J D Salamone

Summary

Affiliation: University of Connecticut
Country: USA

Publications

  1. ncbi request reprint Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine
    John D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 137:3-25. 2002
  2. ncbi request reprint Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243
    John D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 156:173-9. 2005
  3. ncbi request reprint Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine
    J D Salamone
    Division of Behavioral Neuroscience, Dept of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
    Curr Opin Pharmacol 5:34-41. 2005
  4. ncbi request reprint Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse
    J D Salamone
    Division of Behavioral Neuroscience, Dept of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
    J Pharmacol Exp Ther 305:1-8. 2003
  5. ncbi request reprint Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement
    J D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 105:863-70. 2001
  6. ncbi request reprint A critique of recent studies on placebo effects of antidepressants: importance of research on active placebos
    J D Salamone
    Department of Psychology, University of Connecticut, Storrs 06269 1020, USA
    Psychopharmacology (Berl) 152:1-6. 2000
  7. ncbi request reprint Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism
    J D Salamone
    Dept of Psychology, University of Connecticut, Storrs 06269 1020, USA
    Life Sci 68:2579-84. 2001
  8. doi request reprint Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
  9. doi request reprint Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats
    K S Sink
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 206:223-32. 2009
  10. doi request reprint Effects of the adenosine A 2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide
    A J Betz
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 163:97-108. 2009

Collaborators

  • F Velasco
  • A Makriyannis
  • P J McLaughlin
  • Jack Bergman
  • Mariana Pereira
  • C E Muller
  • Merce Correa
  • Linda A Parker
  • James J Chrobak
  • O Valverde
  • M F O'Neill
  • C M Brown
  • A J Mayorga
  • M Morales
  • Q Liu
  • Zachary A Rodd
  • K A Grant
  • E Quertemont
  • K S Sink
  • Susana Mingote
  • K N Segovia
  • Keita Ishiwari
  • Andrew M Farrar
  • E J Nunes
  • V K Vemuri
  • Jorg Hockemeyer
  • P A Randall
  • Lyndsey E Collins
  • Kelly S Sink
  • L E Collins
  • A M Farrar
  • Russell G Port
  • Lila T Worden
  • Laura Font
  • B B Carlson
  • Maria N Arizzi-LaFrance
  • Adrienne J Betz
  • Suzanne M Weber
  • S J Podurgiel
  • A Betz
  • Daniel J Galtieri
  • J L Santerre
  • Brian B Carlson
  • E J Markus
  • Anna Wisniecki
  • T N Sager
  • Maria N Arizzi
  • Allison M Mott
  • A J Betz
  • L Font
  • V Kiran Vemuri
  • Theodora Papanikolaou
  • Janel Hodge
  • J T Trevitt
  • Adrienne Betz
  • Trisha L Chuck
  • Ania Wisniecki
  • M N Arizzi
  • T Trevitt
  • J Barber
  • C A Lee
  • L Lopez-Cruz
  • M Milligan
  • C Lendent
  • A Thompson
  • S E Yohn
  • M Pardo
  • Y Baqi
  • K L Nowend
  • Shawnet K Jones
  • Nicholas E Paul
  • A B Given
  • E Ferreris Torres
  • Lise T Brennum
  • C M Stopper
  • Patricia Collins
  • James R Hinman
  • S Hosmer
  • J Hockemeyer
  • R G Port
  • J Sink
  • Thomas N Sager
  • Mona Shahriari
  • J Valenta
  • Eric J Nunes
  • L Worden
  • G Thakur
  • J Wood
  • R Vontell
  • Yan Pang

Detail Information

Publications73

  1. ncbi request reprint Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine
    John D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 137:3-25. 2002
    ....
  2. ncbi request reprint Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243
    John D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 156:173-9. 2005
    ....
  3. ncbi request reprint Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine
    J D Salamone
    Division of Behavioral Neuroscience, Dept of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
    Curr Opin Pharmacol 5:34-41. 2005
    ....
