Ashok Saluja

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization
    Sulagna Banerjee
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43020. 2012
  2. pmc miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death
    Zhiyu Chen
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cancer 12:105. 2013
  3. pmc Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation
    Tiffany N Mackenzie
    Department of Pharmacology, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cancer Ther 12:1266-75. 2013
  4. doi request reprint Heat shock proteins in pancreatic diseases
    Ashok Saluja
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    J Gastroenterol Hepatol 23:S42-5. 2008
  5. ncbi request reprint Why does pancreatic overstimulation cause pancreatitis?
    Ashok K Saluja
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Physiol 69:249-69. 2007
  6. pmc Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo
    Ilona Rousalova
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 8:e77411. 2013
  7. pmc Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma
    Kimberly A Clawson
    Department of Surgery, Division of Basic and Translational Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Surg Res 163:244-9. 2010
  8. pmc TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells
    Daniel Borja-Cacho
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Gastrointest Surg 14:252-60. 2010
  9. pmc Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways
    Nameeta Mujumdar
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    Gastroenterology 139:598-608. 2010
  10. ncbi request reprint A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies
    Kaustav Majumder
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, MN, 55455, USA
    J Gastrointest Surg . 2015

Research Grants

Collaborators

Detail Information

Publications31

  1. pmc MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization
    Sulagna Banerjee
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e43020. 2012
    ..The cytosolic end of MUC1 (MUC1-c) is extensively involved in a number of signaling pathways. MUC1-c is reported to inhibit apoptosis in a number of cancer cells, but the mechanism of inhibition is unclear...
  2. pmc miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death
    Zhiyu Chen
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cancer 12:105. 2013
    ..Cancer cell survival is dependent upon up-regulation of the pro-survival response, mediated by anti-apoptotic proteins such as Mcl-1...
  3. pmc Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation
    Tiffany N Mackenzie
    Department of Pharmacology, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cancer Ther 12:1266-75. 2013
    ..This is the first description of an miRNA-mediated mechanism of HSP70 regulation in cancer, making miR-142-3p an attractive target for PDAC therapeutic intervention...
  4. doi request reprint Heat shock proteins in pancreatic diseases
    Ashok Saluja
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    J Gastroenterol Hepatol 23:S42-5. 2008
    ..Moreover, triptolide is highly efficacious in reducing growth as well as locoregional spread of pancreatic tumors in an orthotopic model of pancreatic cancer and has tremendous potential as a novel therapeutic agent...
  5. ncbi request reprint Why does pancreatic overstimulation cause pancreatitis?
    Ashok K Saluja
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Physiol 69:249-69. 2007
    ....
  6. pmc Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo
    Ilona Rousalova
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 8:e77411. 2013
    ..Minnelide, a pro-drug of triptolide, has recently emerged as a potent anticancer agent. The precise mechanisms of its cytotoxic effects remain unclear...
  7. pmc Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma
    Kimberly A Clawson
    Department of Surgery, Division of Basic and Translational Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Surg Res 163:244-9. 2010
    ..The principal objective of this study was to determine the effects of combination therapy with TRAIL and triptolide in cholangiocarcinoma...
  8. pmc TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells
    Daniel Borja-Cacho
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Gastrointest Surg 14:252-60. 2010
    ..The aim of this study was to evaluate the effects that combined therapy with TRAIL and triptolide have on different parameters of apoptosis...
  9. pmc Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways
    Nameeta Mujumdar
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    Gastroenterology 139:598-608. 2010
    ..We previously showed that triptolide inhibits the growth of pancreatic cancer cells in vitro and prevents tumor growth in vivo. This study investigates the mechanism by which triptolide kills pancreatic cancer cells...
  10. ncbi request reprint A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies
    Kaustav Majumder
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, MN, 55455, USA
    J Gastrointest Surg . 2015
    ..This novel model demonstrates a consistent growth rate and tumor-associated mortality and recapitulates the tumor microenvironment. This convenient model is a valuable tool to evaluate novel therapies...
  11. doi request reprint Sorafenib and triptolide as combination therapy for hepatocellular carcinoma
    Osama A Alsaied
    Division of General Surgery, University of Minnesota, Minneapolis, MN
    Surgery 156:270-9. 2014
    ..Triptolide, a diterpene triepoxide, exhibits antineoplastic properties in multiple tumor cell types. In this study, we examined the effects of these agents and their combination on HCC in vitro and in vivo models...
  12. pmc CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to Minnelide
    Sulagna Banerjee
    Authors Affiliations Division of Basic and Translational Research, Department of Surgery and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Clin Cancer Res 20:2388-99. 2014
    ..These cells are considered as hurdles to cancer therapy as no known chemotherapeutic compound is reported to target them. Thus, there is an urgent need to develop a TIC-targeted therapy for pancreatic cancer...
  13. ncbi request reprint Inflammation and pain in pancreatic disorders: summary of the symposium sponsored by the American Pancreatic Association and the National Pancreas Foundation (Chicago, November 4-5, 2005)
