Research Topics
Genomes and Genes
| Aaron L SarverSummaryAffiliation: University of Minnesota Country: USA Publications
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Detail Information
Publications
TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence dataAaron L Sarver
Biostatistics and Bioinformatics Masonic Cancer Center, University of Minnesota, Minneapolis, USA
BMC Bioinformatics 13:154. 2012..Previous approaches applied to this problem also required significant manual annotation...- Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative statesAaron L Sarver
Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
BMC Cancer 9:401. 2009..Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression... 
Toward understanding the informatics and statistical aspects of micro-RNA profilingAaron L Sarver
Department of Biostatistics and Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
J Cardiovasc Transl Res 3:204-11. 2010..It is the hope of the author that this review will shed light on both the opportunities available to the researcher and the potential pitfalls that exist in this frontier of biomedical research...- Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell linesVenugopal Thayanithy
Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS ONE 7:e43720. 2012..These results suggested that the combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive OS... - DMRT1 prevents female reprogramming in the postnatal mammalian testisClinton K Matson
Developmental Biology Center and Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Nature 476:101-4. 2011..Reprogramming due to loss of Dmrt1 also may help explain the aetiology of human syndromes linked to DMRT1, including disorders of sexual differentiation and testicular cancer... - Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcomaVenugopal Thayanithy
Division of Basic and Translational Research, Department of Surgery, University of Minnesota, USA
Bone 50:171-81. 2012..Together, our data support a model where the deregulation of a network involving 14q32 miRNAs, cMYC and miR-17-92 miRNAs could contribute to osteosarcoma pathogenesis... - A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesisTimothy K Starr
Department of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 108:5765-70. 2011..These findings demonstrate the utility of using transposon mutagenesis to identify low-frequency and cooperating cancer genes; this approach will aid in the development of combinatorial therapies targeting this deadly disease... - DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovaryAnthony D Krentz
Dept of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA
Dev Biol 356:63-70. 2011..Thus DMRT1 controls Stra8 sex-specifically, activating it in the fetal ovary and repressing it in the adult testis... - Hepatic differentiation of liver-derived progenitor cells and their characterization by microRNA analysisYixin Chen
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Liver Transpl 16:1086-97. 2010.... - Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ lineAnthony D Krentz
Department of Genetics, Cell Biology, and Development, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, 6 160 Jackson Laboratory, 321 Church St SE, Minneapolis, MN 55455, USA
Dev Biol 377:67-78. 2013..Given the strong evidence for involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease... - Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcomaLihua Li
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
Lab Invest 92:571-83. 2012..Taken together our data suggest that the RMS state is stabilized by the deregulation of multiple miRNAs and their target genes, supporting a tumor suppressor role for these miRNA... - S-MED: sarcoma microRNA expression databaseAaron L Sarver
Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
Lab Invest 90:753-61. 2010..This comprehensive database is the first of its kind specifically devoted to miRNA expression patterns in sarcomas is available through the URL link http://www.oncomir.umn.edu/... - MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcomaAaron L Sarver
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Orphanet J Rare Dis 8:7. 2013..We showed previously that clusters of miRNAs at the 14q32 locus are downregulated in human osteosarcoma... - MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migrationAaron L Sarver
Biostatistics and Bioinformatics, University of Minnesota, Minneapolis, Minnesota, USA
Cancer Res 70:9570-80. 2010..miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types... - Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testisMark W Murphy
Developmental Biology Center, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 107:13360-5. 2010..Many of the DMRT1 target genes identified here are known to be important for a variety of functions in testicular development; the others are candidates for further investigation... - Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approachMilcah C Scott
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
Bone 49:356-67. 2011..This in turn may enhance prognosis and prediction, and identify relevant therapeutic targets... - The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant miceCharles J Billington
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 0356, USA
Dev Biol 355:21-31. 2011..We postulate that variable responses to stress may contribute to variable craniofacial phenotypes by triggering differential expression of genes and variable cellular apoptosis... - The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotencyAnthony D Krentz
Department of Genetics, Developmental Biology Center, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 106:22323-8. 2009..This work reveals a genetic link between testicular dysgenesis, pluripotency regulation, and teratoma susceptibility that is highly sensitive to genetic background and to gene dosage... - An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis modelRachel J Bergerson
Department of Genetics, Cell Biology and Development, Masonic Cancer Center, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA
Blood 119:4512-23. 2012..Together, our data identified genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL fusion oncogenes... - A transposon-based genetic screen in mice identifies genes altered in colorectal cancerTimothy K Starr
Department of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Science 323:1747-50. 2009..These genes include APC, PTEN, and SMAD4. The screen also identified 17 candidate genes that had not previously been implicated in CRC, including POLI, PTPRK, and RSPO2...