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Genomes and GenesSpecies | Nader SanaiSummaryAffiliation: University of California Country: USA Publications
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Publications
Recent surgical management of gliomasNader Sanai
Department of Neurological Surgery, University of California, San Francisco, CA, USA
Adv Exp Med Biol 746:12-25. 2012..The mounting evidence suggests that, despite persistent limitations in the quality of available studies, a more extensive surgical resection is associated with longer life expectancy for both low-grade and high-grade gliomas...- Glioma extent of resection and its impact on patient outcomeNader Sanai
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Neurosurgery 62:753-64; discussion 264-6. 2008..Although the importance of resection in obtaining tissue diagnosis and alleviating symptoms is clear, a lack of Class I evidence prevents similar certainty in assessing the influence of extent of resection... - Functional outcome after language mapping for glioma resectionNader Sanai
Department of Neurological Surgery and The Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA 94143 0112, USA
N Engl J Med 358:18-27. 2008..Language sites in the cortex of the brain vary among patients. Language mapping while the patient is awake is an intraoperative technique designed to minimize language deficits associated with brain-tumor resection... 
Safety and efficacy of the direct endonasal transsphenoidal approach for challenging sellar tumorsNader Sanai
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, M 779, P O Box 0112, San Francisco, CA 94143, USA
J Neurooncol 87:317-25. 2008..Large macroadenomas (3-4 cm) can still be addressed with this simple, unmodified direct endonasal approach. We present our experience with this unique and challenging patient population...- Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension"Nader Sanai
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143 0112, USA
Science 318:393; author reply 393. 2007.... - Neural stem cells and the origin of gliomasNader Sanai
Department of Neurological Surgery, Brain Tumor Research Center, and the Developmental Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
N Engl J Med 353:811-22. 2005 - Intraoperative stimulation techniques for functional pathway preservation and glioma resectionNader Sanai
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
Neurosurg Focus 28:E1. 2010..Collectively, these surgical strategies represent the cornerstone for operating on gliomas in and around functional pathways... - Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cellsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
J Comp Neurol 494:415-34. 2006..Ultrastructural analysis of this layer revealed a remarkable network of astrocytic and ependymal processes. This work provides a basic description of the organization of the adult human SVZ... - Operative techniques for gliomas and the value of extent of resectionNader Sanai
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, California 94143, USA
Neurotherapeutics 6:478-86. 2009..The mounting evidence suggests that, despite persistent limitations in the quality of available studies, a more extensive surgical resection is associated with longer life expectancy for both low-grade and high-grade gliomas... - An extent of resection threshold for newly diagnosed glioblastomasNader Sanai
Brain Tumor Research Center, University of California, San Francisco, California, USA
J Neurosurg 115:3-8. 2011..The authors attempt to define these values for the patient with newly diagnosed GBM in the modern neurosurgical era... - Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular managementNader Sanai
Department of Neurological Surgery, University of California at San Francisco, California 94143-0112, USA
J Neurosurg 104:82-9. 2006..Parental biases toward nonoperative therapy should be thoroughly addressed before ultimately selecting a treatment strategy... - Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomasMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
J Neurosurg 113:202-9. 2010..The authors present the largest case series to date dealing with these tumors, providing analysis of 63 patients... - Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migrationNader Sanai
Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
Nature 427:740-4. 2004..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain... - Insular glioma resection: assessment of patient morbidity, survival, and tumor progressionNader Sanai
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 112:1-9. 2010.... - The azygos anterior cerebral artery bypass: double reimplantation technique for giant anterior communicating artery aneurysmsZaman Mirzadeh
Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
J Neurosurg 114:1154-8. 2011..The authors conclude that the azygos ACA bypass is a novel option for revascularizing PcaA and CmaA, as part of the overall treatment of giant ACoA aneurysms... 
Corridors of migrating neurons in the human brain and their decline during infancyNader Sanai
Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
Nature 478:382-6. 2011..Together, these findings reveal robust streams of tangentially migrating immature neurons in human early postnatal subventricular zone and cortex. These pathways represent potential targets of neurological injuries affecting neonates...- Treatment of Enneking stage 3 aggressive vertebral hemangiomas with intralesional spondylectomy: report of 10 cases and review of the literatureFrank L Acosta
Department of Neurological Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
J Spinal Disord Tech 24:268-75. 2011..A retrospective review of consecutive series of Enneking stage 3 vertebral hemangiomas surgically treated at a major tertiary spine tumor center... - A modified far-lateral approach for large or giant meningiomas of the posterior fossaNader Sanai
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
J Neurosurg 112:907-12. 2010..Limitations include a restricted angle of view, high venous pressures, and suboptimal brain relaxation. While a far-lateral craniotomy is a viable alternative, the risks associated with condylar resection are undesirable... - Techniques to assess the proliferative potential of brain tumorsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, and Brain Tumor Research Center, University of California, San Francisco, 505 Parnassus Avenue, Moffitt Hospital Room M779, Box 0112, San Francisco, CA 94143 0112, USA
J Neurooncol 74:19-30. 2005..In this article, we present a review of the current techniques utilized to understand the proliferative potential of brain tumors... - The human brain subventricular zone: stem cells in this niche and its organizationAlfredo Quinones-Hinojosa
