D P Salmon

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly
    David P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0948, USA
    Neuropsychology 27:391-401. 2013
  2. doi request reprint Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease
    David P Salmon
    Department of Neurosciences 0948, University of California, 9500 Gilman Drive, La Jolla, CA, 92093 0948, USA
    Curr Top Behav Neurosci 10:187-212. 2012
  3. ncbi request reprint ADCS Prevention Instrument Project: development of a brief verbal memory test for primary prevention clinical trials
    David P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0948, USA
    Alzheimer Dis Assoc Disord 20:S139-46. 2006
  4. ncbi request reprint Alzheimer's disease can be accurately diagnosed in very mildly impaired individuals
    D P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    Neurology 59:1022-8. 2002
  5. pmc Neuropsychological assessment of dementia
    David P Salmon
    Department of Neurosciences, University of California, San Diego, California 92093, USA
    Annu Rev Psychol 60:257-82. 2009
  6. ncbi request reprint Cognitive screening and neuropsychological assessment in early Alzheimer's disease
    D P Salmon
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Clin Geriatr Med 17:229-54. 2001
  7. ncbi request reprint Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer's disease: implications for the integrity of semantic memory
    D P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0948, USA
    J Int Neuropsychol Soc 5:692-703. 1999
  8. pmc Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia
    J M Olichney
    Department of Neurology, University of California, Davis, CA, USA
    Neurology 70:1763-70. 2008
  9. ncbi request reprint Regional cerebral volume loss associated with verbal learning and memory in dementia of the Alzheimer type
    J C Stout
    Department of Psychiatry, University of California, San Diego, and Veterans Affairs Medical Center, USA
    Neuropsychology 13:188-97. 1999
  10. pmc Spatial and object working memory deficits in Parkinson's disease are due to impairment in different underlying processes
    Katherine L Possin
    University of California, San Diego, CA, USA
    Neuropsychology 22:585-95. 2008

Detail Information

Publications89

  1. pmc Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly
    David P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0948, USA
    Neuropsychology 27:391-401. 2013
    ....
  2. doi request reprint Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease
    David P Salmon
    Department of Neurosciences 0948, University of California, 9500 Gilman Drive, La Jolla, CA, 92093 0948, USA
    Curr Top Behav Neurosci 10:187-212. 2012
    ..The pattern and progression of these neuropsychological changes fit well with the proposed distribution and spread of AD pathology and serve as important cognitive markers of early disease...
  3. ncbi request reprint ADCS Prevention Instrument Project: development of a brief verbal memory test for primary prevention clinical trials
    David P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0948, USA
    Alzheimer Dis Assoc Disord 20:S139-46. 2006
    ....
  4. ncbi request reprint Alzheimer's disease can be accurately diagnosed in very mildly impaired individuals
    D P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    Neurology 59:1022-8. 2002
    ..Unfortunately, there is little systematically acquired information about the accuracy of the AD diagnosis in very mildly impaired patients...
  5. pmc Neuropsychological assessment of dementia
    David P Salmon
    Department of Neurosciences, University of California, San Diego, California 92093, USA
    Annu Rev Psychol 60:257-82. 2009
    ....
  6. ncbi request reprint Cognitive screening and neuropsychological assessment in early Alzheimer's disease
    D P Salmon
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Clin Geriatr Med 17:229-54. 2001
    ..Until effective and easily obtainable biological markers for detecting the onset and progression of Alzheimer's disease are developed, neuropsychological assessment will continue to have an important role in the dementia evaluation...
  7. ncbi request reprint Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer's disease: implications for the integrity of semantic memory
    D P Salmon
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0948, USA
    J Int Neuropsychol Soc 5:692-703. 1999
    ..These results are consistent with the notion that patients with AD suffer a gradual deterioration of the organization and content of semantic memory as the disease progresses...
  8. pmc Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia
    J M Olichney
    Department of Neurology, University of California, Davis, CA, USA
    Neurology 70:1763-70. 2008
    ..We sought cognitive event-related potential (ERP) biomarkers of disease progression and subsequent conversion to dementia in mild cognitive impairment (MCI)...
