Research Topics
Species | CURT ALAN SANDMANSummaryAffiliation: University of California Country: USA Publications
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Publications
Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetusCurt A Sandman
Department of Psychiatry and Human Behavior, Women and Children s Health and Well Being Project, Orange, CA 92868, USA
Neuroendocrinology 95:7-21. 2012..Accumulating evidence from a relatively small number of prospective studies indicates that exposure to prenatal stress profoundly influences the developing human fetus with consequences that persist into childhood and very likely forever...
The role of self-injury in the organisation of behaviourC A Sandman
Department of Psychiatry and Human Behaviour, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
J Intellect Disabil Res 56:516-26. 2012..Sophisticated sequential and temporal analysis of behaviour has provided alternative descriptions of self-injury that provide new insights into its initiation and maintenance...- Prescient human fetuses thriveCurt A Sandman
Department of Psychiatry and Human Behavior, University of California, Irvine, 333 City Dr West, Suite 1200, Orange, CA 92686, USA
Psychol Sci 23:93-100. 2012..Congruence between prenatal and postnatal environments prepares the fetus for postnatal life and confers an adaptive advantage for critical survival functions during early development... 
Human fetal heart rate dishabituation between thirty and thirty-two weeks gestationC A Sandman
University of California, Irvine, Costa Mesa 92626, USA
Child Dev 68:1031-40. 1997....- Maternal hypothalamic-pituitary-adrenal disregulation during the third trimester influences human fetal responsesCurt A Sandman
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
Dev Neurosci 25:41-9. 2003..Results indicate that maternal stress and stress-related peptides influence fetal response patterns. It is possible that this influence persists over the life span... - The role of proopiomelanocortin (POMC) in sequentially dependent self-injurious behaviorCurt A Sandman
Department of Psychiatry and Human Behavior, University of California, 2501 Harbor Blvd, Costa Mesa, Irvine, CA 92626, USA
Dev Psychobiol 50:680-9. 2008..85, p < .01). The pattern of results supported the conclusion that the stress axis played a significant role in the maintenance of complex episodes of self-injury... - Disregulation of proopiomelanocortin and contagious maladaptive behaviorCurt A Sandman
Department of Psychiatry, University of California, Irvine, CA, USA
Regul Pept 108:179-85. 2002..e. contagious patterns; F=8.17, P<0.01). These findings suggest that subjects with "contagious" SIB may represent a behavioral phenotype associated with disregulated expression of the POMC gene... - beta-Endorphin and ACTH are dissociated after self-injury in adults with developmental disabilitiesCurt A Sandman
University of California, Irvine, USA
Am J Ment Retard 108:414-24. 2003..The lowest dosage of NTX significantly reduced SIB in subjects with baseline levels of beta-E higher than after SIB. Results support previous reports that the HPA axis is disturbed among subjects exhibiting SIB... - Uncoupling of proopiomelanocortin (POMC) fragments is related to self-injuryC A Sandman
The Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
Peptides 21:785-91. 2000..Results indicated that the co-release (coupling) of POMC fragments were stable over time and the profile of POMC fragments in plasma predicted the effectiveness of a CNS acting drug in autistic subjects who self-injure... - The auditory event-related potential is a stable and reliable measure in elderly subjects over a 3 year periodC A Sandman
Department of Psychiatry, University of California, CA, Irvine, USA
Clin Neurophysiol 111:1427-37. 2000..Valid markers of psychobiological processes, including changes over the lifespan, must be reliable. This study investigated the reliability of the auditory event-related potential (ERP) over a 3 year period... - Long-term effects of naltrexone on self-injurious behaviorC A Sandman
University of California, Irvine, USA
Am J Ment Retard 105:103-17. 2000..Discussion of these complex effects considered the role of background opioid levels, dosing, and treatment regimen of naltrexone and other factors limiting receptor adaptation among patients who exhibit SIB... - Corticotrophin-releasing hormone and fetal responses in human pregnancyC A Sandman
Department of Psychiatry and Human Behavior, University of California, Irvine 92697, USA
Ann N Y Acad Sci 897:66-75. 1999..The impaired fetal responses to novelty and increased arousal observed in this study suggest that neurological systems may be targets for placental CRH during sensitive developmental periods... - Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): priming the placental clockCurt A Sandman
