Erik R Sampson

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis
    Erik R Sampson
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Sci Transl Med 3:101ra93. 2011
  2. doi request reprint The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy
    Erik R Sampson
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Orthop Res 29:623-32. 2011
  3. doi request reprint The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model
    Erik R Sampson
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Bone Miner Res 26:1283-94. 2011
  4. pmc Establishment of an index with increased sensitivity for assessing murine arthritis
    Erik R Sampson
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 29:1145-51. 2011
  5. pmc Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice
    Qiuqian Wu
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 58:3132-44. 2008
  6. pmc Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes
    Kyung Ok Kim
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York 14642, USA
    J Cell Biochem 113:2156-66. 2012
  7. doi request reprint Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling
    Jonathan D Holz
    Department of Orthopaedics, University of Rochester School of Medicine and Dentristry, Rochester, NY 14642, USA
    J Orthop Res 30:1760-6. 2012
  8. pmc Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis
    Tian Fang Li
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 62:2359-69. 2010
  9. pmc High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
  10. pmc Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage
    Qiuqian Wu
    Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Cell Res 315:2386-98. 2009

Collaborators

Detail Information

Publications12

  1. pmc Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis
    Erik R Sampson
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Sci Transl Med 3:101ra93. 2011
    ..These preclinical findings provide proof of concept that Forteo may be useful for decelerating cartilage degeneration and inducing matrix regeneration in patients with osteoarthritis...
  2. doi request reprint The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy
    Erik R Sampson
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Orthop Res 29:623-32. 2011
    ..2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:623-632, 2011...
  3. doi request reprint The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model
    Erik R Sampson
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Bone Miner Res 26:1283-94. 2011
    ..PF-2341066 may represent an effective new systemic therapy for localized and potentially disseminated osteosarcoma...
  4. pmc Establishment of an index with increased sensitivity for assessing murine arthritis
    Erik R Sampson
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 29:1145-51. 2011
    ..Enhanced sensitivity can be achieved by performing the Arthritis Index calculation, a novel method for quantitatively assessing mouse knee arthritis...
  5. pmc Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice
    Qiuqian Wu
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 58:3132-44. 2008
    ..To determine whether Smurf2, an E3 ubiquitin ligase known to inhibit transforming growth factor beta (TGFbeta) signaling, is expressed in human osteoarthritic (OA) cartilage and can initiate OA in mice...
  6. pmc Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes
    Kyung Ok Kim
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York 14642, USA
    J Cell Biochem 113:2156-66. 2012
    ..These results suggest that inhibition of TGF-β signaling by Ski, which involves its association with phospho-Smad3 and recruitment of HDAC4 and 5, leads to accelerated chondrocyte differentiation...
  7. doi request reprint Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling
    Jonathan D Holz
    Department of Orthopaedics, University of Rochester School of Medicine and Dentristry, Rochester, NY 14642, USA
    J Orthop Res 30:1760-6. 2012
    ..These changes closely parallel those seen in osteoarthritis. Over time this phenotypic shift could compromise maintenance of the joint matrix...
  8. pmc Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis
    Tian Fang Li
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 62:2359-69. 2010
    ....
  9. pmc High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
    ..This study was undertaken to establish a causal relation between the HF diet and accelerated OA progression in a mouse model and to determine the relative roles of weight gain and metabolic dysregulation in this progression...
  10. pmc Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage
    Qiuqian Wu
    Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Cell Res 315:2386-98. 2009
    ....
  11. pmc Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Orthop Res 30:325-33. 2012
    ..05) more vegf-a (10-fold) and 20- to 30-fold less ang-1 versus the other lines. These data demonstrate the utility of this model to study the unique vasculogenic properties of RCC bone metastases...
  12. pmc Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue
    Meina Wang
    University of Rochester, Rochester, New York, USA
    Arthritis Rheum 64:2611-23. 2012
    ..The mechanism of this disease is currently unknown. This study was undertaken to investigate the role of β-catenin signaling in IVD tissue function...