Research Topics
| M H SamoreSummaryAffiliation: University of Utah Country: USA Publications
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Publications
Automatic de-identification of textual documents in the electronic health record: a review of recent researchStephane M Meystre
Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah, USA
BMC Med Res Methodol 10:70. 2010..Well aware of these issues, several authors have investigated automated de-identification of narrative text documents from the electronic health record, and a review of recent research in this domain is presented here...- Modeling the variations in pediatric respiratory syncytial virus seasonal epidemicsMolly Leecaster
Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah, USA
BMC Infect Dis 11:105. 2011..Prediction of epidemic characteristics would support management of resources and treatment... - Developing a manually annotated clinical document corpus to identify phenotypic information for inflammatory bowel diseaseBrett R South
VA Salt Lake City Health Care System, IDEAS Center, Salt Lake City, Utah 84148, USA
BMC Bioinformatics 10:S12. 2009..These tasks are time consuming, expensive, and require considerable effort on the part of human reviewers... 
Epidemiology of nosocomial clostridium difficile diarrhoeaM H Samore
University of Utah School of Medicine, Department of Internal Medicine, Salt Lake City, Utah 84132, USA
J Hosp Infect 43:S183-90. 1999..Thus, a consideration of C. difficile in the larger context of the world-wide spread of antibiotic resistance offers useful insights that may help form the basis for the development of more effective control measures...- Clinical decision support and appropriateness of antimicrobial prescribing: a randomized trialMatthew H Samore
VA Salt Lake City Health Care System, USA
JAMA 294:2305-14. 2005..The impact of clinical decision support systems (CDSS) on antimicrobial prescribing in ambulatory settings has not previously been evaluated... - Genotypic and phenotypic analysis of Clostridium difficile correlated with previous antibiotic exposureMatthew H Samore
VA Salt Lake City Health Care System, and Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Microb Drug Resist 12:23-8. 2006..Resistance of specific C. difficile strains to clindamycin and other antimicrobial agents may contribute to their hospital dissemination and explain, in part, the propensity of clindamycin to trigger nosocomial outbreaks... - Mechanisms by which antibiotics promote dissemination of resistant pneumococci in human populationsMatthew H Samore
Division of Clinical Epidemiology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
Am J Epidemiol 163:160-70. 2006..Penicillins accelerate clearance of susceptible strains. The effect of penicillins in increasing resistance is shared equally by treated and untreated members of the population... - A simulation-based evaluation of methods to estimate the impact of an adverse event on hospital length of stayMatthew H Samore
VA Salt Lake City Health Care System, Salt Lake City, Utah, USA
Med Care 45:S108-15. 2007..Conventional analytic methods were compared with inverse probability weighting (IPW)... - High rates of multiple antibiotic resistance in Streptococcus pneumoniae from healthy children living in isolated rural communities: association with cephalosporin use and intrafamilial transmissionM H Samore
Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
Pediatrics 108:856-65. 2001.... - Impact of outpatient antibiotic use on carriage of ampicillin-resistant Escherichia coliMatthew H Samore
Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Antimicrob Agents Chemother 55:1135-41. 2011..coli may promote population spread of resistant E. coli. Examining changes in both resistant and susceptible organisms in antibiotic-treated individuals and their close contacts improves understanding of antibiotic selection pressure... - Rapid identification of hospitalized patients at high risk for MRSA carriageR Scott Evans
Department of Medical Informatics, LDS Hospital, Intermountain Healthcare, Salt Lake City, Utah, USA
J Am Med Inform Assoc 15:506-12. 2008..Previous MRSA colonization was the best predictor but other risk factors were needed to increase the sensitivity of the algorithm... - Drug-resistant Escherichia coli, Rural IdahoElizabeth L Hannah
