Paul R Sanberg

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Nutraceuticals synergistically promote proliferation of human stem cells
    Paula C Bickford
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 15:118-23. 2006
  2. pmc Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain
    Adam D Bachstetter
    Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    BMC Neurosci 9:22. 2008
  3. pmc The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention
    Brian Giunta
    James A Haley Veterans Administration Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroinflammation 9:185. 2012
  4. doi request reprint Advantages and challenges of alternative sources of adult-derived stem cells for brain repair in stroke
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Prog Brain Res 201:99-117. 2012
  5. pmc Neurological disorders and the potential role for stem cells as a therapy
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Br Med Bull 101:163-81. 2012
  6. doi request reprint Stem cell transplants at childbirth
    Paul R Sanberg
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA
    Stem Cell Rev 6:27-30. 2010
  7. doi request reprint The proliferation and differentiation of stem cell journals
    Paul R Sanberg
    Office of Research and Innovation, University of South Florida, 3702 Spectrum Boulevard, Suite 175, Tampa, FL 33612 9444, USA
    Stem Cell Rev 6:497-9. 2010
  8. doi request reprint Monocyte transplantation for neural and cardiovascular ischemia repair
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    J Cell Mol Med 14:553-63. 2010
  9. pmc Neural stem cells for Parkinson's disease: to protect and repair
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, MDC 78, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Proc Natl Acad Sci U S A 104:11869-70. 2007
  10. doi request reprint The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Cell Transplant 20:85-94. 2011

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Nutraceuticals synergistically promote proliferation of human stem cells
    Paula C Bickford
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 15:118-23. 2006
    ..This demonstrates that nutrients can act to promote healing via an interaction with stem cell populations...
  2. pmc Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain
    Adam D Bachstetter
    Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    BMC Neurosci 9:22. 2008
    ..This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammation...
  3. pmc The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention
    Brian Giunta
    James A Haley Veterans Administration Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroinflammation 9:185. 2012
    ..In the end, a better understanding of neuroinflammation could open therapeutic avenues for abrogation of secondary cell death and behavioral symptoms that may mediate the progression of TBI to later AD...
  4. doi request reprint Advantages and challenges of alternative sources of adult-derived stem cells for brain repair in stroke
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Prog Brain Res 201:99-117. 2012
    ..While the optimal conditions are still to be determined, these cells may prove to be at the forefront of stem cell research and ultimately therapy for stroke and other disorders...
  5. pmc Neurological disorders and the potential role for stem cells as a therapy
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Br Med Bull 101:163-81. 2012
    ..In addition, the use of stem cells to develop disease models should not be overlooked...
  6. doi request reprint Stem cell transplants at childbirth
    Paul R Sanberg
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA
    Stem Cell Rev 6:27-30. 2010
    ....
  7. doi request reprint The proliferation and differentiation of stem cell journals
    Paul R Sanberg
    Office of Research and Innovation, University of South Florida, 3702 Spectrum Boulevard, Suite 175, Tampa, FL 33612 9444, USA
    Stem Cell Rev 6:497-9. 2010
    ..We discuss here a prophetic path of survival for these journals which likely will closely mimic the core scientific and translational value of stem cells, namely their capacity to proliferate and differentiate into something meaningful!..
  8. doi request reprint Monocyte transplantation for neural and cardiovascular ischemia repair
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    J Cell Mol Med 14:553-63. 2010
    ..In this review, we present general characteristics and potential of monocytes/macrophages for cell-based therapy, especially focusing on neovascularization and UCB-derived monocytes...
  9. pmc Neural stem cells for Parkinson's disease: to protect and repair
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, MDC 78, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Proc Natl Acad Sci U S A 104:11869-70. 2007
  10. doi request reprint The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Cell Transplant 20:85-94. 2011
    ..Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells...
  11. pmc Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation
    Adam D Bachstetter
    Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 5:e10496. 2010
    ..These results support the hypothesis that a diet enriched with spirulina and other nutraceuticals may help protect the stem/progenitor cells from insults...
  12. ncbi request reprint Maternal transplantation of human umbilical cord blood cells provides prenatal therapy in Sanfilippo type B mouse model
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    FASEB J 20:485-7. 2006
    ....
