M J Sanderson

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices
    Albrecht Bergner
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 119:187-98. 2002
  2. ncbi request reprint Regulation of airway smooth muscle cell contractility by Ca2+ signaling and sensitivity
    Michael J Sanderson
    Department of Physiology University of Massachusetts Medical School Worcester, MA 01655, USA
    Proc Am Thorac Soc 5:23-31. 2008
  3. pmc The contraction of smooth muscle cells of intrapulmonary arterioles is determined by the frequency of Ca2+ oscillations induced by 5-HT and KCl
    Jose F Perez
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 125:555-67. 2005
  4. pmc The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles
    Jose F Perez
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 125:535-53. 2005
  5. pmc A multi-scale approach to airway hyperresponsiveness: from molecule to organ
    Anne Marie Lauzon
    Meakins Christie Laboratories, Department of Medicine, McGill University Montreal, QC, Canada
    Front Physiol 3:191. 2012
  6. pmc Nitric oxide induces airway smooth muscle cell relaxation by decreasing the frequency of agonist-induced Ca2+ oscillations
    Jose F Perez-Zoghbi
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 135:247-59. 2010
  7. pmc Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor
    Yan Bai
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Respir Res 7:34. 2006
  8. pmc Exploring lung physiology in health and disease with lung slices
    Michael J Sanderson
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Pulm Pharmacol Ther 24:452-65. 2011
  9. doi request reprint Ca(2+) oscillations regulate contraction of intrapulmonary smooth muscle cells
    Michael J Sanderson
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA
    Adv Exp Med Biol 661:77-96. 2010
  10. ncbi request reprint High-speed digital microscopy
    M J Sanderson
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655, USA
    Methods 21:325-34. 2000

Research Grants

  1. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2004
  2. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2004
  3. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2005
  4. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2005
  5. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2006
  6. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2007
  7. Airway Hyper-responsiveness: from molecule to organ
    Michael Sanderson; Fiscal Year: 2007
  8. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2003
  9. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2003
  10. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 1999

