Lauren H Sansing
Affiliation: University of Pennsylvania
- Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhageLauren H Sansing
Department of Neurology, University of Pennsylvania Medical Center, 3 W Gates, 3400 Spruce Street, Philadelphia, PA, USA
Acta Neurochir Suppl 111:173-8. 2011..These findings indicate that neutrophil infiltration into the site of hemorrhage contributes to brain injury either by direct cellular damage or the recruitment of monocytes...
- CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhageMatthew D Hammond
Department of Neuroscience and Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, Department of Internal Medicine II, University Hospital Regensberg, 93053 Regensberg, Germany, and Department of Neurology and Department of Neurosurgery, Hartford Hospital, Hartford, Connecticut 06102
J Neurosci 34:3901-9. 2014..Together, these findings suggest that inflammatory monocytes worsen early disability after murine ICH and may represent a therapeutic target for patients...
- Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhageLauren H Sansing
Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Ann Neurol 70:646-56. 2011..This study aimed to determine the role of Toll-like receptor 4 (TLR4) in the innate immune response after ICH and its impact on neurobehavioral outcome...
- Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratomaJosep Dalmau
Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Neurol 61:25-36. 2007..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
- Noninflammatory cerebral vasculopathy associated with recurrent ischemic strokesJames S McKinney
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Stroke Cerebrovasc Dis 21:417-21. 2012..Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail...
- A patient with encephalitis associated with NMDA receptor antibodiesLauren H Sansing
Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Nat Clin Pract Neurol 3:291-6. 2007..There was muscle rigidity, frequent facial grimacing, rhythmic abdominal contractions, kicking motions of the legs, and intermittent dystonic postures of the right arm...
- Differential effects of aging and sex on stroke induced inflammation across the lifespanBharti Manwani
Department of Neurology, University of Connecticut Health Center, Farmington, CT, USA Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA
Exp Neurol 249:120-31. 2013..We conclude that aging and sex have differential effects on the post stroke inflammatory milieu. Putative immunomodulatory therapies need to account for this heterogeneity...
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activationBart R Anderson
Department of Medicine, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
Nucleic Acids Res 38:5884-92. 2010..These results indicate that the enhanced translation of mRNAs containing pseudouridine, compared to those containing uridine, is mediated by decreased activation of PKR...
- Prophylactic antiepileptic drug use is associated with poor outcome following ICHSteven R Messe
Department of Neurology, University of Pennsylvania Medical Center, 3W Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Neurocrit Care 11:38-44. 2009..Intracerebral hemorrhage (ICH) is associated with a risk of early seizure and guidelines recommend consideration of prophylactic antiepileptic drugs (AEDs) for some patients, although the utility is uncertain...
- Obstructive hydrocephalus from venous sinus thrombosisMichael T Mullen
Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19103, USA
Neurocrit Care 10:359-62. 2009..Cerebral venous sinus thrombosis (CVST) is a rare form of stroke. Although increased intracranial pressure is a well-described complication of CVST, hydrocephalus has rarely been reported...
- Edema after intracerebral hemorrhage: correlations with coagulation parameters and treatmentLauren H Sansing
Department of Neurology, General Clinical Research Center, State University of New York at Stony Brook, New York, USA
J Neurosurg 98:985-92. 2003..Recent research has identified thrombin as a key mediator in the development of edema in animal models; however, little has been published correlating the coagulation cascade and edema in humans...