RAMAN R SANKAR

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint GABA metabolism during status epilepticus in the developing rat brain
    R Sankar
    Department of Neurology, UCLA School of Medicine 90095 1752, USA
    Brain Res Dev Brain Res 98:60-4. 1997
  2. ncbi request reprint Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics
    R Sankar
    David Geffen School of Medicine and Mattel Children s Hospital, UCLA, Los Angeles, CA 90095 1752, USA
    Acta Neurol Scand 116:65-71. 2007
  3. doi request reprint Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series
    Raman Sankar
    Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Room 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    J Med Case Rep 8:429. 2014
  4. pmc Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms
    Jason T Lerner
    Departments of Pediatrics
    Neuropsychiatr Dis Treat 6:731-40. 2010
  5. pmc Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain
    Young Se Kwon
    Department of Pediatrics, Division of Neurology, David Geffen School of Medicine at UCLA, 22 474 MDCC in CHS, Los Angeles, CA 90095 1752, USA
    J Neuroinflammation 10:30. 2013
  6. ncbi request reprint Initial treatment of epilepsy with antiepileptic drugs: pediatric issues
    Raman Sankar
    David Geffen School of Medicine and Mattel Children s Hospital at University of California Los Angeles, Room 22 474 MDCC, UCLA Medical Center, Los Angeles, CA 90095 1752, USA
    Neurology 63:S30-9. 2004
  7. ncbi request reprint Understanding therapeutic equivalence in epilepsy
    Raman Sankar
    David Geffen School of Medicine at UCLA, Mattel Children s Hospital, Los Angeles, CA 90095 1752, USA
    CNS Spectr 15:112-23. 2010
  8. ncbi request reprint Neuroprotection in epilepsy: the Holy Grail of antiepileptogenic therapy
    Raman Sankar
    Division of Pediatric Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 7:S1-2. 2005
  9. doi request reprint A multicenter, outpatient, open-label study to evaluate the dosing, effectiveness, and safety of topiramate as monotherapy in the treatment of epilepsy in clinical practice
    Raman Sankar
    David Geffen School of Medicine, Mattel Children s Hospital at UCLA, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Epilepsy Behav 15:506-12. 2009
  10. ncbi request reprint Inflammation contributes to seizure-induced hippocampal injury in the neonatal rat brain
    R Sankar
    Division of Neurology, Department of Pediatrics, David Geffen School of Medicine at UCLA and Mattel Children s Hospital at UCLA, Los Angeles, CA 90095, USA
    Acta Neurol Scand 115:16-20. 2007

Research Grants

  1. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007

Detail Information

Publications64

  1. ncbi request reprint GABA metabolism during status epilepticus in the developing rat brain
    R Sankar
    Department of Neurology, UCLA School of Medicine 90095 1752, USA
    Brain Res Dev Brain Res 98:60-4. 1997
    ..Our data describe an aspect of developmental GABA neurochemistry which may in part explain the relative resistance of the immature hippocampus to seizure spread and of certain types of seizure-induced damage...
  2. ncbi request reprint Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics
    R Sankar
    David Geffen School of Medicine and Mattel Children s Hospital, UCLA, Los Angeles, CA 90095 1752, USA
    Acta Neurol Scand 116:65-71. 2007
    ....
  3. doi request reprint Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series
    Raman Sankar
    Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Room 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    J Med Case Rep 8:429. 2014
    ..However, no published guidelines assist clinicians in successfully accomplishing this change safely...
  4. pmc Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms
    Jason T Lerner
    Departments of Pediatrics
    Neuropsychiatr Dis Treat 6:731-40. 2010
    ..This review provides a brief description of these concerns, and the regulatory safety monitoring and mitigation systems that have been put in place to enhance benefit over risk...
  5. pmc Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain
    Young Se Kwon
    Department of Pediatrics, Division of Neurology, David Geffen School of Medicine at UCLA, 22 474 MDCC in CHS, Los Angeles, CA 90095 1752, USA
    J Neuroinflammation 10:30. 2013
    ....
  6. ncbi request reprint Initial treatment of epilepsy with antiepileptic drugs: pediatric issues
    Raman Sankar
    David Geffen School of Medicine and Mattel Children s Hospital at University of California Los Angeles, Room 22 474 MDCC, UCLA Medical Center, Los Angeles, CA 90095 1752, USA
    Neurology 63:S30-9. 2004
    ..There remains a continuing need for the development of newer AEDs that are targeted for the developing brain to improve the efficacy and tolerability of treatment in childhood seizure disorders...