  9. ncbi request reprint Regional cerebral volume loss associated with verbal learning and memory in dementia of the Alzheimer type
    J C Stout
    Department of Psychiatry, University of California, San Diego, and Veterans Affairs Medical Center, USA
    Neuropsychology 13:188-97. 1999
    ....
  10. pmc Spatial and object working memory deficits in Parkinson's disease are due to impairment in different underlying processes
    Katherine L Possin
    University of California, San Diego, CA, USA
    Neuropsychology 22:585-95. 2008
    ..These results suggest that deficits in working memory for spatial and object information are mediated by distinct cognitive processes in nondemented patients with PD and may differ in their pathophysiological basis...
  11. pmc Space-based but not object-based inhibition of return is impaired in Parkinson's disease
    Katherine L Possin
    Department of Psychiatry, University of California, San Diego, United States
    Neuropsychologia 47:1694-700. 2009
    ..This dissociation supports the view that space-based and object-based components of attention involve distinct neurocognitive processes...
  12. ncbi request reprint Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease
    M W Bondi
    San Diego Veterans Affairs Medical Center and Department of Psychiatry and School of Medicine, University of California, 92161, USA
    Psychol Aging 14:295-303. 1999
    ..Results support the importance of specific episodic memory changes and possession of the ApoE-epsilon4 allele in the preclinical detection of AD...
  13. ncbi request reprint Rate of progression differs in frontotemporal dementia and Alzheimer disease
    K Rascovsky
    University of California, San Diego, La Jolla, CA 92093 0948, USA
    Neurology 65:397-403. 2005
    ..To compare survival and rates of cognitive and functional decline in patients with autopsy-confirmed frontotemporal dementia (FTD) and Alzheimer disease (AD) in a large multicenter study...
  14. ncbi request reprint In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease
    C Fennema-Notestine
    Veterans Affairs San Diego Healthcare System, CA, USA
    Neurology 63:989-95. 2004
    ..To investigate the regional pattern of white matter and cerebellar changes, as well as subcortical and cortical changes, in Huntington disease (HD) using morphometric analyses of structural MRI...
  15. pmc APOE genotype is associated with left-handedness and visuospatial skills in children
    Cinnamon S Bloss
    SDSU UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120 4913, USA
    Neurobiol Aging 31:787-95. 2010
    ..Results may be consistent with the theory of antagonistic pleiotropy, which suggests that APOE may have different protective effects at different developmental stages...
  16. ncbi request reprint Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease
    Katya Rascovsky
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neuropsychology 21:20-30. 2007
    ..These unique patterns of letter and semantic category fluency deficits may be indicative of differences in the relative contribution of frontal-lobe-mediated retrieval deficits and temporal-lobe-mediated semantic deficits in FTD and AD...
  17. ncbi request reprint Heterogeneity in verbal memory: a marker of preclinical Alzheimer's disease?
    Spencer R Wetter
    Veterans Affairs San Diego Healthcare System, California, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:503-15. 2006
    ..Implications of these findings for the detection of a preclinical phase of AD are discussed...
  18. ncbi request reprint Measuring cognitive change in a cohort of patients with Alzheimer's disease
    D R Galasko
    Department of Neurosciences, University of California, San Diego, 3350 La Jolla Village Drive, V127 San Diego, CA 92161, USA
    Stat Med 19:1421-32. 2000
    ..The metric properties and longitudinal characteristics of cognitive tests and the statistical methods used to calculate change are key factors in obtaining reliable estimates of change in studying cohorts of patients with AD...
  19. pmc Abnormal verbal event related potentials in mild cognitive impairment and incipient Alzheimer's disease
    J M Olichney
    Department of Neurosciences, University of California, San Diego, California, USA
    J Neurol Neurosurg Psychiatry 73:377-84. 2002
    ..It has been reported that patients with amnesia have a reduced effect of word repetition upon the late positive component of the event related potential (ERP), which peaks at around 600 ms after word onset...
  20. ncbi request reprint Word repetition in amnesia. Electrophysiological measures of impaired and spared memory
    J M Olichney
    Department of Neurosciences, University of California, San Diego, USA
    Brain 123:1948-63. 2000
    ..Instead, the sensitivity of the N400 to both semantic context and repetition may reflect a short-term memory process that serves language comprehension in realtime...
