Aaron L Sarver

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
  2. pmc TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data
    Aaron L Sarver
    Biostatistics and Bioinformatics Masonic Cancer Center, University of Minnesota, Minneapolis, USA
    BMC Bioinformatics 13:154. 2012
  3. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
  4. ncbi request reprint Toward understanding the informatics and statistical aspects of micro-RNA profiling
    Aaron L Sarver
    Department of Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    J Cardiovasc Transl Res 3:204-11. 2010
  5. pmc Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line
    Anthony D Krentz
    Department of Genetics, Cell Biology, and Development, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, 6 160 Jackson Laboratory, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 377:67-78. 2013
  6. pmc Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
    Venugopal Thayanithy
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
    Bone 50:171-81. 2012
  7. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012
  8. pmc DMRT1 prevents female reprogramming in the postnatal mammalian testis
    Clinton K Matson
    Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 476:101-4. 2011
  9. pmc A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis
    Timothy K Starr
    Department of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 108:5765-70. 2011
  10. pmc DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary
    Anthony D Krentz
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA
    Dev Biol 356:63-70. 2011

Collaborators

Detail Information

Publications22

  1. pmc MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Orphanet J Rare Dis 8:7. 2013
    ..We showed previously that clusters of miRNAs at the 14q32 locus are downregulated in human osteosarcoma...
  2. pmc TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data
    Aaron L Sarver
    Biostatistics and Bioinformatics Masonic Cancer Center, University of Minnesota, Minneapolis, USA
    BMC Bioinformatics 13:154. 2012
    ..Previous approaches applied to this problem also required significant manual annotation...
  3. pmc Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
    Aaron L Sarver
    Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    BMC Cancer 9:401. 2009
    ..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression...
  4. ncbi request reprint Toward understanding the informatics and statistical aspects of micro-RNA profiling
    Aaron L Sarver
    Department of Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    J Cardiovasc Transl Res 3:204-11. 2010
    ..It is the hope of the author that this review will shed light on both the opportunities available to the researcher and the potential pitfalls that exist in this frontier of biomedical research...
  5. pmc Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line
    Anthony D Krentz
    Department of Genetics, Cell Biology, and Development, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, 6 160 Jackson Laboratory, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 377:67-78. 2013
    ..Given the strong evidence for involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease...
  6. pmc Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma
    Venugopal Thayanithy
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
    Bone 50:171-81. 2012
    ..Together, our data support a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 miRNAs could contribute to osteosarcoma pathogenesis...
  7. pmc Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines
    Venugopal Thayanithy
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43720. 2012
    ..These results suggested that the combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive OS...
  8. pmc DMRT1 prevents female reprogramming in the postnatal mammalian testis
    Clinton K Matson
    Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Nature 476:101-4. 2011
    ..Reprogramming due to loss of Dmrt1 also may help explain the aetiology of human syndromes linked to DMRT1, including disorders of sexual differentiation and testicular cancer...
  9. pmc A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis
    Timothy K Starr
    Department of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 108:5765-70. 2011
    ..These findings demonstrate the utility of using transposon mutagenesis to identify low-frequency and cooperating cancer genes; this approach will aid in the development of combinatorial therapies targeting this deadly disease...
  10. pmc DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary
    Anthony D Krentz
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA
    Dev Biol 356:63-70. 2011
    ..Thus DMRT1 controls Stra8 sex-specifically, activating it in the fetal ovary and repressing it in the adult testis...
  11. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011
    ..This in turn may enhance prognosis and prediction, and identify relevant therapeutic targets...
  12. doi request reprint S-MED: sarcoma microRNA expression database
    Aaron L Sarver
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
    Lab Invest 90:753-61. 2010
    ..This comprehensive database is the first of its kind specifically devoted to miRNA expression patterns in sarcomas is available through the URL link http://www.oncomir.umn.edu/...
  13. doi request reprint Hepatic differentiation of liver-derived progenitor cells and their characterization by microRNA analysis
    Yixin Chen
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Liver Transpl 16:1086-97. 2010
    ....
  14. doi request reprint MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration
    Aaron L Sarver
    Biostatistics and Bioinformatics, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 70:9570-80. 2010
    ..miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types...
  15. doi request reprint Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma
    Lihua Li
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Lab Invest 92:571-83. 2012
    ..Taken together our data suggest that the RMS state is stabilized by the deregulation of multiple miRNAs and their target genes, supporting a tumor suppressor role for these miRNA...
  16. pmc Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis
    Mark W Murphy
    Developmental Biology Center, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 107:13360-5. 2010
    ..Many of the DMRT1 target genes identified here are known to be important for a variety of functions in testicular development; the others are candidates for further investigation...
  17. ncbi request reprint Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice
    Raha A Been
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, United States of America Department of Comparative and Molecular Biosciences, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 9:e97280. 2014
    ..Importantly, several new potential drivers of histiocytic sarcoma were identified and could serve as targets for therapy for histiocytic sarcoma patients. ..
  18. doi request reprint Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization
    BRANDI H GORDEN
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota
    Am J Pathol 184:985-95. 2014
    ..Improved understanding of the mechanisms that determine the molecular and phenotypic differentiation of tumor cells in vivo could change paradigms regarding the origin and progression of endothelial sarcomas...
  19. pmc A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
    Timothy K Starr
    Department of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Science 323:1747-50. 2009
    ..These genes include APC, PTEN, and SMAD4. The screen also identified 17 candidate genes that had not previously been implicated in CRC, including POLI, PTPRK, and RSPO2...
  20. pmc The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice
    Charles J Billington
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 0356, USA
    Dev Biol 355:21-31. 2011
    ..We postulate that variable responses to stress may contribute to variable craniofacial phenotypes by triggering differential expression of genes and variable cellular apoptosis...
  21. pmc The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency
    Anthony D Krentz
    Department of Genetics, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:22323-8. 2009
    ..This work reveals a genetic link between testicular dysgenesis, pluripotency regulation, and teratoma susceptibility that is highly sensitive to genetic background and to gene dosage...
  22. pmc An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model
    Rachel J Bergerson
    Department of Genetics, Cell Biology and Development, Masonic Cancer Center, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
    Blood 119:4512-23. 2012
    ..Together, our data identified genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL fusion oncogenes...