Maria Dolors Sans

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells
    Maria Dolors Sans
    Department of Physiology, University of Michigan, 1301 St Catherine St, 7737 Med Sci II, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 282:G267-76. 2002
  2. ncbi request reprint Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Biochem Biophys Res Commun 319:144-51. 2004
  3. ncbi request reprint Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 287:G667-75. 2004
  4. ncbi request reprint Calcineurin is required for translational control of protein synthesis in rat pancreatic acini
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E Catherine St, 7737 Med Sci II, Ann Arbor, MI 48109 0622, USA
    Am J Physiol Cell Physiol 287:C310-9. 2004
  5. ncbi request reprint Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 285:G517-28. 2003
  6. ncbi request reprint Translational control of protein synthesis in pancreatic acinar cells
    Maria Dolors Sans
    Department of Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Gastrointest Cancer 31:107-15. 2002
  7. ncbi request reprint CCK-induced pancreatic growth is not limited by mitogenic capacity in mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1148-57. 2008
  8. ncbi request reprint Induction of early response genes in trypsin inhibitor-induced pancreatic growth
    Lili Guo
    Dept of Molecular and Integrative Physiology, Univ of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 292:G667-77. 2007
  9. ncbi request reprint Calcineurin-dependent and calcineurin-independent signal transduction pathways activated as part of pancreatic growth
    Mitsuo Tashiro
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Pancreas 32:314-20. 2006
  10. pmc Molecular characterization of the endoplasmic reticulum: insights from proteomic studies
    Xuequn Chen
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI, USA
    Proteomics 10:4040-52. 2010

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells
    Maria Dolors Sans
    Department of Physiology, University of Michigan, 1301 St Catherine St, 7737 Med Sci II, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 282:G267-76. 2002
    ....
  2. ncbi request reprint Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Biochem Biophys Res Commun 319:144-51. 2004
    ..Translation elongation in pancreatic acinar cells is likely regulated by eEF2 through the mTOR, p38, and MEK pathways, and modulated through PP2A...
  3. ncbi request reprint Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 287:G667-75. 2004
    ..By contrast, feeding did not affect eIF2B activity. Thus food intake stimulates pancreatic protein synthesis and translational effectors without increasing digestive enzyme mRNA levels...
  4. ncbi request reprint Calcineurin is required for translational control of protein synthesis in rat pancreatic acini
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E Catherine St, 7737 Med Sci II, Ann Arbor, MI 48109 0622, USA
    Am J Physiol Cell Physiol 287:C310-9. 2004
    ..From these results, we conclude that calcineurin activity is required for protein synthesis, and this action may be related to an effect on the formation of the mRNA cap binding complex and the elongation processes...
  5. ncbi request reprint Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 285:G517-28. 2003
    ....
  6. ncbi request reprint Translational control of protein synthesis in pancreatic acinar cells
    Maria Dolors Sans
    Department of Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Gastrointest Cancer 31:107-15. 2002
    ..eIF4E is itself phosphorylated by a distinct pathway. Inhibition of acinar protein synthesis can be mediated by inhibition of eIF2B following phosphorylation of eIF2alpha...
  7. ncbi request reprint CCK-induced pancreatic growth is not limited by mitogenic capacity in mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1148-57. 2008
    ..These results indicate that CCK-stimulated growth of the pancreas is not limited by acinar cell mitogenic capacity but is due, at least in part, to inhibition of promitogenic Akt signaling...
  8. ncbi request reprint Induction of early response genes in trypsin inhibitor-induced pancreatic growth
    Lili Guo
    Dept of Molecular and Integrative Physiology, Univ of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 292:G667-77. 2007
    ..These results indicate that camostat feeding induces a spectrum of early response gene expression and AP-1 DNA binding and that these effects are mainly CCK dependent...
  9. ncbi request reprint Calcineurin-dependent and calcineurin-independent signal transduction pathways activated as part of pancreatic growth
    Mitsuo Tashiro
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Pancreas 32:314-20. 2006
    ..In the present study, we evaluated a number of signal transduction pathways for their activation as part of the growth response and whether their activation was dependent on calcineurin...
  10. pmc Molecular characterization of the endoplasmic reticulum: insights from proteomic studies
    Xuequn Chen
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI, USA
    Proteomics 10:4040-52. 2010
    ....
  11. pmc c-Jun/AP-1 is required for CCK-induced pancreatic acinar cell dedifferentiation and DNA synthesis in vitro
    Lili Guo
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1381-96. 2012
    ..Monolayer culture can serve as a model to study acinar cell proliferation similar to regeneration after pancreatitis in vivo...
  12. pmc Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas
    Xuequn Chen
    Departments of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Proteome Res 9:885-96. 2010
    ..These results suggest that the early stages of AP involve changes of multiple RER proteins that may affect the synthesis and processing of digestive enzymes...
  13. pmc Secretin is not necessary for exocrine pancreatic development and growth in mice
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109 5622, USA
    Am J Physiol Gastrointest Liver Physiol 301:G791-8. 2011
    ..Camostat-fed littermate secretin and secretin receptor-deficient mice had similar pancreatic mass to WT mice. These results indicate that secretin is not required for normal pancreatic development or adaptive growth mediated by CCK...
  14. pmc Regulation of transforming growth factor beta-induced responses by protein kinase A in pancreatic acinar cells
    Huibin Yang
    Department of Surgery and Molecular, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Physiol Gastrointest Liver Physiol 295:G170-G178. 2008
    ..This study demonstrates that this novel cross talk between TGF-beta and PKA signaling pathways may play an important role in regulating TGF-beta signaling in the pancreas...
  15. ncbi request reprint Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin
    Maria Dolors Sans
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
    J Nutr 136:1792-9. 2006
    ..We conclude that leucine may participate, as a signal as well as a substrate, in activating the translational machinery in pancreatic acinar cells independently of hormonal effects and that this action is through the mTOR pathway...
  16. ncbi request reprint Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis
    Constanze H Kubisch
    Department of Cancer Biology, University of Texas, M D Anderson Cancer Center, Houston, TX 77230 1429, USA
    Am J Physiol Gastrointest Liver Physiol 291:G238-45. 2006
    ..These results indicate that ER stress is an important early acinar cell event that likely contributes to the development of acute pancreatitis in the arginine model...