C E Samuel

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Antiviral actions of interferons
    C E Samuel
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Clin Microbiol Rev 14:778-809, table of contents. 2001
  2. ncbi request reprint Reoviruses and the interferon system
    C E Samuel
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara 93106 9610, USA
    Curr Top Microbiol Immunol 233:125-45. 1998
  3. ncbi request reprint The role of gamma interferon in antimicrobial immunity
    R Shtrichman
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    Curr Opin Microbiol 4:251-9. 2001
  4. ncbi request reprint Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity
    Y Liu
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    Virology 289:378-87. 2001
  5. ncbi request reprint Mouse interferon-inducible RNA-dependent protein kinase Pkr gene: cloning and sequence of the 5'-flanking region and functional identification of the minimal inducible promoter
    H Tanaka
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Gene 246:373-82. 2000
  6. pmc Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible
    C X George
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 96:4621-6. 1999
  7. ncbi request reprint Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase
    Y Liu
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 272:4419-28. 1997
  8. ncbi request reprint Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes
    K L Kuhen
    Interdepartmental Program of Biochemistry and Molecular Biology, University of California, Santa Barbara, California, 93106, USA
    Virology 227:119-30. 1997
  9. ncbi request reprint Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones
    K L Kuhen
    Interdepartmental Graduate Program of Biochemistry and Molecular Biology, University of California, Santa Barbara 93106, USA
    Gene 178:191-3. 1996
  10. ncbi request reprint The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2
    H U Weier
    Center for Molecular Cytogenetics, University of California, Lawrence Berkeley National Laboratory 94720, USA
    Genomics 30:372-5. 1995

Collaborators

  • Otto Haller
  • Y Liu
  • C X George
  • H Tanaka
  • K L Kuhen
  • R Shtrichman
  • J B Patterson
  • K C Wolff
  • B L Jacobs
  • D C Thomis
  • N A McMillan
  • H U Weier
  • X Shen
  • T W Mak
  • K M Greulich
  • R F Chun
  • W M Toone
  • A G Hovanessian
  • B R Williams
  • K T Jeang
  • D P Siderovski
  • J Galabru
  • S J McCormack
  • J P Doohan
  • X X Zhang
  • G Floyd-Smith
  • M Aebi
  • D Thomis
  • J Fah
  • J Pavlovic
  • N Hurt
  • L Bazzigher
  • P Staeheli

