Minoru Satoh

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases
    Yoshioki Yamasaki
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, PO Box 100221, Gainesville, Florida 32610, USA
    Arthritis Res Ther 8:R111. 2006
  2. ncbi request reprint Autoantibodies that stabilize U1snRNP are a significant component of human autoantibodies to snRNP and delay proteolysis of sm antigens in vitro
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    J Rheumatol 31:2382-9. 2004
  3. ncbi request reprint Induction of lupus autoantibodies by adjuvants
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, P O Box 100221, 1600 SW Archer Road, Gainesville, FL 32610 0221, USA
    J Autoimmun 21:1-9. 2003
  4. ncbi request reprint Clinical implication of autoantibodies in patients with systemic rheumatic diseases
    Minoru Satoh
    University of Florida, Division of Rheumatology and Clinical Immunology, Department of Medicine, Department of Pathology, Immunology, and Laboratory Medicine, PO Box 100221, Gainesville, FL 32610 0221, USA
    Expert Rev Clin Immunol 3:721-38. 2007
  5. ncbi request reprint X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupus
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Int Immunol 15:1117-24. 2003
  6. pmc B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus
    Dina C Nacionales
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610, USA
    J Immunol 182:4226-36. 2009
  7. pmc Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)
    Dina C Nacionales
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Am J Pathol 168:1227-40. 2006
  8. ncbi request reprint Pristane-induced autoimmunity in germ-free mice
    Akiei Mizutani
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Clin Immunol 114:110-8. 2005
  9. pmc Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
  10. pmc Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis
    Prasanthi Kakumanu
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, Florida 32610 0221, USA
    J Rheumatol 36:2682-90. 2009

Research Grants

Detail Information

Publications81

  1. pmc Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases
    Yoshioki Yamasaki
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, PO Box 100221, Gainesville, Florida 32610, USA
    Arthritis Res Ther 8:R111. 2006
    ..4% of SLE and other diseases). Other autoantibodies found in SLE were rare in this subset, suggesting that patients with anti-RPA may form a unique clinical and immunological subset...
  2. ncbi request reprint Autoantibodies that stabilize U1snRNP are a significant component of human autoantibodies to snRNP and delay proteolysis of sm antigens in vitro
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    J Rheumatol 31:2382-9. 2004
    ..The biological significance of stabilizing antibodies was investigated by titering anti-U1-C/U1-A compared to stabilizing antibodies, and by examining the effects of stabilizing antibodies on antigen processing...
  3. ncbi request reprint Induction of lupus autoantibodies by adjuvants
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, P O Box 100221, 1600 SW Archer Road, Gainesville, FL 32610 0221, USA
    J Autoimmun 21:1-9. 2003
    ..The potential to induce autoimmunity may complicate the use of oil adjuvants in human and veterinary vaccines...
  4. ncbi request reprint Clinical implication of autoantibodies in patients with systemic rheumatic diseases
    Minoru Satoh
    University of Florida, Division of Rheumatology and Clinical Immunology, Department of Medicine, Department of Pathology, Immunology, and Laboratory Medicine, PO Box 100221, Gainesville, FL 32610 0221, USA
    Expert Rev Clin Immunol 3:721-38. 2007
    ..Clinical approaches in differential diagnosis of antinuclear antibodies and the significance of antinuclear antibodies in healthy individuals are also discussed...
  5. ncbi request reprint X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupus
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Int Immunol 15:1117-24. 2003
    ..The spontaneous production of anti-RHA by xid mice and its suppression by pristane treatment at the level of autoantibody induction supports the idea that lupus autoantibodies may be generated through a variety of mechanisms...
  6. pmc B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus
    Dina C Nacionales
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610, USA
    J Immunol 182:4226-36. 2009
    ....
  7. pmc Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)
    Dina C Nacionales
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Am J Pathol 168:1227-40. 2006
    ..In view of the increased IFN-I production in systemic lupus erythematosus, these studies suggest that IFN-I from ectopic lymphoid tissue could play a role in the pathogenesis of experimental lupus in mice...
  8. ncbi request reprint Pristane-induced autoimmunity in germ-free mice
    Akiei Mizutani
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Clin Immunol 114:110-8. 2005
    ..Although microbial stimulation acts synergistically with pristane, these results clearly indicate that pristane does not act merely by increasing exposure to microbial products such as LPS...