  13. pmc Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice
    William V Nikolic
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Stem Cells Dev 17:423-39. 2008
    ..Increased microglial phagocytic activity in this scenario was inhibited by addition of recombinant CD40L protein. These data suggest that HUCBC infusion mitigates AD-like pathology by disrupting CD40L activity...
  14. ncbi request reprint Anti-inflammatory effects of human cord blood cells in a rat model of stroke
    Martina Vendrame
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 14:595-604. 2005
    ..Once thought of as "cell replacement therapy," we now propose that cord blood treatment in stroke reduces inflammation and provides neuroprotection. Both of these components are necessary for effective therapy...
  15. pmc Optimized turmeric extract reduces β-Amyloid and phosphorylated Tau protein burden in Alzheimer's transgenic mice
    R Douglas Shytle
    Center for Excellence in Aging and Brain Repair, Dept of Neurosurgery, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Curr Alzheimer Res 9:500-6. 2012
    ....
  16. pmc Human umbilical cord blood progenitors: the potential of these hematopoietic cells to become neural
    Ning Chen
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    Stem Cells 23:1560-70. 2005
    ....
  17. pmc Long-term cultured human umbilical cord neural-like cells transplanted into the striatum of NOD SCID mice
    Piotr Walczak
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL, USA
    Brain Res Bull 74:155-63. 2007
    ..In mice, these cells do not survive a month. This may relate to the differentiated state of the cells transplanted into the unlesioned striatum, rather than T cell-mediated immunological rejection...
  18. ncbi request reprint Novel cell therapy approaches for brain repair
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, MDC 78, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Prog Brain Res 157:207-22. 2006
    ..These protective effects may prove essential to maintaining restored tissue integrity over the course of various diseases or injuries...
  19. doi request reprint Increased neuronal proliferation in the dentate gyrus of aged rats following neural stem cell implantation
    Dong Hyuk Park
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 19:175-80. 2010
    ..The data suggest that implants of exogenous NSCs may promote regeneration in aging organisms through stimulation of endogenous neurogenesis...
  20. doi request reprint Human cord blood mononuclear cells decrease cytokines and inflammatory cells in acute myocardial infarction
    Robert J Henning
    Center for Cardiovascular Research, Department of Medicine of the James A Haley Medical Center, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 17:1207-19. 2008
    ....
  21. pmc Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 19:439-52. 2010
    ..The present neurostructural and behavioral benefits afforded by transplanted menstrual blood-derived cells support their use as a stem cell source for cell therapy in stroke...
  22. ncbi request reprint Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds
    R Douglas Shytle
    Department of Neurosurgery, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Rejuvenation Res 10:173-8. 2007
    ....
  23. doi request reprint Intravenous administration of human umbilical cord blood cells in an animal model of MPS III B
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Comp Neurol 515:93-101. 2009
    ..Our results demonstrate the advantages of intravenously administering hUCB cells into a mouse model of Sanfilippo Syndrome type B, the advantages probably a result of Naglu delivery to enzyme-deficient organs...
  24. ncbi request reprint Umbilical cord blood-derived stem cells and brain repair
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC 78, Tampa, FL 33612, USA
    Ann N Y Acad Sci 1049:67-83. 2005
    ..We discuss how transplantation of HUCB cells affects these disorders and we present recent clinical studies with promising outcome...
  25. ncbi request reprint Cord blood mesenchymal stem cells: Potential use in neurological disorders
    Nagwa S El-Badri
    Department of Neurosurgery, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612 4742, USA
    Stem Cells Dev 15:497-506. 2006
    ..These data indicate that CB MSCs possess multiple utilities that may contribute to their therapeutic potency in the treatment of neurological disorders...
  26. ncbi request reprint Cord blood rescues stroke-induced changes in splenocyte phenotype and function
    Martina Vendrame
    Center for Excellence in Aging and Brain Repair, MDC 78, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Exp Neurol 199:191-200. 2006
    ..Taken together, these results suggest a novel immunomodulatory mechanism by which HUCBC mediate protection in the rat MCAO model of stroke...