University of Utah School of Medicine, Salt Lake City, Utah 84132 2901, USA
Emerg Infect Dis 11:1614-7. 2005..coli was associated with recent use of antimicrobial agents in the household. Household clustering of drug-resistant E. coli was observed. Most carriers of drug-resistant E. coli lacked conventional risk factors... - Nutrition and racial differences in cardiovascular events and survival in elderly dialysis patientsDonald Morris
Renal Section, Salt Lake VA Healthcare System; Division of Nephrology and Hypertension, University of Utah School of Medicine, Salt Lake City, Utah, USA
Am J Med 118:671-5. 2005 - Temporal trends of invasive disease due to Streptococcus pneumoniae among children in the intermountain west: emergence of nonvaccine serogroupsCarrie L Byington
Department of Pediatrics, University of Utah, Salt Lake City, UT 84132, USA
Clin Infect Dis 41:21-9. 2005..Use of the heptavalent pneumococcal conjugate vaccine (PCV-7 [Prevnar]) has been associated with decreased a incidence of invasive pneumococcal disease (IPD) among children in the United States... - Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) projectJonathan R Nebeker
Veterans Administration Salt Lake City, Salt Lake City, Utah, USA
J Am Coll Cardiol 47:175-81. 2006..We undertook the review of all available cases of hypersensitivity reactions after placement of a drug-eluting stent (DES) and classified potential causes... - Influenza, Winter Olympiad, 2002Adi V Gundlapalli
University of Utah School of Medicine, Salt Lake City, Utah, USA
Emerg Infect Dis 12:144-6. 2006..Influenza A/B was diagnosed in 36 of 188 patients, including 13 athletes. Prompt management limited the spread of this outbreak... - Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stayGary M Oderda
Pharmacotherapy Outcomes Research Center, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
Ann Pharmacother 41:400-6. 2007..Opioid analgesics remain a mainstay in the treatment of pain associated with surgical procedures. Such use is associated with adverse drug events (ADEs)... - Use of a personal digital assistant for managing antibiotic prescribing for outpatient respiratory tract infections in rural communitiesMichael A Rubin
Department of Internal Medicine, University of Utah School of Medicine, 300 North 1900 East, Room AC 230A, Salt Lake City, UT 84132, USA
J Am Med Inform Assoc 13:627-34. 2006..To assess the acceptability and usage of a standalone personal digital assistant (PDA)-based clinical decision-support system (CDSS) for the diagnosis and management of acute respiratory tract infections (RTIs) in the outpatient setting... - Development of an electronic public health case report using HL7 v2.5 to meet public health needsDeepthi Rajeev
Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
J Am Med Inform Assoc 17:34-41. 2010..The HL7 v2.5 message model is currently being implemented to transmit electronic case reports from Intermountain Healthcare to the Utah Department of Health... - Urgent care providers' knowledge and attitude about public health reporting and pertussis control measures: implications for informaticsCatherine J Staes
Department of Biomedical Informatics, School of Medicine, University of Utah, Salt Lake City, City, Utah 84112, USA
J Public Health Manag Pract 15:471-8. 2009.... - Developing indicators of inpatient adverse drug events through nonlinear analysis using administrative dataJonathan R Nebeker
VA Salt Lake City Geriatrics, Research, Education, and Clinical Center GRECC, Salt Lake City, Utah, USA
Med Care 45:S81-8. 2007..Rules based on nonlinear associations among all types of available administrative data may be more accurate... - Hospital electronic medical record-based public health surveillance system deployed during the 2002 Winter Olympic GamesAdi V Gundlapalli
Hospital Epidemiology Unit, Divisions of Clinical Epidemiology and Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Am J Infect Control 35:163-71. 2007..Several computer biosurveillance systems are in place to detect events of public health (PH) significance; however, most lack access to timely and detailed patient-level data and investigation of alerts places a strain on PH resources... - A multifaceted intervention to improve antimicrobial prescribing for upper respiratory tract infections in a small rural communityMichael A Rubin
Department of Internal Medicine, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA
