Maike Sander

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance
    Ashleigh E Schaffer
    Department of Cellular and Molecular Medicine, The University of California, San Diego, USA
    Mol Endocrinol 25:1904-14. 2011
  2. ncbi Progenitor cell domains in the developing and adult pancreas
    Janel L Kopp
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
    Cell Cycle 10:1921-7. 2011
  3. ncbi Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010

Research Grants

  1. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2007
  2. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2009
  3. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010
  4. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010

Collaborators

  • Ashleigh E Schaffer
  • Janel L Kopp
  • Fabrizio Thorel
  • Pedro L Herrera
  • Ergeng Hao
  • Claire L Dubois
  • Almira J Yang
  • Kristine K Freude
  • Shelley B Nelson

Detail Information

Publications3

  1. ncbi Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance
    Ashleigh E Schaffer
    Department of Cellular and Molecular Medicine, The University of California, San Diego, USA
    Mol Endocrinol 25:1904-14. 2011
    ..Thus, raising cellular Nkx6.1 levels in β-cells in vivo is unlikely to have a positive impact on type 2 diabetes...
  2. ncbi Progenitor cell domains in the developing and adult pancreas
    Janel L Kopp
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
    Cell Cycle 10:1921-7. 2011
    ..Based upon the combined evidence from these studies, we propose that multipotency is associated with a specific transcriptional signature...
  3. ncbi Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
    ..Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development...

Research Grants9

  1. Nkx6 gene function in pancreas development
    Maike Sander; Fiscal Year: 2007
    ..Using selective inactivation of Nkx6 genes in beta-cells, it will be studied if NKX6 factors control aspects of beta-cell function, such as insulin synthesis or insulin secretion. ..
  2. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2009
    ..This will be tested by transcriptional profiling of isolated cells and by tracking their fate in cell transplantation experiments. ..
  3. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010
    ..This will be tested by transcriptional profiling of isolated cells and by tracking their fate in cell transplantation experiments. ..
  4. Mechanisms of cell regeneration in the pancreas
    Maike Sander; Fiscal Year: 2010
    ..This will be tested by transcriptional profiling of isolated cells and by tracking their fate in cell transplantation experiments. ..