  9. pmc Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
    ..Continuous monocyte recruitment and the lack of terminal differentiation induced by IFN-I may help sustain the chronic inflammatory response...
  10. pmc Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis
    Prasanthi Kakumanu
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, Florida 32610 0221, USA
    J Rheumatol 36:2682-90. 2009
    ..We investigated the citrulline dependence of anti-CCP and its significance in the arthritis of SLE...
  11. pmc Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus
    Yuan Xu
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 188:4113-21. 2012
    ..Additionally, we uncovered a new, IFN-I-independent role of IRF5 in regulating chemokines involved in the homing of pDCs and certain lymphocyte subsets...
  12. pmc Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane
    Tolga T Barker
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Lab Invest 91:1540-50. 2011
    ..028). Pristane-induced alveolar hemorrhage is a useful model to study the pathogenesis and develop new therapy for this underappreciated and often life-threatening complication of SLE...
  13. pmc Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus
    Yi Li
    Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0221, USA
    Arthritis Res Ther 12:R90. 2010
    ..The aim of this study was to identify a surrogate marker for IFN-I activity in clinical samples for monitoring disease activity and response to therapy...
  14. pmc Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL, 32610 USA
    Arthritis Res Ther 13:R73. 2011
    ..Here the clinical association of anti-topo I was reevaluated in unselected patients seen in a rheumatology clinic setting...
  15. pmc TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Exp Med 205:2995-3006. 2008
    ..Collectively, the data demonstrate that TMPD-stimulated IFN-I production requires TLR7/MyD88 signaling and is independent of autoantibody-mediated uptake of ribonucleoproteins by FcgammaRs...
  16. ncbi request reprint Autoantibodies to RNA helicase A: a new serologic marker of early lupus
    Yoshioki Yamasaki
    University of Florida, Gainesville, FL 32610, USA
    Arthritis Rheum 56:596-604. 2007
    ..To investigate the clinical and immunologic significance of autoantibodies to RNA helicase A (RHA) in patients with systemic rheumatic diseases...
  17. pmc IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1747-54. 2011
    ..Taken together, our findings uncover an IL-1α-dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation...
  18. pmc Deficiency of the type I interferon receptor protects mice from experimental lupus
    Dina C Nacionales
    University of Florida College of Medicine, Gainesville, Florida, USA
    Arthritis Rheum 56:3770-83. 2007
    ..The objective of this study was to examine the role of IFN-I signaling in the pathogenesis of murine lupus induced by 2,6,10,14-tetramethylpentadecane (TMPD)...
  19. ncbi request reprint Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice
    Yoshiki Kuroda
    Division of Rheumatology and Clinical Immunology, Department of Medicine, ARB R2 156, 1600 SW Archer Road, Box 100221, Gainesville, FL 32610 0221, USA
    Toxicology 218:186-96. 2006
    ..These previously unrecognized immunological effects of n-hexadecane may have implications in monitoring human exposure to hydrocarbons and in the pathogenesis of autoimmune diseases...
  20. pmc Atypical clinical presentation of a subset of patients with anti-RNA polymerase III--non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining
    Angela Ceribelli
    Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL 32610 0424, USA
    Arthritis Res Ther 13:R119. 2011
    ..The clinical presentation of anti-RNAP III positive patients, onset of Raynaud's phenomenon (RP) and SSc in unselected patients in a rheumatology clinic were evaluated...
  21. pmc Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cells
    Kaleb M Pauley
    Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
    Immunol Cell Biol 88:205-12. 2010
    ..These data show that the increase in size and number of GWB may serve as a biomarker for miRNA-mediated gene regulation, and miR-146a has a significant role in the regulation of LPS-induced cytokine production in THP-1 cells...
  22. ncbi request reprint In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen
    Kindra M Kelly-Scumpia
    University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
    Arthritis Rheum 56:3379-86. 2007
    ..This study was undertaken to examine whether U1 RNA possesses adjuvant activity in vivo...
  23. pmc Effect of an exogenous trigger on the pathogenesis of lupus in (NZB x NZW)F1 mice
    Hideo Yoshida
    Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Arthritis Rheum 46:2235-44. 2002
    ..This study examined the interactions between exogenous and endogenous factors shaping the phenotype of lupus in autoimmune (NZB x NZW)F(1) mice exposed to pristane, a model environmental trigger...
