Research Topics
| Sanjiv Sam GambhirSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
AMIDE: a free software tool for multimodality medical image analysisAndreas Markus Loening
Stanford University, Department of Radiology and the Bio-X Program, 318 Campus Drive, East Wing, 1st Floor, Stanford, CA 94305-542, USA
Mol Imaging 2:131-7. 2003..AMIDE runs on UNIX, Macintosh OS X, and Microsoft Windows platforms, and it is freely available with source code under the terms of the GNU General Public License...
Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancerF Berger
Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, California, USA
Breast Cancer Res 3:28-35. 2001..Continued development of new technology, probes and assays should help in the better understanding of basic breast cancer biology and in the improved management of breast cancer patients...- Analytical decision model for the cost-effective management of solitary pulmonary nodulesS S Gambhir
Crump Institute for Biological Imaging, University of California Los Angeles School of Medicine 90095 1770, USA
J Clin Oncol 16:2113-25. 1998..An incremental cost-effectiveness ratio (ICER) was used to compare all strategies to the wait and watch strategy... - A new method to estimate parameters of linear compartmental models using artificial neural networksS S Gambhir
The Crump Institute for Biological Imaging, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1770, USA
Phys Med Biol 43:1659-78. 1998..These results are primarily due to the inability of weighted nonlinear regression to converge. These results establish that artificial neural networks are powerful tools for estimating parameters for simple compartmental models... - Assays for noninvasive imaging of reporter gene expressionS S Gambhir
The Crump Institute for Biological Imaging, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1770, USA
Nucl Med Biol 26:481-90. 1999..Specific examples utilizing adenoviral-mediated delivery of a reporter gene as well as tumors expressing reporter genes are discussed... - A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomographyS S Gambhir
The Crump Institute for Biological Imaging, University of California Department of Energy Laboratory of Structural Biology and Molecular Medicine, University of California School of Medicine, Los Angeles, CA 90095 1770, USA
Proc Natl Acad Sci U S A 97:2785-90. 2000..The use of HSV1-sr39tk as a PET reporter gene and FPCV as a PET reporter probe results in significantly enhanced sensitivity for imaging reporter gene expression in vivo... - Imaging transgene expression with radionuclide imaging technologiesS S Gambhir
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1770, USA
Neoplasia 2:118-38. 2000..We also describe the advantages/disadvantages of each of the assays developed and discuss future animal and human applications... - Economic evaluation studies in nuclear medicine: a methodological review of the literatureS S Gambhir
Crump Institute for Biological Imaging, UCLA School of Medicine 90095 1770, USA
Q J Nucl Med 44:121-37. 2000.... - Molecular imaging of cancer with positron emission tomographySanjiv Sam Gambhir
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 700 Westwood Boulevard, Los Angeles, California 90095 1770, USA
Nat Rev Cancer 2:683-93. 2002..PET should become increasingly important in cancer imaging in the next decade... - Long-term monitoring of transplanted islets using positron emission tomographyYuxin Lu
Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1735, USA
Mol Ther 14:851-6. 2006..These studies suggest that PET imaging of lentivirus-transduced islets could provide a safe and feasible method for long-term monitoring of islet graft survival... - Noninvasive imaging of islet grafts using positron-emission tomographyYuxin Lu
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1735, USA
Proc Natl Acad Sci U S A 103:11294-9. 2006..These studies lay a foundation for noninvasive quantitative assessments of islet graft survival using PET... - Noninvasive imaging of lentiviral-mediated reporter gene expression in living miceAbhijit De
The Crump Institute for Molecular Imaging, Los Angeles, California 90095-1770, USA
Mol Ther 7:681-91. 2003.... - Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetesJing Yong
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA
Diabetes 60:1383-92. 2011..This should enable the noninvasive imaging of β-cells by charge-coupled device (CCD) and micro-positron emission tomography (PET), as well as the identification of β-cells at the cellular level by fluorescent microscopy... - Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapyMakoto Sato
Department of Urology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
