Youssef Sari


Affiliation: University of Toledo
Country: USA


  1. Sari Y, Franklin K, Alazizi A, Rao P, Bell R. Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats. Neuroscience. 2013;241:229-38 pubmed publisher
    ..These findings provide further support for GLT1-associated mechanisms in high alcohol-consuming behavior, and hold promise for the development of effective treatments targeting alcohol abuse and dependence. ..
  2. Sari Y, Sreemantula S, Lee M, Choi D. Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats. J Mol Neurosci. 2013;51:779-87 pubmed publisher
    ..Importantly, CEF treatment reversed these effects in both NAc core and shell. These findings provide evidence for potential regulatory effects of CEF on both GLT1 and ENT1 expression in reducing ethanol intake. ..
  3. Althobaiti Y, Alshehri F, Hakami A, Hammad A, Sari Y. Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol. J Mol Neurosci. 2019;67:1-15 pubmed publisher
    ..These findings suggest that these glutamate transporters and mGluR2/3 might be potential therapeutic targets for the attenuation of reinstatement to METH-seeking. ..
  4. Alasmari F, Goodwani S, McCullumsmith R, Sari Y. Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence. Prog Neurobiol. 2018;171:32-49 pubmed publisher
    ..Finally, we provided some limitations on targeting the glutamatergic system for potential therapeutic options for the treatment alcohol use disorders. ..
  5. Hakami A, Alshehri F, Sari Y. β-lactams modulate astroglial glutamate transporters and attenuate dependence to CP 55,940, a CB1 receptor agonist, in rat model. Behav Brain Res. 2019;359:709-718 pubmed publisher
    ..These findings suggest that β-lactams may play a potential therapeutic role in attenuating dependence to cannabinoids, in part, through upregulation of GLT-1 and xCT. ..
  6. Sari Y, Sakai M, Weedman J, Rebec G, Bell R. Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats. Alcohol Alcohol. 2011;46:239-46 pubmed publisher
    ..These results indicate that CEF effectively reduces ethanol intake, possibly through activation of GLT1, and may be a potential therapeutic drug for alcohol addiction treatment. ..
  7. Yacila G, Sari Y. Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis. Curr Med Chem. 2014;21:3583-93 pubmed
    ..Interestingly, the uses of stem cell therapy and immunotherapy are promising for the treatment of ALS. ..
  8. request reprint
    Sari Y, Khalil A. Monoamine Oxidase Inhibitors Extracted from Tobacco Smoke as Neuroprotective Factors for Potential Treatment of Parkinson's Disease. CNS Neurol Disord Drug Targets. 2015;14:777-85 pubmed
  9. Rao P, Goodwani S, Bell R, Wei Y, Boddu S, Sari Y. Effects of ampicillin, cefazolin and cefoperazone treatments on GLT-1 expressions in the mesocorticolimbic system and ethanol intake in alcohol-preferring rats. Neuroscience. 2015;295:164-74 pubmed publisher
    ..In addition, these results suggest that pAKT may be an important player in this effect, possibly through increased transcription of GLT-1. ..

