Mohammed Sajid

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase
    Mohammed Sajid
    Department of Pathology, Tropical Disease Research Unit and Sandler Centre for Basic Research in Parasitic Diseases, University of California San Francisco, Box 0511, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 131:65-75. 2003
  2. pmc SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni
    Jan Dvorak
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS Negl Trop Dis 3:e449. 2009
  3. pmc Identification of the major cysteine protease of Giardia and its role in encystation
    Kelly N DuBois
    Department of Pathology, the Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, CA 94158, USA
    J Biol Chem 283:18024-31. 2008
  4. ncbi request reprint A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite
    Melaine Delcroix
    Department of Pathology, Tropical Disease Research Unit and Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California 94158, USA
    J Biol Chem 281:39316-29. 2006
  5. pmc The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion
    Ryan K Swenerton
    Department of Pathology, Sandler Center for Drug Discovery, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:429-40. 2011
  6. pmc Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity
    Iain D Kerr
    Department of Cellular and Molecular Pharmacology and Department of Pathology, University of California, San Francisco, California 94158, USA
    J Med Chem 52:852-7. 2009
  7. ncbi request reprint Differential use of protease families for invasion by schistosome cercariae
    Jan Dvorak
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biomedical Research QB3, 1700 4th Street, University of California, San Francisco, CA 94158 2550, USA
    Biochimie 90:345-58. 2008
  8. pmc A blood fluke serine protease inhibitor regulates an endogenous larval elastase
    Landys A Lopez Quezada
    Biomedical Science Graduate Program, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:7074-83. 2012
  9. ncbi request reprint SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni
    Conor R Caffrey
    Tropical Disease Research Unit, Department of Pathology, Box 0511, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 121:49-61. 2002
  10. ncbi request reprint Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries
    Mary A Mathieu
    Department of Pathology, UCSF, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 121:99-105. 2002

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase
    Mohammed Sajid
    Department of Pathology, Tropical Disease Research Unit and Sandler Centre for Basic Research in Parasitic Diseases, University of California San Francisco, Box 0511, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 131:65-75. 2003
    ..This study characterizes the major digestive cysteine peptidase in schistosomes and defines novel trans-processing events required to activate the SmCB1 zymogen in vitro which may facilitate the digestive process in vivo...
  2. pmc SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni
    Jan Dvorak
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS Negl Trop Dis 3:e449. 2009
    ..Digestion of nutrients from the host bloodstream is essential for parasite development and reproduction. A network of proteolytic enzymes (proteases) facilitates hydrolysis of host hemoglobin and serum proteins...
  3. pmc Identification of the major cysteine protease of Giardia and its role in encystation
    Kelly N DuBois
    Department of Pathology, the Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, CA 94158, USA
    J Biol Chem 283:18024-31. 2008
    ..These data suggest that Giardia cysteine protease 2 is not only the major cysteine endoprotease expressed in Giardia, but is also central to the encystation process...
  4. ncbi request reprint A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite
    Melaine Delcroix
    Department of Pathology, Tropical Disease Research Unit and Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California 94158, USA
    J Biol Chem 281:39316-29. 2006
    ..It also provides insights into which of these proteases are logical targets for development of chemotherapy for schistosomiasis, a major global health problem...
  5. pmc The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion
    Ryan K Swenerton
    Department of Pathology, Sandler Center for Drug Discovery, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:429-40. 2011
    ..Additionally, these OPB(-/-) parasites displayed decreased virulence in the murine footpad infection model...
  6. pmc Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity
    Iain D Kerr
    Department of Cellular and Molecular Pharmacology and Department of Pathology, University of California, San Francisco, California 94158, USA
    J Med Chem 52:852-7. 2009
    ..The cumulative effect of subtle differences, including those at "gatekeeper" positions, may explain the observed kinetic differences between these two closely related enzymes...
  7. ncbi request reprint Differential use of protease families for invasion by schistosome cercariae
    Jan Dvorak
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biomedical Research QB3, 1700 4th Street, University of California, San Francisco, CA 94158 2550, USA
    Biochimie 90:345-58. 2008
    ..Computational analysis of serine protease phylogeny revealed an extraordinarily distant relationship between S. mansoni serine proteases and other members of the Clan PA family S1 proteases...
  8. pmc A blood fluke serine protease inhibitor regulates an endogenous larval elastase
    Landys A Lopez Quezada
    Biomedical Science Graduate Program, University of California, San Francisco, California 94158, USA
    J Biol Chem 287:7074-83. 2012
    ..The results of this study suggest that cercarial elastase degradation of skin tissue is carefully regulated by SmSrpQ...
  9. ncbi request reprint SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni
    Conor R Caffrey
    Tropical Disease Research Unit, Department of Pathology, Box 0511, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 121:49-61. 2002
    ..By immunohistochemistry, SmCB2 was localized in the tegumental tubercles and parenchyma of males with less product being visualized in the parenchyma of females. The enzyme may be lysosomal and function at the host parasite-interface...
  10. ncbi request reprint Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries
    Mary A Mathieu
    Department of Pathology, UCSF, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 121:99-105. 2002
    ..Predictions of substrate specificity from the library screen were confirmed using single peptide substrates for kinetic assays...
  11. pmc Vinyl sulfones as antiparasitic agents and a structural basis for drug design
    Iain D Kerr
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158 2550, USA
    J Biol Chem 284:25697-703. 2009
    ....
  12. pmc A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia
    Marla Abodeely
    Department of Pathology, the Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, CA 94158, USA
    Eukaryot Cell 8:1665-76. 2009
    ..This system also may have functional similarity to the retrograde transport of toxins and major histocompatibility complex class I function in the ER of mammals...