Mol Ther 8:726-37. 2003..Based on these findings, we hope to refine the TSTA Ads further to improve the efficacy and safety of prostate cancer gene therapy... - 124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic miceGobalakrishnan Sundaresan
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Nucl Med 44:1962-9. 2003..CONCLUSION: (124)I labeling of engineered antibody fragments provides a promising new class of tumor-specific probes for PET imaging of tumors and metastases... - Bioluminescent monitoring of islet graft survival after transplantationYuxin Lu
Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1735, USA
Mol Ther 9:428-35. 2004..Such imaging technologies may allow earlier detection of graft rejection and the adjustment of therapies to prolong graft survival posttransplantation... - Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancerMakoto Sato
Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Clin Cancer Res 11:3743-9. 2005..Together with the fact that majority of recurrent prostate cancers express AR and PSA, we foresee that the TSTA approach can be a promising gene therapy strategy for the advanced stages of prostate cancer... - Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applicationsTove Olafsen
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095
Protein Eng Des Sel 17:21-7. 2004..This format will provide a versatile platform for targeting a variety of agents to CEA-positive tumors... - Molecular engineering of a two-step transcription amplification (TSTA) system for transgene delivery in prostate cancerLiqun Zhang
Department of Biological Chemistry, University of California, Los Angeles School of Medicine, Los Angeles, California 90095-1737, USA
Mol Ther 5:223-32. 2002..We discuss the implications of this strategy and its application to molecular imaging and therapy... - Positron-emission tomography reporter gene expression imaging in rat myocardiumMasayuki Inubushi
Department of Molecular and Medical Pharmacology, The Crump Institute for Molecular Imaging, University of California, Los Angeles 90095-1735, USA
Circulation 107:326-32. 2003..Cardiac PET reporter gene imaging offers the potential of monitoring the expression of therapeutic genes in cardiac gene therapy... - Positron emission tomography imaging of cardiac reporter gene expression in living ratsJoseph C Wu
Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif 90095-1770, USA
Circulation 106:180-3. 2002..The presence of [18F]-FHBG uptake is confirmed by gamma counting and the presence of HSV1-sr39TK protein by thymidine kinase enzyme assay. Cardiac reporter gene imaging by PET may eventually be applied toward human gene therapy studies... - A potent, imaging adenoviral vector driven by the cancer-selective mucin-1 promoter that targets breast cancer metastasisSteven T Huyn
Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
Clin Cancer Res 15:3126-34. 2009..Improvements in these areas will play a profound role in reducing mortality from breast cancer... - Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene deliveryIan Y Chen
Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif 94305-5427, USA
Circulation 109:1415-20. 2004..CONCLUSIONS: The IRES-based bicistronic adenoviral vector can potentially be used in conjunction with PET for indirect imaging of therapeutic gene expression by replacing 1 of the 2 PET reporter genes with a therapeutic gene of choice... - Noninvasive imaging of enhanced prostate-specific gene expression using a two-step transcriptional amplification-based lentivirus vectorMeera Iyer
The Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Mol Ther 10:545-52. 2004.... - CL1-SR39: A noninvasive molecular imaging model of prostate cancer suicide gene therapy using positron emission tomographyAllan J Pantuck
Department of Urology, Pharmacology and Crump Institute for Molecular Imaging, University of California School of Medicine, Los Angeles, California, USA
J Urol 168:1193-8. 2002.... - Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imagingKaty M Venisnik
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Mol Imaging Biol 9:267-77. 2007..4% ID/g) at 21 hours. Although further optimization of this fusion protein may be needed to improve in vivo performance, the diabody-GLDelta15 is a promising optical imaging probe for tumor detection in vivo... - Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomographyShahriar S Yaghoubi
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095-1770, USA
Cancer Gene Ther 12:329-39. 2005..18F]FHBG and [18F]FDG imaging data indicate that exposure of C6sr39 tumors to GCV causes the elimination of [18F]FHBG-accumulating C6sr39 cells and selects for re-growth of tumors unable to accumulate [18F]FHBG... - Bioluminescence imaging of systemic tumor targeting using a prostate-specific lentiviral vectorMeera Iyer
Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA 90095-1770, USA
Hum Gene Ther 17:125-32. 2006..Noninvasive imaging using such vectors should be useful for monitoring long-term gene expression in gene therapy applications... - Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft modelRomyla Ilagan
Department of Biological Chemistry, School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, CHS 33 142, Los Angeles, California 90095 1737, USA
Mol Cancer Ther 4:1662-9. 2005..The application of imaging technology to study animal models of cancer provides mechanistic insight into antiandrogen targeting of androgen receptor during disease progression... - Small animal imaging center design: the facility at the UCLA Crump Institute for Molecular ImagingDavid B Stout
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Mol Imaging Biol 7:393-402. 2005.... - Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategySunetra Ray
Department of Molecular and Medical Pharmacology, University of California at Los Angeles UCLA School of Medicine, Los Angeles, California, USA
Mol Ther 16:1848-56. 2008..These studies demonstrate the potential of the bidirectional TSTA system to achieve high levels of gene expression from a weak promoter, while preserving specificity and the ability to image expression of the TG noninvasively... - Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imagingTove Olafsen
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California at Los Angeles, 90095, USA
Cancer Res 65:5907-16. 2005..1 +/- 1.5% ID/g). Thus, by manipulating the size and format of anti-p185(HER2) antibody fragments, the kidney activity was reduced and high or low expression of p185HER2 in xenografts could be distinguished by microPET imaging... - Molecular imaging of the kinetics of vascular endothelial growth factor gene expression in ischemic myocardiumJoseph C Wu
Department of Molecular and Medical Pharmacology, the Crump Institute of Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif, USA
Circulation 110:685-91. 2004..The principles demonstrated here can be used to evaluate other therapeutic genes of interest in animal models before future clinical trials are initiated... - Noninvasive imaging of ex vivo intracoronarily delivered nonviral therapeutic transgene expression in heartLuyi Sen
Division of Cardiothoracic Surgery, Department of Surgery, UCLA Medical Center, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Mol Ther 12:49-57. 2005..Our results demonstrate for the first time that PET reporter-therapeutic linked gene imaging is applicable for noninvasively monitoring ex vivo intracoronarily delivered therapeutic transgene expression in the whole heart... - A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PETLeeta Alison Green
The Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Nucl Med 45:1560-70. 2004..The model parameter k3 from the 3-compartment model can be used as a noninvasive estimate for HSV1-sr39TK reporter protein activity and can predict the relative percentage of metabolites... - Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefitsDaniel H S Silverman
Department of Molecular and Medical Pharmacology and Ahmanson Biological Imaging Center, UCLA School of Medicine, University of California, Los Angeles 90095 6942, USA
J Nucl Med 43:253-66. 2002..The precise diagnostic role of PET and its economic impact in this context, however, have not been systematically examined previously... - Synthesis of a new heterobifunctional linker, N-[4-(aminooxy)butyl]maleimide, for facile access to a thiol-reactive 18F-labeling agentTatsushi Toyokuni
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1770, USA
Bioconjug Chem 14:1253-9. 2003.... - Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variantsAllan J Pantuck
Department of Urology, School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Hum Gene Ther 13:777-89. 2002..Both in vitro and in vivo studies suggest improved killing with the sr39tk variant. Thus, the results suggest that the use of sr39tk in future trials of prostate cancer tk suicide gene therapy may be beneficial... - MicroPET imaging of prostate cancer in LNCAP-SR39TK-GFP mouse xenograftsHonghao Yang
Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
Prostate 55:39-47. 2003..Extension of this approach may allow repetitive imaging of tumor metastases... - Ex vivo cell labeling with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomographyNona Adonai
The Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, CA 90095-1770, USA
