Research Topics
| MARTIN F SARTERSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Revitalizing psychiatric drug discoveryMartin Sarter
Department of Psychology, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, Michigan 48103 8862, USA
Nat Rev Drug Discov 11:423-4. 2012..Psychiatric drug discovery needs to close the systems neuroscience gap to improve the clinical success rates of candidate drugs with novel mechanisms of action...- Cholinergic contributions to the cognitive symptoms of schizophrenia and the viability of cholinergic treatmentsMartin Sarter
Department of Psychology and Neuroscience Program, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, MI 48109, USA
Neuropharmacology 62:1544-53. 2012..The limited evidence available from patient studies and animal models indicates pressing research needs in order to guide the development of cholinergic treatments of the cognitive symptoms of schizophrenia... 
Cortical cholinergic transmission and cortical information processing in schizophreniaMartin Sarter
Department of Psychology, University of Michigan, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
Schizophr Bull 31:117-38. 2005....- The substantia innominata remains incognita: pressing research themes on basal forebrain neuroanatomyMartin Sarter
Department of Psychology, University of Michigan, 4032 East Hall, 530 Church Street, Ann Arbor, MI 48109 1043, USA
Brain Struct Funct 213:11-5. 2008.... - More attention must be paid: the neurobiology of attentional effortMartin Sarter
Department of Psychology, University of Michigan, Ann Arbor, 48109, USA
Brain Res Rev 51:145-60. 2006.... - The consequences of atheoretical, task-driven experimentation: theoretical comment on Paban, Chambon, Jaffard, and Alescio-Lautier (2005)Martin Sarter
University of Michigan, Ann Arbor, MI 48109 1043, USA
Behav Neurosci 120:493-5. 2006.... - Preclinical research into cognition enhancersMartin Sarter
Department of Psychology, University of Michigan, 4032 East Hall, 530 Church Street, Ann Arbor, MI 48109 1043, USA
Trends Pharmacol Sci 27:602-8. 2006..We stress the need for basic biopsychological research approaches in preclinical programs to find and characterize drugs to treat cognitive disorders... - Forebrain dopaminergic-cholinergic interactions, attentional effort, psychostimulant addiction and schizophreniaMartin Sarter
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
EXS 98:65-86. 2006 - Abnormal neurotransmitter release underlying behavioral and cognitive disorders: toward concepts of dynamic and function-specific dysregulationMartin Sarter
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
Neuropsychopharmacology 32:1452-61. 2007.... - Animal cognition: defining the issuesMartin Sarter
Department of Psychology, University of Michigan, 4032 East Hall, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
Neurosci Biobehav Rev 28:645-50. 2004..Therefore, the test of hypotheses regarding the validity of procedures used to assess cognitive functions in animals is an inherent part of the research process... 
A neurocognitive animal model dissociating between acute illness and remission periods of schizophreniaMartin Sarter
Department of Psychology, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, MI 48109 8862, USA
Psychopharmacology (Berl) 202:237-58. 2009..The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects...- Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detectionMartin Sarter
Department of Psychology, University of Michigan, 525 E University Ave, Ann Arbor, MI 48109 1109, USA
Brain Res Brain Res Rev 48:98-111. 2005.... - Cholinergic control of attention to cues guiding established performance versus learning: theoretical comment on Maddux, Kerfoot, Chatterjee, and Holland (2007)Martin Sarter
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Behav Neurosci 121:233-5. 2007..Separate yet interacting components of the cortical cholinergic input system modulate the attentional processing of cues that guide well-practiced performance or that serve as conditioned stimuli during learning... - nAChR agonist-induced cognition enhancement: integration of cognitive and neuronal mechanismsMartin Sarter
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1043, USA
Biochem Pharmacol 78:658-67. 2009..Collectively, this evidence forms the basis for hypothesis-guided development and characterization of cognition enhancers... - Phasic acetylcholine release and the volume transmission hypothesis: time to move onMartin Sarter
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
Nat Rev Neurosci 10:383-90. 2009.... - Choline transporters, cholinergic transmission and cognitionMartin Sarter
Department of Psychology, University of Michigan, 4032 East Hall, 525 East University Avenue, Ann Arbor, Michigan 48109, USA
Nat Rev Neurosci 6:48-56. 2005..Therefore, the CHT might represent a productive target for the development of new pharmacological treatments for these conditions... - Deficits in attentional control: cholinergic mechanisms and circuitry-based treatment approachesMartin Sarter
Department of Psychology, University of Michigan, Ann Arbor, MI 48103 8862, USA
Behav Neurosci 125:825-35. 2011..This circuitry model guides the development of treatments of deficits in attentional control... - Toward a neuro-cognitive animal model of the cognitive symptoms of schizophrenia: disruption of cortical cholinergic neurotransmission following repeated amphetamine exposure in attentional task-performing, but not non-performing, ratsRouba Kozak
