Research Topics
Species | John SalamoneSummaryAffiliation: University of Connecticut Country: USA Publications
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Publications
Dopamine and food addiction: lexicon badly neededJohn D Salamone
Department of Psychology, University of Connecticut, Storrs, Connecticut Electronic address
Biol Psychiatry 73:e15-24. 2013....- Insulin and Ventral Tegmental Dopamine: What's Impaired and What's Intact?John D Salamone
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA Electronic address
Cell Metab 17:469-70. 2013..Labouèbe et al. (2013) show that insulin induced long-term depression in ventral tegmental neurons, which was associated with reduced responsiveness to food-related stimuli but spared aspects of food-seeking behavior... - The mysterious motivational functions of mesolimbic dopamineJohn D Salamone
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Neuron 76:470-85. 2012..In this review, we discuss the complex roles of dopamine in behavioral functions related to motivation... 
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyondJohn D Salamone
Dept of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
J Exp Anal Behav 97:125-46. 2012..Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as symptoms such as psychomotor slowing, fatigue or anergia in depression and other neurological disorders...
Effort-related functions of nucleus accumbens dopamine and associated forebrain circuitsJ D Salamone
Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
Psychopharmacology (Berl) 191:461-82. 2007....- Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonismJohn D Salamone
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Front Biosci 13:3594-605. 2008..Adenosine A2A antagonists may be useful for their tremorolytic effects, and may help in treating both idiopathic and antipsychotic-induced parkinsonian symptoms... - Will the last person who uses the term 'reward' please turn out the lights? Comments on processes related to reinforcement, learning, motivation and effortJohn D Salamone
Department of Psychology, University of Connecticut, CT 06269 1020, USA
Addict Biol 11:43-4. 2006 - Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonismJohn D Salamone
Behavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Parkinsonism Relat Disord 14:S130-4. 2008..In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function... - Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice taskJ D Salamone
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Psychopharmacology (Berl) 160:371-80. 2002..In previous work with this task, dopamine antagonists and accumbens dopamine depletions decreased lever pressing but increased chow consumption... - Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonismJohn D Salamone
Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Behav Brain Res 201:216-22. 2009.... - Dopamine/adenosine interactions involved in effort-related aspects of food motivationJohn D Salamone
Dept of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Appetite 53:422-5. 2009..These studies have implications for understanding the neurochemical interactions that underlie activational aspects of motivation... - Dopamine, effort, and decision making: theoretical comment on Bardgett et al. (2009)John D Salamone
Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Behav Neurosci 123:463-7. 2009..These studies illustrate features of the neurochemical regulation of effort-related decision making, and may have implications for the understanding of both natural and pathological features of motivation... - Preladenant, a novel adenosine A(2A) receptor antagonist for the potential treatment of parkinsonism and other disordersJohn D Salamone
University of Connecticut, Behavioral Neuroscience Division, Department of Psychology, 406 Babbidge Road, Unit 1020, Storrs, CT 06269 1020, USA
IDrugs 13:723-31. 2010..At the time of publication, phase III clinical trials were recruiting patients with Parkinson's disease... - Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversionsJohn D Salamone
Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269 1020, USA
Physiol Behav 91:383-8. 2007..These results suggest that CB1 receptor neutral antagonists may decrease appetite by blocking endogenous cannabinoid tone, and that these drugs may be less associated with nausea than is the case for CB1 inverse agonists... - Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowingAndrew M Farrar
Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
Psychopharmacology (Berl) 191:579-86. 2007..Dopamine antagonism and accumbens dopamine depletions cause rats performing on choice tasks to reallocate their behavior away from food-reinforced tasks that have high response requirements... - The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedureAllison M Mott
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Psychopharmacology (Berl) 204:103-12. 2009.... - Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPXLyndsey E Collins