Clin Infect Dis 40:546-53. 2005..Antibiotic prescribing for upper respiratory tract infections (URTIs) is widespread, is often inappropriate, and may contribute to antibiotic resistance among community-acquired pathogens, such as Streptococcus pneumoniae... - An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associationsCarrie L Byington
Department of Pediatrics, University of Utah, Salt Lake City, UT, 84132, USA
Clin Infect Dis 34:434-40. 2002..0001 for each factor). The increasing incidence of empyema was associated with infection due to S. pneumoniae serotype 1, outpatient treatment with certain antibiotics, ibuprofen use, and varicella... - Risk factors associated with ampicillin-resistant infection in newborns in the era of group B streptococcal prophylaxisAlison C Rentz
Department of Pediatrics, Divisions of Neonatology, University of Utah School of Medicine, Salt Lake City 84132, USA
Arch Pediatr Adolesc Med 158:556-60. 2004.... - Impact of timing of initiation of dialysis on mortalitySrinivasan Beddhu
Renal Section, Salt Lake VA Healthcare System, Division of Nephrology and Hypertension, and Division of Clinical Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
J Am Soc Nephrol 14:2305-12. 2003..Furthermore, these data do not support earlier initiation of dialysis. Therefore, for patients without clinical indications for initiation of dialysis, the appropriate GFR level for initiation of dialysis is unknown... - Creatinine production, nutrition, and glomerular filtration rate estimationSrinivasan Beddhu
Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
J Am Soc Nephrol 14:1000-5. 2003..The fundamental assumption of the MDRD formula is invalid in patients with advanced renal failure, and the use of this formula in these patients might introduce biases... - Malnutrition and atherosclerosis in dialysis patientsSrinivasan Beddhu
Renal Section, Salt Lake VA Healthcare System, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
J Am Soc Nephrol 15:733-42. 2004..Further longitudinal studies are warranted to provide definitive evidence of malnutrition as a uremic risk factor for atherosclerosis... - System-wide surveillance for clinical encounters by patients previously identified with MRSA and VRER Scott Evans
Department of Medical Informatics, LDS Hospital Intermountain Health Care, 8th Avenue and C Street, Salt Lake City, UT 84143, USA
Stud Health Technol Inform 107:212-6. 2004..In addition, the new surveillance system was able to alert infection control personnel when ever these patients visited any IHC inpatient or outpatient facility... 
Dissemination and sustainability of a hospital-wide hand hygiene program emphasizing positive reinforcementJeanmarie Mayer
Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Infect Control Hosp Epidemiol 32:59-66. 2011..To increase and sustain hospital-wide compliance with hand hygiene through a long-term ongoing multidimensional improvement program emphasizing behavioral factors...- Surveillance of medical device-related hazards and adverse events in hospitalized patientsMatthew H Samore
University of Utah School of Medicine, Salt Lake City 84132, USA
JAMA 291:325-34. 2004..Several detection methods had low efficiency in detecting AMDEs. The high rate of AMDEs suggests that AMDEs are an important patient safety issue, but additional research is necessary to identify optimal AMDE detection strategies... - Risk factors for adverse drug events: a 10-year analysisR Scott Evans
Department of Medical Informatics, LDS Hospital and Intermountain Health Care, Salt Lake City, UT 84143 0001, USA
Ann Pharmacother 39:1161-8. 2005..Many adverse drug events (ADEs) are the result of known pharmacologic properties, and some result from medication errors. However, some are the result of patient-specific risk factors... - Molecular analysis of antimicrobial-susceptible and -resistant Escherichia coli from retail meats and human stool and clinical specimens in a rural community settingElizabeth Lyon Hannah
University of Utah School of Medicine, Salt Lake City, USA
Foodborne Pathog Dis 6:285-95. 2009..Foodborne antimicrobial-resistant Escherichia coli may colonize and cause infections in humans, but definitive proof is elusive and supportive evidence is limited... - Cost-effectiveness of adding decolonization to a surveillance strategy of screening and isolation for methicillin-resistant Staphylococcus aureus carriersR E Nelson