  7. ncbi request reprint Understanding therapeutic equivalence in epilepsy
    Raman Sankar
    David Geffen School of Medicine at UCLA, Mattel Children s Hospital, Los Angeles, CA 90095 1752, USA
    CNS Spectr 15:112-23. 2010
    ..Thus, no substitutions should be made for people with epilepsy without the knowledge and approval of the prescribing physician. Patients should be consulted about the substitution, with all risks and benefits carefully explained...
  8. ncbi request reprint Neuroprotection in epilepsy: the Holy Grail of antiepileptogenic therapy
    Raman Sankar
    Division of Pediatric Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 7:S1-2. 2005
  9. doi request reprint A multicenter, outpatient, open-label study to evaluate the dosing, effectiveness, and safety of topiramate as monotherapy in the treatment of epilepsy in clinical practice
    Raman Sankar
    David Geffen School of Medicine, Mattel Children s Hospital at UCLA, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Epilepsy Behav 15:506-12. 2009
    ..2% of patients discontinued topiramate because of a TEAE, 5.1% reported serious TEAEs, and no deaths were reported during the study...
  10. ncbi request reprint Inflammation contributes to seizure-induced hippocampal injury in the neonatal rat brain
    R Sankar
    Division of Neurology, Department of Pediatrics, David Geffen School of Medicine at UCLA and Mattel Children s Hospital at UCLA, Los Angeles, CA 90095, USA
    Acta Neurol Scand 115:16-20. 2007
    ..Neonatal seizures often occur in clinical settings that include an inflammatory component. We examined the potential contributory role of pre-existing inflammation as an important variable in mediating neuronal injury...
  11. ncbi request reprint Do seizures affect the developing brain? Lessons from the laboratory
    Raman Sankar
    David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    J Child Neurol 22:21S-9S. 2007
    ..For now, prevention of prolonged seizures with early intervention is important and is the most effective available option to minimize the potential short- and long-term adverse effects of prolonged seizures and optimize patient outcomes...
  12. ncbi request reprint Inflammation contributes to seizure-induced hippocampal injury in the neonatal rat brain
    R Sankar
    Division of Neurology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Mattel Children s Hospital at UCLA, Los Angeles, CA 90095, USA
    Acta Neurol Scand Suppl 186:16-20. 2007
    ..Neonatal seizures often occur in clinical settings that include an inflammatory component. We examined the potential contributory role of pre-existing inflammation as an important variable in mediating neuronal injury...
  13. ncbi request reprint Inflammation modifies status epilepticus-induced hippocampal injury during development
    Raman Sankar
    Department of Pediatrics, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 48:16-8. 2007
  14. ncbi request reprint Mechanisms of action for the commonly used antiepileptic drugs: relevance to antiepileptic drug-associated neurobehavioral adverse effects
    Raman Sankar
    Department of Pediatric Neurology, Room 22474 MDCC, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    J Child Neurol 19:S6-14. 2004
    ..Antiglutamatergic drugs have the potential to be a double-edged sword: they can interfere with consolidation of learning and memory but can also provide neuroprotection in addition to their antiseizure effects...
  15. ncbi request reprint Metabolic and endocrine aspects of the ketogenic diet
    R Sankar
    Department of Neurology, Pediatric Neurology, UCLA School of Medicine, and Mattel Children s Hospital at UCLA, Los Angeles, CA 90095 1752, USA
    Epilepsy Res 37:191-201. 1999
    ..Only limited information is available regarding the interaction of the diet with the commonly used antiepileptic drugs...
  16. ncbi request reprint Granule cell neurogenesis after status epilepticus in the immature rat brain
    R Sankar
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1752, USA
    Epilepsia 41:S53-6. 2000
    ..We investigated seizure-induced granule cell neurogenesis in developing rat pups to study the association between hilar injury, granule cell neurogenesis, and epilepsy...
  17. pmc Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindling
    Raman Sankar
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 51:39-42. 2010
    ..Although the utility of this model for screening the antiepileptogenic therapies requires further validation, it introduces the ability to undertake development-specific testing and a more rapid throughput than conventional methods...
  18. ncbi request reprint Ontogeny of self-sustaining status epilepticus
    R Sankar
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Dev Neurosci 21:345-51. 1999
    ..This model of SE differs from in vitro models of SE, in which immature animals show an increased susceptibility to epileptogenic stimuli, and provides us with a novel method to study epileptogenicity in the developing brain...
