IGNACIO E SANZ

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks
    Jennifer H Anolik
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester, NY 14642, USA
    J Immunol 180:688-92. 2008
  2. pmc Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor
    James J Kobie
    Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R209. 2011
  3. doi request reprint B cells as therapeutic targets in SLE
    Inaki Sanz
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Nat Rev Rheumatol 6:326-37. 2010
  4. pmc Phenotypic and functional heterogeneity of human memory B cells
    Inaki Sanz
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Semin Immunol 20:67-82. 2008
  5. ncbi request reprint B cell depletion therapy in autoimmune diseases
    Inaki Sanz
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Front Biosci 12:2546-67. 2007
  6. pmc Reconstitution of the adult B cell repertoire after treatment with rituximab
    Inaki Sanz
    Division of Clinical Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Arthritis Res Ther 7:175-6. 2005
  7. ncbi request reprint A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus
    Chungwen Wei
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Immunol 178:6624-33. 2007
  8. pmc Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
    Amedeo Cappione
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Clin Invest 115:3205-16. 2005
  9. ncbi request reprint Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy
    Jennifer H Anolik
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 56:3044-56. 2007
  10. pmc Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy
    Jie Li
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 19642, USA
    J Immunol 184:6142-50. 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks
    Jennifer H Anolik
    Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester, NY 14642, USA
    J Immunol 180:688-92. 2008
    ..This study provides initial evidence in humans to support the notion that anti-TNF treatment disrupts GC reactions at least in part via effects on follicular dendritic cells...
  2. pmc Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor
    James J Kobie
    Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R209. 2011
    ..Therefore, we asked if short-term effector (d5-d10) and memory (1 month or later) B cell responses to antigen were compromised in RA patients treated with anti-TNF therapy...
  3. doi request reprint B cells as therapeutic targets in SLE
    Inaki Sanz
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Nat Rev Rheumatol 6:326-37. 2010
    ..Combined, the available information identifies several new avenues for the therapeutic targeting of B cells in SLE...
  4. pmc Phenotypic and functional heterogeneity of human memory B cells
    Inaki Sanz
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Semin Immunol 20:67-82. 2008
    ....
  5. ncbi request reprint B cell depletion therapy in autoimmune diseases
    Inaki Sanz
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Front Biosci 12:2546-67. 2007
    ..Finally, we will discuss some of the many challenges and opportunities that the medical and scientific community should address in the foreseeable future...
  6. pmc Reconstitution of the adult B cell repertoire after treatment with rituximab
    Inaki Sanz
    Division of Clinical Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Arthritis Res Ther 7:175-6. 2005
    ..The results presented by Rouzière and coworkers in their study of rheumatoid arthritis patients shed some light on this question and are discussed in this commentary...
  7. ncbi request reprint A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus
    Chungwen Wei
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Immunol 178:6624-33. 2007
    ..These findings enhance our understanding of the B cell diversification pathways and provide mechanistic insight into the immunopathogenesis of SLE...
  8. pmc Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
    Amedeo Cappione
    Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Clin Invest 115:3205-16. 2005
    ..To our knowledge, this work represents the first comparative analysis of the fate of a specific autoreactive human B cell population. The results identify a defective tolerance checkpoint that appears to be specific for human SLE...
  9. ncbi request reprint Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy
    Jennifer H Anolik
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 56:3044-56. 2007
    ..This study was undertaken to determine the magnitude, duration, and cause of these defects in rituximab-treated systemic lupus erythematosus (SLE) patients...
  10. pmc Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy
    Jie Li
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 19642, USA
    J Immunol 184:6142-50. 2010
    ..On the basis of these findings, we propose a model whereby B cells contribute to arthritis in mice, and possibly RA, by directly affecting the structure, composition, and function of joint-draining lymph nodes...
  11. ncbi request reprint Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes
    Amedeo J Cappione
    Department of Medicine, Clinical Immunology and Rheumatology Unit, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 172:4298-307. 2004
    ..Overall, our data indicate that V(H)4.34 Abs represent a major component of the lupus IgG autoantibody repertoire and suggest that the carbohydrate moiety they recognize may act as a selecting Ag in SLE...
  12. pmc Altered B cell receptor signaling in human systemic lupus erythematosus
    Scott A Jenks
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Autoimmun Rev 8:209-13. 2009
    ..Intracellular flow cytometric analysis of signaling is a useful approach to accomplish this goal...
  13. ncbi request reprint B cell depletion therapy in systemic lupus erythematosus
    Jennifer Anolik
    Department of Medicine Immunology and Rheumatology, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA
    Curr Rheumatol Rep 5:350-6. 2003
    ..Recent open-label studies indicate that rituximab is safe and may be efficacious in the treatment of SLE, and continued study with randomized clinical trials is justified...
  14. pmc Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults
    F Eun Hyung Lee
    Division of Pulmonary and Critical Care Medicine, University of Rochester and Rochester General Hospital, Rochester, New York, USA
    J Infect Dis 202:1659-66. 2010
    ..The specificity and duration of circulating human antibody-secreting cells (ASCs) after vaccination have been well described, but characteristics of ASCs during acute respiratory infections have not been well studied...
  15. ncbi request reprint Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus
    Jennifer H Anolik
    University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Rheum 50:3580-90. 2004
    ....
  16. ncbi request reprint Down-regulation of CD20 on B cells upon CD40 activation
    Jennifer Anolik
    Department of Medicine, University of Rochester School of Medicine, Rochester 14642, USA
    Eur J Immunol 33:2398-409. 2003
    ....
  17. ncbi request reprint Treatment of SLE with anti-CD20 monoclonal antibody
    R John Looney
    Allergy Immunology, Rheumatology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Dir Autoimmun 8:193-205. 2005
    ..This article will review the role of B cells in human SLE as well as the currently available data on the treatment of SLE by depleting B cells with anti-CD20 (rituximab)...
  18. ncbi request reprint B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab
    R John Looney
    University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Arthritis Rheum 50:2580-9. 2004
    ..B lymphocytes have been shown to play fundamental pathogenic roles in SLE, and therefore, elimination of B cells with the use of rituximab may represent a new therapy for SLE...
  19. ncbi request reprint New therapies for systemic lupus erythematosus: cellular targets
    R John Looney
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14420, USA
    Rheum Dis Clin North Am 32:201-15, xi. 2006
    ..This article discusses the B-cell abnormalities found in systemic lupus erythematosus and the clinical and immunologic effects of anti-B-cell therapies...
  20. ncbi request reprint B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny
    Jennifer H Anolik
    Department of Medicine, Division of Clinical Immunology and Rheumatology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Immunol 122:139-45. 2007
    ..0001). Expansion of functionally immature B cells and decreased memory B cells may contribute to an immunodeficient state in patients recovering from rituximab mediated B cell depletion, particularly with repeated treatment...
  21. pmc Novel human transitional B cell populations revealed by B cell depletion therapy
    Arumugam Palanichamy
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 182:5982-93. 2009
    ..The characterization of multiple transitional B cell subpopulations provides important insights into human B cell development...
  22. pmc Human innate B cells: a link between host defense and autoimmunity?
    Eric C B Milner
    Department of Medicine, Clinical Immunology and Rheumatology Unit, University of Rochester Medical School, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA
    Springer Semin Immunopathol 26:433-52. 2005
    ....
  23. ncbi request reprint B cells in human and murine systemic lupus erythematosus
    Jennifer Anolik
    Department of Medicine, Clinical Immunology and Rheumatology Unit, Rochester, New York 14642, USA
    Curr Opin Rheumatol 16:505-12. 2004
    ....
  24. pmc B cells and immunological tolerance
    Nataly Manjarrez-Orduno
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Invest Dermatol 129:278-88. 2009
    ....
  25. ncbi request reprint Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning?
    Ismael Calero
    Department of Internal Medicine, Hospital Virgen de la Luz, Cuenca, Spain
    Discov Med 10:416-24. 2010
    ..These models could also help frame the design and evaluation of current and future B cell therapies...