  21. pmc Distinct cognitive profiles and rates of decline on the Mattis Dementia Rating Scale in autopsy-confirmed frontotemporal dementia and Alzheimer's disease
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, California, USA
    J Int Neuropsychol Soc 14:373-83. 2008
    ..8 points/year) on MDRS total and specific subscale scores. These results suggest that the MDRS may be a useful adjunct to other clinical measures for distinguishing FTD from AD and tracking the progression of the disorder...
  22. pmc Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal study
    Eric M Fine
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 16:366-74. 2008
    ....
  23. pmc fMRI responses to words repeated in a congruous semantic context are abnormal in mild Alzheimer's disease
    John M Olichney
    Department of Neurology, University of California, Davis, Davis, CA 95618 5412, USA
    Neuropsychologia 48:2476-87. 2010
    ..We hypothesized that AD would be associated with reduced differential response to New/Old congruous words...
  24. ncbi request reprint Neuromotor abnormalities and risk for psychosis in Alzheimer's disease
    M P Caligiuri
    Department of Psychiatry, University of California, San Diego, and the UCSD Alzheimer s Disease Research Center, La Jolla, CA 92093, USA
    Neurology 61:954-8. 2003
    ....
  25. ncbi request reprint Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD
    K Rascovsky
    Department of Neurosciences, University of California at San Diego, La Jolla 92093 0948, USA
    Neurology 58:1801-8. 2002
    ..Therefore, a retrospective examination of neuropsychological test performance in autopsy-confirmed patients is warranted...
  26. ncbi request reprint The ubiquity of memory retrieval deficits in patients with frontal-striatal dysfunction
    Vanessa S Zizak
    University of California, San Diego, CA 92161, USA
    Cogn Behav Neurol 18:198-205. 2005
    ..In this study, we examined the ubiquity of this "retrieval deficit" profile in a relatively large sample of patients with Parkinson disease (PD) or Huntington disease (HD)...
  27. pmc Absent event-related potential (ERP) word repetition effects in mild Alzheimer's disease
    John M Olichney
    Department of Neurosciences, University of California, San Diego, CA 92161, USA
    Clin Neurophysiol 117:1319-30. 2006
    ..The P600 (a late positive component, or 'LPC'), and the N400, are sensitive indices of memory encoding and semantic processing, respectively...
  28. pmc Differential age effects on cerebral blood flow and BOLD response to encoding: associations with cognition and stroke risk
    Katherine J Bangen
    San Diego State University University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120 4913, USA
    Neurobiol Aging 30:1276-87. 2009
    ..Stroke risk was associated with both CBF and BOLD response. Results suggest that aging effects on CBF and BOLD responses to encoding are dissociable and that cerebrovascular alterations contribute to findings of age-related differences...
  29. pmc Elevated pulse pressure is associated with age-related decline in language ability
    D A Nation
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, USA
    J Int Neuropsychol Soc 16:933-8. 2010
    ..Results indicate that increases in the pulsatile component of blood pressure may convey added risk of global cognitive decline and specific impairment in language abilities...
  30. ncbi request reprint Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults
    Spencer R Wetter
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 27:943-52. 2005
    ..The association between these subtle executive-function deficits and the overall cognitive functioning of at-risk individuals provides further evidence of their utility as a possible preclinical marker of AD...
  31. ncbi request reprint Neuropsychology of cortical versus subcortical dementia syndromes
    David P Salmon
    Department of Neurosciences 0948, University of California, San Diego9500 Gilman Drive, La Jolla, CA 92093 0948, USA
    Semin Neurol 27:7-21. 2007
    ....
  32. ncbi request reprint Electrophysiological insights into the nature of the semantic deficit in Alzheimer's disease
    T J Schwartz
    Department of Psychiatry, University of California, San Diego, USA
    Neuropsychologia 34:827-41. 1996
    ....
  33. pmc Behavioural abnormalities contribute to functional decline in Huntington's disease
    J M Hamilton
    Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, MC 0948, La Jolla, CA, USA
    J Neurol Neurosurg Psychiatry 74:120-2. 2003
    ....
  34. pmc Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies
    Joanne M Hamilton
    Department of Neurosciences, University of California, USA
    Neuropsychology 22:729-37. 2008
    ....
