Fred Sattler

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trial
    Fred R Sattler
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Clin Nutr 88:1313-21. 2008
  2. pmc Testosterone and growth hormone improve body composition and muscle performance in older men
    Fred R Sattler
    Departments of Medicine, Division of Biokinesiology, Keck School of Medicine, University of Southern California, 1200 North State Street, Room 6442, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:1991-2001. 2009
  3. ncbi request reprint Metabolic effects of nandrolone decanoate and resistance training in men with HIV
    Fred R Sattler
    Departments of Medicine, Biokinesiology and Physical Therapy, and of Biometry, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Endocrinol Metab 283:E1214-22. 2002
  4. ncbi request reprint Body habitus changes related to lipodystrophy
    Fred Sattler
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Clin Infect Dis 36:S84-90. 2003
  5. pmc Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial
    Fred Sattler
    Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    J Gerontol A Biol Sci Med Sci 66:122-9. 2011
  6. ncbi request reprint A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:4474-82. 2005
  7. ncbi request reprint Effects of androgen therapy on adipose tissue and metabolism in older men
    E Todd Schroeder
    Department of Medicine and Division of Infectious Diseases, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 89:4863-72. 2004
  8. ncbi request reprint Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies
    E Todd Schroeder
    Division of Infectious Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 285:E16-24. 2003
  9. ncbi request reprint Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 284:E120-8. 2003
  10. ncbi request reprint Treatment with oxandrolone and the durability of effects in older men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    J Appl Physiol 96:1055-62. 2004

