospital Drive, Room M588, Columbia, MO 65212, USA
    Cancer Epidemiol Biomarkers Prev 13:1745-50. 2004
    ..Among these, prostaglandin E(2) (PGE(2)) has tumor growth-promoting activity. The COX-2 isoform is the primary enzyme involved in PGE(2) production in cancerous tissue...
  6. ncbi request reprint Analysis of nipple aspirate fluid for diagnosis of breast cancer: an alternative to invasive biopsy
    Edward R Sauter
    University of Missouri, One Hospital Drive, Columbia, MO 65212, USA
    Expert Rev Mol Diagn 5:873-81. 2005
    ..Herein, the technology is reviewed as it was, as it is today, and its future potential is discussed...
  7. ncbi request reprint Ductoscopic cytology and image analysis to detect breast carcinoma
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, 65212, USA
    Cancer 101:1283-92. 2004
    ....
  8. ncbi request reprint Breast cancer detection using mammary ductoscopy
    Edward Sauter
    University of Missouri, Columbia, MO 65212, USA
    Future Oncol 1:385-93. 2005
    ..Additional sample evaluation using image or molecular analysis may improve the sensitivity and specificity of MD in breast cancer detection...
  9. pmc Celecoxib decreases prostaglandin E2 concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer
    Edward R Sauter
    Surgery, University of Missouri, Columbia, MO 65212, USA
    BMC Cancer 6:248. 2006
    ..The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer...
  10. ncbi request reprint Prostate-specific antigen expression in nipple aspirate fluid is associated with advanced breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, M588 Health Sciences Center, One Hospital Drive, Columbia, MO 65212, USA
    Cancer Detect Prev 28:27-31. 2004
    ..009), nodal status (P = 0.005), disease stage (P = 0.004), and distant metastases (P = 0.04). NAF PSA provides useful prognostic information which may assist with breast cancer treatment...
  11. ncbi request reprint Ductoscopic cytology to detect breast cancer
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, Columbia, Missouri 65212, USA
    Cancer J 10:33-41; discussion 15-6. 2004
    ....
  12. pmc Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings
    Edward R Sauter
    Department of Surgery, Ellis Fischel Cancer Center at the University of Missouri, Columbia, One Hospital Drive, Columbia, MO 65212, United States
    Cancer Detect Prev 31:50-8. 2007
    ....
  13. pmc Celecoxib concentration predicts decrease in prostaglandin E2 concentrations in nipple aspirate fluid from high risk women
    Edward R Sauter
    Department of Surgery, University of Missouri, Columbia, MO, USA
    BMC Cancer 8:49. 2008
    ....
  14. ncbi request reprint Prospective multicenter trial to determine the feasibility of collection and predictive ability of breast fluid analysis in postmenopausal women receiving SERMs
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, One Hospital Drive, Rm N510, Columbia, MO 65212, USA
    Breast 16:489-94. 2007
    ..Multiinstitutional clinical trials in postmenopausal women using NAF biomarkers as the primary endpoints are feasible...
  15. ncbi request reprint Fiberoptic ductoscopy findings in women with and without spontaneous nipple discharge
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, Columbia, Missouri 65212, USA
    Cancer 103:914-21. 2005
    ....
  16. ncbi request reprint Association of kallikrein expression in nipple aspirate fluid with breast cancer risk
    Edward R Sauter
    Department of Surgery, University of Missouri, Columbia, MO 65212, USA
    Int J Cancer 108:588-91. 2004
    ..hK2 and PSA, and hK6 and hK10 are highly associated. Higher premenopausal PSA levels suggest the influence of ovarian steroids. PSA shows the most promise in aiding in the early detection of breast cancer...
  17. ncbi request reprint Ethnic variation in kallikrein expression in nipple aspirate fluid
    Edward R Sauter
    Department of Surgery, Thomas Jefferson University, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA
    Int J Cancer 100:678-82. 2002
    ....
  18. ncbi request reprint Thomsen-Friedenreich and Tn antigens in nipple fluid: carbohydrate biomarkers for breast cancer detection
    Senthil R Kumar
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    Clin Cancer Res 11:6868-71. 2005
    ..A sensitive and specific antigen capture immunoassay for TF and Tn detection in NAF was developed for this purpose...
  19. pmc Nipple aspirate cytology and pathologic parameters predict residual cancer and nodal involvement after excisional breast biopsy
    E R Sauter
    Department of Surgery, Thomas Jefferson University, Philadephia, PA 19107, USA
    Br J Cancer 85:1952-7. 2001
    ..We propose an algorithm which, if confirmed in a larger study, may allow clinicians to be more selective in their recommendations of re-excision breast biopsy or mastectomy...
  20. pmc uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancer
    Wenyi Qin
    Department of Surgery, University of North Dakota, Grand Forks, ND, USA
    BMC Cancer 8:298. 2008
    ....
  21. ncbi request reprint Prostate-specific antigen and insulin-like growth factor binding protein-3 in nipple aspirate fluid are associated with breast cancer
    Edward R Sauter
    Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Detect Prev 26:149-57. 2002
    ..001). When considered jointly, only NAF PSA was significant. Therefore, NAF PSA, and to a lesser extent NAF IGFBP-3 and serum PSA, seem to be important predictors of breast cancer...
