DHARAMBIR SANGHERA

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2
    Eric W Howard
    Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, 940 Stanton L, Young Blvd, Rm 317 BMSB, Oklahoma City, OK, 73104, USA
    BMC Genet 14:28. 2013
  2. ncbi Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US
    Latonya F Been
    Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, USA
    BMC Med Genet 12:18. 2011
  3. ncbi Genome-wide linkage scan to identify loci associated with type 2 diabetes and blood lipid phenotypes in the Sikh Diabetes Study
    Dharambir K Sanghera
    Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e21188. 2011
  4. ncbi Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Hum Genet 54:162-8. 2009
  5. ncbi Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
  6. ncbi TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels
    D K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Ann Hum Genet 72:499-509. 2008
  7. ncbi Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity
    Dharambir K Sanghera
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 72:72-81. 2008
  8. ncbi The Khatri Sikh Diabetes Study (SDS): study design, methodology, sample collection, and initial results
    Dharambir K Sanghera
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Hum Biol 78:43-63. 2006
  9. ncbi Role of an intronic polymorphism in the PDCD1 gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid antibodies
    Dharambir K Sanghera
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Genet 115:393-8. 2004
  10. ncbi Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 68:285-99. 2004

Research Grants

  1. Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in Asian
    Dharambir K Sanghera; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2
    Eric W Howard
    Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, 940 Stanton L, Young Blvd, Rm 317 BMSB, Oklahoma City, OK, 73104, USA
    BMC Genet 14:28. 2013
    ..This study examines the role of a novel frame-shift insertion discovered in a conserved region of WNT16a, and it is proposed that this mutation affects T2D susceptibility in conjunction with gene variants in TCF7L2...
  2. ncbi Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US
    Latonya F Been
    Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma, USA
    BMC Med Genet 12:18. 2011
    ..The purpose of this investigation is to examine the role of these variants with T2D in populations of Asian Indian descent from India and the US...
  3. ncbi Genome-wide linkage scan to identify loci associated with type 2 diabetes and blood lipid phenotypes in the Sikh Diabetes Study
    Dharambir K Sanghera
    Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 6:e21188. 2011
    ..More detailed examination of these regions with more informative genotyping, sequencing, and functional studies should lead to rapid detection of novel targets of therapeutic importance...
  4. ncbi Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Hum Genet 54:162-8. 2009
    ..To our knowledge, this is the first study reporting the role of recently emerging loci in this high-risk population from the South Asian subcontinent...
  5. ncbi Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
    ....
  6. ncbi TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels
    D K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Ann Hum Genet 72:499-509. 2008
    ..It also provides new information about the significant impact of TCF7L2 gene variants on plasma cholesterol levels that appear to be independent of BMI...
  7. ncbi Genetic variation in the paraoxonase-3 (PON3) gene is associated with serum PON1 activity
    Dharambir K Sanghera
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 72:72-81. 2008
    ..To our knowledge, this is the first study reporting the association of the PON3 gene variants with PON1 activity...
  8. ncbi The Khatri Sikh Diabetes Study (SDS): study design, methodology, sample collection, and initial results
    Dharambir K Sanghera
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Hum Biol 78:43-63. 2006
    ..Such well-characterized population isolates may offer unique advantages in mapping genes for common complex diseases...
  9. ncbi Role of an intronic polymorphism in the PDCD1 gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid antibodies
    Dharambir K Sanghera
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Genet 115:393-8. 2004
    ..399, 95% CI: 0.19-0.82; P=0.0098) and SLE cases (OR=0.566, 95% CI: 0.32-1.01; P=0.054). Our data indicate polymorphism in intron 4 of the PDCD1 gene affects the occurrence of APA and may slightly modify the risk of sporadic SLE...
  10. ncbi Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Hum Genet 68:285-99. 2004
    ..We also found that these haplotypes are associated with the occurrence of APA. Recombinant APOH haplotypes, expressed in COS-1 cells, showed that these mutations also affect the binding of APOH to anionic PL...

Research Grants2

  1. Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in Asian
    Dharambir K Sanghera; Fiscal Year: 2010
    ..Identifying the susceptibility loci in a population with high diabetic/cardiovascular risk may be important beyond Indians and will increase our understanding of the disease in other groups. ..