Leslie J Saucedo

Summary

Affiliation: University of Puget Sound
Country: USA

Publications

  1. ncbi request reprint Filling out the Hippo pathway
    Leslie J Saucedo
    Department of Biology, University of Puget Sound, 1500 North Warner Street, Tacoma, Washington 98416, USA
    Nat Rev Mol Cell Biol 8:613-21. 2007
  2. pmc Drosophila PRL-1 is a growth inhibitor that counteracts the function of the Src oncogene
    Krystle T Pagarigan
    Department of Biology, University of Puget Sound, Tacoma, Washington, USA
    PLoS ONE 8:e61084. 2013
  3. ncbi request reprint Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    Yong Zhang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Nat Cell Biol 5:578-81. 2003
  4. ncbi request reprint Why size matters: altering cell size
    Leslie J Saucedo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Curr Opin Genet Dev 12:565-71. 2002
  5. ncbi request reprint Rheb promotes cell growth as a component of the insulin/TOR signalling network
    Leslie J Saucedo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Nat Cell Biol 5:566-71. 2003
  6. ncbi request reprint Chewing the fat; regulating autophagy in Drosophila
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 USA
    Dev Cell 7:148-50. 2004

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Filling out the Hippo pathway
    Leslie J Saucedo
    Department of Biology, University of Puget Sound, 1500 North Warner Street, Tacoma, Washington 98416, USA
    Nat Rev Mol Cell Biol 8:613-21. 2007
    ..Although poorly characterized in mammals, several components of the Hippo pathway seem to be tumour suppressors in humans...
  2. pmc Drosophila PRL-1 is a growth inhibitor that counteracts the function of the Src oncogene
    Krystle T Pagarigan
    Department of Biology, University of Puget Sound, Tacoma, Washington, USA
    PLoS ONE 8:e61084. 2013
    ..This first examination of PRL in a model organism demonstrates that PRL performs as a tumor suppressor and underscores the necessity of identifying the conditions that enable it to transform into an oncogene in cancer...
  3. ncbi request reprint Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    Yong Zhang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Nat Cell Biol 5:578-81. 2003
    ..Point mutations in the GAP domain of Tsc2 disrupted its ability to regulate Rheb without affecting the ability of Tsc2 to form a complex with Tsc1. Our studies identify Rheb as a molecular target of the TSC tumour suppressors...
  4. ncbi request reprint Why size matters: altering cell size
    Leslie J Saucedo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Curr Opin Genet Dev 12:565-71. 2002
    ..Several physiological repercussions of altering cell size have been identified...
  5. ncbi request reprint Rheb promotes cell growth as a component of the insulin/TOR signalling network
    Leslie J Saucedo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Nat Cell Biol 5:566-71. 2003
    ..Levels of rheb mRNA are rapidly induced in response to protein starvation, and overexpressed Rheb can drive cell growth in starved animals, suggesting a role for Rheb in the nutritional control of cell growth...
  6. ncbi request reprint Chewing the fat; regulating autophagy in Drosophila
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 USA
    Dev Cell 7:148-50. 2004
    ..Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues...