MARTIN F SARTER

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Forebrain dopaminergic-cholinergic interactions, attentional effort, psychostimulant addiction and schizophrenia
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    EXS 98:65-86. 2006
  2. doi request reprint Revitalizing psychiatric drug discovery
    Martin Sarter
    Department of Psychology, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, Michigan 48103 8862, USA
    Nat Rev Drug Discov 11:423-4. 2012
  3. doi request reprint Cholinergic contributions to the cognitive symptoms of schizophrenia and the viability of cholinergic treatments
    Martin Sarter
    Department of Psychology and Neuroscience Program, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, MI 48109, USA
    Neuropharmacology 62:1544-53. 2012
  4. ncbi request reprint Cortical cholinergic transmission and cortical information processing in schizophrenia
    Martin Sarter
    Department of Psychology, University of Michigan, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
    Schizophr Bull 31:117-38. 2005
  5. doi request reprint The substantia innominata remains incognita: pressing research themes on basal forebrain neuroanatomy
    Martin Sarter
    Department of Psychology, University of Michigan, 4032 East Hall, 530 Church Street, Ann Arbor, MI 48109 1043, USA
    Brain Struct Funct 213:11-5. 2008
  6. ncbi request reprint More attention must be paid: the neurobiology of attentional effort
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, 48109, USA
    Brain Res Rev 51:145-60. 2006
  7. ncbi request reprint The consequences of atheoretical, task-driven experimentation: theoretical comment on Paban, Chambon, Jaffard, and Alescio-Lautier (2005)
    Martin Sarter
    University of Michigan, Ann Arbor, MI 48109 1043, USA
    Behav Neurosci 120:493-5. 2006
  8. ncbi request reprint Preclinical research into cognition enhancers
    Martin Sarter
    Department of Psychology, University of Michigan, 4032 East Hall, 530 Church Street, Ann Arbor, MI 48109 1043, USA
    Trends Pharmacol Sci 27:602-8. 2006
  9. ncbi request reprint Abnormal neurotransmitter release underlying behavioral and cognitive disorders: toward concepts of dynamic and function-specific dysregulation
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Neuropsychopharmacology 32:1452-61. 2007
  10. ncbi request reprint Animal cognition: defining the issues
    Martin Sarter
    Department of Psychology, University of Michigan, 4032 East Hall, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
    Neurosci Biobehav Rev 28:645-50. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Forebrain dopaminergic-cholinergic interactions, attentional effort, psychostimulant addiction and schizophrenia
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    EXS 98:65-86. 2006
  2. doi request reprint Revitalizing psychiatric drug discovery
    Martin Sarter
    Department of Psychology, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, Michigan 48103 8862, USA
    Nat Rev Drug Discov 11:423-4. 2012
    ..Psychiatric drug discovery needs to close the systems neuroscience gap to improve the clinical success rates of candidate drugs with novel mechanisms of action...
  3. doi request reprint Cholinergic contributions to the cognitive symptoms of schizophrenia and the viability of cholinergic treatments
    Martin Sarter
    Department of Psychology and Neuroscience Program, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, MI 48109, USA
    Neuropharmacology 62:1544-53. 2012
    ..The limited evidence available from patient studies and animal models indicates pressing research needs in order to guide the development of cholinergic treatments of the cognitive symptoms of schizophrenia...
  4. ncbi request reprint Cortical cholinergic transmission and cortical information processing in schizophrenia
    Martin Sarter
    Department of Psychology, University of Michigan, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
    Schizophr Bull 31:117-38. 2005
    ....
  5. doi request reprint The substantia innominata remains incognita: pressing research themes on basal forebrain neuroanatomy
    Martin Sarter
    Department of Psychology, University of Michigan, 4032 East Hall, 530 Church Street, Ann Arbor, MI 48109 1043, USA
    Brain Struct Funct 213:11-5. 2008
    ....
  6. ncbi request reprint More attention must be paid: the neurobiology of attentional effort
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, 48109, USA
    Brain Res Rev 51:145-60. 2006
    ....
  7. ncbi request reprint The consequences of atheoretical, task-driven experimentation: theoretical comment on Paban, Chambon, Jaffard, and Alescio-Lautier (2005)
    Martin Sarter
    University of Michigan, Ann Arbor, MI 48109 1043, USA
    Behav Neurosci 120:493-5. 2006
    ....