  19. ncbi request reprint Serum neuron-specific enolase is a marker for neuronal damage following status epilepticus in the rat
    R Sankar
    Department of Neurology, UCLA School of Medicine, USA
    Epilepsy Res 28:129-36. 1997
    ..4 +/- 0.4 in the control animals to 30.4 +/- 1.3 after SE. The different brain regions examined had distinctive ontogenic profiles for SE-induced damage. Elevation of s-NSE after SE correlated with overall histologic evidence for damage...
  20. ncbi request reprint Epileptogenesis during development: injury, circuit recruitment, and plasticity
    Raman Sankar
    Department of Pediatrics, 22 474 MDCC, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Epilepsia 43:47-53. 2002
    ..To use animal models of variable seizure induction in rats at different developmental stages to determine contributing factors for spontaneous seizures resulting from status epilepticus (SE) early in life...
  21. pmc Age-dependent effects of topiramate on the acquisition and the retention of rapid kindling
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Epilepsia 48:765-73. 2007
    ..To examine antiepileptogenic, disease modifying, and anticonvulsant effects of topiramate under conditions of rapid kindling at different stages of development...
  22. pmc Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms
    Eduardo Pineda
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 51:110-4. 2010
    ....
  23. ncbi request reprint Inflammation exacerbates seizure-induced injury in the immature brain
    Stéphane Auvin
    Department of Pediatrics, Division of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Epilepsia 48:27-34. 2007
    ....
  24. ncbi request reprint Differential induction of p53 in immature and adult rat brain following lithium-pilocarpine status epilepticus
    Zhiqun Tan
    Department of Neurology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street MCH 142, Los Angeles, CA 90033, USA
    Brain Res 928:187-93. 2002
    ..This was supported by colocalization of activated caspase 3 in some cells with damaged DNA. These results provide additional evidence for a critical role for the p53 pathway in excitotoxic neuronal cell death due to status epilepticus...
  25. ncbi request reprint Children with ESES: variability in the syndrome
    Michele Van Hirtum-Das
    Department of Pediatrics and Neurology, David Geffen School of Medicine at UCLA, Mattel Children s Hospital at UCLA, Los Angeles, CA, USA
    Epilepsy Res 70:S248-58. 2006
    ..We undertook a retrospective study of children who present with significant activation of paroxysmal discharges during sleep to examine the clinical spectrum of disorders that present with such an EEG abnormality...
  26. ncbi request reprint Short-term plasticity of hippocampal neuropeptides and neuronal circuitry in experimental status epilepticus
    Claude G Wasterlain
    Department of Neurology, VA Greater Los Angeles Healthcare System 127, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Epilepsia 43:20-9. 2002
    ....
  27. pmc Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA
    Stéphane Auvin
    Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
    Epilepsia 51:34-8. 2010
    ..We showed that inflammation provoked by LPS enhanced rapid kindling epileptogenesis in immature rat brains. IL1RA was also able to mitigate this augmentation of epileptogenesis enhanced by LPS...
  28. ncbi request reprint Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus
    Zhiqun Tan
    Department of Neurology, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Brain Res 929:129-38. 2002
    ..The data indicate that p53 induction following LPSE may activate downstream pro-apoptotic genes leading to neurodegeneration...
  29. pmc Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Brain 131:2071-83. 2008
    ..The finding that behavioural equivalents of depression were resistant to an antidepressant medication suggested that depression in epilepsy might have distinct underlying mechanisms beyond alterations in serotonergic pathways...
  30. doi request reprint Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities
    Rochelle Caplan
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
    Epilepsia 49:1838-46. 2008
    ..This cross-sectional study examined behavioral/emotional, cognitive, and linguistic comorbidities as well as their correlates in children with CAE...
  31. pmc Thought disorder and frontotemporal volumes in pediatric epilepsy
    Rochelle Caplan
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 13:593-9. 2008
    ..These findings suggest that thought disorder might represent a developmental disability involving frontotemporal regions associated with language in pediatric CPS...
  32. doi request reprint Paroxysmal fast activity: an interictal scalp EEG marker of epileptogenesis in children
    Joyce Y Wu
    Division of Pediatric Neurology, Mattel Children s Hospital at UCLA, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    Epilepsy Res 82:99-106. 2008
    ..This study explored if beta- and gamma-frequency paroxysmal fast activity (PFA), recorded interictally during non-REM sleep, could be used as a scalp EEG marker of epileptogenesis in children...
