Maike Sander

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity
    Ashleigh E Schaffer
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 9:e1003274. 2013
  2. pmc Sox9-haploinsufficiency causes glucose intolerance in mice
    Claire L Dubois
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e23131. 2011
  3. doi request reprint Pancreas organogenesis: from lineage determination to morphogenesis
    Hung Ping Shih
    Departments of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, California 92093 0695 email
    Annu Rev Cell Dev Biol 29:81-105. 2013
  4. pmc Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance
    Ashleigh E Schaffer
    Department of Cellular and Molecular Medicine, The University of California, San Diego, USA
    Mol Endocrinol 25:1904-14. 2011
  5. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
  6. pmc Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    Janel L Kopp
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 138:653-65. 2011
  7. pmc A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
    Hung Ping Shih
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 139:2488-99. 2012
  8. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
  9. pmc A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
    Philip A Seymour
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 139:3363-72. 2012
  10. pmc Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells
    Talitha van der Meulen
    Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS ONE 7:e52181. 2012

Research Grants

  1. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2004
  2. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2005
  3. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2006
  4. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2007
  5. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2009
  6. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010
  7. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010

Collaborators

  • Olivia G Kelly
  • Anne Grapin-Botton
  • Jan Jensen
  • Mark O Huising
  • Kristin Jensen
  • Kyoung Jae Won
  • Matthias Hebrok
  • Haruhiko Akiyama
  • Philip A Seymour
  • Hung Ping Shih
  • Janel L Kopp
  • Ashleigh E Schaffer
  • Claire L Dubois
  • Allen Wang
  • Ruiyu Xie
  • Nisha A Patel
  • Kristine K Freude
  • Brandon L Taylor
  • Fabrizio Thorel
  • Pedro L Herrera
  • Klaus H Kaestner
  • Fen Fen Liu
  • Talitha van der Meulen
  • Ergeng Hao
  • Allan J Robins
  • Yang Jiao
  • Logan J Everett
  • Jonathan Schug
  • Jacqueline R Benthuysen
  • Jingxuan Liu
  • Evert Kroon
  • Kevin A D'Amour
  • Hee Woong Lim
  • Weiping Yuan
  • CATHERINE LEE MAY
  • Mark A Magnuson
  • Fong Cheng Pan
  • Christopher J Lim
  • Manbir Sandhu
  • Guido von Figura
  • Wylie W Vale
  • Christopher V E Wright
  • John P Morris
  • Erin Mayes
  • Almira J Yang
  • Jenny Ma
  • James M Behrmann
  • Victoria Ngo
  • Shelley B Nelson
  • Ralf Kist
  • Erin E Mayes
  • Man N Tran
  • Gerd Scherer

Detail Information

Publications18

  1. pmc Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity
    Ashleigh E Schaffer
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 9:e1003274. 2013
    ..Given the lack of Nkx6.1 expression and aberrant activation of non-beta endocrine hormones in human embryonic stem cell (hESC)-derived insulin(+) cells, our study has significant implications for developing cell replacement therapies...
  2. pmc Sox9-haploinsufficiency causes glucose intolerance in mice
    Claire L Dubois
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e23131. 2011
    ..Our findings show Sox9 plays an important role in endocrine development by maintaining Ngn3 and Pdx1 expression. Glucose intolerance in Sox9-haploinsufficient mice suggests that mutations in Sox9 could play a role in diabetes in humans...
  3. doi request reprint Pancreas organogenesis: from lineage determination to morphogenesis
    Hung Ping Shih
    Departments of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, California 92093 0695 email
    Annu Rev Cell Dev Biol 29:81-105. 2013
    ..In this review, we provide an overview of the current understanding of pancreatic lineage determination and organogenesis, and we examine future implications of these findings for treatment of diabetes mellitus through cell replacement. ..
  4. pmc Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance
    Ashleigh E Schaffer
    Department of Cellular and Molecular Medicine, The University of California, San Diego, USA
    Mol Endocrinol 25:1904-14. 2011
    ..Thus, raising cellular Nkx6.1 levels in β-cells in vivo is unlikely to have a positive impact on type 2 diabetes...
  5. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
    ..Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development...
  6. pmc Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    Janel L Kopp
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 138:653-65. 2011
    ....
  7. pmc A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
    Hung Ping Shih
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 139:2488-99. 2012
    ....
  8. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
    ..Our findings therefore suggest that defective endocrine specification might underlie the pancreatic phenotype of individuals with CD...
  9. pmc A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
    Philip A Seymour
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 139:3363-72. 2012
    ..This self-promoting Sox9/Fgf10/Fgfr2b loop may regulate cell identity and organ size in a broad spectrum of developmental and regenerative contexts...
  10. pmc Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells
    Talitha van der Meulen
    Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS ONE 7:e52181. 2012
    ..Our study highlights important species differences in Ucn 3 expression, which have implications for its utility as a marker to identify mature beta cells in (re)programming strategies...
  11. pmc Progenitor cell domains in the developing and adult pancreas
    Janel L Kopp
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
    Cell Cycle 10:1921-7. 2011
    ..Based upon the combined evidence from these studies, we propose that multipotency is associated with a specific transcriptional signature...
  12. pmc Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells
    Ruiyu Xie
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Cell Stem Cell 12:224-37. 2013
    ..These studies reveal dynamic chromatin remodeling during developmental lineage progression and identify possible strategies for improving cell differentiation in culture...
  13. pmc Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells
    Brandon L Taylor
    Departments of Pediatrics and Cellular and Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA 92093 0695, USA
    Cell Rep 4:1262-75. 2013
    ..Given that Nkx6.1 levels are reduced in human type 2 diabetic beta cells, our study lends support to the concept that loss of beta cell features could contribute to the pathogenesis of diabetes. ..
  14. pmc Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
    Janel L Kopp
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Cancer Cell 22:737-50. 2012
    ..These results provide insight into the cellular origin of PDA and suggest that its precursors arise via induction of a duct-like state in acinar cells...
  15. doi request reprint Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells
    Allen Wang
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    J Mol Med (Berl) 90:763-71. 2012
    ..This will be followed by a brief discussion of the vast potential of these systems as suitable in vitro models for human embryonic development and disease...
  16. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
  17. ncbi request reprint Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, USA
    Methods Mol Biol 411:13-23. 2007
    ..Such double-staining analyses on tissue sections are a powerful tool to study transgene expression or to trace cells in multicellular tissues...

Research Grants9

  1. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2004
    ..Using selective inactivation of Nkx6 genes in beta-cells, it will be studied if NKX6 factors control aspects of beta-cell function, such as insulin synthesis or insulin secretion. ..
  2. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2005
    ..Using selective inactivation of Nkx6 genes in beta-cells, it will be studied if NKX6 factors control aspects of beta-cell function, such as insulin synthesis or insulin secretion. ..
  3. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2006
    ..Using selective inactivation of Nkx6 genes in beta-cells, it will be studied if NKX6 factors control aspects of beta-cell function, such as insulin synthesis or insulin secretion. ..
  4. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2007
    ..Using selective inactivation of Nkx6 genes in beta-cells, it will be studied if NKX6 factors control aspects of beta-cell function, such as insulin synthesis or insulin secretion. ..
  5. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2009
    ..This will be tested by transcriptional profiling of isolated cells and by tracking their fate in cell transplantation experiments. ..
  6. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010
    ..This will be tested by transcriptional profiling of isolated cells and by tracking their fate in cell transplantation experiments. ..
  7. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010
    ..This will be tested by transcriptional profiling of isolated cells and by tracking their fate in cell transplantation experiments. ..