M C Sanguinetti

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
    M C Sanguinetti
    Department of Medicine, Cardiology Division, University of Utah, Salt Lake City 84112, USA
    Nature 384:80-3. 1996
  2. ncbi Potassium channelopathies
    M C Sanguinetti
    Department of Medicine, University of Utah, Salt Lake City 84112, USA
    Neuropharmacology 36:755-62. 1997
  3. pmc The S4-S5 linker couples voltage sensing and activation of pacemaker channels
    J Chen
    Department of Medicine, Division of Cardiology, Eccles Program in Human Molecular Biology and Genetics, University of Utah, Eccles Institute of Human Genetics, 15 N 2030 E, Room 4220, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 98:11277-82. 2001
  4. ncbi Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel
    F D Huang
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City 84112, USA
    Circulation 104:1071-5. 2001
  5. pmc Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, Division of Cardiology, Department of Medicine, University of Utah, Salt Lake City, UT 84112
    J Physiol 514:667-75. 1999
  6. ncbi Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
    J Chen
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 274:10113-8. 1999
  7. pmc Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
    J S Mitcheson
    Department of Medicine, Division of Cardiology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Gen Physiol 115:229-40. 2000
  8. ncbi Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel
    J Chen
    Department of Medicine, Division of Cardiology and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    J Biol Chem 275:36465-71. 2000
  9. ncbi A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Cell 81:299-307. 1995
  10. ncbi Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits
    L Franqueza
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 274:21063-70. 1999

Collaborators

Detail Information

Publications14

  1. ncbi Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
    M C Sanguinetti
    Department of Medicine, Cardiology Division, University of Utah, Salt Lake City 84112, USA
    Nature 384:80-3. 1996
    ..Coexpression of K(V)LQT1 with minK induced a current that was almost identical to cardiac I(Ks). Therefore, K(V)LQT1 is the subunit that coassembles with minK to form I(Ks) channels and I(Ks) dysfunction is a cause of cardiac arrhythmia...
  2. ncbi Potassium channelopathies
    M C Sanguinetti
    Department of Medicine, University of Utah, Salt Lake City 84112, USA
    Neuropharmacology 36:755-62. 1997
    ..An understanding of the molecular basis of these diseases could facilitate the discovery and development of specific pharmacological therapies...
  3. pmc The S4-S5 linker couples voltage sensing and activation of pacemaker channels
    J Chen
    Department of Medicine, Division of Cardiology, Eccles Program in Human Molecular Biology and Genetics, University of Utah, Eccles Institute of Human Genetics, 15 N 2030 E, Room 4220, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 98:11277-82. 2001
    ..Our findings also suggest that opening of HCN and related channels corresponds to activation of a gate located near the inner pore, rather than recovery of channels from a C-type inactivated state...
  4. ncbi Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel
    F D Huang
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City 84112, USA
    Circulation 104:1071-5. 2001
    ..CONCLUSIONS: These findings define the physiological consequences of mutations in HERG that cause LQTS and indicate the importance of the pore helix of HERG for normal channel function...
  5. pmc Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, Division of Cardiology, Department of Medicine, University of Utah, Salt Lake City, UT 84112
    J Physiol 514:667-75. 1999
    ..5. The results indicate that the S4-S5 linker is a crucial component of the activation gate of HERG channels...
  6. ncbi Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation
    J Chen
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 274:10113-8. 1999
    ..The location of these mutations suggests they may disrupt the PAS domain and interfere with its interaction with the S4-S5 linker of the HERG channel...
  7. pmc Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
    J S Mitcheson
    Department of Medicine, Division of Cardiology, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Gen Physiol 115:229-40. 2000
    ..The ability of HERG channels to trap MK-499, despite its large size, suggests that the vestibule of this channel is larger than the well studied Shaker K(+) channel...
  8. ncbi Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel
    J Chen
    Department of Medicine, Division of Cardiology and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    J Biol Chem 275:36465-71. 2000
    ....
  9. ncbi A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    M C Sanguinetti
    Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
    Cell 81:299-307. 1995
    ..Since block of IKr is a known mechanism for drug-induced cardiac arrhythmias, the finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT...
  10. ncbi Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits
    L Franqueza
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 274:21063-70. 1999
    ..The decrease in I(Ks) caused by loss of function or altered gating properties explains the prolonged QT interval and increased risk of arrhythmia and sudden death associated with these mutations in KVLQT1...
  11. ncbi Mutations in the hminK gene cause long QT syndrome and suppress IKs function
    I Splawski
    Department of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Nat Genet 17:338-40. 1997
    ..This is the first description of KCNE1 as an LQT gene and confirms that hminK is an integral protein of the IKs channel...
  12. ncbi Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia
    M C Sanguinetti
    Department of Medicine, University of Utah, Salt Lake City 84112, USA
    Ann N Y Acad Sci 868:406-13. 1999
    ..The functional consequences of mutations in delayed rectifier K+ channel subunits are delayed cardiac repolarization, lengthened QT interval, and an increased risk of torsade de pointes and sudden death...
  13. ncbi Molecular biology of K(+) channels and their role in cardiac arrhythmias
    M Tristani-Firouzi
    Department of Medicine, Division of Cardiology, University of Utah, Salt Lake City, Utah 84112, USA
    Am J Med 110:50-9. 2001
    ..However, many of these same drugs, as well as other common medications that are structurally unrelated, can also cause long QT syndrome and induce ventricular arrhythmia...
  14. ncbi Long QT syndrome: ionic basis and arrhythmia mechanism in long QT syndrome type 1
    M C Sanguinetti
    Department of Medicine, University of Utah, Salt Lake City 84112, USA
    J Cardiovasc Electrophysiol 11:710-2. 2000
    ..It remains to be proven that an understanding of the molecular basis of LQT1 will lead to more effective therapy...