  8. ncbi request reprint Preclinical research into cognition enhancers
    Martin Sarter
    Department of Psychology, University of Michigan, 4032 East Hall, 530 Church Street, Ann Arbor, MI 48109 1043, USA
    Trends Pharmacol Sci 27:602-8. 2006
    ..We stress the need for basic biopsychological research approaches in preclinical programs to find and characterize drugs to treat cognitive disorders...
  9. ncbi request reprint Abnormal neurotransmitter release underlying behavioral and cognitive disorders: toward concepts of dynamic and function-specific dysregulation
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Neuropsychopharmacology 32:1452-61. 2007
    ....
  10. ncbi request reprint Animal cognition: defining the issues
    Martin Sarter
    Department of Psychology, University of Michigan, 4032 East Hall, 525 E University Avenue, Ann Arbor, MI 48109 1109, USA
    Neurosci Biobehav Rev 28:645-50. 2004
    ..Therefore, the test of hypotheses regarding the validity of procedures used to assess cognitive functions in animals is an inherent part of the research process...
  11. pmc A neurocognitive animal model dissociating between acute illness and remission periods of schizophrenia
    Martin Sarter
    Department of Psychology, University of Michigan, 530 Church Street, 4032 East Hall, Ann Arbor, MI 48109 8862, USA
    Psychopharmacology (Berl) 202:237-58. 2009
    ..The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects...
  12. ncbi request reprint Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
    Martin Sarter
    Department of Psychology, University of Michigan, 525 E University Ave, Ann Arbor, MI 48109 1109, USA
    Brain Res Brain Res Rev 48:98-111. 2005
    ....
  13. ncbi request reprint Cholinergic control of attention to cues guiding established performance versus learning: theoretical comment on Maddux, Kerfoot, Chatterjee, and Holland (2007)
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Behav Neurosci 121:233-5. 2007
    ..Separate yet interacting components of the cortical cholinergic input system modulate the attentional processing of cues that guide well-practiced performance or that serve as conditioned stimuli during learning...
  14. pmc nAChR agonist-induced cognition enhancement: integration of cognitive and neuronal mechanisms
    Martin Sarter
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Biochem Pharmacol 78:658-67. 2009
    ..Collectively, this evidence forms the basis for hypothesis-guided development and characterization of cognition enhancers...
  15. pmc Phasic acetylcholine release and the volume transmission hypothesis: time to move on
    Martin Sarter
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    Nat Rev Neurosci 10:383-90. 2009
    ....
  16. ncbi request reprint Choline transporters, cholinergic transmission and cognition
    Martin Sarter
    Department of Psychology, University of Michigan, 4032 East Hall, 525 East University Avenue, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 6:48-56. 2005
    ..Therefore, the CHT might represent a productive target for the development of new pharmacological treatments for these conditions...
  17. pmc Deficits in attentional control: cholinergic mechanisms and circuitry-based treatment approaches
    Martin Sarter
    Department of Psychology, University of Michigan, Ann Arbor, MI 48103 8862, USA
    Behav Neurosci 125:825-35. 2011
    ..This circuitry model guides the development of treatments of deficits in attentional control...
  18. ncbi request reprint Toward a neuro-cognitive animal model of the cognitive symptoms of schizophrenia: disruption of cortical cholinergic neurotransmission following repeated amphetamine exposure in attentional task-performing, but not non-performing, rats
    Rouba Kozak
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Neuropsychopharmacology 32:2074-86. 2007
    ..Repeated AMPH-induced disruption of prefrontal cholinergic activity and attentional performance represents a useful model to investigate the cholinergic mechanisms contributing to the cognitive impairments of schizophrenia...
  19. ncbi request reprint Glutamate receptors in nucleus accumbens mediate regionally selective increases in cortical acetylcholine release
    Amy Zmarowski
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    Synapse 61:115-23. 2007
    ....
  20. pmc Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling
    Vinay Parikh
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    J Neurosci 30:3518-30. 2010
    ..Prefrontal alpha4beta2* nAChRs play a key role in evoking and facilitating the transient glutamatergic-cholinergic interactions that are necessary for cue detection and attentional performance...
  21. pmc Enhancement of attentional performance by selective stimulation of alpha4beta2(*) nAChRs: underlying cholinergic mechanisms
    William M Howe
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
    Neuropsychopharmacology 35:1391-401. 2010
    ....
  22. pmc Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine
    Lisa A Briand
    Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
    Neuropsychopharmacology 33:2969-80. 2008
    ....
  23. ncbi request reprint Sensitized attentional performance and Fos-immunoreactive cholinergic neurons in the basal forebrain of amphetamine-pretreated rats
    Vicente Martinez
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    Biol Psychiatry 57:1138-46. 2005
    ....
