Theodore A Sarafian

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisole
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
    Toxicol Lett 133:171-9. 2002
  2. ncbi request reprint Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis
    T A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, UCLA School of Medicine, Room 37 131, Center for Health Sciences, Los Angeles, California 90095 1690, USA
    Toxicol Appl Pharmacol 174:264-72. 2001
  3. pmc Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 CHS, Los Angeles, CA 90095, USA
    Toxicol Appl Pharmacol 231:282-90. 2008
  4. ncbi request reprint Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo
    Theodore A Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1202-9. 2006
  5. ncbi request reprint Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Toxicol Lett 158:95-107. 2005
  6. pmc Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro
    Theodore A Sarafian
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9532. 2010
  7. ncbi request reprint Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003
  8. ncbi request reprint Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 10:6872-8. 2004
  9. ncbi request reprint Respiratory and immunologic consequences of marijuana smoking
    Donald P Tashkin
    Deportment of Medicine, UCLA School of Medicine, 90095 1690, USA
    J Clin Pharmacol 42:71S-81S. 2002
  10. ncbi request reprint Expression of the p75 TNF receptor is linked to TNF-induced NFkappaB translocation and oxyradical neutralization in glial cells
    Joel M Dopp
    Mental Retardation Research Center, University of California at Los Angeles, Los Angeles, California, 90024 1759, USA
    Neurochem Res 27:1535-42. 2002

Research Grants

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisole
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
    Toxicol Lett 133:171-9. 2002
    ..The combination was synergistic in this respect, reducing ATP levels to <15% of control. Exposure to marijuana smoke in conjunction with BHA, a common food additive, may promote deleterious health effects in the lung...
  2. ncbi request reprint Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis
    T A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, UCLA School of Medicine, Room 37 131, Center for Health Sciences, Los Angeles, California 90095 1690, USA
    Toxicol Appl Pharmacol 174:264-72. 2001
    ..This shift may affect both the carcinogenic and immunologic consequences of marijuana smoke exposure...
  3. pmc Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 CHS, Los Angeles, CA 90095, USA
    Toxicol Appl Pharmacol 231:282-90. 2008
    ..We conclude that airway epithelial cells are sensitive to both CB2R-dependent and independent effects mediated by THC...
  4. ncbi request reprint Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo
    Theodore A Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1202-9. 2006
    ..These results suggest that inhalation of marijuana smoke has deleterious effects on airway epithelial cell energetics that may contribute to the adverse pulmonary consequences of marijuana smoking...
  5. ncbi request reprint Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Toxicol Lett 158:95-107. 2005
    ..THC, delivered as a component of marijuana smoke, may induce a profile of gene expression that contributes to the pulmonary pathology associated with marijuana use...
  6. pmc Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro
    Theodore A Sarafian
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9532. 2010
    ..We have recently shown that STAT3 is an important regulator of astrocyte reactivity after spinal cord injury in vivo[1]...
  7. ncbi request reprint Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003
    ..These results suggest that exposure of the bronchopulmonary epithelium to THC may have important health and physiological consequences...
  8. ncbi request reprint Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 10:6872-8. 2004
    ....
  9. ncbi request reprint Respiratory and immunologic consequences of marijuana smoking
    Donald P Tashkin
    Deportment of Medicine, UCLA School of Medicine, 90095 1690, USA
    J Clin Pharmacol 42:71S-81S. 2002
    ..Additional well designed epidemiological and immune monitoring studies are required to determine the potential causal relationship between marijuana use and the development of respiratory infection and/or cancer...
  10. ncbi request reprint Expression of the p75 TNF receptor is linked to TNF-induced NFkappaB translocation and oxyradical neutralization in glial cells
    Joel M Dopp
    Mental Retardation Research Center, University of California at Los Angeles, Los Angeles, California, 90024 1759, USA
    Neurochem Res 27:1535-42. 2002
    ..Lacking such signals, oligodendrocytes are considerably more vulnerable to the injurious effects of TNF...

Research Grants1