  35. ncbi request reprint Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease
    Laura Mickes
    Department of Psychology, University of California, San Diego, CA 92093 0109, USA
    Neuropsychology 21:696-705. 2007
    ....
  36. ncbi request reprint Implicit category learning performance predicts rate of cognitive decline in nondemented patients with Parkinson's disease
    J Vincent Filoteo
    Department of Psychiatry, University of California, San Diego, CA 92161, USA
    Neuropsychology 21:183-92. 2007
    ....
  37. pmc Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
    Alzheimer Dis Assoc Disord 24:269-77. 2010
    ..Failure to take into account normal age-related changes risks under-powering trials designed to test disease-modifying properties of potential treatments...
  38. pmc Altered brain response for semantic knowledge in Alzheimer's disease
    Christina E Wierenga
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Neuropsychologia 49:392-404. 2011
    ....
  39. pmc APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study
    Lisa Delano-Wood
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    Int J Geriatr Psychiatry 23:632-6. 2008
    ..The association between the APOE epsilon4 allele and depression was investigated in a retrospective study of 323 AD patients...
  40. pmc Increased functional brain response during word retrieval in cognitively intact older adults at genetic risk for Alzheimer's disease
    Christina E Wierenga
    Department of Psychiatry, Veterans Affairs San Diego Healthcare System, School of Medicine, University of California, San Diego, CA 92161, USA
    Neuroimage 51:1222-33. 2010
    ..Findings are discussed in the context of possible compensatory mechanisms invoked to maintain performance in those at genetic risk for AD...
  41. pmc Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia
    J Vincent Filoteo
    Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    J Clin Exp Neuropsychol 31:823-34. 2009
    ..6% correct classification rate. The results suggest that, despite equivalent levels of general cognitive impairment, patients with DLB or PDD exhibit a different pattern of verbal learning and memory deficits...
  42. pmc The emergence of cognitive discrepancies in preclinical Alzheimer's disease: a six-year case study
    Mark W Jacobson
    Veterans Affairs San Diego Healthcare System, Department 151B, 3350 La Jolla Village Dr, San Diego, CA 92151, USA
    Neurocase 15:278-93. 2009
    ..The present case provides intriguing evidence that cognitive-discrepancy measures could improve our ability to detect subtle changes in cognition at the earliest, preclinical stages of AD...
  43. pmc Quantification of five neuropsychological approaches to defining mild cognitive impairment
    Amy J Jak
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 17:368-75. 2009
    ....
  44. pmc Effects of chronic stress on memory decline in cognitively normal and mildly impaired older adults
    Guerry M Peavy
    UCSD Shiley Marcos Alzheimer s Disease Research Center, University of California San Diego, 8950 Villa La Jolla Drive, La Jolla, CA 92037, USA
    Am J Psychiatry 166:1384-91. 2009
    ..The authors sought to determine the prospective association between subjective and objective measures of chronic stress and rate of memory decline in cognitively normal and mildly impaired older adults...
  45. pmc Identifying the "source" of recognition memory deficits in patients with Huntington's disease or Alzheimer's disease: evidence from the CVLT-II
    Eric M Fine
    Psychology Service 116B Delis Lab, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 30:463-70. 2008
    ..Implications of these findings on the differentiation of the memory disorders associated with HD and AD are discussed...
  46. pmc Comparison of the traditional recall-based versus a new list-based method for computing semantic clustering on the California Verbal Learning Test: evidence from Alzheimer's disease
    Dean C Delis
    Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Clin Neuropsychol 24:70-9. 2010
    ..Logistic regression and score distribution analyses indicated that the new list-based method enhances the detection of differences in semantic-clustering ability between the groups...
  47. pmc Neuropsychological contributions to the early identification of Alzheimer's disease
    Mark W Bondi
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychol Rev 18:73-90. 2008
    ..Finally, we provide a critical examination of the clinical concept of Mild Cognitive Impairment and offer suggestions for an increased focus on the impact of cerebrovascular disease (CVD) and CVD risk during the prodromal period of AD...
  48. pmc Accessibility of the nondominant language in picture naming: a counterintuitive effect of dementia on bilingual language production
    Tamar H Gollan
    Department of Psychiatry, University of California, San Diego, CA 92093 0949, USA
    Neuropsychologia 48:1356-66. 2010
    ..The greater vulnerability of the dominant language may reflect the increased probability of AD affecting richer semantic representations associated with dominant compared to nondominant language names...