  27. pmc Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e53376. 2013
    ..Therapeutic intervention at the chronic stage of TBI may confer abrogation of these deleterious cell death processes...
  28. ncbi request reprint Impaired blood-brain/spinal cord barrier in ALS patients
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL 33612, USA
    Brain Res 1469:114-28. 2012
    ..Pervasive barrier damage discovered in ALS may have implications for disease pathogenesis and progression, as well as for uncovering novel therapeutic targets...
  29. ncbi request reprint Enhancing tyrosine hydroxylase expression and survival of fetal ventral mesencephalon neurons with rat or porcine Sertoli cells in vitro
    Rania Shamekh
    Department of Neurosurgery, Center of Excellence for Aging and Brain Repair, University of South Florida, Tampa, 33612, USA
    Brain Res 1096:1-10. 2006
    ..This suggests that secretion of trophic factors by SCs varies according to the developmental age, and it is critical for the success of graft facilitation that SCs from the appropriate age and species be used...
  30. ncbi request reprint Multiple transplants of hNT cells into the spinal cord of SOD1 mouse model of familial amyotrophic lateral sclerosis
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Health Sciences Center, Tampa, FL 33612, USA
    Amyotroph Lateral Scler 7:221-6. 2006
    ..Therefore, we suggest that the observed postponement of motor deficit symptoms in G93A mice was not a result of neuritic outgrowth from the implanted hNT cells...
  31. pmc Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 2:e1205. 2007
    ..However, the effect of these alterations upon barrier function in ALS is still unclear. The aim of this study was to determine the functional competence of the BSCB in G93A mice at different stages of disease...
  32. ncbi request reprint Timing of cord blood treatment after experimental stroke determines therapeutic efficacy
    Jennifer D Newcomb
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 15:213-23. 2006
    ..Successful treatment at this time point should offer encouragement to clinicians that a therapy with a broader window of efficacy may soon be available to treat stroke...
  33. pmc Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 3:e2494. 2008
    ..Three different doses of MNC hUCB cells, 10x10(6), 25x10(6) and 50x10(6), were administered intravenously into pre-symptomatic G93A mice. Motor function tests and various assays to determine cell effects were performed on these mice...
  34. ncbi request reprint Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair and Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    J Hematother Stem Cell Res 12:255-70. 2003
    ..Most likely, cord blood efficacy is partially due to neuroprotection by modulation of the autoimmune process...
  35. ncbi request reprint MIP-1alpha and MCP-1 Induce Migration of Human Umbilical Cord Blood Cells in Models of Stroke
    Lixian Jiang
    Center of Excellence for Aging and Brain Repair, MDC78, University of South Florida, 12901 Bruce B Downs Blvd, Tampa FL 33612, USA
    Curr Neurovasc Res 5:118-24. 2008
    ..The data suggested that the increased chemokines in the ischemic area can bind cell surface receptors on HUCB, and induce cell infiltration of systemically delivered HUCB cells into the CNS in vivo...
  36. ncbi request reprint Ovarian monocyte progenitor cells: phenotypic and functional characterization
    Cherry J Pascual
    Department of Pediatrics, University of South Florida, St Petersburg, FL 33612, USA
    Stem Cells Dev 14:173-80. 2005
    ..We conclude that in the ovaries, a higher requirement for macrophages is provided by a resident stromal population of progenitors whose progeny is restricted to the production of cells of the monocyte-macrophage lineage...
  37. pmc Human umbilical cord blood cells decrease microglial survival in vitro
    Lixian Jiang
    Center of Excellence for Aging and Brain Repair, University of South Florida, Tampa, Florida 33612, USA
    Stem Cells Dev 19:221-8. 2010
    ..Both CD11b+ and CD19+ HUCB cells decreased microglial viability during normoxia and hypoxia. Our data suggest that HUCB cells may produce a soluble factor that decreases viability of microglia...
  38. doi request reprint Inflammation and stem cell migration to the injured brain in higher organisms
    Dong Hyuk Park
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, and College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Stem Cells Dev 18:693-702. 2009
    ..A better understanding of these mechanism-driven pathways of neural repair will facilitate the clinical application of cell therapy for neurological disorders...
