Lauren H Sansing
Affiliation: University of Pennsylvania
- Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhageLauren H Sansing
Department of Neurology, University of Pennsylvania Medical Center, 3 W Gates, 3400 Spruce Street, Philadelphia, PA, USA
Acta Neurochir Suppl 111:173-8. 2011..These findings indicate that neutrophil infiltration into the site of hemorrhage contributes to brain injury either by direct cellular damage or the recruitment of monocytes...
- Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhageLauren H Sansing
Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Ann Neurol 70:646-56. 2011..This study aimed to determine the role of Toll-like receptor 4 (TLR4) in the innate immune response after ICH and its impact on neurobehavioral outcome...
- Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratomaJosep Dalmau
Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Neurol 61:25-36. 2007..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
- Noninflammatory cerebral vasculopathy associated with recurrent ischemic strokesJames S McKinney
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Stroke Cerebrovasc Dis 21:417-21. 2012..Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail...
- A patient with encephalitis associated with NMDA receptor antibodiesLauren H Sansing
Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Nat Clin Pract Neurol 3:291-6. 2007..There was muscle rigidity, frequent facial grimacing, rhythmic abdominal contractions, kicking motions of the legs, and intermittent dystonic postures of the right arm...
- Obstructive hydrocephalus from venous sinus thrombosisMichael T Mullen
Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19103, USA
Neurocrit Care 10:359-62. 2009..Cerebral venous sinus thrombosis (CVST) is a rare form of stroke. Although increased intracranial pressure is a well-described complication of CVST, hydrocephalus has rarely been reported...
- Prophylactic antiepileptic drug use is associated with poor outcome following ICHSteven R Messe
Department of Neurology, University of Pennsylvania Medical Center, 3W Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Neurocrit Care 11:38-44. 2009..Intracerebral hemorrhage (ICH) is associated with a risk of early seizure and guidelines recommend consideration of prophylactic antiepileptic drugs (AEDs) for some patients, although the utility is uncertain...
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activationBart R Anderson
Department of Medicine, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
Nucleic Acids Res 38:5884-92. 2010..These results indicate that the enhanced translation of mRNAs containing pseudouridine, compared to those containing uridine, is mediated by decreased activation of PKR...
- Edema after intracerebral hemorrhage: correlations with coagulation parameters and treatmentLauren H Sansing
Department of Neurology, General Clinical Research Center, State University of New York at Stony Brook, New York, USA
J Neurosurg 98:985-92. 2003..Recent research has identified thrombin as a key mediator in the development of edema in animal models; however, little has been published correlating the coagulation cascade and edema in humans...