  24. pmc Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    Kaleb M Pauley
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    Arthritis Res Ther 10:R101. 2008
    ..In this study, the expression of selected microRNAs is examined in rheumatoid arthritis...
  25. ncbi request reprint Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine
    Yoshiki Kuroda
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, ARB R2 156, 1600 SW Archer Road, P O Box 100221 Gainesville, FL 32610 0221, USA
    Biomed Pharmacother 58:325-37. 2004
    ..Nevertheless, the potential of adjuvant hydrocarbon oils to induce autoimmunity has implications in the use of oil adjuvants in human and veterinary vaccines as well as basic research...
  26. pmc A novel type I IFN-producing cell subset in murine lupus
    Pui Y Lee
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610 0221, USA
    J Immunol 180:5101-8. 2008
    ..Therefore, immature monocytes rather than DCs appear to be the primary source of IFN-I in this model of IFN-I-dependent lupus...
  27. pmc Autoimmune targeting of key components of RNA interference
    Andrew Jakymiw
    Department of Oral Biology, University of Florida, 1600 S, W, Archer Road, Gainesville, FL 32610, USA
    Arthritis Res Ther 8:R87. 2006
    ..Together, these results demonstrate an autoimmune response to components of the RNAi pathway which could potentially implicate the involvement of an innate anti-viral response in the pathogenesis of autoantibody production...
  28. pmc Autoantibodies to transcription intermediary factor TIF1β associated with dermatomyositis
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, P, O, Box 100221, 1600 SW Archer Rd, Gainesville, FL 32610 0221, USA
    Arthritis Res Ther 14:R79. 2012
    ..A 120 kD protein recognized by certain patients with DM was identified and clinical features of patients with this specificity were characterized...
  29. pmc Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies
    Malgorzata E Krzyszczak
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
    Clin Rheumatol 30:1333-9. 2011
    ..04). The production of SSc-related autoantibodies is gender and race dependent, and this can be highly relevant in understanding their clinical significance...
  30. pmc Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus
    Erinn S Kellner
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
    J Neuroimmunol 223:13-9. 2010
    ..Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE...
  31. pmc Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus
    Yi Li
    Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0221, USA
    Arthritis Res Ther 11:R6. 2009
    ..The goal of this study was to determine whether expression of Fc receptor (FcgammaR) I on circulating monocytes is associated with systemic inflammation and renal disease in SLE patients...
  32. ncbi request reprint The role of GW/P-bodies in RNA processing and silencing
    Andrew Jakymiw
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    J Cell Sci 120:1317-23. 2007
    ..Here, we propose a working model for GW body assembly in terms of its relationship to RNA interference. In this process, one or more heteromeric protein complexes accumulate in successive steps into larger ribonucleoprotein structures...
  33. pmc Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibody
    Keigo Ikeda
    Department of Oral Biology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0424, USA
    J Immunol Methods 317:38-44. 2006
    ..Since Ago2 protein is the effector protein of RNAi, anti-Ago2 monoclonal antibody may be useful in capturing functional miRNAs...
  34. ncbi request reprint Distinctive patterns of autoimmune response induced by different types of mineral oil
    Yoshiki Kuroda
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, Florida 32610 0221, USA
    Toxicol Sci 78:222-8. 2004
    ..Induction of autoantibodies by mineral oils considered nontoxic also may have pathogenetic implications in human autoimmune diseases...
  35. ncbi request reprint Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis
    Yoshioki Yamasaki
    University of Florida, Gainesville, USA
    Arthritis Rheum 54:2004-9. 2006
    ..Although anti-PL-7, similar to anti-Jo-1, is associated with PM/DM with ILD, muscle involvement in the patients with anti-PL-7 appeared to be milder than that in the anti-Jo-1 subset...
  36. ncbi request reprint Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies
    Yoshioki Yamasaki
    University of Florida, Gainesville, FL 32610 0221, USA
    Arthritis Rheum 54:3051-6. 2006
    ..In addition, the relationships between nucleolar staining and levels of anti-RNAP III antibodies were examined by enzyme-linked immunosorbent assay (ELISA) and immunoprecipitation (IP) assay...