  39. doi request reprint Human umbilical cord blood cell grafts for brain ischemia
    Dong Hyuk Park
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 18:985-98. 2009
    ..Eventually, these multiple protective and restorative effects from umbilical cord blood cell grafts may be interdependent and act in harmony in promoting therapeutic benefits for stroke...
  40. pmc Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e63553. 2013
    ..The present study investigated subacute diaschisis in a focal ischemic stroke rat model. Specific focuses were BBB integrity and related pathogenic processes in contralateral brain areas...
  41. pmc Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice
    Donna Darlington
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613, USA
    Stem Cells Dev 22:412-21. 2013
    ..As such, this report lays the groundwork for an HUCBC therapy as potentially novel alternative to oppose AD at the disease-modifying level...
  42. ncbi request reprint Lithium exposure enhances survival of NT2N cells (hNT neurons) in the hemiparkinsonian rat
    Alison E Willing
    Department of Neurosurgery, Center for Aging and Brain Repair, University of South Florida College of Medicine, MDC 78, 12901 Bruce B Downs Blvd, Tampa 33612, USA
    Eur J Neurosci 16:2271-8. 2002
    ..These results suggest that brief Li + exposure may enhance survival to over 60% and increase TH expression of hNT Neurons transplanted in the hemiparkinsonian rat nearly three-fold...
  43. ncbi request reprint Optimized turmeric extracts have potent anti-amyloidogenic effects
    R Douglas Shytle
    Center for Excellence in Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Curr Alzheimer Res 6:564-71. 2009
    ..However, HSS-888 showed strong inhibition of A beta aggregation and secretion, thus indicating that there are novel bioactive molecules in this extract that might be important leads for future AD drug discovery efforts...
  44. ncbi request reprint Transplantation of human umbilical cord blood cells benefits an animal model of Sanfilippo syndrome type B
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 14:384-94. 2005
    ..A hUCB cell transplant may be an effective therapeutic strategy for enzyme delivery in Sanfilippo syndrome type B...
  45. doi request reprint Umbilical cord blood cells
    Jennifer D Newcomb
    Department of Neurosurgery, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Methods Mol Biol 549:119-36. 2009
    ..In the pages to follow, we share protocols for the identification and research use of the mononuclear cell fraction of UCB...
  46. ncbi request reprint Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis
    Svitlana Garbuzova-Davis
    Departments of Neurosurgery, Center for Aging and Brain Repair, Tampa, Florida 33612, USA
    Exp Neurol 174:169-80. 2002
    ..These results suggest that hNT Neuron transplantation may be a promising therapeutic strategy for ALS...
  47. doi request reprint Recent progress in cell therapy for basal ganglia disorders with emphasis on menstrual blood transplantation in stroke
    Maria Carolina Oliveira Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, USA
    Neurosci Biobehav Rev 36:177-90. 2012
    ..We highlight the availability, proliferative capacity, pluripotentiality and angiogenic features of these cells and explore their present and future experimental and clinical applications...
  48. pmc Toward personalized cell therapies: autologous menstrual blood cells for stroke
    Maria Carolina O Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    J Biomed Biotechnol 2011:194720. 2011
    ..Practical aspects of clinical application of menstrual blood cells for stroke will be discussed, from cell harvesting and cryopreservation to administration to the patient...
  49. ncbi request reprint From the basics to application of cell therapy, a steppingstone to the conquest of neurodegeneration: a meeting report
    Dong Hyuk Park
    Center of Excellence for Aging and Brain Repair, Dept Neurosurgery, Tampa, FL, USA
    Med Sci Monit 15:RA23-31. 2009
    ..Finally, well-known or previously un-known dietary supplementation or pharmacological materials that can affect the nervous system positively or negatively, were also important topics...
  50. ncbi request reprint Tumorigenicity issues of embryonic carcinoma-derived stem cells: relevance to surgical trials using NT2 and hNT neural cells
    Mary B Newman
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 14:29-43. 2005
    ....
  51. ncbi request reprint Human cord blood cells and myocardial infarction: effect of dose and route of administration on infarct size
    Robert J Henning
    Department of Medicine of the James A Haley VA Hospital, University of South Florida College of Medicine, Tampa, FL, USA
    Cell Transplant 16:907-17. 2007
    ....
