Buka Samten

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc Immune regulatory activities of early secreted antigenic target of 6-kD protein of Mycobacterium tuberculosis and implications for tuberculosis vaccine design
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Tuberculosis (Edinb) 91:S114-8. 2011
  2. doi Mycobacterium tuberculosis ESX-1 system-secreted protein ESAT-6 but not CFP10 inhibits human T-cell immune responses
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708 3154, USA
    Tuberculosis (Edinb) 89:S74-6. 2009
  3. pmc CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 181:2056-64. 2008
  4. pmc An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis
    Buka Samten
    Department of Microbiology and Immunology, the Center for Pulmonary and Infectious Disease Control, The University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708, USA
    J Leukoc Biol 84:115-23. 2008
  5. ncbi Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 174:6357-63. 2005
  6. ncbi NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 172:130-7. 2004
  7. ncbi IS6110 functions as a mobile, monocyte-activated promoter in Mycobacterium tuberculosis
    Hassan Safi
    Department of Microbiology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 52:999-1012. 2004
  8. pmc Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis
    Peter Klucar
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States
    Vaccine 27:1816-24. 2009
  9. pmc Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth
    Shiping Wu
    Department of Microbiology and Immunology, University of Texas Health Science Center at Tyler, Tyler, TX 75708 3154, USA
    Microbiology 155:1272-81. 2009
  10. ncbi ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells
    Xisheng Wang
    Department of Microbiologyand Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:3668-77. 2009