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Pharmacol Biochem Behav 94:561-9. 2010..Behaviorally active doses of MSX-3 and SCH 58261 showed substantial in vivo occupancy of A(2A) receptors, but DPCPX did not. The results of these studies support the use of adenosine A(2A) antagonists for the treatment of tremor... - Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activityLyndsey E Collins
Dept of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Behav Brain Res 211:148-55. 2010..DA and adenosine receptor antagonists interact in the regulation of locomotor activation, but the nature of this interaction appears to depend upon the receptor selectivity profiles of the specific drugs being tested... - Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathwaySusana Mingote
Department of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
J Neurosci 28:9037-46. 2008..Research on the effort-related functions of these forebrain systems may lead to a greater understanding of pathological features of motivation, such as psychomotor slowing, anergia, and fatigue in depression... - The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonistsLila T Worden
Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Psychopharmacology (Berl) 203:489-99. 2009..Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related choice behavior, emerging evidence demonstrates a role for adenosine A(2A) receptors... - Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in ratsKeita Ishiwari
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Behav Brain Res 178:190-9. 2007..These studies suggest that adenosine and dopamine systems interact to modulate the locomotor and behavioral activation functions of nucleus accumbens core... - The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in ratsKelly S Sink
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Neuropsychopharmacology 33:946-55. 2008..These results suggest that AM4113 may decrease appetite by blocking endogenous cannabinoid tone, and that this drug may be less associated with nausea than CB1 inverse agonists... - Motor effects of GABA(A) antagonism in globus pallidus: studies of locomotion and tremulous jaw movements in ratsAnna Wisniecki
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA
Psychopharmacology (Berl) 170:140-9. 2003..These findings are consistent with some features of current models of basal ganglia function and may lead to an understanding of the specific mechanisms that generate parkinsonian symptoms... - Validation of the tremulous jaw movement model for assessment of the motor effects of typical and atypical antipychotics: effects of pimozide (Orap) in ratsKeita Ishiwari
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA
Pharmacol Biochem Behav 80:351-62. 2005..TJMs induced by acute or subchronic pimozide may be related to early-onset motor syndromes such as drug-induced parkinsonism... - Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in ratsLaura Font
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Psychopharmacology (Berl) 199:515-26. 2008..Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related processes, emerging evidence also implicates adenosine A(2A) receptors... - The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptorsAdrienne J Betz
Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Psychopharmacology (Berl) 194:347-59. 2007..Neostriatal M4 receptors have been implicated in aspects of motor function, and it has been suggested that M4 antagonists could be used as treatments for parkinsonism... - Accumbens dopamine and the regulation of effort in food-seeking behavior: modulation of work output by different ratio or force requirementsKeita Ishiwari
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA
Behav Brain Res 151:83-91. 2004..These studies indicate that DA depletions make animals sensitive to temporal or rate components of work that greatly influence responding on ratio schedules... - Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamineJohn D Salamone
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Behav Brain Res 137:3-25. 2002.... - Nucleus accumbens dopamine and work requirements on interval schedulesMerce Correa
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Behav Brain Res 137:179-87. 2002.... - Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243John D Salamone
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Behav Brain Res 156:173-9. 2005.... - Ratio and time requirements on operant schedules: effort-related effects of nucleus accumbens dopamine depletionsSusana Mingote
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA
Eur J Neurosci 21:1749-57. 2005..Attachment of ratio requirements to interval schedules is a work-related response cost that provides a challenge to the organism, and DA in nucleus accumbens appears to be necessary for adapting to this challenge... - Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehydeMaria N Arizzi-LaFrance
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA
Neuropsychopharmacology 31:997-1008. 2006..These studies have implications for understanding the brain mechanisms involved in mediating the ascending limb of the biphasic dose-response curve for the effect of ethanol on locomotor activity... - Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesiaTrisha L Chuck
