V Sartorelli

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
    V Sartorelli
    Institute for Genetic Medicine, University of Southern California, Los Angeles 90033, USA
    Mol Cell 4:725-34. 1999
  2. pmc HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling
    T Iso
    Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9075, USA
    Mol Cell Biol 21:6080-9. 2001
  3. ncbi request reprint Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A
    Y Hamamori
    Institute for Genetic Medicine, Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033, USA
    Cell 96:405-13. 1999
  4. pmc The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist
    Y Hamamori
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033, USA
    Mol Cell Biol 17:6563-73. 1997
  5. pmc HERP, a new primary target of Notch regulated by ligand binding
    T Iso
    Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9075, USA
    Mol Cell Biol 21:6071-9. 2001
  6. pmc Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C
    V Sartorelli
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033, USA
    Mol Cell Biol 17:1010-26. 1997
  7. pmc Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter
    E Biesiada
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles, California, USA
    Mol Cell Biol 19:2577-84. 1999
  8. ncbi request reprint Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis
    P L Puri
    Department of Biology, University of California San Diego, La Jolla, CA 92093, USA
    Mol Cell 8:885-97. 2001
  9. pmc The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD
    P Bailey
    University of Queensland, Centre for Molecular and Cellular Biology, Ritchie Research Laboratories, B402A, St Lucia, 4072 Queensland, Australia
    Nucleic Acids Res 26:5501-10. 1998
  10. ncbi request reprint Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications
    P L Puri
    Department of Biology, University of California San Diego, La Jolla, California, USA
    J Cell Physiol 185:155-73. 2000

Collaborators

  • L Kedes
  • V Ogryzko
  • Y Nakatani
  • J Huang
  • Jean Y Wang
  • A Giordano
  • R L Schiltz
  • Song Lin Chen
  • Y Hamamori
  • P L Puri
  • T Iso
  • P Bailey
  • G C Minetti
  • G E Muscat
  • H Y Wu
  • S Iezzi
  • G Chung
  • E Biesiada
  • R Maestro
  • P Gallinari
  • M Di Padova
  • R Adami
  • C Colussi
  • S Straino
  • C Steinkuhler
  • C Gaetano
  • S Fortuni
  • C Mozzetta
  • C Serra
  • B Illi
  • V Parente
  • R Bottinelli
  • M C Capogrossi
  • M Sampaolesi
  • P Stiegler
  • T Shichinohe
  • C Poizat
  • T T Chen
  • D H Beach
  • G J Hannon
  • M Downes
  • J Harris
  • A P Dei Tos
  • S Krasnokutsky
  • P Lau
  • C Doglioni
  • B H Howard
  • M Levrero
  • A Graessmann
  • X J Yang

Detail Information

Publications14

  1. ncbi request reprint Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
    V Sartorelli
    Institute for Genetic Medicine, University of Southern California, Los Angeles 90033, USA
    Mol Cell 4:725-34. 1999
    ....
  2. pmc HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling
    T Iso
    Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9075, USA
    Mol Cell Biol 21:6080-9. 2001
    ..Thus, Notch signaling relies on cooperation between HES and HERP, two transcriptional repressors with distinctive repression mechanisms which, either as homo- or as heterodimers, regulate target gene expression...
  3. ncbi request reprint Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A
    Y Hamamori
    Institute for Genetic Medicine, Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033, USA
    Cell 96:405-13. 1999
    ..These findings establish a cogent argument for considering the HAT domains as a direct target for acetyltransferase regulation by both a cellular transcription factor and a viral oncoprotein...
  4. pmc The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist
    Y Hamamori
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033, USA
    Mol Cell Biol 17:6563-73. 1997
    ..These findings demonstrate that M-Twist interacts with MyoD through the basic domains, thereby inhibiting MyoD...
  5. pmc HERP, a new primary target of Notch regulated by ligand binding
    T Iso
    Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9075, USA
    Mol Cell Biol 21:6071-9. 2001
    ..These data establish that HERP2 is a novel primary target gene of Notch that, together with HES, may effect diverse biological activities of Notch...
  6. pmc Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C
    V Sartorelli
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033, USA
    Mol Cell Biol 17:1010-26. 1997
    ..Our results suggest that p300 and CBP may positively influence myogenesis by reinforcing the transcriptional autoregulatory loop established between the myogenic bHLH and the MEF2 factors...
  7. pmc Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter
    E Biesiada
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles, California, USA
    Mol Cell Biol 19:2577-84. 1999
    ....
  8. ncbi request reprint Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis
    P L Puri
    Department of Biology, University of California San Diego, La Jolla, CA 92093, USA
    Mol Cell 8:885-97. 2001
    ..These results suggest that reduced expression of HDAC1 accompanied by its redistribution in alternative nuclear protein complexes is critical for terminal differentiation of skeletal muscle cells...
  9. pmc The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD
    P Bailey
    University of Queensland, Centre for Molecular and Cellular Biology, Ritchie Research Laboratories, B402A, St Lucia, 4072 Queensland, Australia
    Nucleic Acids Res 26:5501-10. 1998
    ....
  10. ncbi request reprint Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications
    P L Puri
    Department of Biology, University of California San Diego, La Jolla, California, USA
    J Cell Physiol 185:155-73. 2000
    ..Since the activity of MRFs are compromised in tumors of myogenic derivation-the rhabdomyosarcomas-the studies summarized in this review can provide a useful tool to uncover the molecular basis underlying the formation of these tumors...
  11. ncbi request reprint Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
    P L Puri
    Laboratory of Gene Expression, Fondazione Andrea Cesalpino, Istituto I Clinica Medica, Policlinico Umberto I, University of Rome, La Sapienza, Italy
    Mol Cell 1:35-45. 1997
    ..These results indicate that recruitment of histone acetyltransferase activity of PCAF by MyoD, through p300/CBP, is crucial for activation of the myogenic program...
  12. ncbi request reprint The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD
    P Bailey
    University of Queensland, Centre for Molecular and Cellular Biology, Ritchie Research Laboratories, Brisbane, Australia
    Mol Endocrinol 13:1155-68. 1999
    ..This work demonstrates that the corepressor N-CoR is a key regulator of MyoD activity and mammalian differentiation, and that N-CoR has a multifaceted role in myogenesis...
  13. pmc Twist is a potential oncogene that inhibits apoptosis
    R Maestro
    Experimental Oncology 1, Centro di Riferimento Oncologico, 33081 Aviano, Italy
    Genes Dev 13:2207-17. 1999
    ..Twist is known to block myogenic differentiation. Thus, Twist may play multiple roles in the formation of rhabdomyosarcomas, halting terminal differentiation, inhibiting apoptosis, and interfering with the p53 tumor-suppressor pathway...
  14. ncbi request reprint Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors
    G C Minetti
    Dulbecco Telethon Institute at Fondazione A Cesalpino, Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome, Via Castel Romano 100, 00128, Rome, Italy
    Nat Med 12:1147-50. 2006
    ..These results provide a rationale for using deacetylase inhibitors in the pharmacological therapy of muscular dystrophies...