ALEJANDRO SANCHEZ ALVARADO

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration
    ALEJANDRO SANCHEZ ALVARADO
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210, USA
    Development 129:5659-65. 2002
  2. pmc Stem cells and the Planarian Schmidtea mediterranea
    ALEJANDRO SANCHEZ ALVARADO
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84132 3401, USA
    C R Biol 330:498-503. 2007
  3. pmc Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis
    Kyle A Gurley
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA
    Science 319:323-7. 2008
  4. ncbi request reprint Bridging the regeneration gap: genetic insights from diverse animal models
    ALEJANDRO SANCHEZ ALVARADO
    Howard Hughes Medical Institute, University of Utah School of Medicine, Deptartment of Neurobiology and Anatomy, Salt Lake City, Utah 84132, USA
    Nat Rev Genet 7:873-84. 2006
  5. ncbi request reprint Planarian regeneration: its end is its beginning
    ALEJANDRO SANCHEZ ALVARADO
    Howard Hughes Medical Institute, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, 84103, USA
    Cell 124:241-5. 2006
  6. doi request reprint Stem cells: time to check our premises
    ALEJANDRO SANCHEZ ALVARADO
    Howard Hughes Medical Institute, University of Utah School of Medicine, Department of Neurobiology and Anatomy, 20N 1900E, Salt Lake City, UT 84132, USA
    Cell Stem Cell 3:25-9. 2008
  7. ncbi request reprint Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, UT 84112, USA
    Exp Cell Res 306:299-308. 2005
  8. ncbi request reprint Planarians
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB, 20 North 1900 East Salt Lake City, Utah 84132 3401, USA
    Curr Biol 14:R737-8. 2004
  9. pmc Regeneration and the need for simpler model organisms
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84132 3401, USA
    Philos Trans R Soc Lond B Biol Sci 359:759-63. 2004
  10. ncbi request reprint The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB 20 North 1900 East, Salt Lake City, Utah 84132 3401, USA
    Curr Opin Genet Dev 13:438-44. 2003

Research Grants

  1. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2002
  2. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2005
  3. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2004
  4. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2003
  5. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2001
  6. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2001
  7. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2001
  8. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2000
  9. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 1999
  10. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2006