  4. ncbi request reprint Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse
    J D Salamone
    Division of Behavioral Neuroscience, Dept of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
    J Pharmacol Exp Ther 305:1-8. 2003
    ..The involvement of accumbens DA in activational aspects of motivation has implications for energy-related disorders in psychiatry, as well as aspects of drug-seeking behavior...
  5. ncbi request reprint Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement
    J D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 105:863-70. 2001
    ....
  6. ncbi request reprint A critique of recent studies on placebo effects of antidepressants: importance of research on active placebos
    J D Salamone
    Department of Psychology, University of Connecticut, Storrs 06269 1020, USA
    Psychopharmacology (Berl) 152:1-6. 2000
    ..Thus, some researchers have called into question the "blind" nature of research using inert placebos, and also have questioned the efficacy of antidepressant drugs...
  7. ncbi request reprint Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism
    J D Salamone
    Dept of Psychology, University of Connecticut, Storrs 06269 1020, USA
    Life Sci 68:2579-84. 2001
    ..Taken together, these data are consistent with the hypothesis that a centrally-acting M4 antagonist may be useful as a treatment for parkinsonian symptoms, including tremor...
  8. doi request reprint Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 166:1056-67. 2010
    ..These findings may have implications for the treatment of psychiatric symptoms such as psychomotor slowing, anergia and fatigue...
  9. doi request reprint Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats
    K S Sink
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 206:223-32. 2009
    ..Drugs that interfere with cannabinoid CB1 transmission suppress food-motivated behaviors and may be useful as appetite suppressants, but there is uncertainty about the locus of action for the feeding-suppression effects of these drugs...
  10. doi request reprint Effects of the adenosine A 2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide
    A J Betz
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 163:97-108. 2009
    ....
  11. pmc Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142
    K S Sink
    Dept of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Eur Neuropsychopharmacol 20:112-22. 2010
    ..This research may lead to the development of novel appetite suppressants with reduced anxiogenic effects...
  12. ncbi request reprint The adenosine A2A antagonist KF17837 reverses the locomotor suppression and tremulous jaw movements induced by haloperidol in rats: possible relevance to parkinsonism
    M Correa
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 148:47-54. 2004
    ..This profile of activity is consistent with the hypothesis that antagonism of adenosine A2A receptors can result in an antiparkinsonian effect in animal models...
  13. ncbi request reprint Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
    J D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:461-82. 2007
    ....
  14. pmc Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior
    K S Sink
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 196:565-74. 2008
    ..If this were true, then the effects of interference with cannabinoid CB1 transmission should closely resemble the effects of interference with DA transmission...
  15. ncbi request reprint Substantia nigra pars reticulata GABA is involved in the regulation of operant lever pressing: pharmacological and microdialysis studies
    M Correa
    Department of Psychology, University of Connecticut, 06269 1020, Storrs, CT, USA
    Neuroscience 119:759-66. 2003
    ..These data support the hypothesis that SNr GABA is involved in the regulation of motor output, and indicate that GABA release in this structure is increased during behavioral stimulation...
  16. ncbi request reprint Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide
    M N Arizzi
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Life Sci 74:1001-11. 2004
    ..This type of procedure can be used to assess a variety of different compounds for their ability to inhibit cannabinoid metabolism...
  17. ncbi request reprint Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor
    Brian B Carlson
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 165:229-37. 2003
    ..Cholinomimetic-induced jaw movements are a putative model of parkinsonian tremor, and the ability of antipsychotic drugs to suppress these movements in rats is correlated with motor side-effect liability in humans...
  18. doi request reprint The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats
    K S Sink
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 95:479-84. 2010
    ..These results suggest that CB1 neutral antagonists may be less likely than CB1 inverse agonists to facilitate the acquisition or consolidation of contextual fear that may contribute to some clinical disorders...
  19. pmc The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure
    Allison M Mott
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 204:103-12. 2009
    ....
  20. ncbi request reprint Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing
    Andrew M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:579-86. 2007
    ..Dopamine antagonism and accumbens dopamine depletions cause rats performing on choice tasks to reallocate their behavior away from food-reinforced tasks that have high response requirements...
