Anil Sapru

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization
    A Sapru
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Am J Transplant 12:1848-54. 2012
  2. ncbi Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization
    Anil Sapru
    Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Franscisco, California 94143, USA
    J Heart Lung Transplant 30:211-7. 2011
  3. ncbi Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury
    Anil Sapru
    Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, Box 0106, San Francisco, CA 94143, USA
    Intensive Care Med 36:157-63. 2010
  4. ncbi 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia
    Anil Sapru
    Department of Pediatrics, Division of Critical Care Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Anesthesiology 110:1086-91. 2009
  5. ncbi Prevalence and characteristics of type 2 diabetes mellitus in 9-18 year-old children with diabetic ketoacidosis
    Anil Sapru
    Pediatric Critical Care Medicine, University of California, San Francisco, CA 94143, USA
    J Pediatr Endocrinol Metab 18:865-72. 2005
  6. ncbi The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury
    Kirsten Neudoerffer Kangelaris
    Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA 94143 0131, USA
    Chest 141:1160-9. 2012
  7. ncbi Early results of the "clamp and sew" Fontan procedure without the use of circulatory support
    Takeshi Shinkawa
    Division of Pediatric Cardiothoracic Surgery, Department of Surgery, UCSF Benioff Children s Hospital, University of California, San Francisco, California 94143 0117, USA
    Ann Thorac Surg 91:1453-9. 2011
  8. ncbi Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
  9. ncbi Early outcomes of primary sutureless repair of the pulmonary veins
    Anthony Azakie
    UCSF Benioff Children s Hospital, Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Ann Thorac Surg 92:666-71; discussion 671-2. 2011
  10. ncbi Lung aeration changes after lung recruitment in children with acute lung injury: a feasibility study
    Juan P Boriosi
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin 53792 4108, USA
    Pediatr Pulmonol 47:771-9. 2012