Women and Children s Health and Well Being Project, Department of Psychiatry, University of California, Irvine, 333 City Drive West, Suite 1200, Orange, CA 92868, USA
Peptides 27:1457-63. 2006..These findings suggested that early detection of stress signals by the placenta stimulated the subsequent release of CRH and resulted in increased risk for preterm delivery... - Low levels of corticotropin-releasing hormone during early pregnancy are associated with precocious maturation of the human fetusQuetzal A Class
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
Dev Neurosci 30:419-26. 2008..The findings suggest that exposure to low levels of pCRH early in gestation may be optimal and associated with a response pattern indicating greater maturity... - Attenuation of maternal psychophysiological stress responses and the maternal cortisol awakening response over the course of human pregnancySonja Entringer
Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA
Stress 13:258-68. 2010..This attenuation is unlikely to be attributable to habituation. Individual differences in the degree of attenuation of stress responses over gestation may represent a novel marker of stress susceptibility in human pregnancy... - Timing of fetal exposure to stress hormones: effects on newborn physical and neuromuscular maturationLauren M Ellman
Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 23, New York, New York 10032, USA
Dev Psychobiol 50:232-41. 2008..Findings suggest that stress hormones have effects on human fetal neurodevelopment that are independent of birth outcome... - High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old childrenClaudia Buss
Department of Psychiatry and Human Behavior, University of California, Irvine, Orange, CA 92868, United States
Psychoneuroendocrinology 35:141-53. 2010..Altered gray matter volume in brain regions affected by prenatal maternal anxiety may render the developing individual more vulnerable to neurodevelopmental and psychiatric disorders as well as cognitive and intellectual impairment... - Maturation of the human fetal startle response: evidence for sex-specific maturation of the human fetusClaudia Buss
Department of Psychiatry and Human Behavior, University of California, Irvine, 333 The City Blvd W, Suite 1200, Orange, CA 92868, USA
Early Hum Dev 85:633-8. 2009..The results indicate that there are different rates of maturation in the male and female fetuses that may have implications for sex-specific programming influences... - An initial report of a new biological marker for bipolar disorder: P85 evoked brain potentialJULIE V PATTERSON
Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, California 92868, USA
Bipolar Disord 11:596-609. 2009..The goal of this research was to determine how gating of an auditory brain potential at 85 ms (P85), not previously examined in sensory gating studies, differentiated control and patient groups... - Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infantsElysia Poggi Davis
Department of Psychiatry and Human Behavior, University of California, 333 City Blvd W, Suite 1200, Orange, CA 92868, USA
Dev Psychobiol 53:175-83. 2011..These data add to accumulating evidence that prenatal exposure to elevated GCs programs the development of the HPA axis... - Risk of postpartum depressive symptoms with elevated corticotropin-releasing hormone in human pregnancyIlona S Yim
Department of Psychology and Social Behavior, University of California Irvine, Irvine, CA 92697 7085, USA
Arch Gen Psychiatry 66:162-9. 2009..A possible link between placental corticotropin-releasing hormone (pCRH) and PPD incidence has been hypothesized, but empirical evidence is lacking... - The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive developmentElysia P Davis
University of California, Irvine, USA
Child Dev 81:131-48. 2010..These data suggest that maternal cortisol and pregnancy-specific anxiety have programming influences on the developing fetus... - The maternal cortisol awakening response in human pregnancy is associated with the length of gestationClaudia Buss
Department of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, CA
Am J Obstet Gynecol 201:398.e1-8. 2009..The purpose of this study was to examine the relationship between intraindividual changes in cortisol responsiveness over pregnancy and the length of human gestation... - Prenatal beta-endorphin as an early predictor of postpartum depressive symptoms in euthymic womenIlona S Yim
Department of Psychology and Social Behavior, University of California, Irvine, USA
