Andrey G Sarafanov
Affiliation: University of Maryland
- Identification of coagulation factor VIII A2 domain residues forming the binding epitope for low-density lipoprotein receptor-related proteinAndrey G Sarafanov
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Biochemistry 45:1829-40. 2006..This further confirms the importance of the mutated residues for interaction of A2 with LRP and suggests the existence of an LRP-dependent mechanism for removing A2 as a product of dissociation of activated fVIII from the circulation...
- Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509Natalya M Ananyeva
Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA
Blood Coagul Fibrinolysis 19:543-55. 2008..We conclude that interaction of factor VIII with the members of the low-density lipoprotein receptor family follows the general mode, requires dissociation of factor VIII from von Willebrand factor, and is activation sensitive...
- Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIIIAndrey G Sarafanov
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Thromb Haemost 98:1170-81. 2007..We conclude that A2 interacts with LRP via multiple binding sites spanning CR 3-8 in cluster II and CR 23-29 in cluster IV, and the minimal A2-binding unit of LRP is formed by two adjacent CR...