Research Grants16

  1. Identification of Biomarkers in Sjogren's Syndrome
    IGNACIO E SANZ; Fiscal Year: 2010
    ....
  2. Understanding the Generation of HIV Broadly Neutralizing Antibodies
    IGNACIO E SANZ; Fiscal Year: 2010
    ..We propose to precisely identify the B cells that produce protective HIV neutralizing antibodies in order to determine how they arise, are maintained, and how vaccines can be modeled to induce them. ..
  3. Suppression and Exacerbation of B and T cell Responses *
    Ignacio Sanz; Fiscal Year: 2007
    ..abstract_text> ..
  4. Identification of Biomarkers in Sjogren's Syndrome
    Ignacio Sanz; Fiscal Year: 2007
    ....
  5. A Model System for the Study of Human B-cell Tolerance
    Ignacio Sanz; Fiscal Year: 2007
    ..Furthermore, we believe that our results will improve our ability to treat patients with SLE and similar diseases. ..
  6. Study of Human B-cell Tolerance by Functional Genomics
    Ignacio Sanz; Fiscal Year: 2005
    ..In addition, although the questions asked are hypothesis-driven, the approach proposed is highly exploratory and, as such, is responsive to this RFA. ..
  7. Understanding the Generation of HIV Broadly Neutralizing Antibodies
    IGNACIO E SANZ; Fiscal Year: 2010
    ..We propose to precisely identify the B cells that produce protective HIV neutralizing antibodies in order to determine how they arise, are maintained, and how vaccines can be modeled to induce them. ..