Jesse J Salk

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Two-temperature LATE-PCR endpoint genotyping
    J Aquiles Sanchez
    Department of Biology, MS008, Brandeis University, Waltham, MA 02454, USA
    BMC Biotechnol 6:44. 2006
  2. pmc Passenger mutations as a marker of clonal cell lineages in emerging neoplasia
    Jesse J Salk
    Department of Pathology, University of Washington School of Medicine MB 357705, 1959 NE Pacific St, Seattle, WA 98195, United States
    Semin Cancer Biol 20:294-303. 2010
  3. pmc Clonal expansions in ulcerative colitis identify patients with neoplasia
    Jesse J Salk
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98105, USA
    Proc Natl Acad Sci U S A 106:20871-6. 2009
  4. pmc Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis
    Jesse J Salk
    Department of Pathology, Department of Medicine, Department of Biostatistics, and Division of Gastroenterology, University of Washington, School of Medicine, Seattle, Washington Division of Anatomic Pathology, University of Utah, Salt Lake City, Utah and Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, Washington
    Inflamm Bowel Dis 19:2593-602. 2013
  5. pmc Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage
    Scott R Kennedy
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 9:e1003794. 2013
  6. pmc Detection of ultra-rare mutations by next-generation sequencing
    Michael W Schmitt
    Departments of Pathology, Genome Sciences, and Biochemistry, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:14508-13. 2012
  7. pmc Decreased mitochondrial DNA mutagenesis in human colorectal cancer
    Nolan G Ericson
    Molecular Diagnostics Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Genet 8:e1002689. 2012
  8. pmc Mutational heterogeneity in human cancers: origin and consequences
    Jesse J Salk
    Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Pathol 5:51-75. 2010
  9. pmc Optimization of DNA polymerase mutation rates during bacterial evolution
    Ern Loh
    Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:1154-9. 2010
  10. pmc Cancer genome sequencing--an interim analysis
    Edward J Fox
    Joseph Gottstein Memorial Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Cancer Res 69:4948-50. 2009

Collaborators

Detail Information

Publications11

  1. pmc Two-temperature LATE-PCR endpoint genotyping
    J Aquiles Sanchez
    Department of Biology, MS008, Brandeis University, Waltham, MA 02454, USA
    BMC Biotechnol 6:44. 2006
    ..Furthermore, the use of only a single colored probe for genotyping enhances the multiplex detection capacity of the assay...
  2. pmc Passenger mutations as a marker of clonal cell lineages in emerging neoplasia
    Jesse J Salk
    Department of Pathology, University of Washington School of Medicine MB 357705, 1959 NE Pacific St, Seattle, WA 98195, United States
    Semin Cancer Biol 20:294-303. 2010
    ..We discuss historical as well as contemporary approaches and consider ways in which powerful new genomic technologies might be harnessed to develop a future generation of early cancer diagnostics...
  3. pmc Clonal expansions in ulcerative colitis identify patients with neoplasia
    Jesse J Salk
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98105, USA
    Proc Natl Acad Sci U S A 106:20871-6. 2009
    ....
  4. pmc Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis
    Jesse J Salk
    Department of Pathology, Department of Medicine, Department of Biostatistics, and Division of Gastroenterology, University of Washington, School of Medicine, Seattle, Washington Division of Anatomic Pathology, University of Utah, Salt Lake City, Utah and Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, Washington
    Inflamm Bowel Dis 19:2593-602. 2013
    ..We have previously reported that cancer progression is associated with the presence of clonal expansions and shorter telomeres in nondysplastic mucosa. We sought to validate these findings in an independent case-control study...
  5. pmc Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage
    Scott R Kennedy
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 9:e1003794. 2013
    ....
  6. pmc Detection of ultra-rare mutations by next-generation sequencing
    Michael W Schmitt
    Departments of Pathology, Genome Sciences, and Biochemistry, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:14508-13. 2012
    ..We apply the method to directly assess the frequency and pattern of random mutations in mitochondrial DNA from human cells...
  7. pmc Decreased mitochondrial DNA mutagenesis in human colorectal cancer
    Nolan G Ericson
    Molecular Diagnostics Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Genet 8:e1002689. 2012
    ..Together these findings raise the intriguing possibility that fidelity of mitochondrial genome is, in fact, increased in cancer as a result of a decrease in reactive oxygen species-mediated mtDNA damage...
  8. pmc Mutational heterogeneity in human cancers: origin and consequences
    Jesse J Salk
    Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Pathol 5:51-75. 2010
    ..The impact of DNA sequencing on future cancer research and personalized therapy is likely to be profound and merits critical evaluation...
  9. pmc Optimization of DNA polymerase mutation rates during bacterial evolution
    Ern Loh
    Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:1154-9. 2010
    ..Our results indicate that under conditions where organism fitness is not yet maximized for a particular environment, competitive adaptation may be facilitated by enhanced mutagenesis...
  10. pmc Cancer genome sequencing--an interim analysis
    Edward J Fox
    Joseph Gottstein Memorial Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Cancer Res 69:4948-50. 2009
    ..Most significantly, however, the cancer genome sequencing strategy, as currently applied, fails to characterize the most relevant genomic features of cancer-the mutational heterogeneity within individual tumors...
  11. ncbi request reprint Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer
    Mariola Kulawiec
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Environ Mol Mutagen 51:427-39. 2010
    ..Finally, we discuss the potential clinical utility of mtDNA mutations for improving the sensitivity of early cancer diagnosis, rapidly detecting cancer recurrence, and predicting the disease outcome...