SUSHIL SARNA

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Cell culture retains contractile phenotype but epigenetically modulates cell-signaling proteins of excitation-contraction coupling in colon smooth muscle cells
    Xuan Zheng Shi
    Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
    Am J Physiol Gastrointest Liver Physiol 304:G337-45. 2013
  2. pmc Nitric oxide modifies chromatin to suppress ICAM-1 expression during colonic inflammation
    Qingjie Li
    Division of Gastroenterology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1083, USA
    Am J Physiol Gastrointest Liver Physiol 303:G103-10. 2012
  3. ncbi request reprint Molecular, functional, and pharmacological targets for the development of gut promotility drugs
    Sushil K Sarna
    Division of Gastroenterology, Dept of Internal Medicine, University of Texas Medical Branch at Galveston, 9 138 Medical Research Bldg, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 291:G545-55. 2006
  4. ncbi request reprint Are interstitial cells of Cajal plurifunction cells in the gut?
    Sushil K Sarna
    Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, Neuroscience, and Cell Biology, The University of Texas Medical Branch at Gavelston, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 294:G372-90. 2008
  5. ncbi request reprint Novel aspects of enteric neural regulation of colonic motility
    S K Sarna
    Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA
    Eur Rev Med Pharmacol Sci 12:134. 2008
  6. ncbi request reprint Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral pain
    Sushil K Sarna
    Division of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 292:G572-81. 2007
  7. ncbi request reprint Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractions
    Sushil K Sarna
    Enteric Neuromusclular Disorders and Visceral Pain Center, Department of Internal Medicine, Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 284:G789-97. 2003
  8. pmc Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2
    Xuan Zheng Shi
    Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Am J Physiol Gastrointest Liver Physiol 300:G99-G108. 2011
  9. ncbi request reprint Tachykinin receptors as drug targets for motility disorders
    Willemijntje A Hoogerwerf
    Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch, Galveston, TX 77555 1064, USA
    Dig Dis 24:83-90. 2006
  10. pmc Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function
    Barun K Choudhury
    Div of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, 8 104 Medical Research Bldg, Galveston, TX 77555 1083, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1238-47. 2009

