J J Sauk

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Cell surface colligin/Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines
    C Hebert
    Department of Pathology, University of Maryland at Baltimore, 21201, USA
    J Cell Biochem 73:248-58. 1999
  2. ncbi request reprint Hsp47 a novel collagen binding serpin chaperone, autoantigen and therapeutic target
    John J Sauk
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, 666 W Baltimore Street, Baltimore, Maryland 21201 1586, USA
    Front Biosci 10:107-18. 2005
  3. ncbi request reprint Binding motifs of CBP2 a potential cell surface target for carcinoma cells
    J J Sauk
    Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
    J Cell Biochem 78:251-63. 2000
  4. ncbi request reprint Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer
    M A Scheper
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, 650 W Baltimore Ave 7 North, Baltimore, MD 21201, USA
    Int J Oral Maxillofac Surg 36:632-9. 2007
  5. ncbi request reprint Non-natural CBP2 binding peptides and peptomers modulate carcinoma cell adhesion and invasion
    C Hebert
    Department of Pathology, University of Maryland, Baltimore 666 W. Baltimore Street Baltimore, Maryland 21201, USA
    J Cell Biochem 82:145-54. 2001
  6. ncbi request reprint Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells
    J Stewart
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, 666 W Baltimore Street, Room 4 E 28, Baltimore, MD 21201 1586, USA
    Oral Oncol 39:862-9. 2003
  7. pmc Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells
    H Siavash
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Br J Cancer 91:1074-80. 2004
  8. ncbi request reprint Targeting the STAT pathway in head and neck cancer: recent advances and future prospects
    N G Nikitakis
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Curr Cancer Drug Targets 4:637-51. 2004
  9. ncbi request reprint Signal transducers and activators of transcription: insights into the molecular basis of oral cancer
    H Siavash
    Department of Biomedical Sciences, University of Maryland, Dental School, 666 West Baltimore Street, Room 4 C 02, Baltimore, MD 21201, USA
    Crit Rev Oral Biol Med 15:298-307. 2004
  10. ncbi request reprint Hsp 47 is localized to regions of type I collagen production in developing murine femurs and molars
    B Shroff
    Department of Pathology, University of Maryland, Baltimore
    Connect Tissue Res 29:273-86. 1993

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Cell surface colligin/Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines
    C Hebert
    Department of Pathology, University of Maryland at Baltimore, 21201, USA
    J Cell Biochem 73:248-58. 1999
    ..These data indicate that colligin/Hsp47 is anchored to the cell membrane in a complex with CD9 where it moderates tumor cell invasion and motility possibly by acting as a serpin protein inhibitor or as a receptor for collagen...
  2. ncbi request reprint Hsp47 a novel collagen binding serpin chaperone, autoantigen and therapeutic target
    John J Sauk
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, 666 W Baltimore Street, Baltimore, Maryland 21201 1586, USA
    Front Biosci 10:107-18. 2005
    ....
  3. ncbi request reprint Binding motifs of CBP2 a potential cell surface target for carcinoma cells
    J J Sauk
    Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
    J Cell Biochem 78:251-63. 2000
    ..These observations were confirmed by cytometric analyses. These data indicate that CBP2 product may provide a molecular target for chemotherapy and/or imaging of malignancies...
  4. ncbi request reprint Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer
    M A Scheper
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, 650 W Baltimore Ave 7 North, Baltimore, MD 21201, USA
    Int J Oral Maxillofac Surg 36:632-9. 2007
    ..These data indicate that survivin is a downstream target and effector of oncogenic Stat3 signalling in SCC, which is targeted by sulindac in a COX-2-independent manner...
  5. ncbi request reprint Non-natural CBP2 binding peptides and peptomers modulate carcinoma cell adhesion and invasion
    C Hebert
    Department of Pathology, University of Maryland, Baltimore 666 W. Baltimore Street Baltimore, Maryland 21201, USA
    J Cell Biochem 82:145-54. 2001
    ..These findings evoke both peptidomimics of native ligands and their peptomers as potential reagents by which to target tumor cells for chemotherapy, imaging, or retargeting viral vectors for gene therapy...
  6. ncbi request reprint Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells
    J Stewart
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, 666 W Baltimore Street, Room 4 E 28, Baltimore, MD 21201 1586, USA
    Oral Oncol 39:862-9. 2003
    ..Furthermore, modulation of the angiogenic switch is most profound during Akt activation than during activation of stress activated kinases...
  7. pmc Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells
    H Siavash
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Br J Cancer 91:1074-80. 2004
    ....
  8. ncbi request reprint Targeting the STAT pathway in head and neck cancer: recent advances and future prospects
    N G Nikitakis
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Curr Cancer Drug Targets 4:637-51. 2004
    ....