  33. doi request reprint Suicidality and brain volumes in pediatric epilepsy
    Rochelle Caplan
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 18:286-90. 2010
    ..Given the role of the orbital frontal gyrus in both emotional regulation and epilepsy, these findings highlight the biological underpinnings of suicidal ideation in pediatric epilepsy...
  34. pmc Bumetanide inhibits rapid kindling in neonatal rats
    Andrey Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 50:2117-22. 2009
    ..To examine the effects of bumetanide, a selective blocker of Na+-K+-2Cl- cotransporter (NKCC1), on hippocampal excitability and rapid kindling in immature rats...
  35. pmc Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
    ..We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression...
  36. doi request reprint Language in pediatric epilepsy
    Rochelle Caplan
    Department of Psychiatry, UCLA, Los Angeles, California, USA
    Epilepsia 50:2397-407. 2009
    ....
  37. doi request reprint Frontal and temporal volumes in Childhood Absence Epilepsy
    Rochelle Caplan
    UCLA David Geffen School of Medicine, Department of Psychiatry, California, USA
    Epilepsia 50:2466-72. 2009
    ..It also examined the association of these volumes with seizure, demographic, perinatal, intelligence quotient (IQ), and psychopathology variables...
  38. pmc Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, D Geffen School of Medicine at UCLA, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 37:461-7. 2010
    ..These findings implicate hippocampal IL-1beta in epilepsy-associated depression and provide a rationale for the introduction of IL-1beta blockers in the treatment of depression in TLE...
  39. pmc Language and brain volumes in children with epilepsy
    Rochelle Caplan
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 17:402-7. 2010
    ....
  40. pmc Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study
    Andrey Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 49:1777-86. 2008
    ..To examine antiepileptogenic and antiictogenic potential of retigabine (RTG) under conditions of rapid kindling epileptogenesis during different stages of development...
  41. ncbi request reprint Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects
    Lucie Suchomelova
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    Pediatr Res 59:237-43. 2006
    ..Diazepam, on the other hand, was a better anticonvulsant than an antiepileptogenic agent in the P15 animals at the dose tested. Such effects were not seen in the older animals...
  42. pmc In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures
    Andrey M Mazarati
    Department of Pediatrics, Division of Pediatric Neurology, D Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurochem 95:1495-503. 2005
    ....
  43. ncbi request reprint Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patients
    Susan Koh
    Division of Pediatric Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Epilepsia 46:1950-4. 2005
    ..However, this concept is based on case reports, and the incidence and clinical characteristics of these patients have not been systematically assessed...
  44. ncbi request reprint Thought disorder: A developmental disability in pediatric epilepsy
    Rochelle Caplan
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 8:726-35. 2006
    ..The relationship of thought disorder to behavioral, academic, and social problems implies that these discourse deficits are one component of the developmental disabilities or comorbidities associated with pediatric CPS and PGE...
  45. pmc Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling
    Andrey Mazarati
    Department of Pediatrics, Division of Pediatric Neurology, D Geffen School of Medicine at UCLA, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    J Pharmacol Exp Ther 318:700-8. 2006
    ..The data are important for understanding endogenous mechanisms regulating epileptogenesis and for the development of novel antiepileptogenic drugs...
  46. ncbi request reprint Hippocampal volume in childhood complex partial seizures
    Melita Daley
    UCLA Department of Psychiatry, Psychiatry and Biobehavioral Sciences, UCLA, Semel Institute, Rm 48 253B, 760 Westwood Plaza, Los Angeles, CA 90095 1759, USA
    Epilepsy Res 72:57-66. 2006
    ..g., age, gender, ethnicity, socioeconomic status). It also examined the relationship between hippocampal volumes and seizure variables in the patients...
  47. ncbi request reprint Psychopathology and pediatric complex partial seizures: seizure-related, cognitive, and linguistic variables
    Rochelle Caplan
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, California, USA
    Epilepsia 45:1273-81. 2004
    ..This study examined the role of cognition, language, seizure-related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence...
  48. ncbi request reprint Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia
    Peter F Morrison
    Department of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pediatr Neurol 35:356-8. 2006
    ....
  49. ncbi request reprint Varicella-zoster virus: an overlooked cause of aseptic meningitis
    Ravi Jhaveri
    Division of Infectious Diseases, Mattel Children s Hospital at UCLA, Los Angeles, CA 90095 1752, USA
    Pediatr Infect Dis J 22:96-7. 2003
    ..We describe a previously healthy child who had aseptic meningitis without exanthem caused by reactivation of varicella-zoster virus. This has not been previously reported in the pediatric literature...