Collaborators

Detail Information

Publications26

  1. pmc Cell culture retains contractile phenotype but epigenetically modulates cell-signaling proteins of excitation-contraction coupling in colon smooth muscle cells
    Xuan Zheng Shi
    Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
    Am J Physiol Gastrointest Liver Physiol 304:G337-45. 2013
    ..However, reactivity to ACh declines because of altered expression of specific cell-signaling proteins involved in excitation-contraction coupling. DNA methylation of the Cpi-17 promoter may contribute to its gene suppression...
  2. pmc Nitric oxide modifies chromatin to suppress ICAM-1 expression during colonic inflammation
    Qingjie Li
    Division of Gastroenterology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1083, USA
    Am J Physiol Gastrointest Liver Physiol 303:G103-10. 2012
    ....
  3. ncbi request reprint Molecular, functional, and pharmacological targets for the development of gut promotility drugs
    Sushil K Sarna
    Division of Gastroenterology, Dept of Internal Medicine, University of Texas Medical Branch at Galveston, 9 138 Medical Research Bldg, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 291:G545-55. 2006
    ....
  4. ncbi request reprint Are interstitial cells of Cajal plurifunction cells in the gut?
    Sushil K Sarna
    Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, Neuroscience, and Cell Biology, The University of Texas Medical Branch at Gavelston, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 294:G372-90. 2008
    ....
  5. ncbi request reprint Novel aspects of enteric neural regulation of colonic motility
    S K Sarna
    Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA
    Eur Rev Med Pharmacol Sci 12:134. 2008
  6. ncbi request reprint Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral pain
    Sushil K Sarna
    Division of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 292:G572-81. 2007
    ..Our findings show that GMCs, but not RPCs, initiate pseudoaffective signals from the gut. In the presence of visceral hypersensitivity or impaired descending inhibition, the GMCs may become a noxious stimulus...
  7. ncbi request reprint Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractions
    Sushil K Sarna
    Enteric Neuromusclular Disorders and Visceral Pain Center, Department of Internal Medicine, Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 284:G789-97. 2003
    ..In conclusion, acetylcholine is the common neurotransmitter for the stimulation of both GMCs and RPCs, but the signaling cascades for their stimulation are partially divergent, and they differ also in the normal and inflamed states...
  8. pmc Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2
    Xuan Zheng Shi
    Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Am J Physiol Gastrointest Liver Physiol 300:G99-G108. 2011
    ..In conclusion, mechanical stretch in obstruction induces marked expression of COX-2 in the colonic SMC, and stretch-induced COX-2 plays a critical role in the suppression of smooth muscle contractility in bowel obstruction...
  9. ncbi request reprint Tachykinin receptors as drug targets for motility disorders
    Willemijntje A Hoogerwerf
    Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch, Galveston, TX 77555 1064, USA
    Dig Dis 24:83-90. 2006
    ..This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state...
  10. pmc Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor function
    Barun K Choudhury
    Div of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, 8 104 Medical Research Bldg, Galveston, TX 77555 1083, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1238-47. 2009
    ..2 channels in circular smooth muscle cells. These findings suggest the potential cellular mechanisms by which heterotypic chronic stress may exacerbate motility dysfunction in patients with irritable bowel syndrome...
  11. pmc Homeostatic and therapeutic roles of VIP in smooth muscle function: myo-neuroimmune interactions
    Xuan Zheng Shi
    Division of Gastroenterology, Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas Medical Branch at Galveston, Texas 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 297:G716-25. 2009
    ..The infusion of exogenous VIP mitigates colonic inflammatory response and smooth muscle dysfunction...
  12. pmc Gene therapy of Cav1.2 channel with VIP and VIP receptor agonists and antagonists: a novel approach to designing promotility and antimotility agents
    Xuan Zheng Shi
    Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 295:G187-G196. 2008
    ....
  13. pmc Gene plasticity in colonic circular smooth muscle cells underlies motility dysfunction in a model of postinfective IBS
    Barun K Choudhury
    Enteric Neuromuscular Disorders and Visceral Pain Center, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, 9 138 Medical Research Bldg, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 296:G632-42. 2009
    ....
  14. ncbi request reprint A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cells
    Xuan Zheng Shi
    Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA
    Gastroenterology 132:1388-400. 2007
    ..The aim of this study was to investigate whether the phosphorylation of CREB induces gene expression of the pore-forming alpha(1C) subunit of Ca(v)1.2 channels (L-type calcium channels), whose promoter has 2 binding sites for CREB...
  15. ncbi request reprint TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1- and NF-kappaB-mediated induction of ICAM-1
    Konrad Pazdrak
    Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, 77555 1064, USA
    Gastroenterology 127:1096-109. 2004
    ....
  16. ncbi request reprint G protein-mediated dysfunction of excitation-contraction coupling in ileal inflammation
    Xuan Zheng Shi
    Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 286:G899-905. 2004
    ..These effects are mediated by the differentially altered expression and binding activity of their respective coupled G alpha(q/11) and G alpha(i3) proteins...
  17. ncbi request reprint NF-kappa B activation by oxidative stress and inflammation suppresses contractility in colonic circular smooth muscle cells
    Xuan Zheng Shi
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, 77555, USA
    Gastroenterology 124:1369-80. 2003
    ..The aim of this study was to investigate whether NF-kappa B is activated by inflammation and oxidative stress in colonic circular smooth muscle cells and whether that leads to suppression of their contractility...
  18. pmc Chronic stress targets posttranscriptional mechanisms to rapidly upregulate α1C-subunit of Cav1.2b calcium channels in colonic smooth muscle cells
    Qingjie Li
    Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1083, USA
    Am J Physiol Gastrointest Liver Physiol 300:G154-63. 2011
    ..2b channels by concurrently suppressing its degradation and enhancing translation of existing transcripts to maintain homeostasis...
  19. pmc Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis
    Xuan Zheng Shi
    Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 300:G41-51. 2011
    ..The inflammatory mediators in TNBS and DSS inflammations target different genes to impair smooth muscle function...
  20. pmc Adrenergic stimulation mediates visceral hypersensitivity to colorectal distension following heterotypic chronic stress
    John H Winston
    Department of Internal Medicine, Division of Gastroenterology, Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas, Medical Branch at Galveston, Texas 77555 1083, USA
    Gastroenterology 138:294-304.e3. 2010
    ..We investigated whether chronic stress increases plasma norepinephrine and sensitizes colon-specific dorsal root ganglion (DRG) neurons by increasing expression of nerve growth factor (NGF) in the colon wall...
  21. ncbi request reprint Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB
    Xuan Zheng Shi
    Department of Internal Medicine, Division of Gastroenterology, Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1064, USA
    Gastroenterology 129:1518-32. 2005
    ..Our aim was to investigate whether the activation of p50 and p65 nuclear factor-kappaB subunits mediates these effects...
  22. ncbi request reprint Smooth muscle uses another promoter to express primarily a form of human Cav1.2 L-type calcium channel different from the principal heart form
    Nehad Saada
    Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555 0641, USA
    Biochem Biophys Res Commun 302:23-8. 2003
    ..These results indicate that expression in smooth muscle is primarily driven by a promoter different from that which drives expression in cardiac myocytes...
  23. ncbi request reprint Cholinergic and nitrergic regulation of in vivo giant migrating contractions in rat colon
    Mona Li
    Departments of Surgery and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Gastrointest Liver Physiol 283:G544-52. 2002
    ..In vivo GMCs are stimulated by neural release of acetylcholine that acts on M3 receptors. Constitutive release of nitric oxide may partially suppress their frequency...
  24. ncbi request reprint Selective modulation of PKC isozymes by inflammation in canine colonic circular muscle cells
    Irshad Ali
    Department of Surgery, Medical College of Wisconsin, and Zablocki Veteran Affairs Medical Center, Milwaukee, Wisconsin, USA
    Gastroenterology 122:483-94. 2002
    ..We investigated whether the attenuated contraction in inflamed colon cells is caused by alterations in the expression, distribution, and activation of specific PKC isozymes...
  25. ncbi request reprint Transcriptional regulation of inflammatory mediators secreted by human colonic circular smooth muscle cells
    Xuan Zheng Shi
    Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, 9 138 Medical Research Bldg, Galveston, TX 77555 1064, USA
    Am J Physiol Gastrointest Liver Physiol 289:G274-84. 2005
    ..We conclude that TNF-alpha induces gene expression in HCCSMC for programmed synthesis and release of pro- and anti-inflammatory mediators...
  26. ncbi request reprint Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice
    Maria Adelaide Micci
    Enteric Neuromuscular Disorders and Pain Laboratory, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas 77555 0764, USA
    Gastroenterology 129:1817-24. 2005
    ..The aim of this study was to evaluate the effect of intrapyloric transplantation of neural stem cells (NSCs) on gastric emptying and pyloric function in nNOS-/- mice, a well-established genetic model of gastroparesis...

