Research Topics
Species | M J SandersonSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slicesAlbrecht Bergner
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Gen Physiol 119:187-98. 2002..These results indicate that Ca(2+) oscillations, induced by ACH in murine bronchial SMCs, are generated by Ca(2+) release from the SR involving IP(3)- and ryanodine receptors, and are required to maintain airway contraction...
Regulation of airway smooth muscle cell contractility by Ca2+ signaling and sensitivityMichael J Sanderson
Department of Physiology University of Massachusetts Medical School Worcester, MA 01655, USA
Proc Am Thorac Soc 5:23-31. 2008....- Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptorYan Bai
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Respir Res 7:34. 2006..Therefore, we hypothesized that the relaxation of airway SMCs induced by agents that increase cAMP results from the down-regulation or slowing of the frequency of the Ca2+ oscillations... - Exploring lung physiology in health and disease with lung slicesMichael J Sanderson
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
Pulm Pharmacol Ther 24:452-65. 2011..Because of the ability to observe changes in cell physiology and how these responses manifest themselves at the level of the organ, lung slices have become a standard tool for the investigation of lung disease... - High-speed digital microscopyM J Sanderson
Department of Physiology, University of Massachusetts Medical School, Worcester 01655, USA
Methods 21:325-34. 2000..The fast [Ca2+]i images are determined using the ratiometric dye fura-2 and a recording technique that monitors rapid changes in fluorescence at a single wavelength and uses intermittent reference images for calibration... 
Ca(2+) oscillations regulate contraction of intrapulmonary smooth muscle cellsMichael J Sanderson
Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA
Adv Exp Med Biol 661:77-96. 2010..The relaxation of SMC tone can be induced by the reduction of the frequency of the Ca(2+) oscillations and the Ca(2+) sensitivity by b(2)-adrenergic agonists or nitric oxide...- Intracellular calcium oscillations induced by ATP in airway epithelial cellsJ H Evans
Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Am J Physiol 277:L30-41. 1999..Thus Ca(2+) oscillations and propagating Ca(2+) waves are two fundamental modes of Ca(2+) signaling that exist and operate simultaneously in airway epithelial cells... - Effects of formoterol on contraction and Ca2+ signaling of mouse airway smooth muscle cellsPhilippe Delmotte
Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Am J Respir Cell Mol Biol 42:373-81. 2010..This action was quickly initiated at high concentrations by decreasing the frequency of Ca(2+) oscillations, but was more usually mediated at lower concentrations by decreasing the Ca(2+) sensitivity of the SMCs... - The role of cGMP in the regulation of rabbit airway ciliary beat frequencyLuo Zhang
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Physiol 551:765-76. 2003..In addition, we suggest that the Ca2+-dependent stimulation of rabbit airway ciliary activity does not initially require PKG activation... - Endothelin-induced contraction of bronchiole and pulmonary arteriole smooth muscle cells is regulated by intracellular Ca2+ oscillations and Ca2+ sensitizationJose F Perez Zoghbi
Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
Am J Physiol Lung Cell Mol Physiol 293:L1000-11. 2007..These results indicate that ET-induced contraction of bronchiole and arteriole SMCs is regulated by the frequency of Ca(2+) oscillations and by increasing the sensitivity of the contractile machinery to Ca(2+)... - Effects of albuterol isomers on the contraction and Ca2+ signaling of small airways in mouse lung slicesPhilippe Delmotte
Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Am J Respir Cell Mol Biol 38:524-31. 2008..In conclusion, (R)-albuterol consistently induced a greater airway relaxation than racemic albuterol, and (S)-albuterol appears to be responsible for this reduced efficacy... - A mathematical model of airway and pulmonary arteriole smooth muscleInga Wang
Department of Mathematics, University of Auckland, Auckland, New Zealand
Biophys J 94:2053-64. 2008..In addition, the model also predicts that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration... - ATP stimulates Ca2+ oscillations and contraction in airway smooth muscle cells of mouse lung slicesAlbrecht Bergner
Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Am J Physiol Lung Cell Mol Physiol 283:L1271-9. 2002..We conclude that ATP can serve as a spasmogen of airway SMCs and that Ca2+ oscillations in SMCs are required to sustain airway contraction... - Mutations in Hydin impair ciliary motility in miceKarl Ferdinand Lechtreck
Department of Cell, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Cell Biol 180:633-43. 2008..Similar defects are observed for cilia in trachea. We conclude that hydrocephalus in hydin mutants is caused by a central pair defect impairing ciliary motility and fluid transport in the brain... - TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cellsIvan M Lorenzo
Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Parc Recerca Biomèdica de Barcelona, Carrer Doctor Aiguader 88, 08003 Barcelona, Spain
Proc Natl Acad Sci U S A 105:12611-6. 2008..Moreover, these studies implicate the participation of TRPV4 in receptor-operated Ca(2+) entry... - Ciliary beat frequency is maintained at a maximal rate in the small airways of mouse lung slicesPhilippe Delmotte
Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue, North Worcester, MA 01655, USA
Am J Respir Cell Mol Biol 35:110-7. 2006..These conditions would ensure that mucociliary clearance is constantly active to provide continuous airway protection... - Contractility and Ca2+ signaling of smooth muscle cells in different generations of mouse airwaysYan Bai
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Am J Respir Cell Mol Biol 36:122-30. 2007..These results indicate that the contractility of airway SMCs varies at different positions along the same airway and that this response partially results from different Ca(2+) signaling and the total amount of the SMCs... - The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchiolesJose F Perez
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Gen Physiol 125:535-53. 2005.... - The contraction of smooth muscle cells of intrapulmonary arterioles is determined by the frequency of Ca2+ oscillations induced by 5-HT and KClJose F Perez
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Gen Physiol 125:555-67. 2005..We hypothesize that the magnitude of the sustained intrapulmonary SMC contraction is determined by the frequency of Ca(2+) oscillations and also by the relaxation rate of the SMC... - Effect of isoproterenol on the regulation of rabbit airway ciliary beat frequency measured with high-speed digital and fluorescence microscopyLuo Zhang
Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Ann Otol Rhinol Laryngol 114:399-403. 2005..We conclude that isoproterenol initially increases CBF through a calcium-independent mechanism, probably via protein kinase A, and subsequently through a calcium-dependent mechanism mediated by an increase in [Ca2+]i... - Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slicesYan Bai
Department of Physiology, University of Massachusetts Medical School, Worcester, 01655, USA
Am J Physiol Lung Cell Mol Physiol 291:L208-21. 2006.... - Airway contractility and smooth muscle Ca(2+) signaling in lung slices from different mouse strainsAlbrecht Bergner
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Appl Physiol 95:1325-32; discussion 1314. 2003..These results suggest that the mechanism responsible for airway hyperreactivity in different mouse strains resides with the Ca2+ sensitivity of the contractile apparatus of the SMCs rather than with the Ca2+ signaling itself... - Oscillations in ciliary beat frequency and intracellular calcium concentration in rabbit tracheal epithelial cells induced by ATPLuo Zhang
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Physiol 546:733-49. 2003.... - The ciliary rootlet maintains long-term stability of sensory ciliaJun Yang
The Berman Gund Laboratory for the Study of Retinal Degenerations, Howe Laboratory, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
Mol Cell Biol 25:4129-37. 2005..Inasmuch as photoreceptors elaborate an exceptionally enlarged sensory cilium, they are especially dependent on the rootlet for structural integrity and long-term survival... - [Measurement of respiratory ciliary beat frequency quantified with high-speed digital microscopy]Luo Zhang
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Affiliated to Capital University of Medical Sciences, Beijing Institute of Otorhinolaryngology, Beijing 100730, China
Zhonghua Er Bi Yan Hou Ke Za Zhi 39:433-7. 2004..To accurately quantify the respiratory cilia activity, a high-speed phase-contrast imaging and ciliary beat frequency (CBF) analysis method were introduced... - M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascadesLiwang Liu
Program in Neuroscience and Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Neurosci 26:11588-98. 2006..Our findings support a model of M(1)R-meditated channel modulation that broadens rather than restricts the roles of phospholipids and fatty acids in regulating ion channel activity...
Research Grants
- The regulation of airway ciliary activityMichael Sanderson; Fiscal Year: 2005..abstract_text> ..
- Calcium signaling in airway smooth muscle in lung slicesMichael Sanderson; Fiscal Year: 2007..abstract_text> ..
- Airway Hyper-responsiveness: from molecule to organMichael Sanderson; Fiscal Year: 2007..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..
- CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLEMichael Sanderson; Fiscal Year: 2002..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
- A multi-scale approach to airway hyperresponsiveness: from molecule to organMERRYN HOWATSON TAWHAI; Fiscal Year: 2010..With this multi-scale approach, we will be able to identify key events in AHR that may serve as targets for therapeutic intervention. ..