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
Neuropsychopharmacology 32:2074-86. 2007..Repeated AMPH-induced disruption of prefrontal cholinergic activity and attentional performance represents a useful model to investigate the cholinergic mechanisms contributing to the cognitive impairments of schizophrenia... - Glutamate receptors in nucleus accumbens mediate regionally selective increases in cortical acetylcholine releaseAmy Zmarowski
Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
Synapse 61:115-23. 2007.... - Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signalingVinay Parikh
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
J Neurosci 30:3518-30. 2010..Prefrontal alpha4beta2* nAChRs play a key role in evoking and facilitating the transient glutamatergic-cholinergic interactions that are necessary for cue detection and attentional performance... - Enhancement of attentional performance by selective stimulation of alpha4beta2(*) nAChRs: underlying cholinergic mechanismsWilliam M Howe
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
Neuropsychopharmacology 35:1391-401. 2010.... - Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaineLisa A Briand
Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
Neuropsychopharmacology 33:2969-80. 2008.... - Sensitized attentional performance and Fos-immunoreactive cholinergic neurons in the basal forebrain of amphetamine-pretreated ratsVicente Martinez
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109-1109, USA
Biol Psychiatry 57:1138-46. 2005..CONCLUSIONS: The evidence supports the hypothesis that abnormally regulated cortical cholinergic inputs represent an integral component of neuronal models of the attentional dysfunctions of schizophrenia... - The neglected constituent of the basal forebrain corticopetal projection system: GABAergic projectionsMartin Sarter
The Ohio State University, Department of Psychology, Columbus, OH 43210, USA
Eur J Neurosci 15:1867-73. 2002.... - Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatmentKathleen S Alexander
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
Neuropsychopharmacology 34:2710-20. 2009.... - Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine releaseChristopher D Herzog
Department of Psychology, The Ohio State University, 31 Townshend Hall, 1885 Neil Avenue, Columbus, OH 43210, USA
Neurobiol Aging 24:861-3. 2003.... - Cholinergic optimization of cue-evoked parietal activity during challenged attentional performanceJohn I Broussard
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
Eur J Neurosci 29:1711-22. 2009..Collectively, these findings indicate that cholinergic inputs to PPC neurons amplify cue detection, and may also act to suppress irrelevant distractors... - Augmented prefrontal acetylcholine release during challenged attentional performanceRouba Kozak
Department of Psychology, University of Michigan, Ann Arbor, MI 48109-1109, USA
Cereb Cortex 16:9-17. 2006..Augmentation of performance-associated increases in mPFC cholinergic transmission is hypothesized to mediate the increased demands on attentional 'effort' that are required to maintain performance under challenging conditions... - Modulators in concert for cognition: modulator interactions in the prefrontal cortexLisa A Briand
University of Michigan, Department of Psychology and Neuroscience Program, Ann Arbor, MI 48109, USA
Prog Neurobiol 83:69-91. 2007.... - Cholinergic mediation of attention: contributions of phasic and tonic increases in prefrontal cholinergic activityVinay Parikh
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1043, USA
Ann N Y Acad Sci 1129:225-35. 2008.... - Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortexVinay Parikh
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
J Neurosci 28:3769-80. 2008..Glutamatergic mechanisms necessarily mediate the cholinergic effects of nAChR agonists in the prefrontal cortex... - Detection of the moderately beneficial cognitive effects of low-dose treatment with haloperidol or clozapine in an animal model of the attentional impairments of schizophreniaVicente Martinez
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 33:2635-47. 2008..As this animal model detects the moderately beneficial cognitive effects of haloperidol and clozapine, it may be useful for preclinical research designed to detect and characterize treatments for the cognitive symptoms of schizophrenia... - Prefrontal acetylcholine release controls cue detection on multiple timescalesVinay Parikh
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor MI 48109, USA
Neuron 56:141-54. 2007..Cortical cholinergic neurotransmission is regulated on multiple timescales to mediate the detection of behaviorally significant cues and to support cognitive performance... - Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites?Chiara Giuliano
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1043, USA
Neurochem Int 52:1343-50. 2008..Collectively, these results indicate that co-coating of microelectrodes with AChE does not enhance the detection of cholinergic activity in the cortex compared with measurements via recording sites coated only with ChOx... - NMDA and dopamine interactions in the nucleus accumbens modulate cortical acetylcholine releaseAmy Zmarowski
Department of Psychology, The Ohio State University, Columbus, OH, USA
