Nader Sanai

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    Nader Sanai
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 427:740-4. 2004
  2. ncbi request reprint Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension"
    Nader Sanai
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143 0112, USA
    Science 318:393; author reply 393. 2007
  3. doi request reprint Intraoperative stimulation techniques for functional pathway preservation and glioma resection
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Neurosurg Focus 28:E1. 2010
  4. doi request reprint Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 113:202-9. 2010
  5. doi request reprint An extent of resection threshold for newly diagnosed glioblastomas
    Nader Sanai
    Brain Tumor Research Center, University of California, San Francisco, California, USA
    J Neurosurg 115:3-8. 2011
  6. doi request reprint Recent surgical management of gliomas
    Nader Sanai
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    Adv Exp Med Biol 746:12-25. 2012
  7. ncbi request reprint Operative techniques for gliomas and the value of extent of resection
    Nader Sanai
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, California 94143, USA
    Neurotherapeutics 6:478-86. 2009
  8. pmc Corridors of migrating neurons in the human brain and their decline during infancy
    Nader Sanai
    Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nature 478:382-6. 2011
  9. doi request reprint Insular glioma resection: assessment of patient morbidity, survival, and tumor progression
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 112:1-9. 2010
  10. ncbi request reprint Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
    J Comp Neurol 494:415-34. 2006