  21. pmc Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
    E J Nunes
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 170:268-80. 2010
    ....
  22. pmc The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
    P A Randall
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 97:179-84. 2010
    ..Although AM6545 did not affect food handling, it did reduce time spent feeding and feeding rate. Taken together, these results suggest that AM6545 is a compound that warrants further study as a potential appetite suppressant drug...
  23. pmc Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior
    A M Farrar
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 152:321-30. 2008
    ..This research may have implications for understanding the brain mechanisms involved in energy-related psychiatric dysfunctions such as psychomotor retardation in depression, anergia, and apathy...
  24. doi request reprint Detailed analysis of food-reinforced operant lever pressing distinguishes effects of a cannabinoid CB1 inverse agonist and dopamine D1 and D2 antagonists
    P J McLaughlin
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 96:75-81. 2010
    ..These results suggest that, while several similarities exist, CB1, D1, and D2 antagonists are not identical in their pattern of suppression of food-maintained lever pressing...
  25. ncbi request reprint Quetiapine (Seroquel) shows a pattern of behavioral effects similar to the atypical antipsychotics clozapine and olanzapine: studies with tremulous jaw movements in rats
    A Betz
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 179:383-92. 2005
    ..Previous studies demonstrated that clozapine and olanzapine suppressed tacrine-induced jaw movements at lower doses than those required for suppression of lever pressing...
  26. ncbi request reprint Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate
    M Correa
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Brain Res Bull 62:197-202. 2003
    ..Moreover, it is possible that some of the motor suppression or sedation produced by ethanol is due to the central actions of acetate...
  27. ncbi request reprint Effects of clozapine, thioridazine, risperidone and haloperidol on behavioral tests related to extrapyramidal motor function
    J T Trevitt
    Department of Psychology, University of Connecticut, Storrs 06269 1020, USA
    Psychopharmacology (Berl) 132:74-81. 1997
    ..The ratio of potencies of these effects (i.e., suppression of tremulous jaw movements versus suppression of lever pressing) could be used as a behavioral procedure for assessing clozapine-like activity in novel compounds...
  28. ncbi request reprint D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
    K L Nowend
    Unit 1020, Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269-1020, USA
    Pharmacol Biochem Behav 69:373-82. 2001
    ..Nevertheless, interference with accumbens DA does appear to set constraints upon which responses are selected for obtaining food, and may impair the ability of animals to overcome work-related response costs in order to obtain food...
  29. doi request reprint Slow phasic changes in nucleus accumbens dopamine release during fixed ratio acquisition: a microdialysis study
    K N Segovia
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 196:178-88. 2011
    ....
  30. ncbi request reprint The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats
    P J McLaughlin
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 180:286-93. 2005
    ..However, the specific mechanisms underlying the reduction in food intake produced by these drugs are not well understood...
  31. ncbi request reprint Substantia nigra pars reticulata is a highly potent site of action for the behavioral effects of the D1 antagonist SCH 23390 in the rat
    J T Trevitt
    Department of Psychology, University of Connecticut, Storrs 06269-1020, USA
    Psychopharmacology (Berl) 156:32-41. 2001
    ..It is possible that blockade of SNr D1 receptors modulates GABA release from striatonigral neurons...
  32. doi request reprint Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX
    Lyndsey E Collins
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 94:561-9. 2010
    ..Behaviorally active doses of MSX-3 and SCH 58261 showed substantial in vivo occupancy of A(2A) receptors, but DPCPX did not. The results of these studies support the use of adenosine A(2A) antagonists for the treatment of tremor...
  33. doi request reprint Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activity
    Lyndsey E Collins
    Dept of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 211:148-55. 2010
    ..DA and adenosine receptor antagonists interact in the regulation of locomotor activation, but the nature of this interaction appears to depend upon the receptor selectivity profiles of the specific drugs being tested...
