Affiliation: University of Oklahoma Health Sciences Center
Sanghera D, Bejar C, Sapkota B, Wander G, Ralhan S. Frequencies of poor metabolizer alleles of 12 pharmacogenomic actionable genes in Punjabi Sikhs of Indian Origin. Sci Rep. 2018;8:15742 pubmed publisher
..These findings underscore the need for evaluation of other endogamous ethnic groups of India and beyond for establishing a global benchmark for pre-emptive genotyping in drug metabolizing genes before beginning therapeutic intervention. ..
Sapkota B, Subramanian A, Priamvada G, Finely H, Blackett P, Aston C, et al
. Association of APOE polymorphisms with diabetes and cardiometabolic risk factors and the role of APOE genotypes in response to anti-diabetic therapy: results from the AIDHS/SDS on a South Asian population. J Diabetes Complications. 2015;29:1191-7 pubmed publisher
..Our preliminary findings point to the need for evaluating population-specific genetic variation and its interactions with therapeutic effects. ..
Sanghera D, Been L, Ralhan S, Wander G, Mehra N, Singh J, et al
. Genome-wide linkage scan to identify loci associated with type 2 diabetes and blood lipid phenotypes in the Sikh Diabetes Study. PLoS ONE. 2011;6:e21188 pubmed publisher
..More detailed examination of these regions with more informative genotyping, sequencing, and functional studies should lead to rapid detection of novel targets of therapeutic importance. ..
Sapkota B, HOPKINS R, Bjonnes A, Ralhan S, Wander G, Mehra N, et al
. Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study. J Steroid Biochem Mol Biol. 2016;158:149-156 pubmed publisher
..Identification of novel association signals in biologically plausible regions with 25(OH)D metabolism will provide new molecular insights on genetic drivers of vitamin D status and its implications in health disparities. ..
Howard E, Been L, Lerner M, Brackett D, Lightfoot S, Bullen E, et al
. Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2. BMC Genet. 2013;14:28 pubmed publisher
..However, further studies would be needed to mechanistically link the two definitively. ..
Sanghera D, Nath S, Ortega L, Gambarelli M, Kim Howard X, Singh J, et al
. TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels. Ann Hum Genet. 2008;72:499-509 pubmed publisher
..It also provides new information about the significant impact of TCF7L2 gene variants on plasma cholesterol levels that appear to be independent of BMI. ..
Sanghera D, Ortega L, Han S, Singh J, Ralhan S, Wander G, et al
. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet. 2008;9:59 pubmed publisher
..Further investigations are warranted to understand the pathway-based functional implications of these important loci in T2D pathophysiology in different ethnicities. ..
Sanghera D, Been L, Ortega L, Wander G, Mehra N, Aston C, et al
. Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs. J Hum Genet. 2009;54:162-8 pubmed publisher
..To our knowledge, this is the first study reporting the role of recently emerging loci in this high-risk population from the South Asian subcontinent. ..