  37. pmc Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 190:1250-63. 2013
    ....
  38. pmc Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis
    Angela Ceribelli
    Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL 32610 0424, USA
    Arthritis Res Ther 14:R97. 2012
    ..Anti-MJ antibodies, which recognize the nuclear protein NXP-2/MORC3, are reported in ~25% of juvenile DM. Prevalence and clinical significance of anti-MJ antibodies in adult Italian PM/DM patients were studied...
  39. doi request reprint Autoantibodies to Argonaute 2 (Su antigen)
    Minoru Satoh
    Department of Medicine, University of Florida, FL 32610 0221, USA
    Adv Exp Med Biol 768:45-59. 2013
    ..The clinical significance and the mechanism of production of anti-Su/Ago2 remains to be clarified...
  40. ncbi request reprint "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60
    Kindra M Kelly
    University of Florida, Gainesville, USA
    Arthritis Rheum 54:1557-67. 2006
    ..We undertook this study to investigate whether the RNA components of these antigens, which contain extensive tracts of single- and double-stranded RNA, signatures of viral infection, activate innate immunity...
  41. ncbi request reprint Ecotropic murine leukemia viruses and exogenous mouse mammary tumor viruses are not essential for pristane-induced lupus
    Jun Akaogi
    University of Florida, Gainesville, FL, USA
    Arthritis Rheum 48:2990-2. 2003
  42. ncbi request reprint Role of non-protein amino acid L-canavanine in autoimmunity
    Jun Akaogi
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Autoimmun Rev 5:429-35. 2006
    ..Alfalfa/L-canavanine-induced lupus will be an interesting model of autoimmunity induced by the modification of self-proteins at the translational level...
  43. ncbi request reprint Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing
    Songqing Li
    Departments of Oral Biology and Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    J Cell Sci 121:4134-44. 2008
    ..Our data demonstrated that GW182 and, probably, TNGW1 acted as a repressor in Ago2-mediated translational silencing. Furthermore, TNGW1 might contribute to diversity in the formation and function of GW and/or P bodies...
  44. ncbi request reprint Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients
    Wendy C Carcamo
    Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
    J Clin Immunol 33:420-6. 2013
    ..Our aim is to examine anti-RR antibodies specificity and correlation with the response to IFN/R therapy in two independent cohorts (US and Italy) of HCV patients...
  45. ncbi request reprint Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089, USA
    J Immunol 171:1564-71. 2003
    ..Furthermore, these results also question the apparent equation of the effect of Stat deficiency with loss of secretion or response to particular cytokines...
  46. pmc Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen
    Jason S Weinstein
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
    J Immunol 181:3259-67. 2008
    ..This has implications for understanding the strong association of humoral autoimmunity with lymphoid neogenesis, which may be associated with deficient censoring of autoreactive cells...
  47. pmc Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins
    Minoru Satoh
    University of Florida, Gainesville, FL, USA
    Arthritis Rheum 63:1972-8. 2011
    ..The purpose of this study was to examine the target antigens and clinical manifestations associated with this specificity...
  48. ncbi request reprint Nephritogenic autoantibodies but absence of nephritis in Il-12p35-deficient mice with pristane-induced lupus
    Nicola Calvani
    Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, Florida, USA
    Kidney Int 64:897-905. 2003
    ..We investigated the role of IL-12 for lupus-like disease induced by pristane. IL-12p35-deficient (-/-) and control (+/+) BALB/c mice were treated with pristane or phosphate-buffered saline (PBS)...
  49. pmc Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies
    Shangli Lian
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Mol Biol Cell 18:3375-87. 2007
    ..We propose that RNAi is a key regulatory mechanism for the assembly of GWB, and in some cases, GWB may serve as markers for RNAi in mammalian cells...
  50. ncbi request reprint Lack of chromatin and nuclear fragmentation in vivo impairs the production of lupus anti-nuclear antibodies
    Lorenza Frisoni
    Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19140, USA
    J Immunol 179:7959-66. 2007
    ..Thus, our work in vivo strongly suggests that apoptotic molecular steps during cell death generate nuclear autoantigens to sustain the specific autoimmune response in systemic lupus erythematosus...
  51. ncbi request reprint Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus
    Haoyang Zhuang
    Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
    Clin Immunol 117:238-50. 2005
    ....