  34. doi request reprint The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor
    S J Podurgiel
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuroscience 250:507-19. 2013
    ..These results indicate that TBZ induces tremor as measured by the TJM model, and that pharmacological antagonism and genetic deletion of adenosine A2A receptors are capable of attenuating this oral tremor. ..
  35. ncbi request reprint Brain implantations of engineered GABA-releasing cells suppress tremor in an animal model of Parkinsonism
    B B Carlson
    College of Liberal Arts and Sciences, Department of Psychology, Division of Behavioral Neuroscience, University of Connecticut, 406 Babbidge Road, U 20, Storrs, CT 06269 1020, USA
    Neuroscience 119:927-32. 2003
    ..These results suggest that implantation of GABA cells into SNr, or possibly into other basal ganglia structures, could provide an alternative transplantation strategy for the treatment of Parkinsonism...
  36. ncbi request reprint The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats
    P J McLaughlin
    Department of Psychology, University of Connecticut, Storrs, Connecticut, USA
    Behav Pharmacol 16:477-86. 2005
    ..In contrast to the cognitive impairment seen after administration of moderate to high doses of CB1 agonists, it appears that low doses of some CB1 agonists may be capable of enhancing stimulus detection processes...
  37. pmc The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats
    Kelly S Sink
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuropsychopharmacology 33:946-55. 2008
    ..These results suggest that AM4113 may decrease appetite by blocking endogenous cannabinoid tone, and that this drug may be less associated with nausea than CB1 inverse agonists...
  38. ncbi request reprint Motor effects of GABA(A) antagonism in globus pallidus: studies of locomotion and tremulous jaw movements in rats
    Anna Wisniecki
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 170:140-9. 2003
    ..Although most rodent studies related to parkinsonian symptoms have focused on locomotion, tremulous jaw movements also have been used as a rodent model of tremor for investigating the circuitry of the basal ganglia...
  39. pmc Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway
    Susana Mingote
    Department of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
    J Neurosci 28:9037-46. 2008
    ..Research on the effort-related functions of these forebrain systems may lead to a greater understanding of pathological features of motivation, such as psychomotor slowing, anergia, and fatigue in depression...
  40. pmc Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats
    Keita Ishiwari
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 178:190-9. 2007
    ..These studies suggest that adenosine and dopamine systems interact to modulate the locomotor and behavioral activation functions of nucleus accumbens core...
  41. pmc The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists
    Lila T Worden
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 203:489-99. 2009
    ..Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related choice behavior, emerging evidence demonstrates a role for adenosine A(2A) receptors...
  42. pmc Oral bioavailability of the novel cannabinoid CB1 antagonist AM6527: effects on food-reinforced behavior and comparisons with AM4113
    K S Sink
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 91:303-6. 2009
    ..In contrast, AM 6527 is an orally active CB1 antagonist, which may be useful for clinical research on the appetite suppressant effects of CB1 antagonists...
  43. ncbi request reprint The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors
    Adrienne J Betz
    Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 194:347-59. 2007
    ..Neostriatal M4 receptors have been implicated in aspects of motor function, and it has been suggested that M4 antagonists could be used as treatments for parkinsonism...
  44. ncbi request reprint Validation of the tremulous jaw movement model for assessment of the motor effects of typical and atypical antipychotics: effects of pimozide (Orap) in rats
    Keita Ishiwari
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 80:351-62. 2005
    ..TJMs induced by acute or subchronic pimozide may be related to early-onset motor syndromes such as drug-induced parkinsonism...
  45. ncbi request reprint Accumbens dopamine and the regulation of effort in food-seeking behavior: modulation of work output by different ratio or force requirements
    Keita Ishiwari
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 151:83-91. 2004
    ..These studies indicate that DA depletions make animals sensitive to temporal or rate components of work that greatly influence responding on ratio schedules...
  46. pmc Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats
    Laura Font
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 199:515-26. 2008
    ..Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related processes, emerging evidence also implicates adenosine A(2A) receptors...