Collaborators

Detail Information

Publications28

  1. pmc Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices
    Albrecht Bergner
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 119:187-98. 2002
    ..These results indicate that Ca(2+) oscillations, induced by ACH in murine bronchial SMCs, are generated by Ca(2+) release from the SR involving IP(3)- and ryanodine receptors, and are required to maintain airway contraction...
  2. ncbi request reprint Regulation of airway smooth muscle cell contractility by Ca2+ signaling and sensitivity
    Michael J Sanderson
    Department of Physiology University of Massachusetts Medical School Worcester, MA 01655, USA
    Proc Am Thorac Soc 5:23-31. 2008
    ....
  3. pmc The contraction of smooth muscle cells of intrapulmonary arterioles is determined by the frequency of Ca2+ oscillations induced by 5-HT and KCl
    Jose F Perez
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 125:555-67. 2005
    ..We hypothesize that the magnitude of the sustained intrapulmonary SMC contraction is determined by the frequency of Ca(2+) oscillations and also by the relaxation rate of the SMC...
  4. pmc The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles
    Jose F Perez
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 125:535-53. 2005
    ....
  5. pmc A multi-scale approach to airway hyperresponsiveness: from molecule to organ
    Anne Marie Lauzon
    Meakins Christie Laboratories, Department of Medicine, McGill University Montreal, QC, Canada
    Front Physiol 3:191. 2012
    ..The goal is to develop this lung model so that it can make predictions about bronchoconstriction and identify the pathophysiologic mechanisms having the greatest impact on AHR and its therapy...
  6. pmc Nitric oxide induces airway smooth muscle cell relaxation by decreasing the frequency of agonist-induced Ca2+ oscillations
    Jose F Perez-Zoghbi
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 135:247-59. 2010
    ..Consequently, we conclude that NO, acting via the cGMP-PKG pathway, induced airway SMC relaxation by predominately inhibiting the release of Ca(2+) via the IP(3) receptor to decrease the frequency of agonist-induced Ca(2+) oscillations...
  7. pmc Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor
    Yan Bai
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Respir Res 7:34. 2006
    ..Therefore, we hypothesized that the relaxation of airway SMCs induced by agents that increase cAMP results from the down-regulation or slowing of the frequency of the Ca2+ oscillations...
  8. pmc Exploring lung physiology in health and disease with lung slices
    Michael J Sanderson
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Pulm Pharmacol Ther 24:452-65. 2011
    ..Because of the ability to observe changes in cell physiology and how these responses manifest themselves at the level of the organ, lung slices have become a standard tool for the investigation of lung disease...
  9. doi request reprint Ca(2+) oscillations regulate contraction of intrapulmonary smooth muscle cells
    Michael J Sanderson
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA
    Adv Exp Med Biol 661:77-96. 2010
    ..The relaxation of SMC tone can be induced by the reduction of the frequency of the Ca(2+) oscillations and the Ca(2+) sensitivity by b(2)-adrenergic agonists or nitric oxide...
  10. ncbi request reprint High-speed digital microscopy
    M J Sanderson
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655, USA
    Methods 21:325-34. 2000
    ..The fast [Ca2+]i images are determined using the ratiometric dye fura-2 and a recording technique that monitors rapid changes in fluorescence at a single wavelength and uses intermittent reference images for calibration...
  11. ncbi request reprint Intracellular calcium oscillations induced by ATP in airway epithelial cells
    J H Evans
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol 277:L30-41. 1999
    ..Thus Ca(2+) oscillations and propagating Ca(2+) waves are two fundamental modes of Ca(2+) signaling that exist and operate simultaneously in airway epithelial cells...
  12. pmc Effects of formoterol on contraction and Ca2+ signaling of mouse airway smooth muscle cells
    Philippe Delmotte
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Am J Respir Cell Mol Biol 42:373-81. 2010
    ..This action was quickly initiated at high concentrations by decreasing the frequency of Ca(2+) oscillations, but was more usually mediated at lower concentrations by decreasing the Ca(2+) sensitivity of the SMCs...
  13. pmc Effects of albuterol isomers on the contraction and Ca2+ signaling of small airways in mouse lung slices
    Philippe Delmotte
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Am J Respir Cell Mol Biol 38:524-31. 2008
    ..In conclusion, (R)-albuterol consistently induced a greater airway relaxation than racemic albuterol, and (S)-albuterol appears to be responsible for this reduced efficacy...
  14. pmc A mathematical model of airway and pulmonary arteriole smooth muscle
    Inga Wang
    Department of Mathematics, University of Auckland, Auckland, New Zealand
    Biophys J 94:2053-64. 2008
    ..In addition, the model also predicts that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration...
  15. pmc Mutations in Hydin impair ciliary motility in mice
    Karl Ferdinand Lechtreck
    Department of Cell, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biol 180:633-43. 2008
    ..Similar defects are observed for cilia in trachea. We conclude that hydrocephalus in hydin mutants is caused by a central pair defect impairing ciliary motility and fluid transport in the brain...
  16. pmc TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells
    Ivan M Lorenzo
    Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Parc Recerca Biom├Ędica de Barcelona, Carrer Doctor Aiguader 88, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 105:12611-6. 2008
    ..Moreover, these studies implicate the participation of TRPV4 in receptor-operated Ca(2+) entry...
  17. ncbi request reprint Endothelin-induced contraction of bronchiole and pulmonary arteriole smooth muscle cells is regulated by intracellular Ca2+ oscillations and Ca2+ sensitization
    Jose F Perez-Zoghbi
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1000-11. 2007