    Ashok Saluja
    University of Massachusetts Medical School, Department of Surgery, Worcester, MA 01605, USA
    Pancreas 33:184-91. 2006
  14. ncbi request reprint Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma
    Ali Aghdassi
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 67:616-25. 2007
    ..These findings indicate that Hsp70 plays an important role in apoptosis and that selective Hsp70 knockdown can be used to induce apoptosis in pancreatic cancer cells...
  15. ncbi request reprint Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70
    Phoebe A Phillips
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55488, USA
    Cancer Res 67:9407-16. 2007
    ..Triptolide is a potential therapeutic agent that can be used to prevent the progression and metastases of pancreatic cancer...
  16. pmc Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms
    Vikas Dudeja
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Gastroenterology 136:1772-82. 2009
    ..We aimed to elucidate the mechanism by which HSP70 inhibits apoptosis in cancer cells...
  17. doi request reprint Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo
    Mara B Antonoff
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Surgery 146:282-90. 2009
    ..Our objectives were to assess the effectiveness of triptolide, an Hsp-70 inhibitor, in treating neuroblastoma in vitro and in vivo, and to measure the associated effects on Hsp-70 levels and apoptosis markers...
  18. pmc Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma
    Mara B Antonoff
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Surg Res 163:72-8. 2010
    ..The principal objective of this study was to investigate the role of Hsp-70 in triptolide-mediated cell death in neuroblastoma...
  19. ncbi request reprint Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation
    Lakshmi Bhagat
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cell Physiol 215:37-46. 2008
    ..Thus, non-thermal pharmacologically induced stress can help prevent or treat pancreatitis...
  20. ncbi request reprint Pathophysiology of alcohol-induced pancreatic injury
    Ashok K Saluja
    Department of Surgery, Medicine and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Pancreas 27:327-31. 2003
    ..These observations lead us to speculate that repeated CCK-mediated, ethanol-induced stimulation of pancreatic digestive enzyme secretion may play a role in the events that link ethanol abuse to the development of pancreatic injury...
  21. pmc Molecular mechanisms of pancreatic injury
    Raghuwansh P Sah
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Opin Gastroenterol 27:444-51. 2011
    ..Despite being a subject of much scientific scrutiny, the pathogenesis of acute pancreatitis is still not well understood. This article reviews recent advances in our understanding of acute pancreatitis...
  22. doi request reprint An improved method for extracting myeloperoxidase and determining its activity in the pancreas and lungs during pancreatitis
    Rajinder Dawra
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Pancreas 37:62-8. 2008
    ....
  23. ncbi request reprint In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury
    Jean Louis Frossard
    Department of Surgery, Beth Israel Hospital Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 283:L541-8. 2002
    ..Our findings indicate that GM-CSF plays a critical role in coupling pancreatitis to ALI and suggest that GM-CSF may act indirectly by regulating the release of other proinflammatory factors including MIP-2...
  24. ncbi request reprint Development of a new mouse model of acute pancreatitis induced by administration of L-arginine
    Rajinder Dawra
    Department of Surgery, University of Minnesota, MMC 195, 420 Delaware St SE, Minneapolis, MN 55416, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1009-18. 2007
    ..Our results indicate that administration of L-arginine to mice results in severe acute pancreatitis. This model should help in elucidating the pathophysiology of pancreatitis...
  25. pmc Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors
    Vikas Dudeja
    Department of Surgery, University of Minnesota, Minneapolis, USA
    Am J Physiol Gastrointest Liver Physiol 300:G948-55. 2011
    ..HSF1 plays a prosurvival role in the pathogenesis of pancreatobiliary tumors. Modulation of HSF1 activity could therefore emerge as a novel therapeutic strategy for cancer treatment...
  26. ncbi request reprint Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity
    Gijs J D Van Acker
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Gastrointest Liver Physiol 283:G794-800. 2002
    ..Our findings also suggest that pharmacological interventions that inhibit cathepsin B may prove useful in preventing acute pancreatitis or reducing its severity...
  27. ncbi request reprint Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury
    Albert M Song
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1166-74. 2002
    ..Our findings support the concept that COX-2 inhibitors may play a beneficial role in the prevention of acute pancreatitis or in the reduction of its severity...
  28. ncbi request reprint Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats
    Lakshmi Bhagat
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 122:156-65. 2002
    ....
  29. pmc Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion
    Vijay P Singh
    Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
    Gut 56:958-64. 2007
    ..However, the mechanism by which it protects against pancreatitis still remains to be elucidated. Acute pancreatitis is associated with premature zymogen activation and a blockage in digestive enzyme secretion...
  30. ncbi request reprint Acute pancreatitis: bench to the bedside
    Stephen J Pandol
    Department of Medicine, Department of Veterans Affairs and University of California, Los Angeles, California, USA
    Gastroenterology 132:1127-51. 2007
  31. ncbi request reprint Pancreatitis and associated lung injury: when MIF miffs
    Ashok K Saluja
    Gastroenterology 124:844-7. 2003

Research Grants1

  1. Pathophysiology of Arginine-induced Pancreatitis in Mice
    Ashok Saluja; Fiscal Year: 2006
    ..Successful completion of these studies will provide an excellent model of pancreatitis for future studies dealing with therapeutic interventions. ..