Stem Cell Laboratory, Brain Tumor Program, Department of Neurological Surgery, Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, Room 253, Baltimore, MD 21231, USA
Neurosurg Clin N Am 18:15-20, vii. 2007..Understanding the organization of the adult human SVZ represents a necessary first step in understanding cellular proliferation, precursor migration, and the neurogenic niche of the largest known germinal region in the adult human brain... - Supracerebellar-supratrochlear and infratentorial-infratrochlear approaches: gravity-dependent variations of the lateral approach over the cerebellumNader Sanai
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
Neurosurgery 66:264-74; discussion 274. 2010.... - Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca areaAlfredo Quinones-Hinojosa
Department of Neurosurgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
J Neurosurg 99:311-8. 2003..These landmarks demonstrate novel structural-functional relationships that can be used preoperatively to predict the location of the Broca area... - Microsurgical management of pediatric intracranial aneurysmsNader Sanai
Department of Neurological Surgery, Barrow Neurological Institute, Phoenix, AZ, USA
Childs Nerv Syst 26:1319-27. 2010..Pediatric aneuryms are rare and have characteristics that distinguish them from their adult counterparts. There is a greater capacity for pediatric aneurysms to arise de novo and progress rapidly... - Intraoperative confocal microscopy for brain tumors: a feasibility analysis in humansNader Sanai
Department of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
Neurosurgery 68:282-90; discussion 290. 2011..Advances in optical imaging enabled production of a handheld intraoperative confocal microscope... - Morbidity profile following aggressive resection of parietal lobe gliomasNader Sanai
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 116:1182-6. 2012..The authors of this study reviewed their experience with parietal gliomas to characterize the impact of resection and the morbidity associated with language... - The current role of microsurgery for posterior circulation aneurysms: a selective approach in the endovascular eraNader Sanai
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 62:1236-49; discussion 1249-53. 2008..We present a large, multidisciplinary team experience with posterior circulation aneurysms in an institution that continues to use microsurgery as a primary treatment modality for selected aneurysms... - Bypass surgery for complex brain aneurysms: an assessment of intracranial-intracranial bypassNader Sanai
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
Neurosurgery 65:670-83; discussion 683. 2009..We compared results with these newer IC-IC bypasses to conventional EC-IC bypasses... - Risk profile associated with convexity meningioma resection in the modern neurosurgical eraNader Sanai
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 112:913-9. 2010..Although meningiomas are commonly found along the supratentorial convexity, the risk profile associated with this subset of lesions in the modern neurosurgical era is unknown... - Transcerebellar stereotactic biopsy for lesions of the brainstem and peduncles under local anesthesiaNader Sanai
Department of Neurological Surgery, University of California San Francisco, San Francisco, California CA 94143 0112, USA
Neurosurgery 63:460-6; discussion 466-8. 2008..For certain brainstem lesions, a diagnostic biopsy is required for treatment planning. We reviewed the indications, safety, and diagnostic effectiveness of a transcerebellar stereotactic biopsy using local anesthesia and sedation... - Assessment of image guided accuracy in a skull model: comparison of frameless stereotaxy techniques vs. frame-based localizationAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA, USA
J Neurooncol 76:65-70. 2006..We sought to evaluate the accuracy of a plastic, disposable burr hole mounted guide for stereotactic biopsy using an IGS and compare the results of different targeting methods with those of frame based localization... - Comprehensive management of symptomatic and aggressive vertebral hemangiomasFrank L Acosta
Department of Neurological Surgery, University of California, San Francisco, R505 Parnassus Avenue, Room M 779, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 19:17-29. 2008..Vertebroplasty is useful for improving pain symptoms, especially when vertebral body compression fracture has occurred in patients without neurological deficit, but is less effective in providing long-term pain relief... - Low-grade gliomas in adultsNader Sanai
Barrow Brain Tumor Research Center, Department of Neurological Surgery, Barrow Neurological Institute, Phoenix, Arizona, USA
J Neurosurg 115:948-65. 2011..In this article, the authors evaluate the recent literature to synthesize a comprehensive review of LGGs in the modern neurosurgical era... - An approach to the management of patients with residual Cushing's diseaseLewis S Blevins
California Center for Pituitary Disorders, University of California at San Francisco, Room A 808, San Francisco, CA 94143 0350, USA
J Neurooncol 94:313-9. 2009.... - Aortocarotid bypass for hemispheric hypoperfusion in a childNader Sanai
Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
J Neurosurg Pediatr 1:343-7. 2008..The bypass graft is amenable to angioplasty with or without stenting if delayed stenosis becomes an issue later in life... - Advanced technical skills are required for microsurgical clipping of posterior communicating artery aneurysms in the endovascular eraNader Sanai
Division of Neurological Surgery, Barrow Neurological Institute, Phoenix, Arizona, USA
Neurosurgery 71:285-94; discussion 294-5. 2012..However, endovascular therapy removes simple aneurysms that would have been easiest to clip with the best results. What remains are aneurysms with complex anatomy and technical challenges that are not well described... - Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNSStephen P J Fancy
Institute for Regeneration Medicine, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California 94143, USA
Genes Dev 23:1571-85. 2009..Evidence of Wnt pathway activity in human MS lesions suggests that its dysregulation might contribute to inefficient myelin repair in human neurological disorders... - Extensive intradural arachnoid cyst of the lumbar spinal canal: case reportAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California-San Francisco, Moffitt Hospital Room M779, 505 Parnassus Avenue, San Francisco, CA 94143-0112, USA
Surg Neurol 60:57-9. 2003.... - Combined microsurgical and endovascular management of complex intracranial aneurysmsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0012, USA
Neurosurgery 52:263-74; discussion 274-5. 2003.... - Biology of brain tumor stem cellsNader Sanai
Neurosurg Focus 24:E26; discussion E26. 2008