More Information


  1. Das S, Yamamoto B, Hristov A, Sari Y. Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats. Neuropharmacology. 2015;97:67-74 pubmed publisher
    ..Our present study demonstrates that ceftriaxone treatment prevents ethanol drinking in part through normalization of extracellular glutamate concentrations in NAc of male P rats via GLT-1. ..
  2. Alasmari F, Abuhamdah S, Sari Y. Effects of ampicillin on cystine/glutamate antiporter and glutamate transporter 1 isoforms as well as ethanol drinking in male P rats. Neurosci Lett. 2015;600:148-52 pubmed publisher
    ..Our findings provide significant role of ampicillin on upregulating xCT and GLT-1 isoforms expression, might be suggested as possible targets for the attenuation of ethanol consumption. ..
  3. Goodwani S, Rao P, Bell R, Sari Y. Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Brain Res. 2015;1622:397-408 pubmed publisher
    ..Thus, GLT-1 and pAKT may serve as molecular targets for the treatment of alcohol and drug abuse/dependence. ..
  4. Alasmari F, Bell R, Rao P, Hammad A, Sari Y. Peri-adolescent drinking of ethanol and/or nicotine modulates astroglial glutamate transporters and metabotropic glutamate receptor-1 in female alcohol-preferring rats. Pharmacol Biochem Behav. 2018;170:44-55 pubmed publisher
    ..Our data further parallel some of the previous findings observed in adult rats. ..
  5. Alshehri F, Hakami A, Althobaiti Y, Sari Y. Effects of ceftriaxone on hydrocodone seeking behavior and glial glutamate transporters in P rats. Behav Brain Res. 2018;347:368-376 pubmed publisher
    ..These findings demonstrate that the attenuating effect of HYD reinstatement with CEF might be mediated through xCT. ..
  6. Sari Y, Weedman J, Nkrumah Abrokwah M. Neurotrophic peptides, ADNF-9 and NAP, prevent alcohol-induced apoptosis at midgestation in fetal brains of C57BL/6 mouse. J Mol Neurosci. 2013;49:150-6 pubmed publisher
    ..These findings may pave the path toward potential therapeutics against alcohol intoxication during pregnancy stages. ..
  7. Rao P, Saternos H, Goodwani S, Sari Y. Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol. Psychopharmacology (Berl). 2015;232:2333-42 pubmed publisher
    ..These findings demonstrate that ceftriaxone treatment induced upregulation of GLT1, GLT1 isoforms, and xCT in association with activation of the Akt-NFκB signaling pathway. ..
  8. Althobaiti Y, Almalki A, Das S, Alshehri F, Sari Y. Effects of repeated high-dose methamphetamine and ceftriaxone post-treatments on tissue content of dopamine and serotonin as well as glutamate and glutamine. Neurosci Lett. 2016;634:25-31 pubmed publisher
    ..These findings demonstrate for the first time the attenuating effects of CEF post-treatment on METH induced alterations in the tissue contents of dopamine, glutamate, and glutamine. ..
  9. Alshehri F, Althobaiti Y, Sari Y. Effects of Administered Ethanol and Methamphetamine on Glial Glutamate Transporters in Rat Striatum and Hippocampus. J Mol Neurosci. 2017;61:343-350 pubmed publisher
    ..These findings demonstrated that sequential exposure to EtOH and MA has additive effect in downregulation of GLT-1 and this effect can be attenuated by CEF treatment. ..
  10. Hakami A, Alshehri F, Althobaiti Y, Sari Y. Effects of orally administered Augmentin on glutamate transporter 1, cystine-glutamate exchanger expression and ethanol intake in alcohol-preferring rats. Behav Brain Res. 2017;320:316-322 pubmed publisher
    ..There was no effect of orally administered Augmentin on GLAST expression in either NAc or PFC. These findings present strong evidence that oral administration of Augmentin can be used as an alternative to parenteral treatment. ..
  11. Das S, Althobaiti Y, Alshehri F, Sari Y. Binge ethanol withdrawal: Effects on post-withdrawal ethanol intake, glutamate-glutamine cycle and monoamine tissue content in P rat model. Behav Brain Res. 2016;303:120-5 pubmed publisher
    ..The tissue content of DA was significantly lower in both mPFC and NAc, whereas tissue content of serotonin was unchanged in both mPFC and NAc. These findings provide important information of the critical role of GLT-1 in context of AWS. ..
  12. Alasmari F, Rao P, Sari Y. Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats. Brain Res. 2016;1634:150-157 pubmed publisher
    ..Overall, our findings suggest that cefazolin and cefoperazone may be considered as potential compounds for the treatment of ethanol dependence. ..
  13. Alasmari F, Al Rejaie S, Alsharari S, Sari Y. Targeting glutamate homeostasis for potential treatment of nicotine dependence. Brain Res Bull. 2016;121:1-8 pubmed publisher
  14. request reprint
    Abuhamdah S, Khalil A, Sari Y. Targeting Dopaminergic System for Treating Nicotine Dependence. Cent Nerv Syst Agents Med Chem. 2016;16:137-42 pubmed
    ..This includes blockade of dopamine transporter and inhibition of MAO as pharmacotherapy for the treatment of nicotine dependence. ..
  15. Sari Y, Toalston J, Rao P, Bell R. Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression. Neuroscience. 2016;326:117-125 pubmed publisher
  16. Goodwani S, Saternos H, Alasmari F, Sari Y. Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder. Neurosci Biobehav Rev. 2017;77:14-31 pubmed publisher
    ..This review provides ample information about the potential therapeutic role of glutamatergic receptors for the treatment of AUD. ..
  17. Alasmari F, Crotty Alexander L, Nelson J, Schiefer I, Breen E, Drummond C, et al. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017;77:1-8 pubmed publisher
    ..Our work may suggest that nicotine exposure via chronic inhalation of e-cigarette vapor may be mediated in part by alterations in the glutamatergic system. ..
  18. Hammad A, Althobaiti Y, Das S, Sari Y. Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats. Mol Cell Neurosci. 2017;82:58-65 pubmed publisher
    ..Our findings demonstrated that chronic cocaine exposure affects ethanol intake; and ethanol and cocaine co-abuse alters the expression of glial glutamate transporters. ..
  19. Hammad A, Alasmari F, Althobaiti Y, Sari Y. Modulatory effects of Ampicillin/Sulbactam on glial glutamate transporters and metabotropic glutamate receptor 1 as well as reinstatement to cocaine-seeking behavior. Behav Brain Res. 2017;332:288-298 pubmed publisher
    ..These findings demonstrated that glial glutamate transporters and mGluR1 in the mesocorticolimbic area could be potential therapeutic targets for the attenuation of reinstatement to cocaine-seeking behavior. ..
  20. Hakami A, Sari Y. β-Lactamase inhibitor, clavulanic acid, attenuates ethanol intake and increases glial glutamate transporters expression in alcohol preferring rats. Neurosci Lett. 2017;657:140-145 pubmed publisher
    ..Thus, we suggest that clavulanic acid might be used as an alternative option to ceftriaxone to attenuate ethanol drinking behavior. ..
  21. Almalki A, Das S, Alshehri F, Althobaiti Y, Sari Y. Effects of sequential ethanol exposure and repeated high-dose methamphetamine on striatal and hippocampal dopamine, serotonin and glutamate tissue content in Wistar rats. Neurosci Lett. 2018;665:61-66 pubmed publisher
    ..This study demonstrated that sequential exposure of ethanol and METH has an additive effect on tissue content of certain neurotransmitters in the brain. ..