  52. ncbi request reprint Stroke-induced migration of human umbilical cord blood cells: time course and cytokines
    Mary B Newman
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 14:576-86. 2005
    ..Last, the chemokines present in the supernatant provide a sound starting point to start examining the mechanisms responsible for the in vivo migration of HUCB cells after the induction of stroke...
  53. ncbi request reprint Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior
    Samuel Saporta
    Center for Aging and Brain Repair and Department of Anatomy, University of South Florida College of Medicine, Tampa, FL 33612, USA
    J Hematother Stem Cell Res 12:271-8. 2003
    ..The results are consistent with the hypothesis that cord blood-derived stem cells migrate to and participate in the healing of neurological defects caused by traumatic assault...
  54. ncbi request reprint Cytokines produced by cultured human umbilical cord blood (HUCB) cells: implications for brain repair
    Mary B Newman
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine and College of Arts and Science, Tampa, FL 33612, USA
    Exp Neurol 199:201-8. 2006
    ..These results provide insights to factors that may be partially responsible for the functional improvements seen in the animal models of injury investigating the therapeutic use of HUCB cells...
  55. doi request reprint Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 9:e90953. 2014
    ..These results suggest that combined treatment rather than monotherapy appears optimal for abrogating histophalogical and motor impairments in chronic TBI. ..
  56. doi request reprint Neurovascular aspects of amyotrophic lateral sclerosis
    Maria Carolina O Rodrigues
    Center of Excellence for Aging and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA
    Int Rev Neurobiol 102:91-106. 2012
    ..The impact of BBB/BSCB damage in ALS pathogenesis is a novel research topic, and this review will reveal some aspects of microvascular pathology involved in the disease and hopefully engender new therapeutic approaches...
  57. pmc Multiple intravenous administrations of human umbilical cord blood cells benefit in a mouse model of ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e31254. 2012
    ..The aim of the present pre-clinical translation study was therefore to evaluate the effects of multiple low dose systemic injections of MNC hUCB cell into G93A SOD1 mice at different disease stages...
  58. doi request reprint Amyotrophic lateral sclerosis: a neurovascular disease
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Brain Res 1398:113-25. 2011
    ..The BBB/BSCB is a promising research area in ALS and this review will reveal some aspects of microvascular pathology in ALS and hopefully provide ideas for the development of new therapeutic strategies...
  59. pmc Novel pathologic findings associated with urinary retention in a mouse model of mucopolysaccharidosis type IIIB
    Sylvia I Gografe
    Center for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida, USA
    Comp Med 59:139-46. 2009
    ..The novel finding of an unexpected mononuclear cell infiltrate in the urinary tract in the knockout mice B6.129S6- Naglu(tm1Efn)/J is reported...
  60. ncbi request reprint Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume
    Martina Vendrame
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Stroke 35:2390-5. 2004
    ..To extend these findings, we examined the behavioral recovery and stroke infarct volume in the presence of increasing doses of HUCBC after permanent middle cerebral artery occlusion (MCAO)...
  61. doi request reprint Methodological study investigating long term laser Doppler measured cerebral blood flow changes in a permanently occluded rat stroke model
    David J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, MDC 78, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neurosci Methods 180:52-6. 2009
    ..These findings suggest that multiple bilateral monitoring of cerebral blood flow over time can show effects of stem cell transplantation efficiently as well as functional tests in an animal stroke model...
  62. ncbi request reprint Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors
    R Douglas Shytle
    Child Development Center, Neuroimmunology Laboratory, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medciine, Tampa, Florida, USA
    J Neurochem 89:337-43. 2004
    ..Negative regulation of microglia activation may also represent additional mechanism underlying nicotine's reported neuroprotective properties...
  63. ncbi request reprint Transplantation of human umbilical cord blood cells in the repair of CNS diseases
    Mary B Newman
    Center of Excellence for Ageing and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Expert Opin Biol Ther 4:121-30. 2004
    ....