VA Salt Lake City Health Care System, George E Whalen Department of Veterans Affairs Medical Center, 500 Foothill Drive, Salt Lake City, UT 84148, USA
Clin Microbiol Infect 16:1740-6. 2010..These results provide a strong economic argument for adding an MRSA decolonization protocol to the current VHA active surveillance strategy... - Detection and prevention of medication errors using real-time bedside nurse chartingNancy C Nelson
Department of Medical Informatics, LDS Hospital, Salt Lake City, UT 84143, USA
J Am Med Inform Assoc 12:390-7. 2005..The aim of this study was to increase the real-time bedside charting behavior of nurses... - Use of strain typing data to estimate bacterial transmission rates in healthcare settingsBrian R Jackson
Department of Medical Informatics, University of Utah, Salt Lake City, Utah, USA
Infect Control Hosp Epidemiol 26:638-45. 2005..A modest level of surveillance sampling substantially improves the estimation accuracy... - Clinical and economic outcomes of conventional amphotericin B-associated nephrotoxicityStephan Harbarth
Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Clin Infect Dis 35:e120-7. 2002..CAB-associated NT was associated with increased mortality, but it did not impact the costs and length of hospital stay... - Shortage of penicillin G: impact on antibiotic prescribing at a US tertiary care centreStephan Harbarth
Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT, USA
Int J Antimicrob Agents 21:484-7. 2003..Shortage-triggered treatment changes had a negative effect on prescribing patterns, which may contribute to antibiotic resistance... - The medical management of central nervous system infections in Uganda and the potential impact of an algorithm-based approach to improve outcomesJoel D Trachtenberg
Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84124, USA
Int J Infect Dis 11:524-30. 2007..This study examines the medical management of CNS infections in Uganda. We also propose a clinical algorithm to manage CNS infections in an effective, systematic, and resource-efficient manner... - Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reportingJonathan R Nebeker
Veterans Affairs Salt Lake City Health Care System and University of Utah School of Medicine, Salt Lake City, Utah, USA
Ann Intern Med 140:795-801. 2004..Examples and rationale for meaningful documentation of adverse drug events are provided, along with an outline of the types of events that should be reported to regulatory agencies... - Recurrent catheter-related bloodstream infections: Risk factors and outcomeAyse Erbay
Division of Clinical Epidemiology, Department of Internal Medicine, University of Utah, School of Medicine, Salt Lake City, Utah, USA
Int J Infect Dis 10:396-400. 2006..The study was undertaken at the University of Utah Hospital and involved patients who had a CR-BSI followed by catheter removal and reinsertion between January 1998 and February 2002... - Antecedent treatment with different antibiotic agents as a risk factor for vancomycin-resistant EnterococcusYehuda Carmeli
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Emerg Infect Dis 8:802-7. 2002..Vancomycin was not a risk factor for isolation of VRE... - Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, Enterococci, and Escherichia coliAnthony D Harris
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, and VA Maryland Health Care System, Baltimore, MD, USA
Clin Infect Dis 34:1558-63. 2002..68). The selection of control patients from the potentially suboptimal control type 1 can falsely identify certain antibiotics and overestimate the OR of the resistance-defining antibiotic... - Antimicrobial use and antimicrobial resistance: a population perspectiveMarc Lipsitch
Department of Epidemiology, Harvard School of Public Health, Boston, Massachussetts 02115, USA
Emerg Infect Dis 8:347-54. 2002..These mechanisms can operate even when treatment has a modest, or even negative, effect on an individual host's colonization with resistant organisms... - Impact of severity of illness bias and control group misclassification bias in case-control studies of antimicrobial-resistant organismsAnthony D Harris
Department of Epidemiology and Preventive Medicine, University of Maryland, College Park, USA
