ANDREA JANINE SANT

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Revealing the role of CD4(+) T cells in viral immunity
    Andrea J Sant
    David H Smith Center for Vaccine Biology and the Immunology Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14623, USA
    J Exp Med 209:1391-5. 2012
  2. ncbi request reprint The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes
    Andrea J Sant
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Immunol Rev 207:261-78. 2005
  3. pmc Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus
    Shabnam Alam
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 609, Rochester, NY 14642, USA
    J Virol 85:13310-21. 2011
  4. ncbi request reprint Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design
    Andrea J Sant
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Expert Rev Vaccines 6:357-68. 2007
  5. pmc An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice
    Paula R Menges
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 180:1619-33. 2008
  6. ncbi request reprint The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance
    Christopher A Lazarski
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Immunity 23:29-40. 2005
  7. pmc The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability
    Christopher A Lazarski
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Exp Med 203:1319-28. 2006
  8. pmc Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin
    Katherine A Richards
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Virol 81:7608-19. 2007
  9. ncbi request reprint Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior
    Francisco A Chaves
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Biochemistry 45:6426-33. 2006
  10. ncbi request reprint CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen
    Joseph Larkin
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 180:2149-57. 2008

Research Grants

Collaborators

  • E K Bikoff
  • Francisco A Chaves
  • Christopher A Lazarski
  • Katherine A Richards
  • Scott A Jenks
  • Paula R Menges
  • Shabnam Alam
  • Joseph Larkin
  • Arunima Bandyopadhyay
  • Jason M Weaver
  • Andrew L Rankin
  • Michael P Riley
  • Lynne Arneson
  • Zackery A G Knowlden
  • Andrew J Caton
  • Cristina Cozzo Picca
  • Craig Beeson
  • David R Friedmann
  • David J Topham
  • Frederick R Krafcik
  • Andrew Torelli
  • Joseph Wedekind
  • J M Weaver
  • Shenhong Wu

Detail Information

Publications13

  1. pmc Revealing the role of CD4(+) T cells in viral immunity
    Andrea J Sant
    David H Smith Center for Vaccine Biology and the Immunology Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14623, USA
    J Exp Med 209:1391-5. 2012
    ..We highlight several recent reports, including one published in this issue, that have employed comprehensive and sophisticated approaches to provide new evidence for CD4(+) T cells as direct effectors in antiviral immunity...
  2. ncbi request reprint The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes
    Andrea J Sant
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Immunol Rev 207:261-78. 2005
    ..We discuss this model in the context of the existing data in the field of immunodominance...
  3. pmc Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus
    Shabnam Alam
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 609, Rochester, NY 14642, USA
    J Virol 85:13310-21. 2011
    ..Together, our results indicate that exposure to seasonal vaccines and infection elicits CD4 T cells that promote the ability of the mammalian host to mount a protective immune response to pandemic strains of influenza virus...
  4. ncbi request reprint Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design
    Andrea J Sant
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Expert Rev Vaccines 6:357-68. 2007
    ....
  5. pmc An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice
    Paula R Menges
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 180:1619-33. 2008
    ..The observed shift in isotype-restriction appeared to be due in part to a modification in the peripheral CD4 T cell repertoire available for peptide recognition...
  6. ncbi request reprint The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance
    Christopher A Lazarski
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Immunity 23:29-40. 2005
    ..Taken collectively, our results suggest the half-life of class II:peptide complexes is the primary parameter that dictates the ultimate hierarchy of the elicited T cell response...
  7. pmc The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability
    Christopher A Lazarski
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Exp Med 203:1319-28. 2006
    ....
  8. pmc Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin
    Katherine A Richards
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Virol 81:7608-19. 2007
    ..The results of these studies offer key insights into the spectrum of peptides recognized by HLA-DR-restricted CD4 T cells that may be the focus of immune responses to infection or to experimental or clinical vaccines in humans...
  9. ncbi request reprint Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior
    Francisco A Chaves
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Biochemistry 45:6426-33. 2006
    ....
  10. ncbi request reprint CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen
    Joseph Larkin
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 180:2149-57. 2008
    ....
  11. ncbi request reprint Measurement of peptide dissociation from MHC class II molecules
    Francisco A Chaves
    University of Rochester, Rochester, New York, USA
    Curr Protoc Immunol . 2007
    ....
  12. pmc Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design
    Jason M Weaver
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 181:3039-48. 2008
    ..These findings are discussed with regard to implications for vaccine design...
  13. ncbi request reprint The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function
    Arunima Bandyopadhyay
    University of Washington, Department of Chemistry, Seattle, WA 98195, USA
    Mol Immunol 45:1248-57. 2008
    ..We discuss these results in light of the proposed mechanism for DM function...

Research Grants20

  1. Selective Presentation of Autoantigens by B Cells
    Andrea Sant; Fiscal Year: 2005
    ..Test whether antigen-specific B cells display potentiated ability to present autoantigenic self peptides. Specific Aim 4. Test the effect of B cell antigen presentation in vivo on breaking of self tolerance to autoantigens. ..
  2. Immunodominance in CD4 T Cell Responses
    Andrea Sant; Fiscal Year: 2006
    ..The experiments within this application thus seek to demonstrate a causative relationship between the kinetic stability of peptide class II complexes with their immunological fate in the developing immune response. | ..
  3. Manipulation of immunodominance to promote heterosubtypic immunity to Influenza
    Andrea Sant; Fiscal Year: 2007
    ..Specific Aim 2: Design and utilize kinetic stability variants of HA-derived peptides to promote immunodominance. Specific Aim 3. Promoting focus of the CD4 T cell responses toward conserved epitopes and protection to virus challenge. ..
  4. REGULATION OF MHC CLASS II INTRACELLULAR TRANSPORT
    Andrea Sant; Fiscal Year: 2002
    ..These experiments will provide insight into the basic molecular mechanism of DM function and may reveal influences of DM on the intracellular targeting of normal class II molecules that relate to peptide occupancy. ..
  5. Immunodomance in CD Responses
    ANDREA JANINE SANT; Fiscal Year: 2010
    ..The results of these experiments will help in the design of vaccines that focus or diversify the immune response to pathogenic organisms. ..