Proc Natl Acad Sci U S A 99:3030-5. 2002..Given the longer t(1/2) of 64Cu (12.7 h) relative to 18F (110 min), longer cell-tracking periods (up to 24-36 h) should be possible now with PET... - Imaging tri-fusion multimodality reporter gene expression in living subjectsPritha Ray
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
Cancer Res 64:1323-30. 2004..Imaging of reporter gene expression from single cells to living animals with the help of a single tri-fusion reporter gene will have the potential to accelerate translational cancer research... - Bifunctional antibody-Renilla luciferase fusion protein for in vivo optical detection of tumorsKaty M Venisnik
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Protein Eng Des Sel 19:453-60. 2006.... - Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter geneYoung J Kim
Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Mol Imaging Biol 6:331-40. 2004..CONCLUSION: The multimodal imaging strategy coupled with lentiviral reporter construct delivery demonstrated here can facilitate future molecular imaging studies... - Optical imaging of cardiac reporter gene expression in living ratsJoseph C Wu
Crump Institute for Molecular Imaging and Department of Medicine, Division of Cardiology, UCLA School of Medicine, Los Angeles, Calif, USA
Circulation 105:1631-4. 2002..Cardiac gene therapy studies could be aided with wider application of this approach... - Interrogating androgen receptor function in recurrent prostate cancerLiqun Zhang
Departments of Biological Chemistry, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
Cancer Res 63:4552-60. 2003..Our data support the concept that AR is fully functional in recurrent cancer and suggest a model by which a poised but largely inactive transcription complex facilitates reactivation by AR at castrate levels of ligand... - Applications of molecular imaging in cancer gene therapyMeera Iyer
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles 90095, USA
Curr Gene Ther 5:607-18. 2005..Coupling PET to gene therapy of cancer has already been implemented in several clinical studies. This approach would help to improve the efficacy and safety of future gene therapy clinical trials... - Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfectionJung-Jun Min
The Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095-1770, USA
Eur J Nucl Med Mol Imaging 30:1547-60. 2003..g., thymidine) when cells are infected with adenovirus. For adenoviral studies, the [(18)F]FHBG/ HSV1-sr39tk combination was shown to be more sensitive than the [(14)C]FIAU/ HSV1-tk combination HSV1-tk... - Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomographyJoseph C Wu
Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, Calif, USA
Circulation 108:1302-5. 2003..With further development, molecular imaging studies should add critical insights into cardiac cell transplantation biology... - Whole-body skeletal imaging in mice utilizing microPET: optimization of reproducibility and applications in animal models of bone diseaseFrank Berger
The Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology University of California School of Medicine, 700 Westwood Blvd, Los Angeles, CA 90095, USA
Eur J Nucl Med Mol Imaging 29:1225-36. 2002..Morphological imaging with microCAT is useful to display correlative changes in anatomy. Detailed in vivo studies of the murine skeleton in various small animal models of bone diseases should now be possible... - Molecular imaging of homodimeric protein-protein interactions in living subjectsTarik F Massoud
The Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
FASEB J 18:1105-7. 2004.... - Imaging mitogen-activated protein kinase function in xenograft models of prostate cancerRomyla Ilagan
Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Cancer Res 66:10778-85. 2006..We conclude that a gene expression-based optical imaging system can accurately detect and quantify MAPK activity in live animals... - Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bicistronic vectorsYanling Wang
The Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Nucl Med 46:667-74. 2005..CONCLUSION: These findings support the use of SIRES bicistronic vectors for a better assessment of therapeutic gene expression based on reporter gene expression in living subjects... - Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living micePritha Ray
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Gefen School of Medicine, University of California, Los Angeles, California 90095, USA
Cancer Res 63:1160-5. 2003..Using a single fusion reporter (PET/optical) gene should accelerate the validation of reporter gene approaches developed in cell culture for translation into preclinical and clinical models... 