  22. ncbi request reprint Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluid
    Hannah Alexander
    Division of Biological Sciences, and Department of Surgery, University of Missouri, Columbia, Missouri 65212, USA
    Clin Cancer Res 10:7500-10. 2004
    ....
  23. ncbi request reprint Association of uPA, PAT-1, and uPAR in nipple aspirate fluid (NAF) with breast cancer
    Wenyi Qin
    Department of Surgery, University of Missouri, Columbia, Missouri 65212, USA
    Cancer J 9:293-301. 2003
    ....
  24. ncbi request reprint The association of bloody nipple discharge with breast pathology
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia Ellis Fischel Cancer Center, Columbia MO 65212, USA
    Surgery 136:780-5. 2004
    ....
  25. ncbi request reprint Nipple aspirate fluid expression of urokinase-type plasminogen activator, plasminogen activator inhibitor-1, and urokinase-type plasminogen activator receptor predicts breast cancer diagnosis and advanced disease
    Wenyi Qin
    Department of Surgery, University of Missouri, Columbia, Missouri 65212, USA
    Ann Surg Oncol 10:948-53. 2003
    ..We determined the association of uPA, PAI-1, and uPAR levels in NAF with breast cancer (1) detection and (2) advanced disease...
  26. pmc Circulating testosterone and prostate-specific antigen in nipple aspirate fluid and tissue are associated with breast cancer
    Edward R Sauter
    Department of Surgery, Thomas Jefferson University Hospital, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA
    Environ Health Perspect 110:241-6. 2002
    ..NAF and serum PSA levels in postmenopausal women are correlated, suggesting that as laboratory assessment of PSA becomes more sensitive, serum PSA may become useful in identifying women with breast cancer...
  27. pmc Proteomic analysis of nipple aspirate fluid to detect biologic markers of breast cancer
    Edward R Sauter
    Department of Surgery, Thomas Jefferson University, 1025 Walnut St, Ste 605, Philadelphia, PA 19107, USA
    Br J Cancer 86:1440-3. 2002
    ..These findings suggest that (1) differential expression of nipple aspirate fluid proteins exists between women with normal and diseased breasts, and (2) analysis of these proteins may predict the presence of breast cancer...
  28. pmc Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women
    Wenyi Qin
    Department of Surgery, University of Missouri School of Medicine Columbia, One Hospital Drive, Columbia, MO 65212, USA
    Nutr Cancer 61:238-44. 2009
    ..Isoflavones induced dose-specific changes in RARbeta2 and CCND2 gene methylation, which correlated with genistein levels. This work provides novel insights into estrogenic and methylation effects of dietary isoflavones...
  29. ncbi request reprint Black cohosh does not exert an estrogenic effect on the breast
    Rachel L Ruhlen
    Department of Surgery, University of Missouri Columbia, Columbia, MO 65212, USA
    Nutr Cancer 59:269-77. 2007
    ..Triterpene content in commercially available black cohosh preparations varies. BCE standardized to 2.5% triterpenes relieved menopausal symptoms without systemic or breast-specific estrogenic effects...
  30. ncbi request reprint Mitochondrial DNA mutations in breast cancer tissue and in matched nipple aspirate fluid
    Weizhu Zhu
    Ellis Fischel Cancer Center, Department of Surgery, University of Missouri, Columbia, MO 65212, USA
    Carcinogenesis 26:145-52. 2005
    ..The high frequency of mtDNA mutations at polymorphic loci requires further investigation. Specific mtDNA mutations can be detected in a subset of NAF samples from women with breast cancer...
  31. ncbi request reprint Increased expression of the inflammatory protein YKL-40 in precancers of the breast
    Wenyi Qin
    Department of Surgery University of Missouri, Columbia, MO 65121, USA
    Int J Cancer 121:1536-42. 2007
    ..NAF levels of YKL-40 are significantly higher in women with precancers than healthy subjects, suggesting that measuring YKL-40 in NAF may improve the identification of women at increased breast cancer risk...
  32. pmc Nipple aspirate fluid and ductoscopy to detect breast cancer
    Edward R Sauter
    Department of Surgery, University of North Dakota, Grand Forks, North Dakota 58203, USA
    Diagn Cytopathol 38:244-51. 2010
    ..The presence of atypical cells arising from an intraductal papilloma in ductoscopic specimens is a potential source of false positive diagnosis in patients with nipple discharge...
  33. pmc Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model
    Rachel L Ruhlen
    Department of Surgery, University of Missouri Columbia, One Hospital Drive, Rm N510, Columbia, MO 65212, USA
    Breast Cancer Res Treat 117:517-24. 2009
    ..ERalpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers...
  34. ncbi request reprint Proteomic analysis of nipple aspirate fluid using SELDI-TOF-MS
    Edward R Sauter
    Department of Surgery, University of Missouri Columbia, Columbia, MO 65212, USA
    Int J Cancer 114:791-6. 2005
    ....