  64. ncbi request reprint The transcription factor Nurr1 in human NT2 cells and hNT neurons
    Iwona E Misiuta
    Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Brain Res Dev Brain Res 145:107-15. 2003
    ..The findings of this study suggest that Nurr1 may be important during the development of hNT neurons and involved in their differentiation into the dopaminergic phenotype...
  65. ncbi request reprint Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke
    Alison E Willing
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Cell Transplant 12:449-54. 2003
    ..In addition, transplantation of G-CSF PBPC and hUCB cells prevented the development of extensive motor asymmetry. Our findings raise the possibility that PBPCs could provide a novel transplantation therapy to treat stroke...
  66. ncbi request reprint Infusion of human umbilical cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury
    Zhenhong Nan
    Department of Neurosurgery, University of Minnesota Medical School, 2001 Sixth St, S E, Minneapolis, MN 55455, USA
    Ann N Y Acad Sci 1049:84-96. 2005
    ..05); and (3) the elevated body-swing test at day 13 (P< 0.05). These results demonstrate that the administration of human umbilical cord blood cells can ameliorate neurologic deficits associated with intracerebral hemorrhage...
  67. ncbi request reprint Reduced Nuclear Factor kappa B activation in dentate gyrus after active avoidance training
    Dionne O L Vernon
    University of South Florida College of Medicine, Department of Molecular Pharmacology and Physiology, 12901 Bruce B Downs Boulevard, MDC 9 Tampa, FL 33612, USA
    Brain Res 1104:39-44. 2006
    ..Therefore, a reduction of NF-kappaB activation and its target genes appears to be a necessary event for early stages of learning and memory consolidation associated with active avoidance training...
  68. ncbi request reprint Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Brain Res 1157:126-37. 2007
    ..Capillary rupture was observed in brainstem in early symptomatic G93A mice. Capillary ultrastructure revealed that endothelial cell membrane and/or basement membrane damage occurred, followed by vascular leakage...
  69. pmc Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
    Kavon Rezai-Zadeh
    Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Neuroinflammation 5:41. 2008
    ..In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators...
  70. ncbi request reprint Human umbilical cord blood mononuclear cells for the treatment of acute myocardial infarction
    Robert J Henning
    Department of Medicine, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 13:729-39. 2004
    ..As a consequence, LV function measurements, determined by LV ejection fraction, wall thickening, and dP/dt, are significantly greater than the same measurements in rats with untreated infarctions...
  71. pmc Reduction of circulating endothelial cells in peripheral blood of ALS patients
    Svitlana Garbuzova-Davis
    Center of Excellence for Aging and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 5:e10614. 2010
    ..Since circulating endothelial cells (CECs) in the peripheral blood are associated with endothelium damage, being detached dysfunctional endothelial cells, we hypothesized that CEC levels may reflect endothelium condition in ALS patients...
  72. doi request reprint Mankind's first natural stem cell transplant
    Jose N Tolosa
    Department of Pediatrics, Division Neonatology, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    J Cell Mol Med 14:488-95. 2010
    ..We highlight the importance of delayed cord clamping in realizing mankind's first stem cell transfer and propose that it should be encouraged in normal births...
  73. ncbi request reprint Human umbilical cord blood (HUCB) cells for central nervous system repair
    Mary B Newman
    Center of Excellence for Aging and Brain Repair, Departments of Neurosurgery, Psychology, Psychiatry, Neurology, Pathology and Pharmacology, University of South Florida, College of Medicine, Tampa FL 33612, USA
    Neurotox Res 5:355-68. 2003
    ..This paper reviews the advantages, utilization and progress of human umbilical cord blood (HUCB) cells in the neural cell transplantation and repair field...
  74. ncbi request reprint Stem cells have the potential to rejuvenate regenerative medicine research
    David J Eve
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Med Sci Monit 16:RA197-217. 2010
    ..A sizeable proportion of the transplantation articles reported on how previously new methods may have aided the ability of the cells or tissue to exert beneficial effects following transplantation...