J Affect Disord 125:128-33. 2010..The opioid peptide beta-endorphin has been implicated in non-puerperal depression but its role in the development of PPD is unknown... - Prenatal maternal stress programs infant stress regulationElysia Poggi Davis
Department of Psychiatry and Human Behavior, University of California, Irvine, Orange, CA 92868, USA
J Child Psychol Psychiatry 52:119-29. 2011..The current investigation examined the influence of prenatal maternal cortisol and maternal psychosocial stress on infant physiological and behavioral responses to stress... - Pattern of perceived stress and anxiety in pregnancy predicts preterm birthLaura M Glynn
Department of Psychiatry and Human Behavior, University of California, Irvine, Orange 92868, USA
Health Psychol 27:43-51. 2008..To determine whether the pattern of prenatal stress, as compared to prenatal stress assessed at a single gestational time point, predicts preterm delivery (PTD)... - Behavioral perinatology: biobehavioral processes in human fetal developmentPathik D Wadhwa
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 4260, USA
Regul Pept 108:149-57. 2002..In this paper, we elaborate on the conceptual and empirical basis for this model, highlight some relevant issues and questions, and make recommendations for future research in this area... - Quantifying temporal distributions of self-injurious behavior: defining bouts versus discrete eventsRose Kroeker
University of California, Irvine Applied Neuro Developmental Research Institute, Costa Mesa, CA 92626, USA
Am J Ment Retard 109:1-8. 2004..This approach may facilitate research on factors that initiate and maintain SIB... - Pregnancy affects appraisal of negative life eventsLaura M Glynn
Department of Psychiatry and Human Behavior, University of California, Irvine, 2501 Harbor Boulevard, No 7, Costa Mesa, CA 92626, USA
J Psychosom Res 56:47-52. 2004..This study investigates whether emotional responding is diminished as well by measuring affective responses to specific life events during pregnancy... - Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigationPathik D Wadhwa
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 4260, USA
Am J Obstet Gynecol 191:1063-9. 2004.... - Corticotropin-releasing hormone during pregnancy is associated with infant temperamentElysia Poggi Davis
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92677, USA
Dev Neurosci 27:299-305. 2005..These data suggest that prenatal exposure to CRH may exert influences that persist into the postnatal period... - Alpha EEG predicts visual reaction timeYi Jin
Department of Psychiatry and Human Behavior, University of California Irvine College of Medicine, Irvine, California 2868 3298, USA
Int J Neurosci 116:1035-44. 2006..These findings are consistent with previous reports and support the hypothesis that alpha EEG represents excitability cycles and may serves as a brain clock for spatial synchronization... - Postnatal maternal cortisol levels predict temperament in healthy breastfed infantsLaura M Glynn
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92868, USA
Early Hum Dev 83:675-81. 2007..Animal models suggest that ingestion of glucocorticoids during the neonatal period influences fear behavior and modifies brain development... - Temporal patterns of self-injurious behavior correlate with stress hormone levels in the developmentally disabledAaron S Kemp
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
Psychiatry Res 157:181-9. 2008..These findings support the hypothesis that the recurrent temporal patterning of SIB represents a unique behavioral phenotype directly related to perturbed levels of POMC-derived stress hormones in certain individuals with severe DD... - Prenatal exposure to maternal depression and cortisol influences infant temperamentElysia Poggi Davis
Department of Psychiatry and Human Behavior, University of California, Irvine, USA
J Am Acad Child Adolesc Psychiatry 46:737-46. 2007..Few prospective studies of human pregnancy have examined the consequences of prenatal exposure to stress and stress hormones... - Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone during pregnancyLaura M Glynn
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92868, United States
Peptides 28:1155-61. 2007..The findings are consistent with the possibility that ethnic disparities in adverse birth outcomes may be due, in part, to differences in HPA axis and placental function... - Familialism, social support, and stress: positive implications for pregnant LatinasBelinda Campos
Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Cultur Divers Ethnic Minor Psychol 14:155-62. 2008..Moreover, higher social support was associated with higher infant birth weight among foreign-born Latinas only. Implications of cultural values for relationships and health are discussed... - A novel mouse model for acute and long-lasting consequences of early life stressCourtney J Rice
