Research Topics
| Ashok SalujaSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Heat shock proteins in pancreatic diseasesAshok Saluja
Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
J Gastroenterol Hepatol 23:S42-5. 2008..Moreover, triptolide is highly efficacious in reducing growth as well as locoregional spread of pancreatic tumors in an orthotopic model of pancreatic cancer and has tremendous potential as a novel therapeutic agent...
Why does pancreatic overstimulation cause pancreatitis?Ashok K Saluja
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
Annu Rev Physiol 69:249-69. 2007....
Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinomaKimberly A Clawson
Department of Surgery, Division of Basic and Translational Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Surg Res 163:244-9. 2010..The principal objective of this study was to determine the effects of combination therapy with TRAIL and triptolide in cholangiocarcinoma...- Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathwaysNameeta Mujumdar
Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Gastroenterology 139:598-608. 2010..We previously showed that triptolide inhibits the growth of pancreatic cancer cells in vitro and prevents tumor growth in vivo. This study investigates the mechanism by which triptolide kills pancreatic cancer cells... - TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cellsDaniel Borja-Cacho
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
J Gastrointest Surg 14:252-60. 2010..The aim of this study was to evaluate the effects that combined therapy with TRAIL and triptolide have on different parameters of apoptosis... - Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinomaAli Aghdassi
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer Res 67:616-25. 2007..These findings indicate that Hsp70 plays an important role in apoptosis and that selective Hsp70 knockdown can be used to induce apoptosis in pancreatic cancer cells... - Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivoMara B Antonoff
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
Surgery 146:282-90. 2009..Our objectives were to assess the effectiveness of triptolide, an Hsp-70 inhibitor, in treating neuroblastoma in vitro and in vivo, and to measure the associated effects on Hsp-70 levels and apoptosis markers... - Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70Phoebe A Phillips
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55488, USA
Cancer Res 67:9407-16. 2007..Triptolide is a potential therapeutic agent that can be used to prevent the progression and metastases of pancreatic cancer... - Role of Hsp-70 in triptolide-mediated cell death of neuroblastomaMara B Antonoff
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Surg Res 163:72-8. 2010..The principal objective of this study was to investigate the role of Hsp-70 in triptolide-mediated cell death in neuroblastoma... - Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanismsVikas Dudeja
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
Gastroenterology 136:1772-82. 2009..We aimed to elucidate the mechanism by which HSP70 inhibits apoptosis in cancer cells... - Inflammation and pain in pancreatic disorders: summary of the symposium sponsored by the American Pancreatic Association and the National Pancreas Foundation (Chicago, November 4-5, 2005)Ashok Saluja
University of Massachusetts Medical School, Department of Surgery, Worcester, MA 01605, USA
Pancreas 33:184-91. 2006 - Pathophysiology of alcohol-induced pancreatic injuryAshok K Saluja
Department of Surgery, Medicine and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Pancreas 27:327-31. 2003..These observations lead us to speculate that repeated CCK-mediated, ethanol-induced stimulation of pancreatic digestive enzyme secretion may play a role in the events that link ethanol abuse to the development of pancreatic injury... - Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activationLakshmi Bhagat
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Cell Physiol 215:37-46. 2008..Thus, non-thermal pharmacologically induced stress can help prevent or treat pancreatitis... - Molecular mechanisms of pancreatic injuryRaghuwansh P Sah
Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
Curr Opin Gastroenterol 27:444-51. 2011..Despite being a subject of much scientific scrutiny, the pathogenesis of acute pancreatitis is still not well understood. This article reviews recent advances in our understanding of acute pancreatitis... - An improved method for extracting myeloperoxidase and determining its activity in the pancreas and lungs during pancreatitisRajinder Dawra
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
Pancreas 37:62-8. 2008.... - Development of a new mouse model of acute pancreatitis induced by administration of L-arginineRajinder Dawra