Detail Information

Publications33

  1. ncbi request reprint Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    Nader Sanai
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 427:740-4. 2004
    ..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain...
  2. ncbi request reprint Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension"
    Nader Sanai
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143 0112, USA
    Science 318:393; author reply 393. 2007
    ....
  3. doi request reprint Intraoperative stimulation techniques for functional pathway preservation and glioma resection
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Neurosurg Focus 28:E1. 2010
    ..Collectively, these surgical strategies represent the cornerstone for operating on gliomas in and around functional pathways...
  4. doi request reprint Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 113:202-9. 2010
    ..The authors present the largest case series to date dealing with these tumors, providing analysis of 63 patients...
  5. doi request reprint An extent of resection threshold for newly diagnosed glioblastomas
    Nader Sanai
    Brain Tumor Research Center, University of California, San Francisco, California, USA
    J Neurosurg 115:3-8. 2011
    ..The authors attempt to define these values for the patient with newly diagnosed GBM in the modern neurosurgical era...
  6. doi request reprint Recent surgical management of gliomas
    Nader Sanai
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    Adv Exp Med Biol 746:12-25. 2012
    ..The mounting evidence suggests that, despite persistent limitations in the quality of available studies, a more extensive surgical resection is associated with longer life expectancy for both low-grade and high-grade gliomas...
  7. ncbi request reprint Operative techniques for gliomas and the value of extent of resection
    Nader Sanai
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, California 94143, USA
    Neurotherapeutics 6:478-86. 2009
    ..The mounting evidence suggests that, despite persistent limitations in the quality of available studies, a more extensive surgical resection is associated with longer life expectancy for both low-grade and high-grade gliomas...
  8. pmc Corridors of migrating neurons in the human brain and their decline during infancy
    Nader Sanai
    Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nature 478:382-6. 2011
    ..Together, these findings reveal robust streams of tangentially migrating immature neurons in human early postnatal subventricular zone and cortex. These pathways represent potential targets of neurological injuries affecting neonates...
  9. doi request reprint Insular glioma resection: assessment of patient morbidity, survival, and tumor progression
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 112:1-9. 2010
    ....
  10. ncbi request reprint Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
    J Comp Neurol 494:415-34. 2006
    ..Ultrastructural analysis of this layer revealed a remarkable network of astrocytic and ependymal processes. This work provides a basic description of the organization of the adult human SVZ...
  11. doi request reprint Supracerebellar-supratrochlear and infratentorial-infratrochlear approaches: gravity-dependent variations of the lateral approach over the cerebellum
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Neurosurgery 66:264-74; discussion 274. 2010
    ....
  12. doi request reprint Morbidity profile following aggressive resection of parietal lobe gliomas
    Nader Sanai
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 116:1182-6. 2012
    ..The authors of this study reviewed their experience with parietal gliomas to characterize the impact of resection and the morbidity associated with language...
  13. doi request reprint A modified far-lateral approach for large or giant meningiomas of the posterior fossa
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 112:907-12. 2010
    ..Limitations include a restricted angle of view, high venous pressures, and suboptimal brain relaxation. While a far-lateral craniotomy is a viable alternative, the risks associated with condylar resection are undesirable...
  14. doi request reprint The current role of microsurgery for posterior circulation aneurysms: a selective approach in the endovascular era
    Nader Sanai
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 62:1236-49; discussion 1249-53. 2008
    ..We present a large, multidisciplinary team experience with posterior circulation aneurysms in an institution that continues to use microsurgery as a primary treatment modality for selected aneurysms...
  15. doi request reprint Glioma extent of resection and its impact on patient outcome
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    Neurosurgery 62:753-64; discussion 264-6. 2008
    ..Although the importance of resection in obtaining tissue diagnosis and alleviating symptoms is clear, a lack of Class I evidence prevents similar certainty in assessing the influence of extent of resection...
  16. ncbi request reprint Neural stem cells and the origin of gliomas
    Nader Sanai
    Department of Neurological Surgery, Brain Tumor Research Center, and the Developmental Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
    N Engl J Med 353:811-22. 2005
  17. ncbi request reprint Bypass surgery for complex brain aneurysms: an assessment of intracranial-intracranial bypass
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Neurosurgery 65:670-83; discussion 683. 2009
    ..We compared results with these newer IC-IC bypasses to conventional EC-IC bypasses...
  18. doi request reprint Risk profile associated with convexity meningioma resection in the modern neurosurgical era
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 112:913-9. 2010
    ..Although meningiomas are commonly found along the supratentorial convexity, the risk profile associated with this subset of lesions in the modern neurosurgical era is unknown...
  19. doi request reprint Functional outcome after language mapping for glioma resection
    Nader Sanai
    Department of Neurological Surgery and The Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA 94143 0112, USA
    N Engl J Med 358:18-27. 2008
    ..Language sites in the cortex of the brain vary among patients. Language mapping while the patient is awake is an intraoperative technique designed to minimize language deficits associated with brain-tumor resection...
  20. ncbi request reprint Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca area
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg 99:311-8. 2003
    ..These landmarks demonstrate novel structural-functional relationships that can be used preoperatively to predict the location of the Broca area...
  21. ncbi request reprint Assessment of image guided accuracy in a skull model: comparison of frameless stereotaxy techniques vs. frame-based localization
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA
    J Neurooncol 76:65-70. 2006
    ..We sought to evaluate the accuracy of a plastic, disposable burr hole mounted guide for stereotactic biopsy using an IGS and compare the results of different targeting methods with those of frame based localization...
  22. doi request reprint Transcerebellar stereotactic biopsy for lesions of the brainstem and peduncles under local anesthesia
    Nader Sanai
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California CA 94143 0112, USA
    Neurosurgery 63:460-6; discussion 466-8. 2008
    ..For certain brainstem lesions, a diagnostic biopsy is required for treatment planning. We reviewed the indications, safety, and diagnostic effectiveness of a transcerebellar stereotactic biopsy using local anesthesia and sedation...
  23. ncbi request reprint Comprehensive management of symptomatic and aggressive vertebral hemangiomas
    Frank L Acosta
    Department of Neurological Surgery, University of California, San Francisco, R505 Parnassus Avenue, Room M 779, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 19:17-29. 2008
    ..Vertebroplasty is useful for improving pain symptoms, especially when vertebral body compression fracture has occurred in patients without neurological deficit, but is less effective in providing long-term pain relief...
  24. ncbi request reprint Safety and efficacy of the direct endonasal transsphenoidal approach for challenging sellar tumors
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, P O Box 0112, San Francisco, CA 94143, USA
    J Neurooncol 87:317-25. 2008
    ..Large macroadenomas (3-4 cm) can still be addressed with this simple, unmodified direct endonasal approach. We present our experience with this unique and challenging patient population...
  25. ncbi request reprint Techniques to assess the proliferative potential of brain tumors
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, and Brain Tumor Research Center, University of California, San Francisco, 505 Parnassus Avenue, Moffitt Hospital Room M779, Box 0112, San Francisco, CA 94143 0112, USA
    J Neurooncol 74:19-30. 2005
    ..In this article, we present a review of the current techniques utilized to understand the proliferative potential of brain tumors...
  26. pmc An approach to the management of patients with residual Cushing's disease
    Lewis S Blevins
    California Center for Pituitary Disorders, University of California at San Francisco, Room A 808, San Francisco, CA 94143 0350, USA
    J Neurooncol 94:313-9. 2009
    ....
  27. ncbi request reprint Extensive intradural arachnoid cyst of the lumbar spinal canal: case report
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California San Francisco, Moffitt Hospital Room M779, 505 Parnassus Avenue, San Francisco, CA 94143 0112, USA
    Surg Neurol 60:57-9. 2003
    ..MRI is considered the diagnostic procedure of choice; however, some arachnoid cysts have been reported to elude diagnosis by MRI due to the similar signal intensity of the cyst and the subarachnoid space...
  28. ncbi request reprint Combined microsurgical and endovascular management of complex intracranial aneurysms
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0012, USA
    Neurosurgery 52:263-74; discussion 274-5. 2003
    ....
  29. pmc Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
    Stephen P J Fancy
    Institute for Regeneration Medicine, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 23:1571-85. 2009
    ..Evidence of Wnt pathway activity in human MS lesions suggests that its dysregulation might contribute to inefficient myelin repair in human neurological disorders...
  30. ncbi request reprint Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular management
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg 104:82-9. 2006
    ..The authors reviewed their experience at one institution regarding patients treated between 1977 and 2003, focusing on the issue of treatment durability...
  31. ncbi request reprint The human brain subventricular zone: stem cells in this niche and its organization
    Alfredo Quinones-Hinojosa
    Stem Cell Laboratory, Brain Tumor Program, Department of Neurological Surgery, Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, Room 253, Baltimore, MD 21231, USA
    Neurosurg Clin N Am 18:15-20, vii. 2007
    ..Understanding the organization of the adult human SVZ represents a necessary first step in understanding cellular proliferation, precursor migration, and the neurogenic niche of the largest known germinal region in the adult human brain...
  32. doi request reprint Biology of brain tumor stem cells
    Nader Sanai
    Neurosurg Focus 24:E26; discussion E26. 2008
  33. doi request reprint Aortocarotid bypass for hemispheric hypoperfusion in a child
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg Pediatr 1:343-7. 2008
    ..The bypass graft is amenable to angioplasty with or without stenting if delayed stenosis becomes an issue later in life...