  47. ncbi request reprint Locomotor stimulant effects of intraventricular injections of low doses of ethanol in rats: acute and repeated administration
    M Correa
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 170:368-75. 2003
    ..Moreover, chronic ethanol administration fails to produce signs of locomotor sensitization in rats...
  48. pmc Dopamine, effort, and decision making: theoretical comment on Bardgett et al. (2009)
    John D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Neurosci 123:463-7. 2009
    ..These studies illustrate features of the neurochemical regulation of effort-related decision making, and may have implications for the understanding of both natural and pathological features of motivation...
  49. pmc Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism
    John D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 201:216-22. 2009
    ....
  50. ncbi request reprint Nucleus accumbens dopamine and work requirements on interval schedules
    Merce Correa
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Behav Brain Res 137:179-87. 2002
    ....
  51. pmc Dopamine/adenosine interactions involved in effort-related aspects of food motivation
    John D Salamone
    Dept of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Appetite 53:422-5. 2009
    ..These studies have implications for understanding the neurochemical interactions that underlie activational aspects of motivation...
  52. ncbi request reprint Preladenant, a novel adenosine A(2A) receptor antagonist for the potential treatment of parkinsonism and other disorders
    John D Salamone
    University of Connecticut, Behavioral Neuroscience Division, Department of Psychology, 406 Babbidge Road, Unit 1020, Storrs, CT 06269 1020, USA
    IDrugs 13:723-31. 2010
    ..At the time of publication, phase III clinical trials were recruiting patients with Parkinson's disease...
  53. pmc Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions
    John D Salamone
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269 1020, USA
    Physiol Behav 91:383-8. 2007
    ..These results suggest that CB1 receptor neutral antagonists may decrease appetite by blocking endogenous cannabinoid tone, and that these drugs may be less associated with nausea than is the case for CB1 inverse agonists...
  54. pmc Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism
    John D Salamone
    Behavioral Neuroscience Division, Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Parkinsonism Relat Disord 14:S130-4. 2008
    ..In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function...
  55. ncbi request reprint Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism
    John D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Front Biosci 13:3594-605. 2008
    ..Adenosine A2A antagonists may be useful for their tremorolytic effects, and may help in treating both idiopathic and antipsychotic-induced parkinsonian symptoms...
  56. ncbi request reprint Will the last person who uses the term 'reward' please turn out the lights? Comments on processes related to reinforcement, learning, motivation and effort
    John D Salamone
    Department of Psychology, University of Connecticut, CT 06269 1020, USA
    Addict Biol 11:43-4. 2006
  57. ncbi request reprint Ratio and time requirements on operant schedules: effort-related effects of nucleus accumbens dopamine depletions
    Susana Mingote
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Eur J Neurosci 21:1749-57. 2005
    ..Attachment of ratio requirements to interval schedules is a work-related response cost that provides a challenge to the organism, and DA in nucleus accumbens appears to be necessary for adapting to this challenge...
  58. ncbi request reprint Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesia
    Trisha L Chuck
    Department of Psychology, University of Connecticut, 406 Babbidge Rd U 1020, Storrs, CT 06269 1020, USA
    Life Sci 79:154-61. 2006
    ..The detection of subtle changes in different motor test across a broad range of ethanol doses is important for understanding ethanol effects in other cognitive, motivational or sensory processes...
  59. ncbi request reprint Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387
    Peter J McLaughlin
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 83:396-402. 2006
    ..It was concluded that AM 1387 may be a useful tool for examining the effects of CB1 receptor antagonism or inverse agonism on food intake...
  60. ncbi request reprint Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehyde
    Maria N Arizzi-LaFrance
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Neuropsychopharmacology 31:997-1008. 2006
    ..These studies have implications for understanding the brain mechanisms involved in mediating the ascending limb of the biphasic dose-response curve for the effect of ethanol on locomotor activity...
  61. doi request reprint The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats
    Janel Hodge
    Department of Psychology, Edinboro University of Pennsylvania, 210 East Normal Street, Edinboro, PA 16444, USA
    Behav Brain Res 193:298-305. 2008
    ....