  9. ncbi request reprint Signal transducers and activators of transcription: insights into the molecular basis of oral cancer
    H Siavash
    Department of Biomedical Sciences, University of Maryland, Dental School, 666 West Baltimore Street, Room 4 C 02, Baltimore, MD 21201, USA
    Crit Rev Oral Biol Med 15:298-307. 2004
    ..Signal transduction pathways mediated by these oncogenic transcription factors and their regulation in oral cancer are the focus of this review...
  10. ncbi request reprint Hsp 47 is localized to regions of type I collagen production in developing murine femurs and molars
    B Shroff
    Department of Pathology, University of Maryland, Baltimore
    Connect Tissue Res 29:273-86. 1993
    ..These results support the hypothesis that Hsp47 is necessary for the assurance of type I procollagen and is not expressed with other homotrimeric procollagen molecules...
  11. doi request reprint Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas
    M A Scheper
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, MD 21201, USA
    Oral Dis 14:561-8. 2008
    ....
  12. ncbi request reprint MDM2+/CDK4+/p53+ oral liposarcoma: case report and review of the literature
    N G Nikitakis
    Oral and Maxi ofacial Pathology, Dental School, University of Maryland, Baltimore 21201 1586, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:194-201. 2001
    ..Possible implications of molecular and cytogenetic analysis for unraveling the pathogenesis and determining the prognosis of liposarcoma are discussed...
  13. ncbi request reprint Targeting of human squamous carcinomas by SPA470-doxorubicin immunoconjugates
    C Hebert
    Department of Dignostic Sciences and pathology University of Maryland, Baltimore, MD 21201, USA
    J Drug Target 11:101-7. 2003
    ..SPA470-DOX conjugates target SCC cells that express Hsp47/CBP2. The demonstration that SPA470-DOX is effective during hypoxia or conditions that mimic hypoxia presumes the further utility of SPA470-DOX in treating head and neck cancers...
  14. pmc 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells
    N G Nikitakis
    Department of Diagnostic Sciences and Pathology, University of Maryland, 666 W Baltimore Street, Room 4 C 02, Baltimore, MD 21201, USA
    Br J Cancer 87:1396-403. 2002
    ....
  15. ncbi request reprint Hsp47 and the translation-translocation machinery cooperate in the production of alpha 1(I) chains of type I procollagen
    J J Sauk
    Department of Pathology, Dental School, University of Maryland, Baltimore 21201
    J Biol Chem 269:3941-6. 1994
    ..Although Hsp47 appears to possess properties similar to grp78/BiP, Hsp47 binding early during translocation favors a more specialized specific function relative to chain selection or completion of stable folding in type I procollagen...
  16. ncbi request reprint In vitro thermal enhancement of human T-cell leukaemia/lymphoma virus type I (HTLV-I) in HTLV-I-transformed cells
    D Sun
    Department of Pathology, School of Dentistry, University of Maryland, Baltimore 21201
    Res Virol 144:185-91. 1993
    ..The results suggest that physiologic thermal elevations may induce viral production in HTLV-I-infected individuals...
  17. ncbi request reprint Ameloblastoma in children
    R A Ord
    Oral and Maxillofacial Surgery, Baltimore College of Dental Surgery, University of Maryland Medical Systems, Baltimore, MD, USA
    J Oral Maxillofac Surg 60:762-70; discussion, 770-1. 2002
    ....
  18. ncbi request reprint Cowden syndrome: report of a case with immunohistochemical analysis and review of the literature
    Mark A Scheper
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:625-31. 2006
    ..A final diagnosis of Cowden syndrome was made on the basis of established criteria and confirmed using immunohistochemistry directed against PTEN and phosphorylated-AKT...
  19. ncbi request reprint Oral plasmablastic lymphoma in an HIV-negative patient: a case report and review of the literature
    Mark A Scheper
    Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, MD 21201, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:198-206. 2005
    ..The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases...
  20. ncbi request reprint Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck
    Panomwat Amornphimoltham
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda 20892 4330, USA
    Cancer Res 65:9953-61. 2005
    ..These findings identify the Akt-mTOR pathway as a potential therapeutic target for HNSCC, and may provide the rationale for the early clinical evaluation of rapamycin and its analogues in patients with HNSCC...
  21. pmc Hypoxia-inducible factor-1alpha polymorphisms and TSC1/2 mutations are complementary in head and neck cancers
    Carla Hebert
    Department of Diagnostic Sciences and Pathology, University of Maryland Baltimore, Maryland 21201 1586, USA
    Mol Cancer 5:3. 2006
    ..Moreover, we assess for the presence of polymorphisms and mutations in TSC1 and TSC2, to ascertain if dysregulation of such might complement HIF-1alpha expression...