  52. pmc Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1723-34. 2011
    ..Our studies have thus demonstrated that miR-146a plays a crucial role for in vitro monocytic cell-based endotoxin-induced cross-tolerance...
  53. pmc miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 284:34590-9. 2009
    ..Thus our studies demonstrated that miR-146a is critical for the in vitro monocytic cell-based endotoxin tolerance...
  54. ncbi request reprint Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production
    Jun Akaogi
    University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
    J Leukoc Biol 76:227-36. 2004
    ..PGE(2) can modulate inflammatory reactions via the EP2/4 receptor through its regulation of TNF-alpha and IL-6. Modification of EP signaling may be a new therapeutic strategy in inflammatory/autoimmune diseases...
  55. pmc Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide
    Prasanthi Kakumanu
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Arthritis Rheum 58:1576-81. 2008
    ....
  56. pmc Induction of autoimmunity by pristane and other naturally occurring hydrocarbons
    Westley H Reeves
    Division of Rheumatology and Clinical Immunology, and Laboratory Medicine, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, United States
    Trends Immunol 30:455-64. 2009
    ..This model is well suited for examining links between dysregulated IFN-I production and the pathogenesis of human SLE, which like TMPD-lupus, is associated with high levels of IFN-I...
  57. ncbi request reprint Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p
    Haoyang Zhuang
    University of Florida, Gainesville, USA
    Arthritis Rheum 54:1573-9. 2006
    ..These latter 2 subjects had 3 copies of the IFN gene cluster...
  58. doi request reprint MicroRNA-146a in autoimmunity and innate immune responses
    Edward K L Chan
    Correspondence to Professor Edward K L Chan, Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
    Ann Rheum Dis 72:ii90-5. 2013
    ....
  59. pmc A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis
    Angela Ceribelli
    Department of Oral Biology, University of Florida, P, O, Box 100424, 1395 Center Drive, Gainesville, FL 32610 0424, USA
    Arthritis Res Ther 14:R128. 2012
    ..We aimed at establishing a novel quantitative real time PCR (qPCR) method to detect these antibodies...
  60. pmc Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 9:21. 2011
    ..In the present study we investigated the feasibility of hAAT monotherapy for the treatment of chronic arthritis in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA)...
  61. pmc MicroRNA in TLR signaling and endotoxin tolerance
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, FL, USA
    Cell Mol Immunol 8:388-403. 2011
    ..Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases...
  62. ncbi request reprint Effective use of autoantibody tests in the diagnosis of systemic autoimmune disease
    Robert Lyons
    Division of Rheumatology and Clinical Immunology, University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
    Ann N Y Acad Sci 1050:217-28. 2005
    ....
  63. pmc MicroRNAs in systemic rheumatic diseases
    Angela Ceribelli
    Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, Florida 32610 0424, USA
    Arthritis Res Ther 13:229. 2011
    ..The ultimate goal is the identification of a miRNA target or targets that could be manipulated through specific therapies, aiming at activation or inhibition of specific miRNAs responsible for the development of disease...
  64. ncbi request reprint Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting
    Sonali Narain
    Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Program in Epidemiology and Public Health, and Department of Biostatistics, University of Florida, Gainesville, USA
    Arch Intern Med 164:2435-41. 2004
    ..Since misdiagnosis of systemic autoimmune diseases can have serious consequences, we evaluated community physicians' accuracy in diagnosing autoimmune diseases and the consequences of misdiagnosis...
  65. doi request reprint Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Clin Rev Allergy Immunol 42:16-25. 2012
    ....
  66. pmc Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells
    Wendy C Carcamo
    Department of Oral Biology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e29690. 2011
    ..In the present study, the formation of these conserved structures in mammalian cells and functions linked to these structures were examined...
  67. doi request reprint Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Gene Med 12:35-44. 2010
    ..In order to develop a new treatment option, the present study employs a gene therapy-based combination therapy using doxycycline and human alpha-1 antitrypsin (hAAT)...
  68. doi request reprint Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
    Fish Shellfish Immunol 30:1080-6. 2011
    ..Evaluation for polyclonal hypergamamglobulinemia and autoimmunity should be included as an important trait when vaccine efficacy and safety are evaluated in future...