Detail Information

Publications18

  1. pmc Antiviral actions of interferons
    C E Samuel
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106 9610, USA
    Clin Microbiol Rev 14:778-809, table of contents. 2001
    ..The use of these IFN system reagents, both in cell culture and in whole animals, continues to provide important contributions to our understanding of the virus-host interaction and cellular antiviral response...
  2. ncbi request reprint Reoviruses and the interferon system
    C E Samuel
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara 93106 9610, USA
    Curr Top Microbiol Immunol 233:125-45. 1998
    ....
  3. ncbi request reprint The role of gamma interferon in antimicrobial immunity
    R Shtrichman
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    Curr Opin Microbiol 4:251-9. 2001
    ..Studies of transgenic mutant mice deficient in proteins of the IFN-gamma response pathway firmly establish the importance of IFN-gamma in immunity...
  4. ncbi request reprint Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity
    Y Liu
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    Virology 289:378-87. 2001
    ..These results demonstrate that the A-to-I RNA editing activity of the IFN-inducible adenosine deaminase is impaired by the product of the vaccinia virus E3L interferon resistance gene...
  5. ncbi request reprint Mouse interferon-inducible RNA-dependent protein kinase Pkr gene: cloning and sequence of the 5'-flanking region and functional identification of the minimal inducible promoter
    H Tanaka
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Gene 246:373-82. 2000
    ..Northern blot analysis showed efficient IFN-alpha induced accumulation of 2.4kb, 4.5kb and approx. 6kb Pkr transcripts, but neither IFN-gamma nor IL-6 induced detectable Pkr mRNA accumulation in L cells...
  6. pmc Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible
    C X George
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 96:4621-6. 1999
    ....
  7. ncbi request reprint Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase
    Y Liu
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 272:4419-28. 1997
    ..However, mutational analysis of the R-motifs revealed that the exon 6 and 7 deletions of ADAR-b and -c variants altered the functional importance of each of the three R-motifs...
  8. ncbi request reprint Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes
    K L Kuhen
    Interdepartmental Program of Biochemistry and Molecular Biology, University of California, Santa Barbara, California, 93106, USA
    Virology 227:119-30. 1997
    ..The strict conservation of sequence, distance, and position of KCS, relative to ISRE, together with mutagenesis results, suggest an important functional role for the newly recognized KCS motif...
  9. ncbi request reprint Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones
    K L Kuhen
    Interdepartmental Graduate Program of Biochemistry and Molecular Biology, University of California, Santa Barbara 93106, USA
    Gene 178:191-3. 1996
    ..We report herein the sequence of the human PKR protein kinase deduced from genomic clones...
  10. ncbi request reprint The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2
    H U Weier
    Center for Molecular Cytogenetics, University of California, Lawrence Berkeley National Laboratory 94720, USA
    Genomics 30:372-5. 1995
    ..1-21.2. Simultaneous multicolor FISH including lambda clones and yeast artificial chromosomes showed a localization of the gene in band 1q21 centromeric of D1S1705...
  11. pmc Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase
    J B Patterson
    Department of Biological Sciences, University of California, Santa Barbara 93106, USA
    Mol Cell Biol 15:5376-88. 1995
    ..These results establish that K88 encodes an IFN-inducible dsRNA-specific adenosine deaminase and suggest that at least two forms of dsRNA-specific adenosine deaminase occur in human cells...
  12. ncbi request reprint Sequence of the murine interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones
    H Tanaka
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Gene 153:283-4. 1995
    ..The genomic nucleotide (nt) sequence, when compared to that of previously determined cDNA nt sequences, revealed 16 exons encoding the 515-amino-acid PKR...
  13. ncbi request reprint HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR
    N A McMillan
    Department of Cancer Biology, Cleveland Clinic Foundation, Ohio 44195, USA
    Virology 213:413-24. 1995
    ..The interaction of Tat with PKR provides a potential mechanism by which HIV could suppress the interferon system...
  14. pmc cDNA structures and regulation of two interferon-induced human Mx proteins
    M Aebi
    Institute for Molecular Biology I, University of Zurich, Switzerland
    Mol Cell Biol 9:5062-72. 1989
    ..In contrast to mouse Mx1 protein, which accumulates in the nuclei of IFN-treated mouse cells, the two human Mx proteins both accumulate in the cytoplasm of IFN-treated cells...
  15. ncbi request reprint Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin
    X X Zhang
    Department of Biological Sciences University of California, Santa Barbara 93106
    Biochem Biophys Res Commun 164:176-84. 1989
    ..Southern gel blot analysis revealed polymorphism within the human B23 gene structure, and suggested the presence of multiple B23 genes and/or extensive splicing of B23 RNA transcripts...
  16. ncbi request reprint Mechanism of interferon action. cDNA structure and regulation of a novel splice-site variant of the catalytic subunit of human protein kinase A from interferon-treated human cells
    D C Thomis
    Department of Biological Sciences, University of California, Santa Barbara 93106
    J Biol Chem 267:10723-8. 1992
    ..These results suggest that alternative splicing may contribute to the structural heterogeneity of C subunits expressed in human cells and that interferon may affect this process...
  17. ncbi request reprint Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase
    S J McCormack
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Virology 188:47-56. 1992
    ....
  18. ncbi request reprint Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells
    D C Thomis
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Virology 188:33-46. 1992
    ..The amino-terminal half of the P1 protein did not possess conserved kinase motifs, but did show extensive homology with vaccinia virus-predicted protein E3L...