Collaborators

Detail Information

Publications26

  1. pmc Immune regulatory activities of early secreted antigenic target of 6-kD protein of Mycobacterium tuberculosis and implications for tuberculosis vaccine design
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Tuberculosis (Edinb) 91:S114-8. 2011
    ..Understanding the molecular mechanisms through which ESAT-6 inhibits immunity will permit design of ESAT-6-based vaccine constructs that elicit protective immune responses with minimal negative effects...
  2. doi Mycobacterium tuberculosis ESX-1 system-secreted protein ESAT-6 but not CFP10 inhibits human T-cell immune responses
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708 3154, USA
    Tuberculosis (Edinb) 89:S74-6. 2009
    ..We conclude that ESAT-6 directly inhibits human T-cell responses by affecting TCR signaling pathways downstream of ZAP70...
  3. pmc CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 181:2056-64. 2008
    ..Additionally, ATF-2 controls expression of CREB and c-Jun during T cell activation...
  4. pmc An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis
    Buka Samten
    Department of Microbiology and Immunology, the Center for Pulmonary and Infectious Disease Control, The University of Texas Health Center, 11937 U S Hwy 271, Tyler, TX 75708, USA
    J Leukoc Biol 84:115-23. 2008
    ..Together, these findings support the hypothesis that SP-A, via SP-R210, suppresses cell-mediated immunity against M. tuberculosis via a mechanism that up-regulates secretion of IL-10 and TGF-beta1...
  5. ncbi Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 174:6357-63. 2005
    ..These findings demonstrate that CREB positively regulates IFN-gamma production by human T cells that respond to M. tuberculosis...
  6. ncbi NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 172:130-7. 2004
    ..tuberculosis and other intracellular pathogens...
  7. ncbi IS6110 functions as a mobile, monocyte-activated promoter in Mycobacterium tuberculosis
    Hassan Safi
    Department of Microbiology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Microbiol 52:999-1012. 2004
    ..The ability to activate genes during infection suggests that IS6110 has the potential to influence growth characteristics of different strains, and indicates another mechanism by which IS6110 can impact M. tuberculosis evolution...
  8. pmc Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis
    Peter Klucar
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States
    Vaccine 27:1816-24. 2009
    ..We conclude that CFP10 is a potential vaccine candidate and that coating vaccines with PEI enhances local protective immunity to tuberculosis..
  9. pmc Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth
    Shiping Wu
    Department of Microbiology and Immunology, University of Texas Health Science Center at Tyler, Tyler, TX 75708 3154, USA
    Microbiology 155:1272-81. 2009
    ..tuberculosis strain 210 to grow in monocytes...
  10. ncbi ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells
    Xisheng Wang
    Department of Microbiologyand Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:3668-77. 2009
    ..We conclude that ESAT-6 directly inhibits human T cell responses to mycobacterial Ags by affecting TCR signaling pathways downstream of ZAP70...
  11. ncbi The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo
    Shiping Wu
    Department of Microbiology and Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX, USA
    Mol Microbiol 51:1551-62. 2004
    ..This effect may be mediated in part by increased resistance to reactive oxygen intermediates...
  12. ncbi Serum cytokine concentrations do not parallel Mycobacterium tuberculosis-induced cytokine production in patients with tuberculosis
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708 3154, USA
    Clin Infect Dis 36:24-8. 2003
    ..tuberculosis-induced cytokine levels, and increased IL-10 serum levels in patients with tuberculosis inhibit IFN-gamma production in response to mycobacterial antigens...
  13. ncbi Reduced expression of nuclear cyclic adenosine 5'-monophosphate response element-binding proteins and IFN-gamma promoter function in disease due to an intracellular pathogen
    Buka Samten
    Department of Microbiology and Immunology, and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 168:3520-6. 2002
    ..These data suggest that reduced expression of CREB nuclear proteins in tuberculosis patients results in decreased IFN-gamma promoter activity and reduced IFN-gamma production...
  14. ncbi CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis
    Buka Samten
    Department of Microbiology and Immunology and Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 170:3180-6. 2003
    ..We conclude that CD40LT can enhance CD8(+) T cell effector function in response to M. tuberculosis...
  15. pmc Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis
    Yan Feng
    Center for Pulmonary and Infectious Disease Control, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Infect Immun 79:229-37. 2011
    ..tuberculosis and influenza virus in a physiologically relevant animal model, increasing susceptibility to both pathogens...
  16. ncbi The CD14 receptor does not mediate entry of Mycobacterium tuberculosis into human mononuclear phagocytes
    Homayoun Shams
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708 3154, USA
    FEMS Immunol Med Microbiol 36:63-9. 2003
    ..tuberculosis; (2) M. tuberculosis infection upregulates CD14 expression on mononuclear phagocytes, and this may facilitate the pathogen's capacity to modulate the immune response...
  17. pmc The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-γ production through the p38 mitogen-activated protein kinase pathway
    Hui Peng
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, Texas 75708, USA
    J Biol Chem 286:24508-18. 2011
    ..Silencing of p38α MAPK with siRNA rendered T cells resistant to ESAT-6 inhibition of IFN-γ production. Taken together, our results demonstrate that ESAT-6 inhibits T cell IFN-γ production in a p38 MAPK-dependent manner...
  18. ncbi Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen
    Benjamin Wizel
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler 75708, USA
    J Immunol 169:2524-35. 2002
    ....
  19. ncbi Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis
    Xiuhua Pang
    Department of Microbiology and Immunology, Center for Pulmonary and Infectious Disease Control, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Microbiology 153:1229-42. 2007
    ....
  20. ncbi Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen
    Peter Klucar
    Department of Microbiology and Immunology, University of Texas Health Center at Tyler, Tyler, TX, USA
    Hum Immunol 69:475-83. 2008
    ....
  21. pmc Early secreted antigenic target of 6 kDa (ESAT-6) protein of Mycobacterium tuberculosis induces interleukin-8 (IL-8) expression in lung epithelial cells via protein kinase signaling and reactive oxygen species
    Vijay Boggaram
    Department of Cell and Molecular Biology and the Center for Pulmonary Infectious Disease Control, University of Texas Health Science Center, Tyler, Texas 75708 3154, USA
    J Biol Chem 288:25500-11. 2013
    ..This has important implications for the understanding of lung innate immune responses to tuberculosis and the pathogenesis of lung injury in tuberculosis. ..
  22. doi Progress in understanding the human immune responses to Mycobacterium tuberculosis
    Peter F Barnes
    Department of Medicine, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Tuberculosis (Edinb) 89:S5-9. 2009
    ....
  23. ncbi Priming reverse transcription with oligo(dT) does not yield representative samples of Mycobacterium tuberculosis cDNA
    David L Lakey
    Center for Pulmonary and Infectious Disease Control, and Department of Microbiology, University of Texas Health Center, Tyler, TX 75708, USA
    Microbiology 148:2567-72. 2002
    ..tuberculosis microarray. These data demonstrate that priming of reverse transcription of mycobacterial mRNA with oligo(dT) does not yield representative samples of cDNA...
  24. pmc Early secreted antigenic target of 6-kDa protein of Mycobacterium tuberculosis primes dendritic cells to stimulate Th17 and inhibit Th1 immune responses
    Xisheng Wang
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 189:3092-103. 2012
    ..We conclude that ESAT-6 increases DC production of IL-23 and IL-1β while inhibiting that of IL-12, thus enhancing Th17 at the expense of protective Th1 responses...
  25. ncbi The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 168:3451-7. 2002
    ....
  26. pmc Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells
    Qin Hao
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    Am J Physiol Cell Physiol 303:C548-53. 2012
    ..Thus we have indentified VEGFR2 as a PTP-MEG2 substrate, and our findings indicate that PTP-MEG2 is a negative regulator of VEGFR2 signaling and function in ECs...