Research Grants

  1. Targeted Genomic Analysis of Coagulation Pathways in Acute Lung Injury
    Anil Sapru; Fiscal Year: 2007

Detail Information

Publications19

  1. ncbi The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization
    A Sapru
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Am J Transplant 12:1848-54. 2012
    ..03) and fewer donors with the 4G/4G genotype achieved the threshold PaO2/FiO2 ratio ≥ 300 (p = 0.05). These findings suggest a role for impaired fibrinolysis resulting in worse gas exchange and decreased donor utilization...
  2. ncbi Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization
    Anil Sapru
    Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Franscisco, California 94143, USA
    J Heart Lung Transplant 30:211-7. 2011
    ..We hypothesized that SNPs in βAR genes would be associated with rates of utilization of donor lung allografts offered for transplantation...
  3. ncbi Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury
    Anil Sapru
    Division of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, Box 0106, San Francisco, CA 94143, USA
    Intensive Care Med 36:157-63. 2010
    ..This relationship has not been examined in children. The objective of this study was to test whether increased plasma PAI-1 levels are associated with worse clinical outcomes in pediatric patients with ALI...
  4. ncbi 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia
    Anil Sapru
    Department of Pediatrics, Division of Critical Care Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Anesthesiology 110:1086-91. 2009
    ..The authors hypothesized that the 4G allele would be associated with worse clinical outcomes (mortality and ventilator-free days) in patients with severe pneumonia...
  5. ncbi Prevalence and characteristics of type 2 diabetes mellitus in 9-18 year-old children with diabetic ketoacidosis
    Anil Sapru
    Pediatric Critical Care Medicine, University of California, San Francisco, CA 94143, USA
    J Pediatr Endocrinol Metab 18:865-72. 2005
    ..To estimate the prevalence of type 2 diabetes mellitus (DM2) in 9-18 year-old children with diabetic ketoacidosis (DKA) and to describe the presenting biochemical characteristics and response to standardized DKA treatment...
  6. ncbi The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury
    Kirsten Neudoerffer Kangelaris
    Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA 94143 0131, USA
    Chest 141:1160-9. 2012
    ..We sought to determine the effect of the functional rs2814778 polymorphism, C/C genotype (Duffy null state), on clinical outcomes in African Americans with acute lung injury...
  7. ncbi Early results of the "clamp and sew" Fontan procedure without the use of circulatory support
    Takeshi Shinkawa
    Division of Pediatric Cardiothoracic Surgery, Department of Surgery, UCSF Benioff Children s Hospital, University of California, San Francisco, California 94143 0117, USA
    Ann Thorac Surg 91:1453-9. 2011
    ..The objective of this study is to assess the outcomes of this novel off-pump "clamp and sew" Fontan procedure...
  8. ncbi Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
    ..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...
  9. ncbi Early outcomes of primary sutureless repair of the pulmonary veins
    Anthony Azakie
    UCSF Benioff Children s Hospital, Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Ann Thorac Surg 92:666-71; discussion 671-2. 2011
    ..The purpose of this study is to determine the early outcomes of primary sutureless repair of pulmonary venoocclusive disease in infants with congenital PV stenosis-hypoplasia or PVs at high risk for progressive stenosis...
  10. ncbi Lung aeration changes after lung recruitment in children with acute lung injury: a feasibility study
    Juan P Boriosi
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin 53792 4108, USA
    Pediatr Pulmonol 47:771-9. 2012
    ..However, there are no published data on the lung aeration changes during or after a RM in ventilated pediatric patients with ALI...
  11. ncbi Cardiac surgery in low birth weight infants: current outcomes
    Anthony Azakie
    UCSF Benioff Children s Hospital, San Francisco, CA, USA
    Interact Cardiovasc Thorac Surg 12:409-13, discussion 414. 2011
    ..Cardiac surgery in LBW infants can be performed with low early and mid-term mortality. LBW infants with chromosomal/genetic anomalies have a higher risk...
  12. ncbi Surgical management of left ventricular outflow tract obstruction
    Petros V Anagnostopoulos
    Department of Surgery, University of California, San Francisco, San Francisco, California, USA
    J Card Surg 27:103-11. 2012
    ..Left ventricular outflow tract obstruction (LVOTO) is caused by a spectrum of lesions. This study was performed to determine the outcomes of surgical management of LVOTO...
  13. ncbi Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury
    Magda Cepkova
    The Cardiovascular Research Institute and the Departments of Medicine and Anesthesia, University of California, San Francisco, 505 Parnassus Avenue, M917, San Francisco, CA 94143 0624, USA
    Crit Care 10:R126. 2006
    ....
  14. ncbi Using acupuncture for acute pain in hospitalized children
    Shelley Wu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
    Pediatr Crit Care Med 10:291-6. 2009
    ..Clinical study to determine the acceptability and feasibility of acupuncture for acute postoperative pain control in hospitalized children...
  15. ncbi Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome
    Jan Hirsch
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Respir Crit Care Med 175:1006-13. 2007
    ..Mechanical ventilation with high tidal volumes leads to increased permeability, generation of inflammatory mediators, and damage to alveolar epithelial cells (ATII)...
  16. ncbi Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways
    Anil Sapru
    Pediatric Critical Care Medicine, University of California, 505 Parnassus Avenue, Moffitt 680 B, San Francisco, CA 94143 0106, USA
    Intensive Care Med 32:1293-303. 2006
    ....
  17. ncbi Efficacy and safety of lung recruitment in pediatric patients with acute lung injury
    Juan P Boriosi
    Department of Pediatrics, University of Wisconsin, Madison, WI, USA
    Pediatr Crit Care Med 12:431-6. 2011
    ..To assess the safety and efficacy of a recruitment maneuver, the Open Lung Tool, in pediatric patients with acute lung injury and acute respiratory distress syndrome...
  18. ncbi Stage II palliation of hypoplastic left heart syndrome without cardiopulmonary bypass
    Anthony Azakie
    UCSF Benioff Children s Hospital, Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Thorac Cardiovasc Surg 141:400-6. 2011
    ..The purpose of this study is to determine the early outcomes for stage II palliation of hypoplastic left heart syndrome without cardiopulmonary bypass...
  19. ncbi Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure
    Anthony Azakie
    Department of Surgery, University of Claifornia, San Francisco, CA 94143, USA
    Ann Thorac Surg 77:1727-33. 2004
    ..06). CONCLUSIONS: In a relatively high-risk group, neonates having an RV-PA conduit as part of the Norwood procedure have favorable postoperative hemodynamics and a good likelihood of stage I survival...

Research Grants1

  1. Targeted Genomic Analysis of Coagulation Pathways in Acute Lung Injury
    Anil Sapru; Fiscal Year: 2007
    ..End of Abstract) ..