Youssef Sari

Summary

Affiliation: University of Toledo
Country: USA

Publications

  1. pmc Potential drugs and methods for preventing or delaying the progression of Huntington's disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, OH 43614, USA
    Recent Pat CNS Drug Discov 6:80-90. 2011
  2. ncbi request reprint Monoamine Oxidase Inhibitors Extracted from Tobacco Smoke as Neuroprotective Factors for Potential Treatment of Parkinson's Disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, HEB282G, Toledo, OH 43614 USA
    CNS Neurol Disord Drug Targets 14:777-85. 2015
  3. pmc Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis
    G Yacila
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614 USA
    Curr Med Chem 21:3583-93. 2014
  4. pmc Therapeutic perspectives of drugs targeting Toll-like receptors based on immune physiopathology theory of Alzheimer's disease
    Andrew R Schneider
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    CNS Neurol Disord Drug Targets 13:909-20. 2014
  5. pmc Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA
    J Mol Neurosci 51:779-87. 2013
  6. pmc Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats
    Y Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    Neuroscience 241:229-38. 2013
  7. pmc Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    J Psychopharmacol 27:3-12. 2013
  8. pmc Glutamate transporter 1: target for the treatment of alcohol dependence
    P S S Rao
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Curr Med Chem 19:5148-56. 2012
  9. pmc Neurotrophic peptides, ADNF-9 and NAP, prevent alcohol-induced apoptosis at midgestation in fetal brains of C57BL/6 mouse
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, USA
    J Mol Neurosci 49:150-6. 2013
  10. pmc Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats
    Y Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, United States
    Neuroscience 227:327-35. 2012

Collaborators

  • R L Bell
  • P S S Rao
  • Fawaz Alasmari
  • Sunil Goodwani
  • G Yacila
  • Andrew R Schneider
  • Abeer M Qrunfleh
  • Shakir D Alsharari
  • Salim S Al-Rejaie
  • Hannah Saternos
  • Adnan Alazizi