Department of Psychology, University of Connecticut, 406 Babbidge Rd. U-1020, Storrs, CT 06269-1020, USA
Life Sci 79:154-61. 2006..The detection of subtle changes in different motor test across a broad range of ethanol doses is important for understanding ethanol effects in other cognitive, motivational or sensory processes... - The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in ratsJanel Hodge
Department of Psychology, Edinboro University of Pennsylvania, 210 East Normal Street, Edinboro, PA 16444, USA
Behav Brain Res 193:298-305. 2008.... - Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387Peter J McLaughlin
Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269-1020, USA
Pharmacol Biochem Behav 83:396-402. 2006..It was concluded that AM 1387 may be a useful tool for examining the effects of CB1 receptor antagonism or inverse agonism on food intake... - Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intakeSusana Mingote
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Pharmacol Biochem Behav 89:345-51. 2008..In conjunction with other studies, the present results suggest that sedative effects may play an important role in some of the behavioral effects produced by systemic administration of adenosine A(2A) agonists... - In-vitro analysis of Pitx3 in mesodiencephalic dopaminergic neuron maturationTheodora Papanikolaou
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269 4243, USA
Eur J Neurosci 29:2264-75. 2009..Our study, using Pitx3-deficient embryonic stem cells in an in-vitro differentiation culture system, allowed us to assess the role of Pitx3 in the specification and final maturation of dopaminergic neurons... - Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: studies with low and high rate operant schedulesMaria N Arizzi
Department of Psychology, University of Connecticut, U-1020, Storrs, CT 06269-1020, USA
Behav Brain Res 147:203-10. 2003.... - The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysisKeita Ishiwari
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA
J Neurosci Methods 140:39-46. 2004..This research may lead to a better understanding of how parkinsonian symptoms are modulated by SNr GABA mechanisms... - Infusions of acetaldehyde into the arcuate nucleus of the hypothalamus induce motor activity in ratsMerce Correa
Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA Area de Psicobiologia, Universitat Jaume I, 12071 Castello, Spain
Life Sci 84:321-7. 2009..In previous studies acetaldehyde injected in the lateral ventricles or in the substantia nigra reticulata (SNR) mimicked the behavioral stimulant effects of centrally administered ethanol... - In vitro generation of dopaminergic neurons from adult subventricular zone neural progenitor cellsTheodora Papanikolaou
Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA
Stem Cells Dev 17:157-72. 2008.... - Behavioral effects of the novel cannabinoid full agonist AM 411Peter J McLaughlin
Department of Psychology, University of Connecticut, 406 Babbidge Rd. Storrs, CT, 06269-1020, USA
Pharmacol Biochem Behav 81:78-88. 2005..It is concluded that AM 411 produces CB1 agonist-like behavior with potency between that of WIN 55,212-2 and AM 356. AM 411 could be a useful tool for understanding the behavioral and neural effects of CB1 receptor stimulation... - Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: effects on lever pressing and response initiationPeter J McLaughlin
Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
Pharmacol Biochem Behav 89:304-13. 2008..The metabolites of ethanol are more potent than ethanol itself in terms of altering patterns of lever pressing. Thus, the effects of ethanol administration could in part be due to the actions of its biologically active metabolites... - Functions of mesolimbic dopamine: changing concepts and shifting paradigmsJohn D Salamone
Psychopharmacology (Berl) 191:389. 2007 - The role of acetaldehyde in the central effects of ethanolEtienne Quertemont
Neuroscience Comportementale et Psychopharmacologie, University of Liege, Liege, Belgium
Alcohol Clin Exp Res 29:221-34. 2005..McBride, Zachary A. Rodd, Avram Goldstein, Alejandro Zaffaroni and Ting-Kai Li; and (5) Acetaldehyde increases dopaminergic transmission in the limbic system, by Milena Pisano and Marco Diana...
Research Grants
- Effort-related Functions of Nucleus Accumbens Adenosine A2A ReceptorsJohn D Salamone; Fiscal Year: 2010....
- Dopamine D2 and Adenosine A2A roles:Tremulous MovementsJohn Salamone; Fiscal Year: 2007..abstract_text> ..
- MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICSJohn Salamone; Fiscal Year: 2003..Taken together, the results of these experiments will help to identify the pharmacological characteristics and brain circuits that underlie the motor effects of clozapine. ..
- BEHAVIORAL EFFECTS OF NIGRAL D1 ANTAGONISMJohn Salamone; Fiscal Year: 2001....
- Effort-related Functions of Nucleus Accumbens Adenosine A2A ReceptorsJohn Salamone; Fiscal Year: 2009....