Noha N Salama

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells
    Noha N Salama
    Department of Pharmaceutics, Box 357610, University of Washington, Seattle, Washington 98195 7610, USA
    J Pharm Sci 95:2293-308. 2006
  2. ncbi request reprint Combining drug and immune therapy: a potential solution to drug resistance and challenges of HIV vaccines?
    Aaron N Endsley
    Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA 98195, USA
    Curr HIV Res 6:401-10. 2008
  3. ncbi request reprint The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice
    Noha N Salama
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA
    J Pharm Sci 94:1216-25. 2005
  4. ncbi request reprint Recent developments in drug targets and delivery of anti-HIV drugs
    Noha N Salama
    Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA 98195, USA
    Infect Disord Drug Targets 6:107-19. 2006
  5. ncbi request reprint Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol
    Noha N Salama
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, MD 21201, USA
    Int J Pharm 251:113-21. 2003
  6. ncbi request reprint The influence of enaminones on the transport and oral bioavailability of P-glycoprotein substrate therapeutic agents
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Rm 543, Baltimore, MD 21201, USA
    Int J Pharm 273:135-47. 2004
  7. ncbi request reprint The effect of delta G on the transport and oral absorption of macromolecules
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, Maryland 21201, USA
    J Pharm Sci 93:1310-9. 2004
  8. ncbi request reprint DM27, an enaminone, modifies the in vitro transport of antiviral therapeutic agents
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, MD 21201, USA
    Biopharm Drug Dispos 25:227-36. 2004
  9. ncbi request reprint Enaminones: Exploring additional therapeutic activities
    Ivan O Edafiogho
    Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    J Pharm Sci 96:2509-31. 2007

Collaborators

  • Aaron N Endsley
  • Ivan O Edafiogho
  • Rodney J Y Ho
  • Mariano S Alexander
  • Natalie D Eddington
  • K R Scott
  • Clive D Hanson
  • Kethireddy V V Ananthalakshmi
  • Samuel B Kombian
  • Tiffany L Wilson
  • Patrice L Jackson

Detail Information

Publications9

  1. ncbi request reprint MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells
    Noha N Salama
    Department of Pharmaceutics, Box 357610, University of Washington, Seattle, Washington 98195 7610, USA
    J Pharm Sci 95:2293-308. 2006
    ..Results suggest that MDR1 polymorphisms at the 1236, 2677, and/or 3435 positions significantly minimize P-gp functionality in vitro, the extent of which appears to be substrate dependant...
  2. ncbi request reprint Combining drug and immune therapy: a potential solution to drug resistance and challenges of HIV vaccines?
    Aaron N Endsley
    Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA 98195, USA
    Curr HIV Res 6:401-10. 2008
    ..We will review the progress to date of anti-HIV drugs, preventative vaccines, and therapeutic vaccines and discuss the future strategies of combination drug and vaccine therapeutic strategies in the fight against HIV...
  3. ncbi request reprint The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice
    Noha N Salama
    Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA
    J Pharm Sci 94:1216-25. 2005
    ..05) drug accumulation in the brain ( approximately 21-fold) and heart (3.3-fold). Our results suggest mdr1a/1b-independant mechanisms may also contribute to nelfinavir tissue distribution in mice...
  4. ncbi request reprint Recent developments in drug targets and delivery of anti-HIV drugs
    Noha N Salama
    Department of Pharmaceutics, University of Washington School of Pharmacy, Seattle, WA 98195, USA
    Infect Disord Drug Targets 6:107-19. 2006
    ....
  5. ncbi request reprint Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol
    Noha N Salama
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, MD 21201, USA
    Int J Pharm 251:113-21. 2003
    ....
  6. ncbi request reprint The influence of enaminones on the transport and oral bioavailability of P-glycoprotein substrate therapeutic agents
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Rm 543, Baltimore, MD 21201, USA
    Int J Pharm 273:135-47. 2004
    ..This study investigated the potential inhibition of the enaminones on paclitaxel efflux in vitro compared to cyclosporin A, a known P-gp inhibitor, and the effectiveness of select enaminones on paclitaxel oral absorption in rats...
  7. ncbi request reprint The effect of delta G on the transport and oral absorption of macromolecules
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, Maryland 21201, USA
    J Pharm Sci 93:1310-9. 2004
    ..This study suggests that DeltaG may be used to enhance the oral bioavailability of macromolecules (e.g., proteins) after coadministration through modulation of paracellular transport...
  8. ncbi request reprint DM27, an enaminone, modifies the in vitro transport of antiviral therapeutic agents
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, MD 21201, USA
    Biopharm Drug Dispos 25:227-36. 2004
    ..This study investigates the influence of DM27, an enaminone, on the in vitro transport of antiviral agents and the possibility of using DM27 as a P-gp inhibitor to prevent the efflux of certain antiretroviral agents...
  9. ncbi request reprint Enaminones: Exploring additional therapeutic activities
    Ivan O Edafiogho
    Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    J Pharm Sci 96:2509-31. 2007
    ..This review provides the background and current research in this area with emphasis of these agents as potential anticonvulsants, their proposed mechanisms of action, and as potential modulators of multidrug resistance (MDR)...