  22. ncbi request reprint The nonsteroidal anti-inflammatory drug sulindac causes down-regulation of signal transducer and activator of transcription 3 in human oral squamous cell carcinoma cells
    Nikolaos G Nikitakis
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, Maryland 21201 1586, USA
    Cancer Res 62:1004-7. 2002
    ..Our results suggest that down-modulation of Stat3 can be induced by sulindac treatment, thus possibly contributing to the antineoplastic effect of this drug...
  23. ncbi request reprint COX-independent antineoplastic effects of sulindac in oral cancer are mediated by survivin down-regulation
    Mark A Scheper
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Anticancer Res 26:4103-13. 2006
    ..Cyclooxygenase (COX) inhibitors are reported to exert anti-proliferative and pro-apoptotic effects on cancer. The effects of COX inhibitors on oral squamous cell carcinoma (SCC) and survivin expression were assessed...
  24. pmc High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma
    Carla Hebert
    Diagnostic Sciences and Pathology, University of Maryland Baltimore, Baltimore, Maryland 21201 1586, USA
    Mol Cancer 6:5. 2007
    ....
  25. ncbi request reprint Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer
    Kalu U E Ogbureke
    Department of Oral Biology and Maxillofacial Pathology, AD1442, Medical College of Georgia, 1120 Fifteenth Avenue, Augusta, GA 30912, USA
    Oral Oncol 43:920-32. 2007
    ..While the production of these SIBLINGs is independent of T, they correlate with oral location of tumor, cognate MMP expression, and for DSPP, the degree of tumor differentiation...
  26. ncbi request reprint Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma
    Gary Warburton
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4532, USA
    J Oral Maxillofac Surg 65:475-84. 2007
    ..In this study, we assess various clinical, histopathological and lymphangiogenic parameters in early stage oral SCC and their association with DNM...
  27. pmc Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma
    Mark A Scheper
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, MD 21201, USA
    Neoplasia 9:192-9. 2007
    ....
  28. ncbi request reprint Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers
    Nikolaos G Nikitakis
    Department of Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore 666 W Baltimore Street, Room 4 C 02, Baltimore, MD 21201 1586, USA
    Oral Oncol 38:201-8. 2002
    ..The literature, pertinent to oral leiomyosarcoma and to molecular analysis of smooth muscle tumors, is reviewed...
  29. doi request reprint Novel adenoviral gene delivery system targeted against head and neck cancer
    Daqing Li
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 118:650-8. 2008
    ..Here, we present a novel recombinant adenovirus vector (Ad5-Flag-LDS) that demonstrated a marked targeting bias against Hsp47, a biomarker for head and neck squamous cell carcinoma (HNSCC)...
  30. ncbi request reprint Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck
    Anjan Nan
    Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, 21201, USA
    J Drug Target 13:189-97. 2005
    ..The results suggest that targetable polymeric conjugates have potential to improve systemic head and neck cancer chemotherapy by increasing tumor localization and reducing dose-limiting toxicity...
  31. ncbi request reprint Targeting of epidermal growth factor receptor by cyclopentenone prostaglandin 15-Deoxy-Delta12,14-prostaglandin J2 in human oral squamous carcinoma cells
    Hessam Siavash
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Cancer Lett 211:97-103. 2004
    ..These findings provide evidence for EGFR downregulation in oral SCC cells through a novel anticancer effect of 15d-PGJ2 that is attributed to the reactive cyclopentenone ring system...
  32. ncbi request reprint The role of apoptosis in oral disease: mechanisms; aberrations in neoplastic, autoimmune, infectious, hematologic, and developmental diseases; and therapeutic opportunities
    Nikolaos G Nikitakis
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore 21201, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:476-90. 2004
    ....
  33. ncbi request reprint Inhibition of cysteine proteinases by autolytic digestion is mediated by CBP2/Hsp47
    Hessam Siavash
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore 21201, USA
    Connect Tissue Res 43:589-94. 2002
    ..Moreover, if CBP2/Hsp47 is shown to involve the multiplexin subclass of collagens, it may further provide a mechanism by which the motogen and angiogenic properties during development and/or neoplasia are regulated...
  34. ncbi request reprint Primary Sjögren syndrome in childhood: report of a case and review of the literature
    Nikolaos G Nikitakis
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore 21201 1586, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:42-7. 2003
    ..The salient features of this rare disease are summarized on the basis of a comprehensive review of the epidemiologic, clinical, and serologic findings of the previously reported cases of PSS in children...
