Wade S Samowitz

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Cancer Res 65:6063-9. 2005
  2. pmc Microsatellite instability and survival in rectal cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Cancer Causes Control 20:1763-8. 2009
  3. pmc Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    Cancer Epidemiol Biomarkers Prev 18:3384-8. 2009
  4. pmc Somatic alterations, metabolizing genes and smoking in rectal cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 125:158-64. 2009
  5. pmc The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Genes Chromosomes Cancer 47:835-44. 2008
  6. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
  7. pmc Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Nutr Cancer 63:357-66. 2011
  8. ncbi request reprint Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 120:656-63. 2007
  9. pmc MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Mol Carcinog 48:989-94. 2009
  10. ncbi request reprint Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    J Natl Cancer Inst 98:1731-8. 2006

Detail Information

Publications39

  1. ncbi request reprint Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    Cancer Res 65:6063-9. 2005
    ....
  2. pmc Microsatellite instability and survival in rectal cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Cancer Causes Control 20:1763-8. 2009
    ..Very few studies have evaluated the effect of MSI-H on rectal cancer survival. We assessed MSI-H and other genetic and epigenetic changes on survival of 990 individuals diagnosed with first primary rectal cancer...
  3. pmc Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    Cancer Epidemiol Biomarkers Prev 18:3384-8. 2009
    ..02-1.9). These findings point to the importance of studying tumor mutations when examining DNA repair polymorphisms and cigarette smoke exposure to identify potentially relevant associations with colorectal cancer...
  4. pmc Somatic alterations, metabolizing genes and smoking in rectal cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 125:158-64. 2009
    ..ETS may increase risk of KRAS2 mutations; association with TP53 mutations and ETS may be influenced by NAT2...
  5. pmc The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Genes Chromosomes Cancer 47:835-44. 2008
    ....
  6. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
    ..1, 95% CI = 1.3-3.4 versus AA/high risk; P-interaction = 0.03). These results provide only limited support for a role of polymorphisms in one-carbon metabolism in the etiology of CIMP colon cancer...
  7. pmc Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Nutr Cancer 63:357-66. 2011
    ....
  8. ncbi request reprint Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 120:656-63. 2007
    ..Our data suggest multiple pathways to colon cancer. They do not support a unique role for dietary folate, alcohol, vitamins B(6) and B(12) and methionine in a CpG island methylator phenotype...
  9. pmc MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Mol Carcinog 48:989-94. 2009
    ..Age at diagnosis, family history, and alcohol use did not interact with MSH6 G39E and CIMP. The MSH6 G39E germline polymorphism may be associated with CIMP+ colon cancer...
  10. ncbi request reprint Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    J Natl Cancer Inst 98:1731-8. 2006
    ..We investigated whether the association between smoking and all colon cancers could be explained through induction of CIMP and/or BRAF mutations...
  11. ncbi request reprint Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Clin Gastroenterol Hepatol 4:894-901. 2006
    ....
  12. pmc Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival
    Martha L Slattery
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Int J Cancer 128:2726-34. 2011
    ..These data suggest that genetic variation in the CRP gene influences risk of both colon and rectal cancer development...
  13. ncbi request reprint Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Gastroenterology 129:837-45. 2005
    ....
  14. doi request reprint Genetic and epigenetic changes in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    Exp Mol Pathol 85:64-7. 2008
    ..In addition, recent data on APC gene mutations challenges the existing paradigm for colon cancer carcinogenesis and precursor lesions, which may in turn have clinical implications for cancer prevention...
  15. ncbi request reprint Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Int J Cancer 120:2226-32. 2007
    ..This study provides some support for associations between TS genotype and colon cancer tumor characteristics...
  16. ncbi request reprint APC mutations and other genetic and epigenetic changes in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Mol Cancer Res 5:165-70. 2007
    ..The relationships of APC mutations to other genetic and epigenetic alterations add to the already impressive genetic heterogeneity of colon cancer...
  17. ncbi request reprint Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer
    Wade S Samowitz
    Department of Pathology, University of Utah, Salt Lake City, UT 84108, USA
    Mutat Res 595:117-24. 2006
    ....
  18. ncbi request reprint Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instability
    Wade S Samowitz
    Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
    Genes Chromosomes Cancer 35:368-71. 2002
    ..We conclude that instability-induced mutations in BAX or TGFBRII do not have a significant impact on the good prognosis of colon cancers with microsatellite instability...
  19. doi request reprint A PIK3CA pyrosequencing-based assay that excludes pseudogene interference
    Christine L Baker
    ARUP Institute for Clinical and Experimental Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA
    J Mol Diagn 14:56-60. 2012
    ..Thus, we have developed a PIK3CA pyrosequencing assay capable of detecting mutations in all three positions in the three hot spot codons with no pseudogene interference...
  20. doi request reprint Clinical analysis of PMS2: mutation detection and avoidance of pseudogenes
    Cecily P Vaughn