Infect Control Hosp Epidemiol 26:342-5. 2005..If this bias exists, these studies might be expected to report lower odds ratios (ORs) because control-patients would be more like case-patients... - Assessing the status of infection control programs in small rural hospitals in the western United StatesKurt B Stevenson
Qualis Health, Boise, Idaho 83712 7756, USA
Am J Infect Control 32:255-61. 2004..Rural community hospitals, although contributing significantly to the US health care system, have rarely been assessed regarding the nature and quality of their IC programs... - Body mass index and survival in incident dialysis patients: the answer depends on the questionSrinivasan Beddhu
Am J Clin Nutr 81:534-6; author reply 536. 2005 - Experience with a clinical decision support system in community pharmacies to recommend narrow-spectrum antimicrobials, nonantimicrobial prescriptions, and OTC products to decrease broad-spectrum antimicrobial useKarl J Madaras-Kelly
ISU College of Pharmacy, c o Boise VA Medical Center, 500 W Fort St 119A, Boise, ID 83702, USA
J Manag Care Pharm 12:390-7. 2006..Overuse of antibiotics increases the incidence of bacterial resistance and contributes avoidable costs to the health care system... - Evaluation of antibiotic use in a hospital with an antibiotic restriction policyAyse Erbay
Ankara Numune Education and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey
Int J Antimicrob Agents 21:308-12. 2003..001). Irrational antibiotic use was high for unrestricted antibiotics. Additional interventions such as postgraduate training programmes and elaboration of local guidelines could be beneficial... - Understanding keys to successful implementation of electronic decision support in rural hospitals: analysis of a pilot study for antimicrobial prescribingKurt B Stevenson
Qualis Health, Boise, Idaho, USA
Am J Med Qual 20:313-8. 2005..These barriers are discussed to understand keys for successful future implementation of CDSS in rural hospitals, drawing on experience with cultural barriers from other industries, specifically aviation... - The paradox of the "body mass index paradox" in dialysis patients: associations of adiposity with inflammationSrinivasan Beddhu
Am J Clin Nutr 82:909-10; author reply 910-11. 2005 - Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United StatesKeith S Kaye
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Antimicrob Agents Chemother 48:1520-5. 2004.... - The Research on Adverse Drug Events and Reports (RADAR) projectCharles L Bennett
Jesse Brown VA Medical Center Mid West Center for Health Services and Policy Research, Chicago, Ill 60611, USA
JAMA 293:2131-40. 2005.... - Transmission dynamics and control of severe acute respiratory syndromeMarc Lipsitch
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Science 300:1966-70. 2003..Public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic... - Interventional study to evaluate the impact of an alcohol-based hand gel in improving hand hygiene complianceStephan Harbarth
Infection Control Program, Children's Hospital, Boston, MA, USA
Pediatr Infect Dis J 21:489-95. 2002..When appropriately implemented, alcohol-based HH may be effective in improving compliance... - Antimicrobial resistance determinants and future controlStephan Harbarth
University of Geneva Hospitals, Geneva, Switzerland
Emerg Infect Dis 11:794-801. 2005..We describe determinants likely to influence the future epidemiology and health impact of antimicrobial-resistant infections. Understanding these factors will ultimately optimize preventive strategies for an unpredictable future... - Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United StatesAlthea W McCormick
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Nat Med 9:424-30. 2003....
Research Grants
- Rural Trial of Clinic Order Entry with Decision SupportMatthew Samore; Fiscal Year: 2006..The cost impact of the intervention will be measured to allow a comprehensive assessment of the value of this HIT. ..
- Intermountain Center of Excellence for Infection Prevention StrategiesMatthew Samore; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
- Patient-Centered Informatics System to Enhance Health Care in Rural CommunitiesMatthew Samore; Fiscal Year: 2007..Our implementation of an education campaign within a rural public health framework will help extend the benefits to underserved populations and to guide nationwide dissemination efforts. ..