  35. ncbi request reprint The production of the endostatin precursor collagen XVIII in head and neck carcinomas is modulated by CBP2/Hsp47
    Gabriel J Ollins
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, 21201, USA
    Anticancer Res 22:1977-82. 2002
    ..These findings imply that CBP2/Hsp47 may play a role in tumor progression by mediating the endogenous processing of collagen XVIII in tumor cells...
  36. ncbi request reprint Endostatin inhibits nitric oxide and diminishes VEGF and collagen XVIII in squamous carcinoma cells
    Carla Hebert
    Department of Diagnostic Sciences and Pathology, University of Maryland Baltimore, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Int J Cancer 114:195-201. 2005
    ..In conclusion, the direct effect of endostatins on tumor cells is most effective under conditions of low oxygen tension and can be potentiated by the use of nitric oxide synthase inhibitors or NO scavengers...
  37. ncbi request reprint PPARgamma-mediated antineoplastic effect of NSAID sulindac on human oral squamous carcinoma cells
    Nikolaos G Nikitakis
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, MD 21201 1586, USA
    Int J Cancer 98:817-23. 2002
    ..We suggest that upregulation of PPARgamma expression and activation may be, at least partially, responsible for sulindac's antiproliferative effect...
  38. ncbi request reprint Estrogen suppression induces papillary gingival overgrowth in pregnant baboons
    Mark A Reynolds
    Department of Periodontics, University of Maryland, Dental School, Baltimore, MD 21201, USA
    J Periodontol 75:693-701. 2004
    ..Currently, few experimental animal models similar to humans are available to examine regulatory pathways involving sex steroids and the periodontium...
  39. ncbi request reprint Myofibromatosis: a case report with a unique clinical presentation
    Mark A Scheper
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, MD 21201, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:325-30. 2005
    ..All were treated with excision, without recurrence at the primary site...
  40. ncbi request reprint Immunohistochemical expression of angiogenesis-related markers in oral squamous cell carcinomas with multiple metastatic lymph nodes
    Nikolaos G Nikitakis
    Dept of Diagnostic Sciences and Pathology, Dental School, University of Maryland, 666 W Baltimore St, Room 4 C 02, Baltimore, MD 21201 1586, USA
    Am J Clin Pathol 119:574-86. 2003
    ....
  41. ncbi request reprint Cyclic acetal hydrogel system for bone marrow stromal cell encapsulation and osteodifferentiation
    Martha W Betz
    Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA
    J Biomed Mater Res A 86:662-70. 2008
    ..Also, encapsulated BMSCs maintained viability within EH-PEG hydrogels for 7 days. This work demonstrates that the EH-PEG hydrogel is a viable option for the encapsulation and osteodifferentiation of BMSCs...
  42. ncbi request reprint Oral and dental manifestations of vitamin D-dependent rickets type I: report of a pediatric case
    Marlene Zambrano
    Central University of Venezuela, Caracas, Venezuela
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:705-9. 2003
    ..Light microscopic and ultrastructural examination showed abnormalities of dental hard tissues, affecting both enamel and dentin. The differential diagnosis and treatment of VDDRI are discussed...
  43. ncbi request reprint Immunohistochemical evaluation of cell proliferation antigen Ki-67 and apoptosis-related proteins Bcl-2 and caspase-3 in oral granular cell tumor
    Evanthia Chrysomali
    University of Athens, Department of Oral Pathology, Faculty of Dentistry, Greece
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:566-72. 2003
    ..We sought to evaluate the cell proliferation activity and immunohistochemical expression of proteins that promote or inhibit apoptosis in oral granular cell tumor (GCT)...
  44. ncbi request reprint Oral inflammatory myofibroblastic tumor demonstrating ALK, p53, MDM2, CDK4, pRb, and Ki-67 immunoreactivity in an elderly patient
    John K Brooks
    Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, 666 West Baltimore Street, Baltimore, MD 21201 1586, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:716-26. 2005
    ..The recorded positivity for ALK, p53, MDM2, CDK4, pRb, and Ki-67, despite the absence of bcl-2 reactivity, strongly favors the neoplastic origin of the studied tumor...
  45. ncbi request reprint Intraoral proliferative myositis: case report and literature review
    John K Brooks
    Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, Maryland, USA
    Head Neck 29:416-20. 2007
    ..Here we present only the third oral case of proliferative myositis, arising from the tongue of a 65-year-old man...
  46. ncbi request reprint Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome
    Helen Rivera
    Faculty of Dentistry, Central University of Venezuela, Venezuela
    J Oral Pathol Med 32:431-7. 2003
    ..The diffuse infiltrative lymphocytosis syndrome (DILS) in HIV patients is characterized by the persistence of CD8-circulating lymphocytes and lymphocytic infiltration, predominantly in salivary glands...