    ARUP Institute for Clinical and Experimental Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Hum Mutat 31:588-93. 2010
    ..Our data also support the use of IHC screening to direct germline testing of PMS2...
  21. ncbi request reprint Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Suite A, 375 Chipeta Way, Salt Lake City, UT 84101, USA
    Cancer Epidemiol Biomarkers Prev 14:1224-9. 2005
    ....
  22. ncbi request reprint Genetic admixture among Hispanics and candidate gene polymorphisms: potential for confounding in a breast cancer study?
    Carol Sweeney
    Department of Internal Medicine Health Research Center, University of Utah, Salt Lake City, Utah, USA
    Cancer Epidemiol Biomarkers Prev 16:142-50. 2007
    ..CRRs from simulated scenarios indicated that appreciable confounding by admixture would occur only when within-group candidate SNP allele frequency differences are much larger than any that we observed...
  23. ncbi request reprint p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry
    Karen Curtin
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Appl Immunohistochem Mol Morphol 12:380-6. 2004
    ..Advantages gained by sequencing are its ability to examine specific mutations and the improved ability to discriminate between cases with p 53 mutation and wild type when evaluating associations...
  24. ncbi request reprint Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis
    Randall W Burt
    Department of Medicine, University of Utah, Salt Lake City, USA
    Gastroenterology 127:444-51. 2004
    ..An attenuated form of familial adenomatous polyposis has been described, but the phenotype remains poorly understood...
  25. pmc Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer
    Deborah W Neklason
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
    J Med Genet 47:692-9. 2010
    ..Fewer than 5% of colon cancers arise in the presence of a clear hereditary cancer condition; however, current estimates suggest that an additional 15-25% of colorectal cancers arise on the basis of unknown inherited factors...
  26. pmc Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors
    Carol Sweeney
    Health Sciences Center, University of Utah, Salt Lake City, UT, USA
    Genes Chromosomes Cancer 48:1-9. 2009
    ..The oncogenetic tree model assumptions are appropriate for the observed heterogeneity of colon tumors, and the model produces a useful visual schematic of the sequence of events in pathways of colon carcinogenesis...
  27. pmc Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Mutat Res 660:12-21. 2009
    ..The important modifying effects of aspirin/NSAIDs on associations with genetic polymorphisms reinforce the underlying role of inflammation in the etiology of colon cancer...
  28. doi request reprint Microsatellite instability and colorectal cancer
    Katherine B Geiersbach
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Arch Pathol Lab Med 135:1269-77. 2011
    ..Identification of individuals with Lynch syndrome allows for increased surveillance of the affected individual and of potentially affected family members...
  29. pmc The CpG island methylator phenotype in colorectal cancer
    Wade S Samowitz
    University of Utah Health Sciences Center, Department of Pathology, Salt Lake City, UT 84132, USA
    J Mol Diagn 9:281-3. 2007
  30. doi request reprint Epidermal growth factor receptor pathway mutations and colorectal cancer therapy
    Allie H Grossmann
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Arch Pathol Lab Med 135:1278-82. 2011
    ..This is true for colorectal cancer in which mutations in signaling mediators predict resistance to anti-epidermal growth factor receptor (anti-EGFR) therapy...
  31. pmc CpG island methylation in colorectal cancer: past, present and future
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    Patholog Res Int 2011:902674. 2011
    ....
  32. ncbi request reprint Prognostic significance of p53 mutations in colon cancer at the population level
    Wade S Samowitz
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int J Cancer 99:597-602. 2002
    ..However, specific classes of mutations, namely, the G245 hot spot mutation and mutations in proximal tumors, are related to significantly worse survival even after adjusting for age and stage...
  33. ncbi request reprint Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database
    Richard A Kerber
    Department of Oncological Sciences, University of Utah, School of Medicine, USA
    Fam Cancer 4:239-44. 2005
    ....
  34. doi request reprint DNA methylation in breast and colorectal cancers
    Wade S Samowitz
    Mod Pathol 21:1054; author reply 1054-5. 2008
  35. ncbi request reprint An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases
    Angel Ferrandez
    Department of Outreach and Prevention, Huntsman Cancer Institute, Salt Lake City, Utah, USA
    Dis Colon Rectum 49:1781-90. 2006
    ....
  36. ncbi request reprint Hyperplastic-like colon polyps preceding microsatellite-unstable adenocarcinomas
    Wade S Samowitz
    Am J Clin Pathol 120:633; author reply 634. 2003
  37. pmc Confirmation of single exon deletions in MLH1 and MSH2 using quantitative polymerase chain reaction
    Cecily P Vaughn
    ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    J Mol Diagn 10:355-60. 2008
    ..Single exon deletions in MLH1 and MSH2 can be verified using quantitative PCR. Assays using this method are simple to design and easy to perform, making them ideal for confirmatory testing...
  38. ncbi request reprint Missense mismatch repair gene alterations, microsatellite instability, and hereditary nonpolyposis colorectal cancer
    Wade S Samowitz
    J Clin Oncol 20:3178; author reply 3178-9. 2002
  39. pmc Colonic adenoma risk in familial colorectal cancer--a study of six extended kindreds
    Deborah W Neklason
    Huntsman Cancer Institute, Salt Lake City, Utah 84112 5550, USA
    Am J Gastroenterol 103:2577-84. 2008
    ..This issue is clinically relevant since several medical societies currently recommend earlier and more rigorous colorectal screening for individuals with a strong family history of CRC...