Christopher Sassetti

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis
    Amit K Pandey
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    PLoS Pathog 5:e1000500. 2009
  2. pmc Metabolic regulation of mycobacterial growth and antibiotic sensitivity
    Seung Hun Baek
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 9:e1001065. 2011
  3. pmc High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
    Jennifer E Griffin
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 7:e1002251. 2011
  4. doi request reprint Inducible expression systems for mycobacteria
    Christopher M Sassetti
    Department of Microbiology and Molecular Genetics, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA 01655, USA
    Methods Mol Biol 465:255-64. 2009
  5. pmc Nitrile-inducible gene expression in mycobacteria
    Amit K Pandey
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Tuberculosis (Edinb) 89:12-6. 2009
  6. pmc Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages
    Jinhee Lee
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e18367. 2011
  7. ncbi request reprint A new site-specific integration system for mycobacteria
    Jeffrey Murry
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Tuberculosis (Edinb) 85:317-23. 2005

Research Grants

  1. Mce transport systems of Mycobacterium tuberculosis
    Christopher Sassetti; Fiscal Year: 2007
  2. Targets for short-course TB therapy
    Christopher Sassetti; Fiscal Year: 2007
  3. Mce transport systems of Mycobacterium tuberculosis
    Christopher Sassetti; Fiscal Year: 2009
  4. Mce transport systems of Mycobacterium tuberculosis
    Christopher M Sassetti; Fiscal Year: 2010
  5. Mce transport systems of Mycobacterium tuberculosis
    Christopher M Sassetti; Fiscal Year: 2010

Collaborators

  • Thomas R Ioerger
  • Jinhee Lee
  • Hardy Kornfeld
  • Amit K Pandey
  • Seung Hun Baek
  • Jennifer E Griffin
  • Eric J Rubin
  • Jeffrey Murry
  • Alice H Li
  • Jeffrey D Gawronski
  • Brian J Akerley
  • Michael A Dejesus
  • Yibin Yang
  • Francois Coulombe
  • Sarah M Fortune
  • Robert N Husson
  • Katherine A Fitzgerald
  • Michelle A Kelliher
  • Choong Min Kang
  • Sahadevan Raman
  • Swati Joshi
  • Marcel A Behr
  • Zhaozhao Jiang
  • Rose Proff
  • Jonathan Moreira
  • James Lane

Detail Information

Publications7

  1. pmc NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis
    Amit K Pandey
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    PLoS Pathog 5:e1000500. 2009
    ....
  2. pmc Metabolic regulation of mycobacterial growth and antibiotic sensitivity
    Seung Hun Baek
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 9:e1001065. 2011
    ..Thus, this regulatory pathway contributes to antibiotic tolerance in vivo, and its modulation may represent a novel strategy for accelerating TB treatment...
  3. pmc High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
    Jennifer E Griffin
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 7:e1002251. 2011
    ..This work provides the most comprehensive genetic characterization of a sterol catabolic pathway to date, suggests putative roles for uncharacterized virulence genes, and precisely maps genes encoding potential drug targets...
  4. doi request reprint Inducible expression systems for mycobacteria
    Christopher M Sassetti
    Department of Microbiology and Molecular Genetics, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA 01655, USA
    Methods Mol Biol 465:255-64. 2009
    ..Each of the currently available systems has specific advantages and limitations, and the conditions that recommend the use of each will be discussed...
  5. pmc Nitrile-inducible gene expression in mycobacteria
    Amit K Pandey
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Tuberculosis (Edinb) 89:12-6. 2009
    ..High-level overexpression is also possible, facilitating biochemical and structural studies of mycobacterial proteins produced in their native host...
  6. pmc Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages
    Jinhee Lee
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e18367. 2011
    ..tuberculosis suppress this host response. We previously reported that virulent M. tuberculosis induces cell death when bacillary load exceeds ∼20 per macrophage but the precise nature of this demise has not been defined...
  7. ncbi request reprint A new site-specific integration system for mycobacteria
    Jeffrey Murry
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Tuberculosis (Edinb) 85:317-23. 2005
    ..Plasmids based on the phiC31 integration system could make useful tools for the study of mycobacterial genetics...

Research Grants7

  1. Mce transport systems of Mycobacterium tuberculosis
    Christopher Sassetti; Fiscal Year: 2007
    ....
  2. Targets for short-course TB therapy
    Christopher Sassetti; Fiscal Year: 2007
    ..Short-course therapy could impact the worldwide tuberculosis epidemic both by making treatment more widely available and by reducing the rate at which drug-resistant strains emerge. ..
  3. Mce transport systems of Mycobacterium tuberculosis
    Christopher Sassetti; Fiscal Year: 2009
    ....
  4. Mce transport systems of Mycobacterium tuberculosis
    Christopher M Sassetti; Fiscal Year: 2010
    ....
  5. Mce transport systems of Mycobacterium tuberculosis
    Christopher M Sassetti; Fiscal Year: 2010
    ....