Akihiko Saitoh

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 52:2825-30. 2008
  2. doi request reprint Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0672, USA
    Pediatrics 121:e513-21. 2008
  3. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
  4. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 51:4236-42. 2007
  5. ncbi request reprint Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 45:280-5. 2007
  6. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
  7. ncbi request reprint Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 185:1409-16. 2002
  8. ncbi request reprint An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 19:371-80. 2005
  9. pmc Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla 92093 0672, USA
    J Allergy Clin Immunol 117:909-15. 2006
  10. ncbi request reprint Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 189:1216-20. 2004

Research Grants

  1. The Impact of HLA in Children Receiving HAART
    Akihiko Saitoh; Fiscal Year: 2007

Detail Information

Publications16

  1. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 52:2825-30. 2008
    ..These findings may be of particular importance in developing countries, where ddI is widely used for first-line treatment of HIV-infected children...
  2. doi request reprint Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0672, USA
    Pediatrics 121:e513-21. 2008
    ..The objective of this study was to investigate the actual prevalence and clinical outcomes of a treatment interruption in children and adolescents with perinatally acquired HIV-1 infection...
  3. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
    ....
  4. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 51:4236-42. 2007
    ..This may be of particular importance in resource-limited countries where didanosine is widely used for the treatment of HIV-infected children...
  5. ncbi request reprint Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 45:280-5. 2007
    ..The impact of CYP2B6-G516T polymorphisms on EFV concentrations may be different in children because of differences in liver maturation and drug dosage...
  6. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
    ....
  7. ncbi request reprint Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 185:1409-16. 2002
    ..Thus, despite prolonged maintenance of undetectable levels of plasma HIV-1 RNA, HIV-1 DNA remains detectable in PBMC of children and may be a useful marker of further virus suppression...
  8. ncbi request reprint An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 19:371-80. 2005
    ..This research examined the impact of single nucleotide polymorphisms (SNP) of MDR1 and CYP genes on nelfinavir and efavirenz pharmacokinetics and the response to highly active antiretroviral therapy (HAART) in HIV-1 infected children...
  9. pmc Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla 92093 0672, USA
    J Allergy Clin Immunol 117:909-15. 2006
    ....
  10. ncbi request reprint Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 189:1216-20. 2004
    ..These data suggest that the increased proportion of naive lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults...
  11. ncbi request reprint Prediction of neurologic sequelae in childhood tuberculous meningitis: a review of 20 cases and proposal of a novel scoring system
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, CA, USA
    Pediatr Infect Dis J 24:207-12. 2005
    ..In the current era of critical care medicine and corticosteroid therapy, a new scoring system is needed to predict NS more accurately in children with TBM...
  12. ncbi request reprint Mitochondrial dysfunction: prevention of HIV-1 mother-to-infant transmission outweighs fear
    Stephen A Spector
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA, USA
    AIDS 20:1777-8. 2006
  13. ncbi request reprint Myelomeningocele in an infant with intrauterine exposure to efavirenz
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Perinatol 25:555-6. 2005
    ..Thus, we suggest that efavirenz only be prescribed for women of childbearing potential when no other comparable antiretroviral options are available...
  14. ncbi request reprint Fulminant bacterial meningitis complicating sphenoid sinusitis
    Akihiko Saitoh
    Division of Pediatric Infectious Diseases, University of California, San Diego, La Jolla 92093, USA
    Pediatr Emerg Care 19:415-7. 2003
  15. ncbi request reprint Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz
    Elizabeth A Lowenhaupt
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    Clin Infect Dis 45:e128-30. 2007
    ..We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T...
  16. ncbi request reprint Treatment of infants coinfected with HIV-1 and cytomegalovirus with combination antiretrovirals and ganciclovir
    Akihiko Saitoh
    J Allergy Clin Immunol 114:983-5. 2004

Research Grants2

  1. The Impact of HLA in Children Receiving HAART
    Akihiko Saitoh; Fiscal Year: 2007
    This application for a Mentored Patient-Oriented Research Career Developmental Award (K23) seeks support for Akihiko Saitoh, M.D...