Department of Anatomy and Neurobiology, Med Sci I, ZOT 4475, University of California, Irvine, Irvine, California 92697 4475, USA
Endocrinology 149:4892-900. 2008..This model should facilitate the examination of the specific genes and molecules involved in the generation of this stress as well as in its consequences... - Sequential analysis reveals a unique structure for self-injurious behaviorSarah Deboard Marion
Applied Neurodevelopmental Research Institute at Fairview Developmental Center, Irvine, CA, USA
Am J Ment Retard 108:301-13. 2003..It may be the first in which this analytic tool was used to investigate systematically successive occurrences of SIB as it takes place in vivo... - Sensitization of cardiac responses to pain in preterm infantsBeth L Pineles
Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA
Neonatology 91:190-5. 2007..There is evidence from both animal and human studies that exposure to pain during the neonatal period may have persisting consequences for development... - Racial differences in birth outcomes: the role of general, pregnancy, and racism stressTyan Parker Dominguez
School of Social Work, University of Southern California, Los Angeles, CA 90089 0411, USA
Health Psychol 27:194-203. 2008..This study examined the role of psychosocial stress in racial differences in birth outcomes... - Male violence, stress, and neuroendocrine parameters in pregnancy: a pilot studyPam Talley
Department of Family and Child Nursing, University of Washington, Seattle 98195, USA
Biol Res Nurs 7:222-33. 2006..These results suggest that the maternal experience of stress alters the relationship of hypothalamic-pituitary-adrenal-placental axis hormones despite the lack of absolute differences in blood levels... - Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior rating and sexCarolyn M Crockett
National Primate Research Center, Box 357330, University of Washington, Seattle, WA 98195 7330, USA
Peptides 28:1987-97. 2007..The positive relation of the N-terminal fragment of betaE to abnormal behavior is a new finding... - Stressed-out, or in (utero)?Sarit Avishai-Eliner
Dept of Anatomy and Neurobiology, University of California at Irvine, 92697, USA
Trends Neurosci 25:518-24. 2002..Importantly, these CRH-mediated processes could be targets of preventive and interventional strategies...
Research Grants
- Fetal Programming of Early DevelopmentCurt Sandman; Fiscal Year: 2009..Prenatal influences of CRH on HPA reactivity (Aim 4) will be evaluated by assessing salivary cortisol at rest and after mild stress. These studies in children are the first to examine the role of prenatal CRH on human development. ..
- Maternal Stress and Fetal/Infant DevelopmentCurt Sandman; Fiscal Year: 2006..abstract_text> ..
- Emergence of SIB in Developmentally Delayed IndividualsCurt Sandman; Fiscal Year: 2007..Findings from this project will contribute to the understanding of the emergence and maintenance of SIB. ..
- Fetal Programming of Early DevelopmentCurt Sandman; Fiscal Year: 2007..Prenatal influences of CRH on HPA reactivity (Aim 4) will be evaluated by assessing salivary cortisol at rest and after mild stress. These studies in children are the first to examine the role of prenatal CRH on human development. ..
- Emergence of SIB in Developmentally Delayed IndividualsCurt Sandman; Fiscal Year: 2009..Findings from this project will contribute to the understanding of the emergence and maintenance of SIB. ..
- Emergence of SIB in Developmentally Delayed IndividualsCURT ALAN SANDMAN; Fiscal Year: 2010..Findings from this project will contribute to the understanding of the emergence and maintenance of SIB. ..
- Winter Neuropeptides ConferenceCurt Sandman; Fiscal Year: 2004..The conference is inclusive for all groups. Half of the organizing and steering committees are women. Efforts are made to include minorities and persons with disabilities. ..
- STRESS AND BIRTH OUTCOMESCurt Sandman; Fiscal Year: 1993..Birth and delivery outcomes will be determined. Multivariate models to predict the effects of stress and strain on birth complications will be constructed...
- STRESS AND BIRTH OUTCOMESCurt Sandman; Fiscal Year: 2001..The study design and analytic methods allows for estimation of the unique effects of CRH and psychosocial stress on the length of gestation. ..
- Fetal Programming of Early DevelopmentCURT ALAN SANDMAN; Fiscal Year: 2010..Prenatal influences of CRH on HPA reactivity (Aim 4) will be evaluated by assessing salivary cortisol at rest and after mild stress. These studies in children are the first to examine the role of prenatal CRH on human development. ..