Kaoru Saijo

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Cell 145:584-95. 2011
  2. doi request reprint Regulation of microglia activation and deactivation by nuclear receptors
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA
    Glia 61:104-11. 2013
  3. pmc Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature
    Jana C Möller
    Division of Rheumatology and Immunology, Children s Hospital, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstr, 74, 01307 Dresden, Germany
    Pediatr Rheumatol Online J 9:5. 2011
  4. pmc A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California, CA 92093, USA
    Cell 137:47-59. 2009
  5. doi request reprint Nuclear receptors, inflammation, and neurodegenerative diseases
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Adv Immunol 106:21-59. 2010
  6. doi request reprint Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, GPL Room 217A, La Jolla, California 92093 0651, USA
    Nat Rev Immunol 10:365-76. 2010
  7. doi request reprint Microglial cell origin and phenotypes in health and disease
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    Nat Rev Immunol 11:775-87. 2011
  8. pmc Mechanisms underlying inflammation in neurodegeneration
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 92093, USA
    Cell 140:918-34. 2010
  9. pmc Coronin 2A mediates actin-dependent de-repression of inflammatory response genes
    Wendy Huang
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    Nature 470:414-8. 2011

Collaborators

  • Beate Winner
  • Christopher K Glass
  • Wendy Huang
  • Jana C Möller
  • Bruce L Goode
  • Akiko Kukita
  • Michael P Czech
  • Deborah M Levy
  • Hermann J Girschick
  • Randy Q Cron
  • Daniel W Young
  • Dawn X Zhang
  • Meghal Gandhi
  • Serena Ghisletti
  • Michael G Rosenfeld
  • David D Sherry
  • Myriam Aouadi
  • Joyee Yao
  • Greg J Tesz
  • Frank Pessler
  • Maria Carolina Marchetto
  • Fred H Gage

Detail Information

Publications9

  1. pmc An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Cell 145:584-95. 2011
    ..These findings provide evidence for an ADIOL/ERβ/CtBP-transrepression pathway that regulates inflammatory responses in microglia and can be targeted by selective ERβ modulators...
  2. doi request reprint Regulation of microglia activation and deactivation by nuclear receptors
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA
    Glia 61:104-11. 2013
    ..Here, we review recent advances in our understanding of the regulation of microglia activation and deactivation with a focus on counter-regulation of microglia activation by nuclear receptors...
  3. pmc Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature
    Jana C Möller
    Division of Rheumatology and Immunology, Children s Hospital, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstr, 74, 01307 Dresden, Germany
    Pediatr Rheumatol Online J 9:5. 2011
    ..In summary, pediatric spinal epidural lipomatosis remains a potentially serious untoward effect of corticosteroid treatment, which, if recognized in a timely manner, can have a good outcome with conservative treatment...
  4. pmc A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California, CA 92093, USA
    Cell 137:47-59. 2009
    ..These studies suggest that Nurr1 protects against loss of dopaminergic neurons in Parkinson's disease in part by limiting the production of neurotoxic mediators by microglia and astrocytes...
  5. doi request reprint Nuclear receptors, inflammation, and neurodegenerative diseases
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Adv Immunol 106:21-59. 2010
    ....
  6. doi request reprint Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, GPL Room 217A, La Jolla, California 92093 0651, USA
    Nat Rev Immunol 10:365-76. 2010
    ..These nuclear receptor-dependent transrepression pathways are proposed to have roles in controlling the initiation, magnitude and duration of pro-inflammatory gene expression and are amenable to pharmacological manipulation...
  7. doi request reprint Microglial cell origin and phenotypes in health and disease
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    Nat Rev Immunol 11:775-87. 2011
    ..Here, we discuss recent studies that provide new insights into the origin and phenotypes of microglia in health and disease...
  8. pmc Mechanisms underlying inflammation in neurodegeneration
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 92093, USA
    Cell 140:918-34. 2010
    ..A major unanswered question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease...
  9. pmc Coronin 2A mediates actin-dependent de-repression of inflammatory response genes
    Wendy Huang
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    Nature 470:414-8. 2011
    ....