  13. pmc Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor
    Maha Hamadien Abdulla
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America
    PLoS Med 4:e14. 2007
    ..Due to the lack of a vaccine, patient therapy is heavily reliant on chemotherapy with praziquantel as the World Health Organization-recommended drug, but concerns over drug resistance encourage the search for new drug leads...
  14. ncbi request reprint Blood 'n' guts: an update on schistosome digestive peptidases
    Conor R Caffrey
    Sandler Center for Basic Research in Parasitic Diseases, Box 0511, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Parasitol 20:241-8. 2004
  15. pmc Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology
    Ryan K Swenerton
    Department of Pathology, Sandler Center for Drug Discovery, University of California, San Francisco, California 94158, USA
    J Biol Chem 285:31120-9. 2010
    ..In addition, knock-out parasites showed increased sensitivity to hydroperoxide. These data suggest that subtilisin is the maturase for tryparedoxin peroxidases and is necessary for full virulence...
  16. pmc A surface amebic cysteine proteinase inactivates interleukin-18
    Xuchu Que
    Department of Pathology, University of California, San Diego, California 92103, USA
    Infect Immun 71:1274-80. 2003
    ..E. histolytica may block the host inflammatory response by a novel mechanism, inactivation of IL-18...
  17. pmc Proteomic analysis of skin invasion by blood fluke larvae
    Elizabeth Hansell
    Sandler Center, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, California, United States of America
    PLoS Negl Trop Dis 2:e262. 2008
    ..To better understand the pathobiology of this initial event in schistosome infection, a proteome analysis of human skin was carried out following invasion by cercariae of Schistosoma mansoni...
  18. ncbi request reprint Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors
    Conor R Caffrey
    Sandler Center for Basic Research in Parasitic Diseases, University of California at San Francisco, Box 0511, San Francisco, CA 94143, USA
    Biol Chem 386:339-49. 2005
    ..The unique steric barrier identified here provides a structural focus for further development of more specific SjCD inhibitors...
  19. ncbi request reprint Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria
    Anjan Debnath
    Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, San Francisco, CA 94158, USA
    Int J Parasitol 37:897-906. 2007
    ..The enhanced expression of this gene cluster is consistent with enhanced phagocytosis of E. histolytica during interaction with bacteria...
  20. ncbi request reprint Proteases in parasitic diseases
    James H McKerrow
    Department of Pathology, Sandler Center, University of California, San Francisco, California 94143, USA
    Annu Rev Pathol 1:497-536. 2006
    ....
  21. ncbi request reprint Giardia lamblia cysteine proteases
    Kelly N DuBois
    Department of Pathology and the Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, CA 94158 2550, USA
    Parasitol Res 99:313-6. 2006
  22. pmc The global cysteine peptidase landscape in parasites
    Holly J Atkinson
    UCSF Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, CA 94158 2330, USA
    Trends Parasitol 25:573-81. 2009
    ..This snapshot of the landscape of parasite cysteine peptidases is complex and highly populated, suggesting that expansion of research beyond the few 'model' parasite peptidases is now timely...
  23. ncbi request reprint Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition
    Jan Dvorak
    Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, CZ 12844 Prague, Czech Republic
    Int J Parasitol 35:895-910. 2005
    ..Also, both isoforms degraded myelin basic protein, the major protein component of nervous tissue, but were inefficient against hemoglobin, thus supporting the adaptation of T. regenti gut peptidases to parasitism of host nervous tissue...
  24. ncbi request reprint Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression
    Volker Wippersteg
    Insitute for Genetics, Heinrich Heine University, Dusseldorf, Germany
    Int J Parasitol 35:583-9. 2005
    ..Promoter-deletion of the SmCF gene indicated the importance of one or more transcription factor binding sites in the first 169 bp for both GFP-expression and its tissue specificity...
  25. ncbi request reprint Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum
    Natthawan Kongkerd
    Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Biochem Parasitol 160:129-37. 2008
    ..Mouse anti-GST-proGsCL1 serum showed reactivity with 35-, 38- and 45-kDa proteins in the aL3 extracts. These proteins were shown to localize inside the intestinal cells of aL3...
  26. ncbi request reprint A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms
    Angela L Williamson
    Department of Microbiology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA
    J Biol Chem 279:35950-7. 2004
    ....
  27. pmc IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus
    Daniel Sojka
    Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic
    Int J Parasitol 37:713-24. 2007
    ..The possible functions of IrAE in the gut digestive processes of I. ricinus are compared with those suggested for other hematophagous parasites...
  28. ncbi request reprint Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica
    Anjan Debnath
    National Institute of Cholera and Enteric Diseases, Kolkata, India
    J Infect Dis 190:448-57. 2004
    ..These results provide important new clues about how a pathogen orchestrates responses to the host environment as well as a new tool for the analysis of other aspects of Entamoeba species infection and pathogenicity...
  29. ncbi request reprint Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design
    Dietmar Steverding
    Biomedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Mini Rev Med Chem 6:1025-32. 2006
    ..This article reviews the biology and physicochemistry of parasite proteinases and the ongoing design of peptidyl and non-peptidyl inhibitors to generate anti-parasitic compounds of greater efficacy with decreased toxicity to the host...
  30. ncbi request reprint Clan CD cysteine peptidases of parasitic protozoa
    Jeremy C Mottram
    Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, G11 6NU, Glasgow, UK
    Trends Parasitol 19:182-7. 2003
    ..The main characteristics of clan CD enzymes are outlined here, in particular glycosylphosphatidylinositol (GPI):protein transamidase, metacaspase and separase, and their differences from the clan CA enzymes are described...