Research Topics
Species | SUSHIL SARNASummaryAffiliation: University of Texas Medical Branch Country: USA Publications
Research Grants
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Publications
Cell culture retains contractile phenotype but epigenetically modulates cell-signaling proteins of excitation-contraction coupling in colon smooth muscle cellsXuan Zheng Shi
Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
Am J Physiol Gastrointest Liver Physiol 304:G337-45. 2013..However, reactivity to ACh declines because of altered expression of specific cell-signaling proteins involved in excitation-contraction coupling. DNA methylation of the Cpi-17 promoter may contribute to its gene suppression...- Nitric oxide modifies chromatin to suppress ICAM-1 expression during colonic inflammationQingjie Li
Division of Gastroenterology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1083, USA
Am J Physiol Gastrointest Liver Physiol 303:G103-10. 2012.... 
Molecular, functional, and pharmacological targets for the development of gut promotility drugsSushil K Sarna
Division of Gastroenterology, Dept of Internal Medicine, University of Texas Medical Branch at Galveston, 9 138 Medical Research Bldg, Galveston, TX 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 291:G545-55. 2006....- Are interstitial cells of Cajal plurifunction cells in the gut?Sushil K Sarna
Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, Neuroscience, and Cell Biology, The University of Texas Medical Branch at Gavelston, Galveston, TX 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 294:G372-90. 2008.... - Novel aspects of enteric neural regulation of colonic motilityS K Sarna
Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA
Eur Rev Med Pharmacol Sci 12:134. 2008 - Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral painSushil K Sarna
Division of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, Galveston, TX 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 292:G572-81. 2007..Our findings show that GMCs, but not RPCs, initiate pseudoaffective signals from the gut. In the presence of visceral hypersensitivity or impaired descending inhibition, the GMCs may become a noxious stimulus... - Neuronal locus and cellular signaling for stimulation of ileal giant migrating and phasic contractionsSushil K Sarna
Enteric Neuromusclular Disorders and Visceral Pain Center, Department of Internal Medicine, Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 0632, USA
Am J Physiol Gastrointest Liver Physiol 284:G789-97. 2003..In conclusion, acetylcholine is the common neurotransmitter for the stimulation of both GMCs and RPCs, but the signaling cascades for their stimulation are partially divergent, and they differ also in the normal and inflamed states... - Pathophysiology of motility dysfunction in bowel obstruction: role of stretch-induced COX-2Xuan Zheng Shi
Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
Am J Physiol Gastrointest Liver Physiol 300:G99-G108. 2011..In conclusion, mechanical stretch in obstruction induces marked expression of COX-2 in the colonic SMC, and stretch-induced COX-2 plays a critical role in the suppression of smooth muscle contractility in bowel obstruction... - Tachykinin receptors as drug targets for motility disordersWillemijntje A Hoogerwerf
Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch, Galveston, TX 77555 1064, USA
Dig Dis 24:83-90. 2006..This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state... - Norepinephrine mediates the transcriptional effects of heterotypic chronic stress on colonic motor functionBarun K Choudhury
Div of Gastroenterology, Dept of Internal Medicine, The Univ of Texas Medical Branch at Galveston, 8 104 Medical Research Bldg, Galveston, TX 77555 1083, USA
Am J Physiol Gastrointest Liver Physiol 296:G1238-47. 2009..2 channels in circular smooth muscle cells. These findings suggest the potential cellular mechanisms by which heterotypic chronic stress may exacerbate motility dysfunction in patients with irritable bowel syndrome... - Homeostatic and therapeutic roles of VIP in smooth muscle function: myo-neuroimmune interactionsXuan Zheng Shi
Division of Gastroenterology, Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas Medical Branch at Galveston, Texas 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 297:G716-25. 2009..The infusion of exogenous VIP mitigates colonic inflammatory response and smooth muscle dysfunction... - Gene therapy of Cav1.2 channel with VIP and VIP receptor agonists and antagonists: a novel approach to designing promotility and antimotility agentsXuan Zheng Shi
Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 295:G187-G196. 2008.... - Gene plasticity in colonic circular smooth muscle cells underlies motility dysfunction in a model of postinfective IBSBarun K Choudhury
Enteric Neuromuscular Disorders and Visceral Pain Center, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, 9 138 Medical Research Bldg, Galveston, TX 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 296:G632-42. 2009.... - A novel role of VIP in colonic motility function: induction of excitation-transcription coupling in smooth muscle cellsXuan Zheng Shi
Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA
Gastroenterology 132:1388-400. 2007..The aim of this study was to investigate whether the phosphorylation of CREB induces gene expression of the pore-forming alpha(1C) subunit of Ca(v)1.2 channels (L-type calcium channels), whose promoter has 2 binding sites for CREB... - TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1- and NF-kappaB-mediated induction of ICAM-1Konrad Pazdrak
Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, 77555-1064, USA
Gastroenterology 127:1096-109. 2004..The expression of ICAM-1 plays a critical role in the suppression of cell contractility in response to TNFalpha... - G protein-mediated dysfunction of excitation-contraction coupling in ileal inflammationXuan-Zheng Shi
Department of Internal Medicine, Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, The University of Texas Medical Branch at Galveston, 77555-0632, USA
Am J Physiol Gastrointest Liver Physiol 286:G899-905. 2004..These effects are mediated by the differentially altered expression and binding activity of their respective coupled G alpha(q/11) and G alpha(i3) proteins... - NF-kappa B activation by oxidative stress and inflammation suppresses contractility in colonic circular smooth muscle cellsXuan-Zheng Shi