Eur J Neurosci 22:1731-40. 2005..This modulation may underlie the coordinated linking of attentional processes and motor output following exposure to salient and behaviorally relevant stimuli... - Interactions between cognition and circadian rhythms: attentional demands modify circadian entrainmentHoward J Gritton
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
Behav Neurosci 123:937-48. 2009..These results form the basis for future research on the role of neuronal systems mediating interactions between cognitive activity and circadian rhythms... - Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levelsVinay Parikh
Psychobiology and Behavioural Neuroscience, Department of Psychology, Ohio State University, Columbus, OH, USA
Eur J Neurosci 20:1545-54. 2004..Choline signals assessed using enzyme-selective microelectrode arrays may represent a rapid, sensitive and spatially discrete measure of cholinergic transmission... - Stimulation of cortical acetylcholine release following blockade of ionotropic glutamate receptors in nucleus accumbensGretchen Neigh-McCandless
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
Eur J Neurosci 16:1259-66. 2002..These results reveal a significant glutamatergic tone within the accumbens of awake rats and support the hypothesis that accumbens efferents to basal forebrain modulate the excitability of the basal forebrain cortical cholinergic system... - Lateralized attentional functions of cortical cholinergic inputsVicente Martinez
Department of Psychology, Ohio State University, OH, USA
Behav Neurosci 118:984-91. 2004..Cortical cholinergic inputs represent a major component of the brain's lateralized attention systems... - Visceral afferent bias on cortical processing: role of adrenergic afferents to the basal forebrain cholinergic systemDayan Knox
Department of Psychology, Ohio State University, Columbus, OH 43120, USA
Behav Neurosci 118:1455-9. 2004..Results support the hypothesis that noradrenergic afferents to the basal forebrain cholinergic system represent a component of an ascending visceral afferent system... - D2-like receptors in nucleus accumbens negatively modulate acetylcholine release in prefrontal cortexJulie M Brooks
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
Neuropharmacology 53:455-63. 2007..This negative modulation may contribute to the integration of normal attentional processing and goal directed behavior and to the therapeutic effects of antipsychotic medication on cognition in psychopathologies such as schizophrenia... - Rats and humans paying attention: cross-species task development for translational researchElise Demeter
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
Neuropsychology 22:787-99. 2008..This task provides a useful tool for integrative, cross-species research and may help to determine how specific neurotransmitter systems contribute to the hemodynamic changes observed in human functional neuroimaging experiments...
Research Grants
- AGING, ATTENTION, AND BENZODIAZEPINE RECEPTOR LIGANDSMartin Sarter; Fiscal Year: 1993....
- Cholinergic plasticity in auditory input processingMartin Sarter; Fiscal Year: 2006....
- Amphetamine, cortical acetylcholine and cognitionMartin Sarter; Fiscal Year: 2006..abstract_text> ..
- ATTENTION, CORTICAL ACH RELEASE AND NEURONAL ACTIVITYMartin Sarter; Fiscal Year: 2006....
- Regulation of cortical ACh and CognitionMartin Sarter; Fiscal Year: 2007..The renewal of the KO2 would allow this candidate to devote at least 75% of his time for multidisciplinary research on the neurobiology of attentional functions. ..
- In vivo screening of cholinergic cognition enhancersMartin Sarter; Fiscal Year: 2007..The development of new drug finding ..
- Nicotinic regulation of cortical ACh release and behavioral functionMartin Sarter; Fiscal Year: 2007..This research will reveal critical neuronal and cognitive mechanisms underlying the pro-cognitive effects of nicotinic receptor ligands and thereby assist in defining and predicting the clinical potential of this group of compounds. ..
- Nicotinic regulation of cortical ACh release and behavioral functionMartin Sarter; Fiscal Year: 2009..This research will reveal critical neuronal and cognitive mechanisms underlying the pro-cognitive effects of nicotinic receptor ligands and thereby assist in defining and predicting the clinical potential of this group of compounds. ..
- Nicotinic regulation of cortical ACh release and behavioral functionMARTIN F SARTER; Fiscal Year: 2010..This research will reveal critical neuronal and cognitive mechanisms underlying the pro-cognitive effects of nicotinic receptor ligands and thereby assist in defining and predicting the clinical potential of this group of compounds. ..
- ATTENTION, CORTICAL ACH RELEASE AND NEURONAL ACTIVITYMartin Sarter; Fiscal Year: 2001..The determination of the specific cognitive functions of cortical ACh will lead to a better understanding of the disastrous cognitive consequences of deviations in the integrity of cortical cholinergic afferents. ..
- AGING, ATTENTION AND BENZODIAZEPINE RECEPTOR LIGANDSMartin Sarter; Fiscal Year: 2002....
- Amphetamine, cortical acetylcholine and cognitionMartin Sarter; Fiscal Year: 2003..abstract_text> ..
- Choline transporter capacity limits motivated behavior on mice, rats, and humansMARTIN F SARTER; Fiscal Year: 2010..The results from this research are of direct significance for hypotheses concerning the role of this major neuromodulator system in cognitive disorders and for the development of new treatments for such disorders. ..