Research Grants

Collaborators

Detail Information

Publications26

  1. pmc Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trial
    Fred R Sattler
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Clin Nutr 88:1313-21. 2008
    ..HIV patients with wasting are at increased risk of opportunistic complications and fatality...
  2. pmc Testosterone and growth hormone improve body composition and muscle performance in older men
    Fred R Sattler
    Departments of Medicine, Division of Biokinesiology, Keck School of Medicine, University of Southern California, 1200 North State Street, Room 6442, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:1991-2001. 2009
    ..Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat...
  3. ncbi request reprint Metabolic effects of nandrolone decanoate and resistance training in men with HIV
    Fred R Sattler
    Departments of Medicine, Biokinesiology and Physical Therapy, and of Biometry, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Endocrinol Metab 283:E1214-22. 2002
    ..05). These metabolic effects were favorable (other than for HDL), but changes were generally transient (except for HDL in group 2), with measurements returning to baseline 2 mo after the interventions were completed...
  4. ncbi request reprint Body habitus changes related to lipodystrophy
    Fred Sattler
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Clin Infect Dis 36:S84-90. 2003
    ..Very limited evidence in persons infected with HIV has suggested that a supervised exercise program may be beneficial...
  5. pmc Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial
    Fred Sattler
    Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    J Gerontol A Biol Sci Med Sci 66:122-9. 2011
    ....
  6. ncbi request reprint A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment
    Thomas W Storer
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 90:4474-82. 2005
    ....
  7. ncbi request reprint Effects of androgen therapy on adipose tissue and metabolism in older men
    E Todd Schroeder
    Department of Medicine and Division of Infectious Diseases, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 89:4863-72. 2004
    ..Thus, therapy with an androgen that does not adversely affect lipids may be beneficial for some components of the metabolic syndrome in overweight older men with low testosterone levels...
  8. ncbi request reprint Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies
    E Todd Schroeder
    Division of Infectious Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 285:E16-24. 2003
    ..001) for hamstrings, and 0.73 +/- 0.19 to 1.07 +/- 0.16 kg/cm2 (+55 +/- 36%; P < 0.001) for quadriceps. Thus androgen therapy alone did not improve muscle quality, but the addition of RT to nandrolone produced substantive improvements...
  9. ncbi request reprint Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 284:E120-8. 2003
    ..001), and HDL-cholesterol decreased by -19 +/- 9 and -23 +/- 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength and decreased fat mass in older men...
  10. ncbi request reprint Treatment with oxandrolone and the durability of effects in older men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    J Appl Physiol 96:1055-62. 2004
    ..Anabolic improvements were lost 12 wk after discontinuing oxandrolone, whereas improvements in fat mass were largely sustained...
  11. ncbi request reprint Reliability of maximal voluntary muscle strength and power testing in older men
    E Todd Schroeder
    University of Southern California, Departments of Medicine and Biokinesiology and Physical Therapy, 1540 East Alcazar St, CHP 155, Los Angeles, CA 90089, USA
    J Gerontol A Biol Sci Med Sci 62:543-9. 2007
    ..We hypothesized that performing these measures twice within 7-10 days would demonstrate a >5% increase due to learning and familiarization of the testing procedures...
  12. ncbi request reprint Six-week improvements in muscle mass and strength during androgen therapy in older men
    E Todd Schroeder
    Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90089, USA
    J Gerontol A Biol Sci Med Sci 60:1586-92. 2005
    ..The purpose of our study was to assess the early effects of a potent anabolic androgen on muscle mass and strength, lower extremity power, and functional performance in older men...
  13. ncbi request reprint B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patients
    William Stohl
    Division of Rheumatology, Department of Medicine, Los Angeles County, Los Angeles, CA, USA
    Clin Immunol 104:115-22. 2002
    ..This raises the possibility that the combination of a BLyS protein antagonist with an agent that targets (helper) T cells may have salutary synergistic effects on autoantibody production in diseases such as systemic lupus erythematosus...
  14. ncbi request reprint Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial
    Kathleen Mulligan
    Department of Medicine, University of California, San Francisco, California 94110, USA
    J Clin Endocrinol Metab 92:563-70. 2007
    ..Reduced energy intake is a primary factor in HIV-associated wasting. Megestrol acetate (MA) stimulates appetite and weight gain. However, much of the weight gained is fat, possibly as a result of MA-induced hypogonadism...
  15. ncbi request reprint Cardiopulmonary responses to eccentric and concentric resistance exercise in older adults
    Alberto F Vallejo
    University of Southern California, Biokinesiolgy, Los Angeles, CA, USA
    Age Ageing 35:291-7. 2006
    ..In older ambulatory persons, exercise strategies that are expected to generate beneficial muscle adaptations with low cardiopulmonary demands are needed...
  16. ncbi request reprint Satellite cell numbers in young and older men 24 hours after eccentric exercise
    Hans C Dreyer
    Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, USA
    Muscle Nerve 33:242-53. 2006
    ..These data suggest that age-related changes in satellite cell recruitment may contribute to muscle regeneration deficits among the elderly...
  17. doi request reprint Hormone replacement therapy and messenger RNA expression of estrogen receptor coregulators after exercise in postmenopausal women
    Christina M Dieli-Conwright
    Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, University of Southern California, Los Angeles, CA 90033, USA
    Med Sci Sports Exerc 42:422-9. 2010
    ..Specifically, it is unknown if HRT enhances estrogen receptor (ER) transcriptional activation in skeletal muscle at rest and after resistance exercise...
  18. ncbi request reprint Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial
    E Todd Schroeder
    Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
    Clin Trials 4:560-71. 2007
    ..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging...
  19. pmc Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis
    Alejandro Sanchez
    Division of Infectious Diseases, Department of Medicine, The Keck School of Medicine and the School of Pharmacy of the University of Southern California, IRD Building, Room 432, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Tuberc Res Treat 2011:346295. 2011
    ..CRP levels declined by ∼50% at each interval visit. Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation...
  20. doi request reprint Estimation of glomerular filtration rate by using serum cystatin C and serum creatinine concentrations in patients with human immunodeficiency virus
    Paul M Beringer
    Department of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Pharmacotherapy 30:1004-10. 2010
    ....
  21. ncbi request reprint Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy
    Michael P Dube
    Department of Medicine, Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Infect Dis 35:475-81. 2002
    ..A trend toward insulin resistance appeared late in the study following weight gain, particularly of trunk fat, but without loss of limb fat...
  22. ncbi request reprint Pathogenesis and treatment of lipodystrophy: what clinicians need to know
    Fred R Sattler
    Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Top HIV Med 16:127-33. 2008
    ..Sattler, MD, at an International AIDS Society--USA Continuing Medical Education course in Washington, DC, in May 2008. The original presentation is available as a Webcast at www.iasusa.org...
  23. pmc Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal women
    Christina M Dieli-Conwright
    Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, University of Southern California, Los Angeles, California, USA
    J Appl Physiol 107:1381-8. 2009
    ..Furthermore, postmenopausal women using HRT experienced a greater myogenic response to maximal eccentric exercise...
  24. ncbi request reprint Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy
    Erika M Young
    Department of Medicine and Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202 2879, USA
    Cardiovasc Toxicol 4:179-86. 2004
    ..This improvement occurred independent of development of insulin resistance, which occurred only with indinavir...
  25. pmc Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling
    Satoshi Fujita
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0460, USA
    Diabetes 56:1615-22. 2007
    ..05). In conclusion, a bout of aerobic exercise restores the anabolic response of muscle proteins to insulin by improving endothelial function and Akt/mTOR signaling in older subjects...
  26. ncbi request reprint Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trial
    Kathleen Mulligan
    Division of Endocrinology, San Francisco General Hospital, 1001 Potrero Avenue, Rm 3501K, San Francisco, CA 94110, USA
    Arch Intern Med 165:578-85. 2005
    ..Although studies have examined a variety of anabolic therapies in HIV-infected men, the safety and efficacy of such treatments in women have not been adequately studied...

Research Grants7

  1. HORMONAL REGULATORS OF MUSCLE AND METABOLISM IN AGING
    Fred Sattler; Fiscal Year: 2005
    ..The results should also provide valuable information for future testing of new, novel treatment strategies, which are more tolerable and convenient than parenteral therapies for age associated sarcopenia. ..
  2. UNIVERSITY OF SOUTHERN CALIFORNIA CLINICAL TRIALS UNIT
    Fred Sattler; Fiscal Year: 2007
    ..g. East LA) that will often be applicable for the care of patients in developing countries. ADMINISTRATIVE COMPONENT: ..