  62. pmc Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake
    Susana Mingote
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 89:345-51. 2008
    ..In conjunction with other studies, the present results suggest that sedative effects may play an important role in some of the behavioral effects produced by systemic administration of adenosine A(2A) agonists...
  63. ncbi request reprint Interactions between dopamine D1 receptors and gamma-aminobutyric acid mechanisms in substantia nigra pars reticulata of the rat: neurochemical and behavioral studies
    T Trevitt
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 159:229-37. 2002
    ..Yet, there is also a large number of D1 receptors in the substantia nigra pars reticulata (SNr), and these receptors are located mainly on terminals of gamma-aminobutyric acid (GABA)-ergic striatonigral neurons...
  64. ncbi request reprint The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats
    P J McLaughlin
    Department of Psychology, University of Connecticut, 406 Babbidge Rd, Storrs, Connecticut 06269, USA
    Behav Pharmacol 14:583-8. 2003
    ..These findings support the hypothesis that CB1 receptor antagonists could be useful pharmacological tools for the suppression of appetite...
  65. ncbi request reprint Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: studies with low and high rate operant schedules
    Maria N Arizzi
    Department of Psychology, University of Connecticut, U 1020, Storrs, CT 06269 1020, USA
    Behav Brain Res 147:203-10. 2003
    ....
  66. ncbi request reprint The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis
    Keita Ishiwari
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    J Neurosci Methods 140:39-46. 2004
    ..This research may lead to a better understanding of how parkinsonian symptoms are modulated by SNr GABA mechanisms...
  67. ncbi request reprint Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task
    J D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 160:371-80. 2002
    ..In previous work with this task, dopamine antagonists and accumbens dopamine depletions decreased lever pressing but increased chow consumption...
  68. doi request reprint Infusions of acetaldehyde into the arcuate nucleus of the hypothalamus induce motor activity in rats
    Merce Correa
    Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA Area de Psicobiologia, Universitat Jaume I, 12071 Castello, Spain
    Life Sci 84:321-7. 2009
    ..In previous studies acetaldehyde injected in the lateral ventricles or in the substantia nigra reticulata (SNR) mimicked the behavioral stimulant effects of centrally administered ethanol...
  69. doi request reprint In vitro generation of dopaminergic neurons from adult subventricular zone neural progenitor cells
    Theodora Papanikolaou
    Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA
    Stem Cells Dev 17:157-72. 2008
    ....
  70. doi request reprint Central vs. peripheral administration of ethanol, acetaldehyde and acetate in rats: effects on lever pressing and response initiation
    Peter J McLaughlin
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 89:304-13. 2008
    ..The metabolites of ethanol are more potent than ethanol itself in terms of altering patterns of lever pressing. Thus, the effects of ethanol administration could in part be due to the actions of its biologically active metabolites...
  71. ncbi request reprint Behavioral effects of the novel cannabinoid full agonist AM 411
    Peter J McLaughlin
    Department of Psychology, University of Connecticut, 406 Babbidge Rd Storrs, CT, 06269 1020, USA
    Pharmacol Biochem Behav 81:78-88. 2005
    ..It is concluded that AM 411 produces CB1 agonist-like behavior with potency between that of WIN 55,212-2 and AM 356. AM 411 could be a useful tool for understanding the behavioral and neural effects of CB1 receptor stimulation...
  72. ncbi request reprint Functions of mesolimbic dopamine: changing concepts and shifting paradigms
    John D Salamone
    Psychopharmacology (Berl) 191:389. 2007
  73. ncbi request reprint The role of acetaldehyde in the central effects of ethanol
    Etienne Quertemont
    Neuroscience Comportementale et Psychopharmacologie, University of Liege, Liege, Belgium
    Alcohol Clin Exp Res 29:221-34. 2005
    ..McBride, Zachary A. Rodd, Avram Goldstein, Alejandro Zaffaroni and Ting-Kai Li; and (5) Acetaldehyde increases dopaminergic transmission in the limbic system, by Milena Pisano and Marco Diana...