Stefan Sarafianos

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. pmc Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase
    Ryan C Durk
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, United States of America
    PLoS ONE 5:e15049. 2010
  2. pmc K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism
    Atsuko Hachiya
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, United States of America
    PLoS ONE 6:e16242. 2011
  3. pmc Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
    Tanyaradzwa P Ndongwe
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Columbia, MO 65211, USA
    Nucleic Acids Res 40:345-59. 2012
  4. pmc Mechanism of nucleic acid unwinding by SARS-CoV helicase
    Adeyemi O Adedeji
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Columbia, Missouri, United States of America
    PLoS ONE 7:e36521. 2012
  5. pmc Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
    Eleftherios Michailidis
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
    Retrovirology 10:65. 2013
  6. pmc Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase
    Karen A Kirby
    Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
    Antimicrob Agents Chemother 56:2048-61. 2012
  7. pmc The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site
    Michael E Abram
    University of Pittsburgh School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15219, USA
    Retrovirology 7:6. 2010

Collaborators

  • Kamalendra Singh
  • Eleftherios Michailidis
  • Donald H Burke
  • Susan Weiss
  • Marc Johnson
  • Karen A Kirby
  • Bruno Marchand
  • Atsuko Hachiya
  • Tanyaradzwa P Ndongwe
  • Adeyemi O Adedeji
  • Michael A Parniak
  • Yee Tsuey Ong
  • Devendra K Rai
  • Maxwell D Leslie
  • Christopher A Dorst
  • Michael E Abram
  • Ryan C Durk
  • Krista A Delviks-Frankenberry
  • Angela S Whatley
  • Robert L Eoff
  • Ei Ichi Kodama
  • Vinay K Pathak
  • Tracy L Fetterly
  • Shilei Ding
  • Daniel V Sietsema
  • Zhengqiang Wang
  • Eric J Snijder
  • Hiroaki Mitsuya
  • Emily M Ryan
  • Aartjan J W te Velthuis
  • Yi Min Zheng
  • Shan Lu Liu
  • Eiichi N Kodama
  • Shinichi Oka
  • Matthew M Schuckmann
  • Yasuko Sakagami
  • Christie Pautler
  • Jennifer Moran
  • Mark A McIntosh
  • Ceili A Cornelison
  • Adeyemi Adedeji
  • Kayla B Matzek
  • Elizabeth Schafer
  • Elizabeth Rieder
  • Luis L Rodriguez

Detail Information

Publications7

  1. pmc Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase
    Ryan C Durk
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, United States of America
    PLoS ONE 5:e15049. 2010
    ..In the case of an FMD outbreak, emergency vaccination requires at least 7 days to trigger an effective immune response. There are currently no approved inhibitors for the treatment or prevention of FMDV infections...
  2. pmc K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism
    Atsuko Hachiya
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, United States of America
    PLoS ONE 6:e16242. 2011
    ..The novel pattern of TFV-resistance may help adjust therapeutic strategies for NRTI-experienced patients with multi-drug resistant (MDR) mutations...
  3. pmc Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
    Tanyaradzwa P Ndongwe
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Columbia, MO 65211, USA
    Nucleic Acids Res 40:345-59. 2012
    ....
  4. pmc Mechanism of nucleic acid unwinding by SARS-CoV helicase
    Adeyemi O Adedeji
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine, Columbia, Missouri, United States of America
    PLoS ONE 7:e36521. 2012
    ..Our data provide experimental evidence that nsp13 and nsp12 can function in a concerted manner to improve the efficiency of viral replication and enhance our understanding of nsp13 function during SARS-CoV RNA synthesis...
  5. pmc Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
    Eleftherios Michailidis
    Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA
    Retrovirology 10:65. 2013
    ..EFdA is in preclinical development and its effect on clinically relevant drug resistant HIV strains is critically important for the design of optimal regimens prior to initiation of clinical trials...
  6. pmc Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase
    Karen A Kirby
    Christopher S Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
    Antimicrob Agents Chemother 56:2048-61. 2012
    ..5 Å) and determined the molecular details of the XMRV RNase H active site, thus providing a framework that would be useful for the design of antivirals that target RNase H...
  7. pmc The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site
    Michael E Abram
    University of Pittsburgh School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15219, USA
    Retrovirology 7:6. 2010
    ..In this study we have characterized in detail the impact of the T477A mutation on intravirion processing of RT...

Research Grants5