  50. pmc Kindling epileptogenesis in immature rats leads to persistent depressive behavior
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Room 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Epilepsy Behav 10:377-83. 2007
    ..We conclude that neuronal plastic changes associated with the kindling state are accompanied by the development of depressive behavior...
  51. ncbi request reprint Frontal and temporal volumes in children with epilepsy
    Melita Daley
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1759, USA
    Epilepsy Behav 10:470-6. 2007
    ..These findings highlight the need to control for seizure, cognitive, psychiatric, and demographic variables in studies of frontotemporal volumes in pediatric CPS...
  52. ncbi request reprint Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain
    Jerome Niquet
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 48:1203-6. 2007
    ..Caspase-3 was activated in injured (acidophilic) neurons 24 hours following SE, raising the possibility that they died by caspase-dependent "programmed" necrosis...
  53. ncbi request reprint Epileptogenesis after self-sustaining status epilepticus
    Andrey Mazarati
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 43:74-80. 2002
    ..To describe the natural history of chronic epilepsy after experimental self-sustaining status epilepticus (SSSE) and to correlate patterns of SSSE with ictal, interictal, and plastic changes that characterize chronic epilepsy...
  54. pmc Amygdala volume and psychopathology in childhood complex partial seizures
    Melita Daley
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90095 1759, USA
    Epilepsy Behav 13:212-7. 2008
    ..The relationship of amygdala volume to seizure variables and presence of psychopathology was also examined in these patients...
  55. ncbi request reprint Social competence in pediatric epilepsy: insights into underlying mechanisms
    Rochelle Caplan
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 6:218-28. 2005
    ....
  56. ncbi request reprint Reduced anesthetization during the intracarotid amobarbital (Wada) test in patients taking carbonic anhydrase-inhibiting medications
    Susan Bookheimer
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Epilepsia 46:236-43. 2005
    ..After an unusually high rate of recent anesthetization failures, we sought to determine the frequency of reduced anesthetization and any common factors underlying these failures...
  57. doi request reprint Obstacles to mental health care in pediatric epilepsy: insight from parents
    Pamela Vona
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1759, USA
    Epilepsy Behav 14:360-6. 2009
    ..However, the study's findings suggested a need to determine if there are specific obstacles to MHC in pediatric epilepsy...
  58. doi request reprint Teratogenicity of antiepileptic drugs: role of pharmacogenomics
    Raman Sankar
    David Geffen School of Medicine at UCLA, Mattel Children s Hospital at UCLA, Los Angeles, California 90095 1752, USA
    Int Rev Neurobiol 83:215-25. 2008
    ..Such an approach may also lead to novel interventions and therapeutics design to lower the teratogenic potential of pharmacologic treatment of epilepsy during conception...
  59. ncbi request reprint Treatment of myoclonic epilepsies in infancy and early childhood
    Raman Sankar
    Department of Neurology, David Geffen School of Medicine at UCLA and Mattel Children s Hospital at UCLA, Los Angeles, California, USA
    Adv Neurol 95:289-98. 2005
  60. doi request reprint Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience
    Jason T Lerner
    Department of Pediatric Neurology, University of California, Los Angeles, California, USA
    Epilepsia 50:1310-35. 2009
    ..The authors discuss future challenges to identifying and treating medically refractory epilepsy patients with cortical dysplasia...
  61. ncbi request reprint Postnatal hypoxic-ischemic brain injury alters mechanisms mediating neuronal glucose transport
    Ann Zovein
    Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, Los Angeles, CA, USA
    Am J Physiol Regul Integr Comp Physiol 286:R273-82. 2004
    ....
  62. ncbi request reprint Unmet mental health needs in pediatric epilepsy: insights from providers
    Kimberly Smith
    Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 11:401-8. 2007
    ....
  63. doi request reprint Dealing with epilepsy: parents speak up
    Keng Nei Wu
    Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA, USA
    Epilepsy Behav 13:131-8. 2008
    ..They also underscore the importance of educating parents, service providers, and the general public about epilepsy...
  64. ncbi request reprint Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain
    Raman Sankar
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, CA 90095 1752, USA
    Brain Res Mol Brain Res 107:157-65. 2002
    ..These insulin-responsive isoforms may have a unique role in augmenting substrate delivery under conditions of increased demand...

Research Grants1

  1. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..