Research Topics
| ALEJANDRO SANCHEZ ALVARADOSummaryAffiliation: University of Utah Country: USA Publications
Research Grants
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Detail Information
Publications
The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regenerationALEJANDRO SANCHEZ ALVARADO
Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210, USA
Development 129:5659-65. 2002....
Stem cells: time to check our premisesALEJANDRO SANCHEZ ALVARADO
Howard Hughes Medical Institute, University of Utah School of Medicine, Department of Neurobiology and Anatomy, 20N 1900E, Salt Lake City, UT 84132, USA
Cell Stem Cell 3:25-9. 2008....
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasisKyle A Gurley
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA
Science 319:323-7. 2008..We suggest that beta-catenin functions as a molecular switch to specify and maintain anteroposterior identity during regeneration and homeostasis in planarians...- Stem cells and the Planarian Schmidtea mediterraneaALEJANDRO SANCHEZ ALVARADO
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84132 3401, USA
C R Biol 330:498-503. 2007.... - Bridging the regeneration gap: genetic insights from diverse animal modelsALEJANDRO SANCHEZ ALVARADO
Howard Hughes Medical Institute, University of Utah School of Medicine, Deptartment of Neurobiology and Anatomy, Salt Lake City, Utah 84132, USA
Nat Rev Genet 7:873-84. 2006..Our expanding knowledge in these areas not only provides insights into animal biology in general, but also has important implications for regenerative medicine and stem-cell biology... - Planarian regeneration: its end is its beginningALEJANDRO SANCHEZ ALVARADO
Howard Hughes Medical Institute, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, 84103, USA
Cell 124:241-5. 2006..An unlikely model animal, the planarian Schmidtea mediterranea, is proving valuable in this endeavor... - Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterraneaALEJANDRO SANCHEZ ALVARADO
University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, UT 84112, USA
Exp Cell Res 306:299-308. 2005.... - PlanariansALEJANDRO SANCHEZ ALVARADO
University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB, 20 North 1900 East Salt Lake City, Utah 84132 3401, USA
Curr Biol 14:R737-8. 2004 - Regeneration and the need for simpler model organismsALEJANDRO SANCHEZ ALVARADO
University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84132 3401, USA
Philos Trans R Soc Lond B Biol Sci 359:759-63. 2004.... - The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regenerationALEJANDRO SANCHEZ ALVARADO
University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB 20 North 1900 East, Salt Lake City, Utah 84132 3401, USA
Curr Opin Genet Dev 13:438-44. 2003..These advances promise to shed mechanistic insight into basic biological attributes such as regeneration and stem-cell regulation... - Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation responseKyle A Gurley
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA
Dev Biol 347:24-39. 2010.... - Cell death and tissue remodeling in planarian regenerationJason Pellettieri
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Dev Biol 338:76-85. 2010..We propose that apoptosis is a central mechanism working in concert with stem cell division to restore anatomical form and function during metazoan regeneration... - Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to ciliaJochen C Rink
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84103, USA
Science 326:1406-10. 2009..Our study expands the understanding of Hh signaling in the animal kingdom and suggests an ancestral mechanistic link between Hh signaling and the function of cilia... - Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterraneaNéstor J Oviedo
University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, Utah 84132, USA
Dev Dyn 226:326-33. 2003.... - TORC1 is required to balance cell proliferation and cell death in planariansKimberly C Tu
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Dev Biol 365:458-69. 2012..In addition, it is required to initiate appropriate stem cell proliferation during regeneration and for proper tissue remodeling to occur to maintain scale and proportion... - Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterraneaGeorge T Eisenhoffer
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Cell Stem Cell 3:327-39. 2008.... - A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineagesBret J Pearson
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84132, USA
Development 137:213-21. 2010..However, ultimately the stem cell population fails to self-renew. Our results suggest that prior to the vertebrates, an ancestral p53-like molecule already had functions in stem cell proliferation control and self-renewal... - Flow cytometry methods for the study of cell-cycle parameters of planarian stem cellsHara Kang
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84132, USA
Dev Dyn 238:1111-7. 2009..These methods expand on the growing toolkit being developed to study stem cell biology in planarians, and open the door to detailed cytometric studies of a collectively totipotent population of adult stem cells in vivo... - The maintenance and regeneration of the planarian excretory system are regulated by EGFR signalingJochen C Rink
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA
Development 138:3769-80. 2011.... - Formaldehyde-based whole-mount in situ hybridization method for planariansBret J Pearson
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA
Dev Dyn 238:443-50. 2009..Our WISH methodology not only provides significant advancements over current protocols that make it a valuable asset for the planarian community, but should also find wide applicability in WISH methods used in other systems... - Amputation induces stem cell mobilization to sites of injury during planarian regenerationOtto C Guedelhoefer
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Development 139:3510-20. 2012.... - Cell turnover and adult tissue homeostasis: from humans to planariansJason Pellettieri
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 3401, USA
Annu Rev Genet 41:83-105. 2007..Together, these attributes provide an opportunity to investigate the mechanisms, functions, and regulation of cell turnover in adult tissues... - MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomesBrandi L Cantarel
Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
Genome Res 18:188-96. 2008..MAKER should prove especially useful for emerging model organism genome projects for which extensive bioinformatics resources may not be readily available... - SmedGD: the Schmidtea mediterranea genome databaseSofia M C Robb
Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Nucleic Acids Res 36:D599-606. 2008..neuro.utah.edu) will prove useful not only to the planarian research community, but also to those engaged in developmental and evolutionary biology, comparative genomics, stem cell research and regeneration... - Fundamentals of planarian regenerationPeter W Reddien
University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, UT 84132 3401, USA
Annu Rev Cell Dev Biol 20:725-57. 2004....
Research Grants
- MOLECULAR BASIS OF PLANARIAN REGENERATIONALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2002....
- The molecular basis of planarian regenerationALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2006..abstract_text> ..