Research Grants34

  1. VIP-induced gene expression in colonic smooth muscle cells
    SUSHIL SARNA; Fiscal Year: 2007
    ..abstract_text> ..
  2. CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE
    SUSHIL SARNA; Fiscal Year: 2007
    ..The inhibition of NF-kappaB activation is an emerging therapy in treating inflammatory disorders. ..
  3. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    SUSHIL SARNA; Fiscal Year: 2009
    ..The findings of this proposal are expected to identify the potential molecular therapeutic approaches that may prevent or minimize the ill effects of chronic stress on colonic motility function. ..
  4. Control of colonic motility in health and disease.
    SUSHIL SARNA; Fiscal Year: 2009
    ..Our findings are expected to suggest that alternate therapeutic approaches may be required to normalize motility dysfunction in different types of inflammation. ..
  5. VIP-induced gene expression in colonic smooth muscle cells
    SUSHIL SARNA; Fiscal Year: 2009
    ..abstract_text> ..
  6. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    Sushil K Sarna; Fiscal Year: 2010
    ..The findings of this proposal are expected to identify the potential molecular therapeutic approaches that may prevent or minimize the ill effects of chronic stress on colonic motility function. ..
  7. Control of colonic motility in health and disease.
    Sushil K Sarna; Fiscal Year: 2010
    ..Our findings are expected to suggest that alternate therapeutic approaches may be required to normalize motility dysfunction in different types of inflammation. ..
  8. CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE
    SUSHIL SARNA; Fiscal Year: 1992
    ....
  9. CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE
    SUSHIL SARNA; Fiscal Year: 2002
    ..In inflammatory bowel disease and other forms of gut inflammation it would be desirable to selectively stimulation phasic contractions and tone to minimize diarrhea, urgency of defecation and abdominal discomfort. ..
  10. VIP-induced gene expression in colonic smooth muscle cells
    Sushil K Sarna; Fiscal Year: 2010
    ..abstract_text> ..