    ..These results indicate that ET-induced contraction of bronchiole and arteriole SMCs is regulated by the frequency of Ca(2+) oscillations and by increasing the sensitivity of the contractile machinery to Ca(2+)...
  18. pmc The role of cGMP in the regulation of rabbit airway ciliary beat frequency
    Luo Zhang
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Physiol 551:765-76. 2003
    ..In addition, we suggest that the Ca2+-dependent stimulation of rabbit airway ciliary activity does not initially require PKG activation...
  19. ncbi request reprint Airway contractility and smooth muscle Ca(2+) signaling in lung slices from different mouse strains
    Albrecht Bergner
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Appl Physiol 95:1325-32; discussion 1314. 2003
    ..These results suggest that the mechanism responsible for airway hyperreactivity in different mouse strains resides with the Ca2+ sensitivity of the contractile apparatus of the SMCs rather than with the Ca2+ signaling itself...
  20. pmc Oscillations in ciliary beat frequency and intracellular calcium concentration in rabbit tracheal epithelial cells induced by ATP
    Luo Zhang
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Physiol 546:733-49. 2003
    ....
  21. ncbi request reprint Effect of isoproterenol on the regulation of rabbit airway ciliary beat frequency measured with high-speed digital and fluorescence microscopy
    Luo Zhang
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Ann Otol Rhinol Laryngol 114:399-403. 2005
    ..We conclude that isoproterenol initially increases CBF through a calcium-independent mechanism, probably via protein kinase A, and subsequently through a calcium-dependent mechanism mediated by an increase in [Ca2+]i...
  22. ncbi request reprint Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices
    Yan Bai
    Department of Physiology, University of Massachusetts Medical School, Worcester, 01655, USA
    Am J Physiol Lung Cell Mol Physiol 291:L208-21. 2006
    ....
  23. pmc Ciliary beat frequency is maintained at a maximal rate in the small airways of mouse lung slices
    Philippe Delmotte
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue, North Worcester, MA 01655, USA
    Am J Respir Cell Mol Biol 35:110-7. 2006
    ..These conditions would ensure that mucociliary clearance is constantly active to provide continuous airway protection...
  24. ncbi request reprint ATP stimulates Ca2+ oscillations and contraction in airway smooth muscle cells of mouse lung slices
    Albrecht Bergner
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1271-9. 2002
    ..We conclude that ATP can serve as a spasmogen of airway SMCs and that Ca2+ oscillations in SMCs are required to sustain airway contraction...
  25. pmc Contractility and Ca2+ signaling of smooth muscle cells in different generations of mouse airways
    Yan Bai
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Respir Cell Mol Biol 36:122-30. 2007
    ..These results indicate that the contractility of airway SMCs varies at different positions along the same airway and that this response partially results from different Ca(2+) signaling and the total amount of the SMCs...
  26. pmc The ciliary rootlet maintains long-term stability of sensory cilia
    Jun Yang
    The Berman Gund Laboratory for the Study of Retinal Degenerations, Howe Laboratory, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Cell Biol 25:4129-37. 2005
    ..Inasmuch as photoreceptors elaborate an exceptionally enlarged sensory cilium, they are especially dependent on the rootlet for structural integrity and long-term survival...
  27. ncbi request reprint [Measurement of respiratory ciliary beat frequency quantified with high-speed digital microscopy]
    Luo Zhang
    Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Affiliated to Capital University of Medical Sciences, Beijing Institute of Otorhinolaryngology, Beijing 100730, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 39:433-7. 2004
    ..To accurately quantify the respiratory cilia activity, a high-speed phase-contrast imaging and ciliary beat frequency (CBF) analysis method were introduced...
  28. ncbi request reprint M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades
    Liwang Liu
    Program in Neuroscience and Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Neurosci 26:11588-98. 2006
    ..Our findings support a model of M(1)R-meditated channel modulation that broadens rather than restricts the roles of phospholipids and fatty acids in regulating ion channel activity...

Research Grants20

  1. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2004
    ..abstract_text> ..
  2. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2004
    ..abstract_text> ..
  3. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2005
    ..abstract_text> ..
  4. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2005
    ..abstract_text> ..
  5. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2006
    ..abstract_text> ..
  6. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2007
    ..abstract_text> ..
  7. Airway Hyper-responsiveness: from molecule to organ
    Michael Sanderson; Fiscal Year: 2007
    ..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..
  8. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2003
    ..abstract_text> ..
  9. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2003
    ..abstract_text> ..
  10. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 1999
    ..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
  11. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 2000
    ..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
  12. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 2001
    ..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
  13. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2002
    ..abstract_text> ..
  14. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 2002
    ..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
  15. A multi-scale approach to airway hyperresponsiveness: from molecule to organ
    MERRYN HOWATSON TAWHAI; Fiscal Year: 2010
    ..With this multi-scale approach, we will be able to identify key events in AHR that may serve as targets for therapeutic intervention. ..