  69. pmc MicroRNAs in rheumatoid arthritis
    Angela Ceribelli
    Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
    FEBS Lett 585:3667-74. 2011
    ..In fact, the expression of some microRNAs, such as miR-146a, is upregulated in different cell types and tissues in RA patients. MicroRNAs in RA could also be considered as possible future targets for new therapeutic approaches...
  70. pmc Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases
    Minoru Satoh
    Division of Rheumatology and Clinical Immunology, Department of Medicine, and Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA
    Mod Rheumatol 19:219-28. 2009
    ..Clinicians should be able to use autoantibody tests more efficiently and effectively with a basic knowledge on the significance of and potential problems in autoantibody tests...
  71. pmc Requirement of Rac1 in the development of cardiac hypertrophy
    Minoru Satoh
    Cardiovascular and Hematology Divisions, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7432-7. 2006
    ..These results indicate that Rac1 is critical for the hypertrophic response in the heart and suggest that therapies which target myocardial Rac1 may be beneficial in the treatment of cardiac hypertrophy...
  72. ncbi request reprint The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells
    Eric S Sobel
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville 32610, USA
    J Immunol 169:2694-700. 2002
    ....
  73. ncbi request reprint Disruption of GW bodies impairs mammalian RNA interference
    Andrew Jakymiw
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Nat Cell Biol 7:1267-74. 2005
    ..Our data support a model in which GW182 and/or the microenvironment of the cytoplasmic GWBs contribute to the RNA-induced silencing complex and to RNA silencing...
  74. ncbi request reprint Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis
    Jun Qi Yang
    Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:2142-53. 2003
    ..These findings suggest that CD1d may play an immunoregulatory role in the development of lupus in the pristane-induced model...
  75. ncbi request reprint Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome
    Sanil J Manavalan
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:187-98. 2004
    ..g., due to genomic deletion) has functional significance. We examined this question in relation to a known 21.6-kb insertion/deletion-related polymorphism (IDRP) in the human BV locus...
  76. ncbi request reprint [Immunologic tests: Anti SS-A/Ro, anti SS-B/La antibody]
    Tetsuroh Okano
    Department of Immunology, School of Allied Health Science, Kitasato University
    Nihon Rinsho 63:495-8. 2005
  77. ncbi request reprint [Immunologic tests: Anti Ki/PA28gamma antibody]
    Tetsuroh Okano
    Department of Immunology, School of Allied Health Science, Kitasato University
    Nihon Rinsho 63:519-22. 2005
  78. ncbi request reprint Olmesartan ameliorates renovascular injury and oxidative stress in Zucker obese rats enhanced by dietary protein
    Tamehachi Namikoshi
    Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan
    Am J Hypertens 20:1085-91. 2007
    ..This study investigated whether dietary protein intake enhances renal and vascular injuries by oxidative stress, and assessed effects of olmesartan, an angiotensin II type 1 receptor blocker, in this model...
  79. ncbi request reprint Intravenous cyclophosphamide therapy in a case with refractory thrombotic microangiopathic hemolytic anemia and SLE
    Jun Akaogi
    Division of Rheumatology and Allergy, Department of Internal Medicine, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa, 216 8511, Japan
    Clin Rheumatol 23:541-3. 2004
    ..Immunosuppressive therapy at an early stage of the disease may be beneficial in refractory cases of TMHA with autoimmune features...
  80. ncbi request reprint Differential anti-Golgi complex autoantibody production following murine lactate dehydrogenase-elevating virus infection
    Kazuhisa Nozawa
    Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan
    Immunopharmacol Immunotoxicol 30:13-25. 2008
    ..Future comparative characterizations in the immune processing of Golgi complex autoantigens using these viral strains may be useful in obtaining specific insights in the specific anti-Golgi complex autoimmune responses...
  81. ncbi request reprint Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis
    Yoshisuke Haruna
    Kawasaki Medical School, Matsushima, Kurashiki, Japan
    Arthritis Rheum 56:1827-35. 2007
    ..To investigate the effect of statins on vascular dysfunction in rat adjuvant-induced arthritis (AIA)...

Research Grants1

  1. Role of arginine deficiency in pathogenesis of lupus
    Minoru Satoh; Fiscal Year: 2004
    ..abstract_text> ..