  24. ncbi request reprint The neglected constituent of the basal forebrain corticopetal projection system: GABAergic projections
    Martin Sarter
    The Ohio State University, Department of Psychology, Columbus, OH 43210, USA
    Eur J Neurosci 15:1867-73. 2002
    ....
  25. pmc Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment
    Kathleen S Alexander
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Neuropsychopharmacology 34:2710-20. 2009
    ....
  26. ncbi request reprint Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release
    Christopher D Herzog
    Department of Psychology, The Ohio State University, 31 Townshend Hall, 1885 Neil Avenue, Columbus, OH 43210, USA
    Neurobiol Aging 24:861-3. 2003
    ....
  27. pmc Cholinergic optimization of cue-evoked parietal activity during challenged attentional performance
    John I Broussard
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Eur J Neurosci 29:1711-22. 2009
    ..Collectively, these findings indicate that cholinergic inputs to PPC neurons amplify cue detection, and may also act to suppress irrelevant distractors...
  28. ncbi request reprint Augmented prefrontal acetylcholine release during challenged attentional performance
    Rouba Kozak
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Cereb Cortex 16:9-17. 2006
    ..Augmentation of performance-associated increases in mPFC cholinergic transmission is hypothesized to mediate the increased demands on attentional 'effort' that are required to maintain performance under challenging conditions...
  29. pmc Modulators in concert for cognition: modulator interactions in the prefrontal cortex
    Lisa A Briand
    University of Michigan, Department of Psychology and Neuroscience Program, Ann Arbor, MI 48109, USA
    Prog Neurobiol 83:69-91. 2007
    ....
  30. doi request reprint Cholinergic mediation of attention: contributions of phasic and tonic increases in prefrontal cholinergic activity
    Vinay Parikh
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Ann N Y Acad Sci 1129:225-35. 2008
    ....
  31. doi request reprint Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex
    Vinay Parikh
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    J Neurosci 28:3769-80. 2008
    ..Glutamatergic mechanisms necessarily mediate the cholinergic effects of nAChR agonists in the prefrontal cortex...
  32. ncbi request reprint Detection of the moderately beneficial cognitive effects of low-dose treatment with haloperidol or clozapine in an animal model of the attentional impairments of schizophrenia
    Vicente Martinez
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Neuropsychopharmacology 33:2635-47. 2008
    ..As this animal model detects the moderately beneficial cognitive effects of haloperidol and clozapine, it may be useful for preclinical research designed to detect and characterize treatments for the cognitive symptoms of schizophrenia...
  33. pmc Prefrontal acetylcholine release controls cue detection on multiple timescales
    Vinay Parikh
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor MI 48109, USA
    Neuron 56:141-54. 2007
    ..Cortical cholinergic neurotransmission is regulated on multiple timescales to mediate the detection of behaviorally significant cues and to support cognitive performance...
  34. pmc Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites?
    Chiara Giuliano
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Neurochem Int 52:1343-50. 2008
    ..Collectively, these results indicate that co-coating of microelectrodes with AChE does not enhance the detection of cholinergic activity in the cortex compared with measurements via recording sites coated only with ChOx...
  35. ncbi request reprint NMDA and dopamine interactions in the nucleus accumbens modulate cortical acetylcholine release
    Amy Zmarowski
    Department of Psychology, The Ohio State University, Columbus, OH, USA
    Eur J Neurosci 22:1731-40. 2005
    ..This modulation may underlie the coordinated linking of attentional processes and motor output following exposure to salient and behaviorally relevant stimuli...
  36. pmc Interactions between cognition and circadian rhythms: attentional demands modify circadian entrainment
    Howard J Gritton
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
    Behav Neurosci 123:937-48. 2009
    ..These results form the basis for future research on the role of neuronal systems mediating interactions between cognitive activity and circadian rhythms...
  37. ncbi request reprint Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levels
    Vinay Parikh
    Psychobiology and Behavioural Neuroscience, Department of Psychology, Ohio State University, Columbus, OH, USA
    Eur J Neurosci 20:1545-54. 2004
    ..Choline signals assessed using enzyme-selective microelectrode arrays may represent a rapid, sensitive and spatially discrete measure of cholinergic transmission...
  38. ncbi request reprint Stimulation of cortical acetylcholine release following blockade of ionotropic glutamate receptors in nucleus accumbens
    Gretchen Neigh-McCandless
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Eur J Neurosci 16:1259-66. 2002
    ..These results reveal a significant glutamatergic tone within the accumbens of awake rats and support the hypothesis that accumbens efferents to basal forebrain modulate the excitability of the basal forebrain cortical cholinergic system...