  49. pmc The effects of prolonged stress and APOE genotype on memory and cortisol in older adults
    Guerry M Peavy
    Department of Neurosciences, University of California, San Diego, California, USA
    Biol Psychiatry 62:472-8. 2007
    ..Combined effects of stress and APOE status on memory and cortisol in humans have not been studied...
  50. ncbi request reprint A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005
    ..05) increases in cortical 18-fluorodeoxyglucose after treatment. Brain autopsy from one subject suggested robust growth responses to NGF. Additional clinical trials of NGF for Alzheimer disease are warranted...
  51. ncbi request reprint A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease
    Joanne M Hamilton
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0948, USA
    J Int Neuropsychol Soc 10:689-97. 2004
    ..These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients...
  52. pmc Asymmetry in auditory and spatial attention span in normal elderly genetically at risk for Alzheimer's disease
    Mark W Jacobson
    Department of Veterans Affairs Medical Center, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 27:240-53. 2005
    ....
  53. pmc Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response
    S Duke Han
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
    Neurobiol Aging 28:238-47. 2007
    ....
  54. ncbi request reprint The myth of testing construct validity using factor analysis or correlations with normal or mixed clinical populations: lessons from memory assessment
    Dean C Delis
    Psychology Service, Department of Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Int Neuropsychol Soc 9:936-46. 2003
    ..Implications of these findings for research and clinical practice are discussed...
  55. ncbi request reprint Word association in early Alzheimer's disease
    Tamar H Gollan
    Department of Psychiatry, University of California, San Diego, USA
    Brain Lang 99:289-303. 2006
    ..Instead we propose that AD entails a semantic deficit, and that strong associations involve more semantic processing than weak associations (in all speakers)...
  56. ncbi request reprint Information-integration category learning in patients with striatal dysfunction
    J Vincent Filoteo
    Department of Psychiatry, University of California, San Diego, CA, USA
    Neuropsychology 19:212-22. 2005
    ..These findings suggest that the striatum may be particularly involved in information-integration category learning when the rule is highly complex...
  57. pmc Neuropsychological deficits associated with Alzheimer's disease in the very-old: discrepancies in raw vs. standardized scores
    Mark W Bondi
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 9:783-95. 2003
    ..These data suggest that the profile of neuropsychological deficits associated with AD in the Very-Old lacks the disproportionate saliency of episodic memory and executive function deficits typical of the Young-Old...
  58. ncbi request reprint Recall discriminability: utility of a new CVLT-II measure in the differential diagnosis of dementia
    Dean C Delis
    Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 11:708-15. 2005
    ..Implications of these results for clinical practice and theories of memory disorder in dementia are discussed...
  59. ncbi request reprint Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease
    Gilbert J Ho
    Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neuroreport 13:1825-8. 2002
    ..Taken together, these results suggest that for both LBV and AD, earlier age at onset may predict a more aggressive disease course...
  60. ncbi request reprint Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease
    Mark W Bondi
    Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California 92161, USA
    Neuropsychology 16:335-43. 2002
    ..Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance...
  61. ncbi request reprint Do neuropsychological tests detect preclinical Alzheimer's disease: individual-test versus cognitive-discrepancy score analyses
    Mark W Jacobson
    Department of Veterans Affairs Medical Center, San Diego, California 92161, USA
    Neuropsychology 16:132-9. 2002
    ..The PCAD group also had a higher frequency of asymmetric cognitive profiles relative to a normative group...
  62. ncbi request reprint Asymmetries in global-local processing ability in elderly people with the apolipoprotein e-epsilon4 allele
    Mark W Jacobson
    Veterans Affairs San Diego Healthcare System, Research Service, and University of California, San Diego School of Medicine, Department of Psychiatry, CA 92161, USA
    Neuropsychology 19:822-9. 2005
    ..These findings build on previous studies identifying subgroups of elderly people at greater risk for AD who often demonstrate increased cognitive asymmetries relative to groups without significant risk factors...
  63. ncbi request reprint Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease
    Joseph R Sadek
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Neuropsychology 18:692-9. 2004
    ..The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage...
