M J Sanders
Affiliation: University of California
- Chronic failure in the maintenance of long-term potentiation following fluid percussion injury in the ratM J Sanders
Department of Psychology, University of Miami, Coral Gables, FL, USA
Brain Res 861:69-76. 2000..The results have implications for the mechanisms underlying the impaired synaptic plasticity following TBI...
- The place of the hippocampus in fear conditioningMatthew J Sanders
UCLA Psychology Department, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Eur J Pharmacol 463:217-23. 2003..In this review, we examine the evidence that the hippocampus plays a role in fear conditioning. We then critically examine hypotheses concerning its exact role in learning and memory for cued and context fear conditioning...
- Pre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockadeMatthew J Sanders
UCLA Psychology Department, 1285 Franz Hall, Los Angeles, CA 90095 1563, USA
Neurobiol Learn Mem 80:123-9. 2003..The data thus suggest that the neurobiological substrates of context learning and place learning overlap...
- Behavioral, electrophysiological, and histopathological consequences of mild fluid-percussion injury in the ratM J Sanders
Department of Psychology, University of Miami School of Medicine, Miami, FL, USA
Brain Res 904:141-4. 2001..TBI caused mild selective cortical damage and limited axonal swelling at the injury site. Thus mild injury disrupts somatosensory electrophysiology and exploratory behavior...
- Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fearMatthew J Sanders
UCLA Psychology Department, Los Angeles, CA, USA
Neurobiol Learn Mem 84:33-41. 2005..The conditioning deficit seen in this line of mice may be related to impairment in hippocampus function...
- Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient miceFrank Blaeser
Department of Pediatrics, The David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
Mol Cell Biol 26:9105-15. 2006..These results demonstrate a selective role for CaMKKalpha in contextual fear memory and suggest that different combinations of upstream and downstream components of the CaMK cascade may serve distinct physiological functions...
- Lasting neuroendocrine-immune effects of traumatic brain injury in ratsAnna N Taylor
Department of Neurobiology, Brain Research Institute and Brain Injury Research Center, David Geffen School of Medicine at UCLA, West Los Angeles Healthcare Center, Los Angeles, California 90095 1763, USA
J Neurotrauma 23:1802-13. 2006..Given the extensive interactions of the neuroendocrine-immune systems, these results demonstrate that TBI produces lasting dysregulation amidst the central substrates for allostasis and circadian rhythmicity...
- Sex differences, context preexposure, and the immediate shock deficit in Pavlovian context conditioning with miceB J Wiltgen
Department of Psychology, University of California, Los Angeles 90095 1563, USA
Behav Neurosci 115:26-32. 2001..The results are discussed in terms of configural learning theory and are argued to be contrary to the predictions of scalar expectancy theory...
- Cognitive function following traumatic brain injury: effects of injury severity and recovery period in a parasagittal fluid-percussive injury modelM J Sanders
Department of Psychology, University of Miami, Coral Gables, Florida 33124 2070, USA
J Neurotrauma 16:915-25. 1999..They also indicate that the learning/memory deficits in this model are relatively enduring, suggesting that the model is a reasonable one for assessing potential treatment regimens...
- Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptorBrian J Wiltgen
Psychology Department, and the Brain Research Institute, UCLA, Los Angeles, California 90095, USA
Learn Mem 12:327-33. 2005..Knockouts are immune to this effect because of the reduced neurosteroid sensitivity that accompanies deletion of the delta subunit. Relationships between neurosteroids, hippocampal excitability, and memory are discussed...
- Context fear learning in the absence of the hippocampusBrian J Wiltgen
Psychology and the Brain Research Institute, University of California, Los Angeles, California 90095, USA
J Neurosci 26:5484-91. 2006..These results demonstrate that alternative systems can acquire context fear but do so less efficiently than the hippocampus...