Detail Information

Publications21

  1. pmc Potential drugs and methods for preventing or delaying the progression of Huntington's disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, OH 43614, USA
    Recent Pat CNS Drug Discov 6:80-90. 2011
    ..There are current patented drugs that are currently being considered as potential therapeutics for HD. These patented drugs may provide promising therapy for HD...
  2. ncbi request reprint Monoamine Oxidase Inhibitors Extracted from Tobacco Smoke as Neuroprotective Factors for Potential Treatment of Parkinson's Disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, HEB282G, Toledo, OH 43614 USA
    CNS Neurol Disord Drug Targets 14:777-85. 2015
    ....
  3. pmc Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis
    G Yacila
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614 USA
    Curr Med Chem 21:3583-93. 2014
    ..Interestingly, the uses of stem cell therapy and immunotherapy are promising for the treatment of ALS...
  4. pmc Therapeutic perspectives of drugs targeting Toll-like receptors based on immune physiopathology theory of Alzheimer's disease
    Andrew R Schneider
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    CNS Neurol Disord Drug Targets 13:909-20. 2014
    ..The primary drug therapy methods and patents discussed include the use of neurotrophic factors and targeting of the amyloid precursor protein cleavage pathway as prevention of β-amyloid formation and tau aggregation. ..
  5. pmc Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA
    J Mol Neurosci 51:779-87. 2013
    ..Importantly, CEF treatment reversed these effects in both NAc core and shell. These findings provide evidence for potential regulatory effects of CEF on both GLT1 and ENT1 expression in reducing ethanol intake...
  6. pmc Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats
    Y Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    Neuroscience 241:229-38. 2013
    ..These findings provide further support for GLT1-associated mechanisms in high alcohol-consuming behavior, and hold promise for the development of effective treatments targeting alcohol abuse and dependence...
  7. pmc Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    J Psychopharmacol 27:3-12. 2013
    ..This review on the role of 5-HT1B receptors in neurotransmitter release and consequent alcohol intake provides important information about the potential therapeutic role of 5-HT1B receptors for the treatment of alcohol dependence...
  8. pmc Glutamate transporter 1: target for the treatment of alcohol dependence
    P S S Rao
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Curr Med Chem 19:5148-56. 2012
    ..Importantly, ceftriaxone is currently in clinical trials for the treatment of amyotrophic lateral sclerosis. This review provides information about the potential therapeutic role of GLT1 for the treatment of alcohol abuse and dependence...
  9. pmc Neurotrophic peptides, ADNF-9 and NAP, prevent alcohol-induced apoptosis at midgestation in fetal brains of C57BL/6 mouse
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, USA
    J Mol Neurosci 49:150-6. 2013
    ..These findings may pave the path toward potential therapeutics against alcohol intoxication during pregnancy stages...
  10. pmc Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats
    Y Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, United States
    Neuroscience 227:327-35. 2012
    ..These findings demonstrated that neuroimmunophilin GPI-1046 attenuates ethanol intake in part through the upregulation of GLT1 in PFC and NAc-core...
  11. pmc Activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through Bcl2 and c-Jun N-terminal kinase signaling pathways in fetal brain of C57BL/6 mouse
    Y Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Ave Toledo, OH 43614, USA
    Neuroscience 202:465-73. 2012
    ..The neuroprotective mechanism of action of ADNF-9 provides a direction for potential therapeutics against alcohol-induced neural damage involving mitochondrial dysfunction...
  12. pmc Neuroprotective peptide ADNF-9 in fetal brain of C57BL/6 mice exposed prenatally to alcohol
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
    J Biomed Sci 18:77. 2011
    ....
  13. pmc Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Alcohol Alcohol 46:239-46. 2011
    ..We hypothesized that because glutamate transporter 1 (GLT1) is responsible for the removal of most extracellular glutamate, up-regulation or activation of GLT1 would attenuate ethanol consumption...
  14. pmc Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats
    Abeer M Qrunfleh
    Department of Pharmacology, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH 43614, USA
    J Psychopharmacol 27:541-9. 2013
    ..In addition, CEF has no effect on relapse-like sucrose-drinking behavior. These findings suggest that ceftriaxone might be used as a potential therapeutic treatment for the attenuation of relapse-like ethanol-drinking behavior...
  15. doi request reprint Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions
    Sunil Goodwani
    The University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH, USA
    Brain Res 1622:397-408. 2015
    ..Thus, GLT-1 and pAKT may serve as molecular targets for the treatment of alcohol and drug abuse/dependence...
  16. pmc Role of the serotonergic system in alcohol dependence: from animal models to clinics
    Youssef Sari
    Department of Pharmacology, Health Science Campus, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio, USA
    Prog Mol Biol Transl Sci 98:401-43. 2011
    ....
  17. doi request reprint Targeting glutamate homeostasis for potential treatment of nicotine dependence
    Fawaz Alasmari
    Department of Pharmacology and Experimental Therapeutics, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, USA
    Brain Res Bull 121:1-8. 2016
    ....
  18. doi request reprint Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats
    Fawaz Alasmari
    Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
    Brain Res 1634:150-7. 2016
    ..Overall, our findings suggest that cefazolin and cefoperazone may be considered as potential compounds for the treatment of ethanol dependence. ..
  19. pmc Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol
    P S S Rao
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, HEB282G, Toledo, OH, 43614, USA
    Psychopharmacology (Berl) 232:2333-42. 2015
    ..Glial glutamate transporter 1 (GLT1) is one of them that regulates the majority of extracellular glutamate concentration. In addition, cystine/glutamate antiporter (xCT) is another transporter that regulates extracellular glutamate...
  20. pmc Effects of ceftriaxone on chronic ethanol consumption: a potential role for xCT and GLT1 modulation of glutamate levels in male P rats
    P S S Rao
    College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, University of Toledo, 3000 Arlington Avenue, HEB282G, Toledo, OH, 43614, USA
    J Mol Neurosci 54:71-7. 2014
    ..These might be due in part through the upregulation of both xCT and GLT1 levels in brain reward regions. Thus, the drug has a potential therapeutic action for the treatment of alcohol dependence...