  39. ncbi request reprint Lateralized attentional functions of cortical cholinergic inputs
    Vicente Martinez
    Department of Psychology, Ohio State University, OH, USA
    Behav Neurosci 118:984-91. 2004
    ..Cortical cholinergic inputs represent a major component of the brain's lateralized attention systems...
  40. ncbi request reprint Visceral afferent bias on cortical processing: role of adrenergic afferents to the basal forebrain cholinergic system
    Dayan Knox
    Department of Psychology, Ohio State University, Columbus, OH 43120, USA
    Behav Neurosci 118:1455-9. 2004
    ..Results support the hypothesis that noradrenergic afferents to the basal forebrain cholinergic system represent a component of an ascending visceral afferent system...
  41. pmc D2-like receptors in nucleus accumbens negatively modulate acetylcholine release in prefrontal cortex
    Julie M Brooks
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Neuropharmacology 53:455-63. 2007
    ..This negative modulation may contribute to the integration of normal attentional processing and goal directed behavior and to the therapeutic effects of antipsychotic medication on cognition in psychopathologies such as schizophrenia...
  42. pmc Rats and humans paying attention: cross-species task development for translational research
    Elise Demeter
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Neuropsychology 22:787-99. 2008
    ..This task provides a useful tool for integrative, cross-species research and may help to determine how specific neurotransmitter systems contribute to the hemodynamic changes observed in human functional neuroimaging experiments...

Research Grants32

  1. AGING, ATTENTION, AND BENZODIAZEPINE RECEPTOR LIGANDS
    Martin Sarter; Fiscal Year: 1993
    ....
  2. Cholinergic plasticity in auditory input processing
    Martin Sarter; Fiscal Year: 2006
    ....
  3. Amphetamine, cortical acetylcholine and cognition
    Martin Sarter; Fiscal Year: 2006
    ..abstract_text> ..
  4. ATTENTION, CORTICAL ACH RELEASE AND NEURONAL ACTIVITY
    Martin Sarter; Fiscal Year: 2006
    ....
  5. Regulation of cortical ACh and Cognition
    Martin Sarter; Fiscal Year: 2007
    ..The renewal of the KO2 would allow this candidate to devote at least 75% of his time for multidisciplinary research on the neurobiology of attentional functions. ..
  6. In vivo screening of cholinergic cognition enhancers
    Martin Sarter; Fiscal Year: 2007
    ..The development of new drug finding ..
  7. Nicotinic regulation of cortical ACh release and behavioral function
    Martin Sarter; Fiscal Year: 2007
    ..This research will reveal critical neuronal and cognitive mechanisms underlying the pro-cognitive effects of nicotinic receptor ligands and thereby assist in defining and predicting the clinical potential of this group of compounds. ..
  8. Nicotinic regulation of cortical ACh release and behavioral function
    Martin Sarter; Fiscal Year: 2009
    ..This research will reveal critical neuronal and cognitive mechanisms underlying the pro-cognitive effects of nicotinic receptor ligands and thereby assist in defining and predicting the clinical potential of this group of compounds. ..
  9. Nicotinic regulation of cortical ACh release and behavioral function
    MARTIN F SARTER; Fiscal Year: 2010
    ..This research will reveal critical neuronal and cognitive mechanisms underlying the pro-cognitive effects of nicotinic receptor ligands and thereby assist in defining and predicting the clinical potential of this group of compounds. ..
  10. ATTENTION, CORTICAL ACH RELEASE AND NEURONAL ACTIVITY
    Martin Sarter; Fiscal Year: 2001
    ..The determination of the specific cognitive functions of cortical ACh will lead to a better understanding of the disastrous cognitive consequences of deviations in the integrity of cortical cholinergic afferents. ..
  11. AGING, ATTENTION AND BENZODIAZEPINE RECEPTOR LIGANDS
    Martin Sarter; Fiscal Year: 2002
    ....
  12. Amphetamine, cortical acetylcholine and cognition
    Martin Sarter; Fiscal Year: 2003
    ..abstract_text> ..
  13. Choline transporter capacity limits motivated behavior on mice, rats, and humans
    MARTIN F SARTER; Fiscal Year: 2010
    ..The results from this research are of direct significance for hypotheses concerning the role of this major neuromodulator system in cognitive disorders and for the development of new treatments for such disorders. ..