Collaborators

Detail Information

Publications29

  1. ncbi request reprint The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration
    ALEJANDRO SANCHEZ ALVARADO
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210, USA
    Development 129:5659-65. 2002
    ....
  2. pmc Stem cells and the Planarian Schmidtea mediterranea
    ALEJANDRO SANCHEZ ALVARADO
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84132 3401, USA
    C R Biol 330:498-503. 2007
    ....
  3. pmc Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis
    Kyle A Gurley
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA
    Science 319:323-7. 2008
    ..We suggest that beta-catenin functions as a molecular switch to specify and maintain anteroposterior identity during regeneration and homeostasis in planarians...
  4. ncbi request reprint Bridging the regeneration gap: genetic insights from diverse animal models
    ALEJANDRO SANCHEZ ALVARADO
    Howard Hughes Medical Institute, University of Utah School of Medicine, Deptartment of Neurobiology and Anatomy, Salt Lake City, Utah 84132, USA
    Nat Rev Genet 7:873-84. 2006
    ..Our expanding knowledge in these areas not only provides insights into animal biology in general, but also has important implications for regenerative medicine and stem-cell biology...
  5. ncbi request reprint Planarian regeneration: its end is its beginning
    ALEJANDRO SANCHEZ ALVARADO
    Howard Hughes Medical Institute, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, 84103, USA
    Cell 124:241-5. 2006
    ..An unlikely model animal, the planarian Schmidtea mediterranea, is proving valuable in this endeavor...
  6. doi request reprint Stem cells: time to check our premises
    ALEJANDRO SANCHEZ ALVARADO
    Howard Hughes Medical Institute, University of Utah School of Medicine, Department of Neurobiology and Anatomy, 20N 1900E, Salt Lake City, UT 84132, USA
    Cell Stem Cell 3:25-9. 2008
    ....
  7. ncbi request reprint Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, UT 84112, USA
    Exp Cell Res 306:299-308. 2005
    ....
  8. ncbi request reprint Planarians
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB, 20 North 1900 East Salt Lake City, Utah 84132 3401, USA
    Curr Biol 14:R737-8. 2004
  9. pmc Regeneration and the need for simpler model organisms
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84132 3401, USA
    Philos Trans R Soc Lond B Biol Sci 359:759-63. 2004
    ....
  10. ncbi request reprint The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration
    ALEJANDRO SANCHEZ ALVARADO
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, 401 MREB 20 North 1900 East, Salt Lake City, Utah 84132 3401, USA
    Curr Opin Genet Dev 13:438-44. 2003
    ..These advances promise to shed mechanistic insight into basic biological attributes such as regeneration and stem-cell regulation...
  11. ncbi request reprint SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells
    Peter W Reddien
    Howard Hughes Medical Institute, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 310:1327-30. 2005
    ..We suggest that SMEDWI-2 functions within dividing neoblasts to support the generation of cells that promote regeneration and homeostasis...
  12. pmc Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria
    Peter W Reddien
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, 84132, USA
    Dev Cell 8:635-49. 2005
    ....
  13. pmc Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response
    Kyle A Gurley
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA
    Dev Biol 347:24-39. 2010
    ....
  14. pmc Cell death and tissue remodeling in planarian regeneration
    Jason Pellettieri
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Dev Biol 338:76-85. 2010
    ..We propose that apoptosis is a central mechanism working in concert with stem cell division to restore anatomical form and function during metazoan regeneration...
  15. pmc Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia
    Jochen C Rink
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB, 20 North 1900 East, Salt Lake City, UT 84103, USA
    Science 326:1406-10. 2009
    ..Our study expands the understanding of Hh signaling in the animal kingdom and suggests an ancestral mechanistic link between Hh signaling and the function of cilia...
  16. pmc TORC1 is required to balance cell proliferation and cell death in planarians
    Kimberly C Tu
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Dev Biol 365:458-69. 2012
    ..In addition, it is required to initiate appropriate stem cell proliferation during regeneration and for proper tissue remodeling to occur to maintain scale and proportion...
  17. pmc Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea
    George T Eisenhoffer
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell Stem Cell 3:327-39. 2008
    ....
  18. doi request reprint Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells
    Hara Kang
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84132, USA
    Dev Dyn 238:1111-7. 2009
    ..These methods expand on the growing toolkit being developed to study stem cell biology in planarians, and open the door to detailed cytometric studies of a collectively totipotent population of adult stem cells in vivo...
  19. pmc A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages
    Bret J Pearson
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84132, USA
    Development 137:213-21. 2010
    ..However, ultimately the stem cell population fails to self-renew. Our results suggest that prior to the vertebrates, an ancestral p53-like molecule already had functions in stem cell proliferation control and self-renewal...
  20. ncbi request reprint Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea
    Néstor J Oviedo
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, Utah 84132, USA
    Dev Dyn 226:326-33. 2003
    ....
  21. pmc Formaldehyde-based whole-mount in situ hybridization method for planarians
    Bret J Pearson
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Dev Dyn 238:443-50. 2009
    ..Our WISH methodology not only provides significant advancements over current protocols that make it a valuable asset for the planarian community, but should also find wide applicability in WISH methods used in other systems...
  22. pmc The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling
    Jochen C Rink
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA
    Development 138:3769-80. 2011
    ....
  23. pmc Amputation induces stem cell mobilization to sites of injury during planarian regeneration
    Otto C Guedelhoefer
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Development 139:3510-20. 2012
    ....
  24. ncbi request reprint Cell turnover and adult tissue homeostasis: from humans to planarians
    Jason Pellettieri
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 3401, USA
    Annu Rev Genet 41:83-105. 2007
    ..Together, these attributes provide an opportunity to investigate the mechanisms, functions, and regulation of cell turnover in adult tissues...
  25. pmc MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes
    Brandi L Cantarel
    Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Genome Res 18:188-96. 2008
    ..MAKER should prove especially useful for emerging model organism genome projects for which extensive bioinformatics resources may not be readily available...
  26. pmc SmedGD: the Schmidtea mediterranea genome database
    Sofia M C Robb
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Nucleic Acids Res 36:D599-606. 2008
    ..neuro.utah.edu) will prove useful not only to the planarian research community, but also to those engaged in developmental and evolutionary biology, comparative genomics, stem cell research and regeneration...
  27. ncbi request reprint Identification of immunological reagents for use in the study of freshwater planarians by means of whole-mount immunofluorescence and confocal microscopy
    Sofia M Robb
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, 20 North 1900 East, Salt Lake City, UT 84132 3401
    Genesis 32:293-8. 2002
    ..Here we report the identification and characterization of 33 such antibodies recognizing a wide variety of tissues in freshwater planarians...
  28. pmc The history and enduring contributions of planarians to the study of animal regeneration
    Sarah A Elliott
    Howard Hughes Medical Institute and Stowers Institute for Medical Research, Kansas City, MO, USA
    Wiley Interdiscip Rev Dev Biol 2:301-26. 2013
    ..It also synthesizes our current molecular understanding of the mechanisms of planarian regeneration uncovered since this animal's relatively recent entrance into the molecular-genetic age...
  29. ncbi request reprint Fundamentals of planarian regeneration
    Peter W Reddien
    University of Utah School of Medicine, Department of Neurobiology and Anatomy, Salt Lake City, UT 84132 3401, USA
    Annu Rev Cell Dev Biol 20:725-57. 2004
    ....

Research Grants11

  1. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2002
    ....
  2. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2005
    ..abstract_text> ..
  3. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2004
    ..abstract_text> ..
  4. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2003
    ..abstract_text> ..
  5. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2001
    ....
  6. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2001
    ....
  7. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2001
    ....
  8. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2000
    ....
  9. MOLECULAR BASIS OF PLANARIAN REGENERATION
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 1999
    ....
  10. The molecular basis of planarian regeneration
    ALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2006
    ..abstract_text> ..