Department of Surgery, University of Minnesota, MMC 195, 420 Delaware St SE, Minneapolis, MN 55416, USA
Am J Physiol Gastrointest Liver Physiol 292:G1009-18. 2007..Our results indicate that administration of L-arginine to mice results in severe acute pancreatitis. This model should help in elucidating the pathophysiology of pancreatitis... - In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injuryJean Louis Frossard
Department of Surgery, Beth Israel Hospital Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Lung Cell Mol Physiol 283:L541-8. 2002..Our findings indicate that GM-CSF plays a critical role in coupling pancreatitis to ALI and suggest that GM-CSF may act indirectly by regulating the release of other proinflammatory factors including MIP-2... - Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumorsVikas Dudeja
Department of Surgery, University of Minnesota, Minneapolis, USA
Am J Physiol Gastrointest Liver Physiol 300:G948-55. 2011..HSF1 plays a prosurvival role in the pathogenesis of pancreatobiliary tumors. Modulation of HSF1 activity could therefore emerge as a novel therapeutic strategy for cancer treatment... - Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severityGijs J D Van Acker
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Physiol Gastrointest Liver Physiol 283:G794-800. 2002..Our findings also suggest that pharmacological interventions that inhibit cathepsin B may prove useful in preventing acute pancreatitis or reducing its severity... - Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injuryAlbert M Song
Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Physiol Gastrointest Liver Physiol 283:G1166-74. 2002..Our findings support the concept that COX-2 inhibitors may play a beneficial role in the prevention of acute pancreatitis or in the reduction of its severity... - Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in ratsLakshmi Bhagat
Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
Gastroenterology 122:156-65. 2002..The worsening of pancreatitis, which occurs when non-thermally stressed animals are given AS-HSP70 before cerulein, suggests that cerulein-induced HSP70 expression in nontreated animals acts to limit the severity of pancreatitis... - Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretionVijay P Singh
Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
Gut 56:958-64. 2007..However, the mechanism by which it protects against pancreatitis still remains to be elucidated. Acute pancreatitis is associated with premature zymogen activation and a blockage in digestive enzyme secretion... - Acute pancreatitis: bench to the bedsideStephen J Pandol
Department of Medicine, Department of Veterans Affairs and University of California, Los Angeles, California, USA
Gastroenterology 132:1127-51. 2007 - Pancreatitis and associated lung injury: when MIF miffsAshok K Saluja
Gastroenterology 124:844-7. 2003
Research Grants
- The Inhibition of HSP70 Induces Apoptosis in Pancreatic Cancer CellsAshok K Saluja; Fiscal Year: 2010..Understanding the mechanisms by which pancreatic cancer evades apoptosis will help to identify and eventually design novel therapies with which to treat this deadly disease. ..
- HEAT SHOCK PROTEINS AND PANCREATITISAshok K Saluja; Fiscal Year: 2010..Once completed, the data generated from the proposed studies will lead to specific therapies against pancreatitis. ..
- HEAT SHOCK PROTEINS AND PANCREATITISAshok Saluja; Fiscal Year: 2009..Once completed, the data generated from the proposed studies will lead to specific therapies against pancreatitis. ..
- The Inhibition of HSP70 Induces Apoptosis in Pancreatic Cancer CellsAshok Saluja; Fiscal Year: 2009..Understanding the mechanisms by which pancreatic cancer evades apoptosis will help to identify and eventually design novel therapies with which to treat this deadly disease. ..
- The Inhibition of HSP70 Induces Apoptosis in Pancreatic Cancer CellsAshok Saluja; Fiscal Year: 2007..Understanding the mechanisms by which pancreatic cancer evades apoptosis will help to identify and eventually design novel therapies with which to treat this deadly disease. ..
- HEAT SHOCK PROTEINS AND PANCREATITISAshok Saluja; Fiscal Year: 2005..Successful completion of these studies will eventually help us in planning strategies to pharmacologically manipulate the levels of HSPs, so that their induction can be used as a tool to decrease the severity of clinical pancreatitis. ..
- Pathophysiology of Arginine-induced Pancreatitis in MiceAshok Saluja; Fiscal Year: 2006..Successful completion of these studies will provide an excellent model of pancreatitis for future studies dealing with therapeutic interventions. ..
- HEAT SHOCK PROTEINS AND PANCREATITISAshok K Saluja; Fiscal Year: 2010..Once completed, the data generated from the proposed studies will lead to specific therapies against pancreatitis. ..