A generalizable strategy for imaging pre-mRNA levels in living subjects using spliceosome-mediated RNA trans-splicingZachary F Walls
Department of Molecular and Medical Pharmacology, Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Nucl Med 49:1146-54. 2008..Presented here is a class of generalizable probes that can image pre-mRNA in a sequence-specific manner, using signal amplification and a facile method of delivery...- Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirusQianwa Liang
The Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, California 90095, USA
Mol Ther 6:73-82. 2002.... - Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light outputAndreas Markus Loening
The Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Protein Eng Des Sel 19:391-400. 2006.... - Quantitation of cell number by a positron emission tomography reporter gene strategyHelen Su
Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Mol Imaging Biol 6:139-48. 2004..CONCLUSION: These methods and findings provide a strategy for quantitation of cellularity using PET imaging that has implications for both experimental models and clinical diagnosis... - Monitoring the antitumor response of naive and memory CD8 T cells in RAG1-/- mice by positron-emission tomographyHelen Su
Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
J Immunol 176:4459-67. 2006..Positron-emission tomography-based immunologic imaging is a noninvasive modality providing unique and meaningful information on the dynamics of the antitumor CTL response... - Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expressionSunetra Ray
Crump Institute for Molecular Imaging, and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Hum Gene Ther 15:681-90. 2004..This validated approach should prove useful for the development of novel gene therapy vectors, as well as for transgenic models, allowing noninvasive imaging for indirect monitoring and amplification of target gene expression... - Molecular imaging in living subjects: seeing fundamental biological processes in a new lightTarik F Massoud
The Crump Institute for Molecular Imaging, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA
Genes Dev 17:545-80. 2003 - Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumorsDezheng Dong
Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA
Hum Gene Ther 15:553-61. 2004..Thus, transcriptional control through the use of the Grp78 promoter offers multiple novel approaches for human cancer gene therapy... - Visualization of a primary anti-tumor immune response by positron emission tomographyChengyi J Shu
Department of Microbiology, Immunology, and Molecular Genetics, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 102:17412-7. 2005..The method we describe can be used to kinetically measure the induction and therapeutic modulations of cell-mediated immune responses... - 18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterizationHossein Jadvar
Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Nucl Med 50:1820-7. 2009.... - BRET-based method for detection of specific RNA speciesZachary F Walls
Department of Molecular and Medical Pharmacology, Geffen School of Medicine at UCLA, Los Angeles, California, USA
Bioconjug Chem 19:178-84. 2008..11 x 10 (-6), ANOVA, multiple range test). This assay represents a possibility for a less technically demanding, streamlined alternative to canonical RNA assays... - Gene expression tomographyVanessa M Brown
Department of Molecular and Medical Pharmacology, University of California, Los Angeles 90095, USA
Physiol Genomics 8:159-67. 2002..A Monte-Carlo analysis confirmed the good quality of the GET image reconstruction. By speeding acquisition of gene expression patterns, GET may help improve our understanding of the genomics of the brain in both health and disease... - Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogeneLu Q Le
Department of Microbiology, Immunology, and Molecular Genetics, Los Angeles, CA 90095, USA
Cancer Cell 1:381-91. 2002..PET can be successfully applied to the temporal and spatial analysis of Bcr-Abl driven leukemic progression and should have utility for the study of other leukemias and lymphomas... - Noninvasive indirect imaging of vascular endothelial growth factor gene expression using bioluminescence imaging in living transgenic miceYanling Wang
The Crump Institute for Molecular Imaging, Los Angeles, California, USA
Physiol Genomics 24:173-80. 2006.... - The impact of PET on the management of lung cancer: the referring physician's perspectiveMarc A Seltzer
Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic/Nuclear Medicine, UCLA School of Medicine, Los Angeles, California 90095-6948, USA