  35. ncbi request reprint Large-scale mitochondrial DNA deletion mutations and nuclear genome instability in human breast cancer
    Weizhu Zhu
    Ellis Fischel Cancer Center and Department of Surgery, University of Missouri, M588 One Hospital Drive, Columbia, MO 65212, USA
    Cancer Detect Prev 28:119-26. 2004
    ....
  36. doi request reprint Can mitochondrial DNA mutations in circulating white blood cells and serum be used to detect breast cancer?
    Julian E Losanoff
    Department of Surgery, John D Dingell VAMC and Wayne State University, Detroit, MI, USA
    Breast 17:540-2. 2008
    ..The method used did not detect mtDNA mutations in the blood of women with breast cancer, but was extremely sensitive in polymorphism detection...
  37. doi request reprint Breast cancer after severe burn injury: coincidence or consequence?
    Julian E Losanoff
    Department of Surgery, John D Dingell VAMC and Wayne State University, Detroit, Michigan, USA
    Breast J 14:87-9. 2008
    ..Breast lesions in this or a similar clinical scenario should be considered malignant until proven otherwise, and a tissue diagnosis must be pursued without delay...
  38. ncbi request reprint Primary angiosarcoma of the breast: do enlarged axillary nodes matter?
    Julian E Losanoff
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    Breast J 12:371-4. 2006
    ..Pathology found no tumor in the lymph nodes. Based on this experience and data from the literature, we suggest evaluation of the sentinel nodes prior to potentially morbid standard level 1 and 2 axillary lymph node clearance...
  39. ncbi request reprint Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulator
    Carol J Fabian
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Clin Cancer Res 10:5403-17. 2004
    ..We performed a multi-institutional evaluation of arzoxifene in women with newly diagnosed ductal carcinoma in situ or T1/T2 invasive cancer...
  40. ncbi request reprint Nipple aspirate fluids from women with breast cancer contain increased levels of group IIa secretory phospholipase A2
    Ferdinando Mannello
    Institute of Histology and Laboratory Analysis, Faculty of Science and Technology, University of Urbino Carlo Bo, Urbino, 61029, Italy
    Breast Cancer Res Treat 111:209-18. 2008
    ..sPLA2-IIa activity may serve a dual role in breast carcinogenesis, beneficial in its release of arachidonate and detrimental in the metabolic conversion of arachadonic acid into prostaglandins and leukotrienes...
  41. ncbi request reprint Do nipple aspirate fluid epithelial cells and their morphology predict breast cancer development?
    Ferdinando Mannello
    Breast Cancer Res Treat 102:125-7. 2007
  42. ncbi request reprint The 8-epimer of prostaglandin F(2alpha), a marker of lipid peroxidation and oxidative stress, is decreased in the nipple aspirate fluid of women with breast cancer
    Ferdinando Mannello
    Institute of Histology and Laboratory Analysis, University Carlo Bo, Urbino, Italy
    Int J Cancer 120:1971-6. 2007
    ..Active lipid peroxidation may have a physiologic role in the normal mammary gland. Lower levels of 8-iso-PGF(2alpha) in NAF from BC patients suggest altered production of arachidonic acid metabolites during breast carcinogenesis...
  43. ncbi request reprint RE: "Transfer of celecoxib into human milk"
    Rachel L Ruhlen
    J Hum Lact 23:13-4. 2007
  44. ncbi request reprint Monitoring breast skin temperature
    Rachel L Ruhlen
    J Hum Lact 23:232. 2007
  45. ncbi request reprint Imaging oncogene expression
    Xiaobing Tian
    Department of Biochemistry Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Ann N Y Acad Sci 1002:165-88. 2003
    ..This result enables testing of Tc-99m-peptide-PNA probes to image gene expression in tumors...
  46. ncbi request reprint Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters
    Catia Morelli
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 23:7517-26. 2004
    ..In summary, our data suggested that nuclear IRS-1 interacts with ERalpha and that this interaction might influence ERalpha transcriptional activity...
  47. ncbi request reprint Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [99mTc]peptide-peptide nucleic acid-peptide chimera
    Xiaobing Tian
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Bioconjug Chem 16:70-9. 2005
    ..Molecular imaging of oncogene mRNAs in solid tumors with radiolabel-PNA-peptide chimeras might provide additional genetic characterization of preinvasive and invasive breast cancers...
  48. ncbi request reprint External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide-peptide nucleic acid-peptide chimeras
    Xiaobing Tian
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Nucl Med 45:2070-82. 2004
    ....
  49. ncbi request reprint Radionuclide-peptide nucleic acid in diagnosis and treatment of pancreatic cancer
    Eric Wickstrom
    Department of Biochemistry, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Methods Mol Med 106:135-91. 2005

Research Grants5

  1. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
    ..abstract_text> ..
  2. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ....
  3. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  4. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..abstract_text> ..
  5. Epigenetic Effects of Resveratrol
    Edward Sauter; Fiscal Year: 2007
    ..As more and more Americans turn to nutraceuticals for a healthier lifestyle, studies like these are increasingly important in the fight against cancer. ..