  64. ncbi request reprint A phase I study of AIT-082 in healthy elderly volunteers
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    J Mol Neurosci 18:283-93. 2002
    ..In conclusion, AIT-082 was rapidly absorbed by the oral route with a half-life suitable for once daily dosing. No problems with tolerability or safety were demonstrated...
  65. ncbi request reprint Psychometric comparison of standard and computerized administration of the Alzheimer’s Disease Assessment Scale: Cognitive Subscale (ADASCog)
    J P O'Halloran
    NeuroComp Systems, Inc, Irvine, CA, USA
    Curr Alzheimer Res 8:323-8. 2011
    ..The examiner can control administration and pacing, pause or repeat digitized instructions, score verbal report and overt behavioral performance, and freely interact with the subject...
  66. ncbi request reprint Apolipoprotein E status is associated with odor identification deficits in nondemented older persons
    C Murphy
    University of California, San Diego, La Jolla 92093 0957, USA
    Ann N Y Acad Sci 855:744-50. 1998
    ..Early appearance of olfactory deficits in the progression to AD in persons with the epsilon 4 allele suggests diagnostic utility in olfactory testing...
  67. pmc Decreased cognition in children with risk factors for Alzheimer's disease
    Cinnamon S Bloss
    San Diego State University and University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    Biol Psychiatry 64:904-6. 2008
    ....
  68. ncbi request reprint Eyeblink classical conditioning to auditory and olfactory stimuli: performance among older adults with and without the apolipoprotein E epsilon 4 allele
    Anna Bacon Moore
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120 4913, USA
    Neuropsychology 19:437-45. 2005
    ..Both groups acquired the CR to an auditory CS at the same rate. Results support olfactory compromise in the earliest stages of the AD disease process. ((c) 2005 APA, all rights reserved)...
  69. ncbi request reprint The clock drawing test as a measure of executive dysfunction in elderly depressed patients
    Benjamin K P Woo
    University of California, San Diego, CA, USA
    J Geriatr Psychiatry Neurol 17:190-4. 2004
    ..01). The results support the hypothesis that CDT score is lower in elderly depressed patients with executive dysfunction versus nondepressed seniors as well as depressed patients without executive dysfunction...
  70. pmc Stroke risk modifies regional white matter differences in mild cognitive impairment
    Lisa Delano-Wood
    Department of Psychiatry, University of California, San Diego School of Medicine, CA, USA
    Neurobiol Aging 31:1721-31. 2010
    ..Findings demonstrate a relationship between increased vascular burden and white matter changes, and they support the possibility that posterior white matter pathology may contribute to the development of MCI-related cognitive changes...
  71. ncbi request reprint Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000
    D Galasko
    Department of Neurosciences, University of California, San Diego, USA
    Neurology 58:90-7. 2002
    ..Although ALS and PDC were reported to have dramatically declined in the 1980s, new cases are still encountered. Late-life dementia has received little study among Chamorros...
  72. pmc Associations between stroke risk and cognition in normal aging and Alzheimer's disease with and without depression
    Katherine J Bangen
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    Int J Geriatr Psychiatry 25:175-82. 2010
    ..However, few studies have described the relations among stroke risk, cognition, and APOE genotype in AD, and the findings have been equivocal...
  73. ncbi request reprint Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007
    ..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
  74. ncbi request reprint Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation
    Tara T Lineweaver
    Department of Psychology, Butler University, Indianapolis, Indiana 46208, USA
    J Int Neuropsychol Soc 11:30-9. 2005
    ....
  75. ncbi request reprint Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: verbal versus design fluency
    Wes S Houston
    University of Iowa, Department of Neurology, Division of Cognitive Neuroscience, Iowa City, Iowa 52242 1053, USA
    J Int Neuropsychol Soc 11:863-70. 2005
    ..e., fluency plus switching) may serve as a useful preclinical marker of AD...
  76. ncbi request reprint What best differentiates Lewy body from Alzheimer's disease in early-stage dementia?
    Pietro Tiraboschi
    Dipartimento di Scienze Neurologiche, Ospedale Niguarda Ca Granda, Milano, Italy
    Brain 129:729-35. 2006
    ..This suggests that clinical history plus a brief assessment of visuospatial function may be of the greatest value in correctly identifying DLB early during the course of disease...