Department of Internal Medicine, University of Texas Medical Branch, Galveston, 77555, USA
Gastroenterology 124:1369-80. 2003..CONCLUSIONS: Transcription factor NF-kappa B is activated in colonic circular muscle cells by inflammation and oxidative stress. This activation of NF-kappa B mediates the suppression of cell contractility... - Chronic stress targets posttranscriptional mechanisms to rapidly upregulate α1C-subunit of Cav1.2b calcium channels in colonic smooth muscle cellsQingjie Li
Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1083, USA
Am J Physiol Gastrointest Liver Physiol 300:G154-63. 2011..2b channels by concurrently suppressing its degradation and enhancing translation of existing transcripts to maintain homeostasis... - Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitisXuan Zheng Shi
Enteric Neuromuscular Disorders and Visceral Pain Center, Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1064, USA
Am J Physiol Gastrointest Liver Physiol 300:G41-51. 2011..The inflammatory mediators in TNBS and DSS inflammations target different genes to impair smooth muscle function... - Adrenergic stimulation mediates visceral hypersensitivity to colorectal distension following heterotypic chronic stressJohn H Winston
Department of Internal Medicine, Division of Gastroenterology, Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas, Medical Branch at Galveston, Texas 77555 1083, USA
Gastroenterology 138:294-304.e3. 2010..We investigated whether chronic stress increases plasma norepinephrine and sensitizes colon-specific dorsal root ganglion (DRG) neurons by increasing expression of nerve growth factor (NGF) in the colon wall... - Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaBXuan Zheng Shi
Department of Internal Medicine, Division of Gastroenterology, Enteric Neuromuscular Disorders and Visceral Pain Center, The University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1064, USA
Gastroenterology 129:1518-32. 2005..Our aim was to investigate whether the activation of p50 and p65 nuclear factor-kappaB subunits mediates these effects... - Smooth muscle uses another promoter to express primarily a form of human Cav1.2 L-type calcium channel different from the principal heart formNehad Saada
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555 0641, USA
Biochem Biophys Res Commun 302:23-8. 2003..These results indicate that expression in smooth muscle is primarily driven by a promoter different from that which drives expression in cardiac myocytes... - Cholinergic and nitrergic regulation of in vivo giant migrating contractions in rat colonMona Li
Departments of Surgery and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Am J Physiol Gastrointest Liver Physiol 283:G544-52. 2002..In vivo GMCs are stimulated by neural release of acetylcholine that acts on M3 receptors. Constitutive release of nitric oxide may partially suppress their frequency... - Selective modulation of PKC isozymes by inflammation in canine colonic circular muscle cellsIrshad Ali
Department of Surgery, Medical College of Wisconsin, and Zablocki Veteran Affairs Medical Center, Milwaukee, Wisconsin, USA
Gastroenterology 122:483-94. 2002..Contractile dysfunction in inflamed colon cells is, in part, caused by decreased expression and impaired activation of specific PKC isozymes... - Transcriptional regulation of inflammatory mediators secreted by human colonic circular smooth muscle cellsXuan-Zheng Shi
Division of Gastroenterology, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, 9.138 Medical Research Bldg, Galveston, TX 77555-1064, USA
Am J Physiol Gastrointest Liver Physiol 289:G274-84. 2005..We conclude that TNF-alpha induces gene expression in HCCSMC for programmed synthesis and release of pro- and anti-inflammatory mediators... - Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient miceMaria-Adelaide Micci
Enteric Neuromuscular Disorders and Pain Laboratory, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas 77555-0764, USA
Gastroenterology 129:1817-24. 2005..CONCLUSIONS: Our results support the potential of NSC transplantation as a viable therapeutic option for neuroenteric disorders...
Research Grants
- VIP-induced gene expression in colonic smooth muscle cellsSUSHIL SARNA; Fiscal Year: 2007..abstract_text> ..
- CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASESUSHIL SARNA; Fiscal Year: 2007..The inhibition of NF-kappaB activation is an emerging therapy in treating inflammatory disorders. ..
- Chronic stress-induced gene expression in colonic circular smooth muscle cells.SUSHIL SARNA; Fiscal Year: 2009..The findings of this proposal are expected to identify the potential molecular therapeutic approaches that may prevent or minimize the ill effects of chronic stress on colonic motility function. ..
- Control of colonic motility in health and disease.SUSHIL SARNA; Fiscal Year: 2009..Our findings are expected to suggest that alternate therapeutic approaches may be required to normalize motility dysfunction in different types of inflammation. ..
- VIP-induced gene expression in colonic smooth muscle cellsSUSHIL SARNA; Fiscal Year: 2009..abstract_text> ..
- Chronic stress-induced gene expression in colonic circular smooth muscle cells.Sushil K Sarna; Fiscal Year: 2010..The findings of this proposal are expected to identify the potential molecular therapeutic approaches that may prevent or minimize the ill effects of chronic stress on colonic motility function. ..
- Control of colonic motility in health and disease.Sushil K Sarna; Fiscal Year: 2010..Our findings are expected to suggest that alternate therapeutic approaches may be required to normalize motility dysfunction in different types of inflammation. ..
- CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASESUSHIL SARNA; Fiscal Year: 1992....
- CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASESUSHIL SARNA; Fiscal Year: 2002..In inflammatory bowel disease and other forms of gut inflammation it would be desirable to selectively stimulation phasic contractions and tone to minimize diarrhea, urgency of defecation and abdominal discomfort. ..
- VIP-induced gene expression in colonic smooth muscle cellsSushil K Sarna; Fiscal Year: 2010..abstract_text> ..