  75. ncbi request reprint Mouse model of Sanfilippo syndrome type B: relation of phenotypic features to background strain
    Sylvia I Gografe
    Department of Pathology, Division of Comparative Medicine, University of South Florida, College of Medicine, 12901 Bruce B Downs Blvd, MDC 78, Tampa, Florida, 33612, USA
    Comp Med 53:622-32. 2003
    ..Our observations may prove useful in studies of Naglu mutant mice. The necessity for distinguishing background anomalies from signs of the modeled disease is apparent...
  76. ncbi request reprint Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury
    Dunyue Lu
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Cell Transplant 11:275-81. 2002
    ..Some HUCB cells integrated into the vascular walls within the boundary zone of the injured area. Our data suggest that i.v. administration of HUCB may be useful in the treatment of TBI...
  77. ncbi request reprint Effects of middle cerebral artery occlusion on spontaneous activity and cognitive function in rats
    Alison E Willing
    Center for Aging and Brain Repair, Department of Neurosurgery and Anatomy, University of South Florida College of Medicine, Tampa, Florida, USA
    Int J Neurosci 112:503-16. 2002
    ....
  78. ncbi request reprint Effects of Sertoli cell transplants in a 3-nitropropionic acid model of early Huntington's disease: a preliminary study
    Alba I Rodriguez
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, The Neuroscience Program, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Neurotox Res 5:443-50. 2003
    ..Thus, Sertoli cells should be further evaluated as a possible treatment strategy for the early stages of Huntington's disease...
  79. doi request reprint Routes of stem cell administration in the adult rodent
    Alison E Willing
    Center for Aging and Brain Repair Cell Biology, University of South Florida College of Medicine, Tampa, FL, USA
    Methods Mol Biol 438:383-401. 2008
    ..The second, which in our hands has proven to be superior in some instances, is introduction of the stem cells into the circulatory system...
  80. ncbi request reprint Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion
    Tanya L Butler
    Department of Pharmacology, University of South Florida, Tampa, FL 33612, USA
    Brain Res 929:252-60. 2002
    ..Further, the use of this dye has enabled us to demonstrate previously undescribed events of cellular injury resulting from ischemia...
  81. ncbi request reprint Routes of stem cell administration in the adult rodent
    Alison E Willing
    Center for Aging and Brain Repair, Departments of Neurosurgery and Anatomy, College of Medicine, University of South Florida, Tampa, FL, USA
    Methods Mol Biol 198:357-74. 2002
  82. ncbi request reprint Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain
    Tanja Zigova
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa 33612, USA
    Cell Transplant 11:265-74. 2002
    ..These findings suggest that at least some of the transplanted HUCB cells differentiated into cells with distinct glial or neuronal phenotypes after being exposed to instructive signals from the developing brain...
  83. ncbi request reprint A pilot controlled trial of transdermal nicotine in the treatment of attention deficit hyperactivity disorder
    R Douglas Shytle
    Center for Infant and Child Development, Center for Aging and Brain Repair, Departments of Psychiatry, Neurosurgery, Neuroscience Program, University of South Florida, Tampa, Florida, USA
    World J Biol Psychiatry 3:150-5. 2002
    ..To test the hypothesis that transdermal nicotine would be efficacious for the treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD)...
  84. ncbi request reprint Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine
    R Douglas Shytle
    Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33613, USA
    Depress Anxiety 16:89-92. 2002
  85. ncbi request reprint Lymphopenia and spontaneous autorosette formation in SOD1 mouse model of ALS
    Oleg I Kuzmenok
    Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, United States
    J Neuroimmunol 172:132-6. 2006
    ..To our knowledge, this is the first study characterizing hematology and revealing autorosettes in the SOD1 mouse model of ALS at the terminal phase of disease...
  86. ncbi request reprint Mesenchymal stem cells in autoimmune disease
    Nagwa S El-Badri
    Center for Excellence for Aging and Brain Repair, Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Stem Cells Dev 13:463-72. 2004
    ..In this review, we examine the biology of MSCs, and their potential for cell therapy of autoimmune disease...
  87. ncbi request reprint Myasthenia gravis accompanied by thymomas not related to foamy virus genome in Belarusian's patients
    Oleg I Kuzmenok
    Belarusian Research and Production Center for Hematology and Transfusiology, Minsk, Republic of Belarus
    Int J Neurosci 117:1603-10. 2007
    ..The results showed that none of the varied thymuses from the 45 MG patients contained FV genome. No relationship can be confirmed between FV and this disease and the results suggest that no pathological link between FV and MG exists...