  77. ncbi request reprint The centennial of Alzheimer's disease and the publication of "Uber eine eigenartige Erkankung der Hirnrinde" by Alöis Alzheimer
    Robin G Morris
    Cortex 43:821-5. 2007
  78. ncbi request reprint Learning, retention and generalization of a mirror tracing skill in Alzheimer's disease
    Isabelle Rouleau
    Centre de neuroscience de la cognition and Department of Psychology, Université du Québec à Montréal and Neurology Service, Hôpital Notre Dame du CHUM, Montreal, Canada
    J Clin Exp Neuropsychol 24:239-50. 2002
    ....
  79. ncbi request reprint Deterioration of visual-perceptual organization ability in Alzheimer's disease
    Jessica L Paxton
    Department of Psychology, Washington University, Saint Louis, MO, USA
    Cortex 43:967-75. 2007
    ..This deficit may not be a particularly salient early marker of the disease, but it may be useful in tracking disease course...
  80. ncbi request reprint Neocortical disconnectivity disrupts sensory integration in Alzheimer's disease
    Elena K Festa
    Department of Psychology, Brown University, Providence, RI 02912, USA
    Neuropsychology 19:728-38. 2005
    ..These results provide psychophysical support for the presence of functional disconnectivity in AD and demonstrate the utility of AD for investigating the neurocognitive substrates of sensory integration...
  81. pmc Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype
    Kelly L Lange
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, USA
    J Int Neuropsychol Soc 8:943-55. 2002
    ..The presence of an APOE-epsilon4 allele, however, did have a differential effect on the sensitivity of the 2 types of memory tests for tracking progression and made an independent contribution to the prediction of conversion to AD...
  82. ncbi request reprint Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with lewy bodies and Alzheimer's disease
    Carmen Cristea Janvin
    Stavanger University Hospital, Section of Geriatric Psychiatry, Stavanger, Norway
    Mov Disord 21:337-42. 2006
    ..These findings suggest that in some patients with PDD, frontosubcortical changes are the main contributing factor to dementia, whereas in other patients, cortical and hippocampal changes are more important...
  83. ncbi request reprint Performance of three clock scoring systems across different ranges of dementia severity
    Donald J Connor
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Alzheimer Dis Assoc Disord 19:119-27. 2005
    ..Animal Fluency was a better single predictor of dementia. Clinicians are advised to interpret the results of the Clock Drawing Test cautiously in an outpatient setting, where milder forms of dementia and low base rates are likely...
  84. ncbi request reprint Semantic and phonemic sequence effects in random word generation: a dissociation between Alzheimer's and Huntington's disease patients
    Kirsten I Taylor
    Neuropsychology Unit, Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Int Neuropsychol Soc 11:303-10. 2005
    ..AD patients produced more semantic and HD patients more phonemic pairings compared to their respective control groups, indicating selective semantic and phonemic processing deficits in AD and HD patients, respectively...
  85. ncbi request reprint ADCS Prevention Instrument Project: overview and initial results
    Steven H Ferris
    Alzheimer s Disease Center, New York University School of Medicine, New York, NY 10016, USA
    Alzheimer Dis Assoc Disord 20:S109-23. 2006
    ..Initial results for the experimental instruments and for the book club are reported in separate accompanying articles...
  86. ncbi request reprint Electrophysiological analysis of context effects in Alzheimer's disease
    Tanya J Schwartz
    Department of Psychology, Rehabilitation Hospital of the Pacific, Honolulu, Hawaii 96817, USA
    Neuropsychology 17:187-201. 2003
    ..The results do not accord well with either a strictly structural or a strictly functional account of the semantic impairments in AD...
  87. ncbi request reprint Frontal behavioral syndromes and functional status in probable Alzheimer disease
    Julie C Stout
    Department of Psychology, Indiana University, Bloomington, IN 47405 7007, USA
    Am J Geriatr Psychiatry 11:683-6. 2003
    ....
  88. pmc A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium
    Zaven S Khachaturian
    Alzheimers Dement 4:156-63. 2008
  89. ncbi request reprint Robert Katzman honored
    Leon J Thal
    Alzheimer Dis Assoc Disord 20:S27-8. 2006