J Nucl Med 43:752-6. 2002..CONCLUSION: This survey-based study of referring physicians suggests that PET has a major impact on staging and management of lung cancer... - Molecular imaging applications for immunologyIsabel Junie Hildebrandt
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Clin Immunol 111:210-24. 2004..In this paper, we will review the current field of molecular imaging assays (especially those utilizing PET and BIm modalities) and examine how they might impact animal models and human disease in the field of clinical immunology... - Perspectives of molecular imaging and radioimmunotherapy in lymphomaAndrei Iagaru
Department of Radiology, Division of Nuclear Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room H 0101, Stanford, CA 94305 5427, USA
Radiol Clin North Am 46:243-52, viii. 2008..Finally, we discuss advances in molecular imaging that may herald the next generation of PET radiotracers after 18F FDG... - Image-guided cardiac cell delivery using high-resolution small-animal ultrasoundMartin Rodriguez-Porcel
Department of Internal Medicine, Divisions of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Mol Ther 12:1142-7. 2005..We are confident that the use of these technologies will play a significant role in the future of gene and cell therapy... - Molecualr imaging of cancer: from molecules to humans. IntroductionSanjiv Sam Gambhir
Department of Radiology, Stanford University School of Medicine, Stanford, California 94305-5427, USA
J Nucl Med 49:1S-4S. 2008 - Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold moleculesZhen Cheng
Molecular Imaging Program at Stanford, Department of Radiology, Bio X Program, Stanford University, Stanford, California 94305, USA
J Nucl Med 49:804-13. 2008.... - Reporter gene imaging following percutaneous delivery in swine moving toward clinical applicationsMartin Rodriguez-Porcel
J Am Coll Cardiol 51:595-7. 2008 - Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: image-based estimation of the number of cells accumulating in mouse pawsShahriar S Yaghoubi
Stanford University, Department of Radiology, Bio X, Molecular Imaging Program, Stanford, California 94305 5427, USA
J Biomed Opt 12:064025. 2007..The procedures described in this study can be used to derive equations for cells expressing other bioluminescent RGs and in other animal models... - Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living miceZhen Cheng
Molecular Imaging Program at Stanford (MIPS, Department of Radiology, Stanford University, Stanford, California, 94305-5344, USA
Bioconjug Chem 17:662-9. 2006..To develop NIR glucose analogues with the ability to target GLUTs/hexokinase, it is highly important to select NIR dyes with a reasonable molecular size... - 123I MIBG mapping with intraoperative gamma probe for recurrent neuroblastomaAndrei Iagaru
Department of Radiology, Division of Nuclear Medicine, Stanford University Medical Center, Stanford, CA 94305 5427, USA
Mol Imaging Biol 10:19-23. 2008..Intraoperative gamma probe mapping of the liver identified areas with signal above the background, but these were prove to be hemosiderin deposits on histo-pathology examination... - Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxiaIvana Cecic
Department of Radiation Oncology and Molecular Imaging Program, Stanford, Stanford University School of Medicine, Stanford, CA 94305 5847, USA
Mol Imaging 6:219-28. 2007..These results demonstrate that combining beta-galactosidase with the DDAOG optical probe may be a robust reporter system for the in vivo study of tumor hypoxia... - Positron emission tomography in diagnosis and management of invasive breast cancer: current status and future perspectivesDafang Wu
Department of Radiology, Wayne State University, PET Center, Children's Hospital of Michigan, Detroit, MI, USA
Clin Breast Cancer 4:S55-63. 2003..role of FDG-PET in breast cancer is increasing and evolving, and this metabolic imaging modality, in conjunction with newer tracers and other anatomic imaging methods, should improve diagnosis and management of patients with breast cancer.. - Standardized uptake value atlas: characterization of physiological 2-deoxy-2-[18F]fluoro-D-glucose uptake in normal tissuesYingbing Wang
Molecular Imaging Program at Stanford MIPS, Department of Radiology, Division of Nuclear Medicine, Stanford University, Stanford, CA 94305 5427, USA
Mol Imaging Biol 9:83-90. 2007..The purpose of this study was to map the distribution of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake in organs of patients with no known abnormalities in those tissues... - Molecular imaging can accelerate anti-angiogenic drug development and testingAndrei Iagaru
Stanford University School of Medicine, Stanford, CA, USA
Nat Clin Pract Oncol 4:556-7. 2007