Maria Dolors Sans


Affiliation: University of Michigan
Country: USA


  1. request reprint
    Sans M, Kimball S, Williams J. Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2002;282:G267-76 pubmed
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    Sans M, Williams J. Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. Am J Physiol Cell Physiol. 2004;287:C310-9 pubmed
    ..From these results, we conclude that calcineurin activity is required for protein synthesis, and this action may be related to an effect on the formation of the mRNA cap binding complex and the elongation processes. ..
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    Sans M, DiMagno M, D Alecy L, Williams J. Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F. Am J Physiol Gastrointest Liver Physiol. 2003;285:G517-28 pubmed
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    Sans M, Lee S, D Alecy L, Williams J. Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA. Am J Physiol Gastrointest Liver Physiol. 2004;287:G667-75 pubmed
    ..By contrast, feeding did not affect eIF2B activity. Thus food intake stimulates pancreatic protein synthesis and translational effectors without increasing digestive enzyme mRNA levels. ..
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    Sans M, Xie Q, Williams J. Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini. Biochem Biophys Res Commun. 2004;319:144-51 pubmed
    ..Translation elongation in pancreatic acinar cells is likely regulated by eEF2 through the mTOR, p38, and MEK pathways, and modulated through PP2A. ..