  88. pmc Blood-brain barrier impairment in an animal model of MPS III B
    Svitlana Garbuzova-Davis
    College of Medicine, Center of Excellence for Aging and Brain Repair, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 6:e16601. 2011
    ..However, little is known about the competence of the blood-brain barrier (BBB) in MPS III B. BBB dysfunction in this devastating disorder could contribute to neuropathological disease manifestations...
  89. ncbi request reprint Stem cell research in Cell Transplantation: an analysis of geopolitical influence by publications
    David J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 16:867-73. 2007
    ....
  90. ncbi request reprint Regenerative medicine: an analysis of Cell Transplantation's impact
    David J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 16:751-64. 2007
  91. ncbi request reprint The Tourette's Disorder Scale (TODS): development, reliability, and validity
    R Douglas Shytle
    Center for Infant and Child Development, Department of Psychiatry and Behavioral Medicine, College of Medicine, University of South Florida, Tampa 33613, USA
    Assessment 10:273-87. 2003
    ..The TODS is a simple, efficient way for clinicians and parents to rate the severity of multiple symptoms commonly found in patients with Tourette's disorder...
  92. doi request reprint Stem cell research in cell transplantation: sources, geopolitical influence, and transplantation
    David J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 19:1493-509. 2010
    ..Stem cell research shows considerable promise for the treatment of a number of disorders, some of which have entered clinical trials; over the next few years it will be interesting to see how these treatments progress in the clinic...
  93. ncbi request reprint Neural specification of stem cell differentiation
    Denis English
    Stem Cells Dev 15:139-40. 2006
  94. ncbi request reprint The neuroscientist's melting pot: immunology, cell transplantation and other delivery systems, and enlightenment of disease etiology and treatment
    David J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL, USA
    Neurotox Res 13:281-90. 2008
    ..A few reports also shed light on the likelihood of an immune response following transplantation, an important consideration for any potential treatment...
  95. ncbi request reprint Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Stroke 35:2385-9. 2004
    ..Here, we examined whether neuroprotection by systemically delivered human umbilical cord blood (HUCB) cells was dependent on their entry into the central nervous system in a rodent model of acute stroke...
  96. ncbi request reprint Neural transplantation for treatment of Parkinson's disease
    Cesario V Borlongan
    Department of Neurobiology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA
    Drug Discov Today 7:674-82. 2002
    ..This article will review recent studies demonstrating the potential of these alternative cell graft sources and novel drugs for treating Parkinson's disease...
  97. ncbi request reprint Functional recovery after complete contusion injury to the spinal cord and transplantation of human neuroteratocarcinoma neurons in rats
    Samuel Saporta
    Center for Aging and Brain Repair, Department of Anatomy, College of Medicine, University of South Florida, Tampa 33612, USA
    J Neurosurg 97:63-8. 2002
    ..The objective of this study was to examine whether hNT neurons transplanted in an area of complete spinal cord contusion would improve electrophysiological measures of spinal cord function...
  98. ncbi request reprint Umbilical cord blood transfusions for prevention of progressive brain injury and induction of neural recovery: an immunological perspective
    Alison E Willing
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Regen Med 2:457-64. 2007
    ....
  99. ncbi request reprint The 'current state of play' in transplantation and restoration research of the CNS
    Dave J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Neurotox Res 11:145-50. 2007
    ..A few studies related to different animal models of disease. Overall the future for transplantation and restoration of functional activity in diseased states is very promising...
  100. ncbi request reprint Gene therapy, cell transplantation and stroke
    Cesario V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30904, USA
    Front Biosci 11:1090-101. 2006
    ..This chapter will also highlight some of the most recent findings regarding NT2N cells...
  101. doi request reprint Dietary supplementation exerts neuroprotective effects in ischemic stroke model
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Rejuvenation Res 11:201-14. 2008
    ..These data demonstrate the remarkable neuroprotective effects of NT-020 when given prior to stroke, possibly acting via its neurogenic potential...