A Sahni

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Endothelial cell activation by IL-1beta in the presence of fibrinogen requires alphavbeta3
    Abha Sahni
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 25:2222-7. 2005
  2. pmc FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis
    Abha Sahni
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Blood 107:126-31. 2006
  3. ncbi Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells
    A Sahni
    Department of Medicine, Hematology Oncology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Thromb Haemost 2:1629-36. 2004
  4. ncbi Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3
    Abha Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, USA
    Blood 104:3635-41. 2004
  5. ncbi Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form
    Abha Sahni
    Department of Medicine, PO Box 610, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 104:409-14. 2004
  6. ncbi Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2)
    A Sahni
    Hematology Oncology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Thromb Haemost 6:176-83. 2008
  7. ncbi Plasmic degradation modulates activity of fibrinogen-bound fibroblast growth factor-2
    A Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, University Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thromb Haemost 1:1271-7. 2003
  8. ncbi FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth
    A Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, University Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thromb Haemost 1:1304-10. 2003
  9. doi The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells
    Abha Sahni
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Int J Cancer 125:577-84. 2009
  10. ncbi Potential roles for regulatory oxygenases in rickettsial pathogenesis
    Sanjeev K Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1063:207-14. 2005

Detail Information

Publications18

  1. ncbi Endothelial cell activation by IL-1beta in the presence of fibrinogen requires alphavbeta3
    Abha Sahni
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 25:2222-7. 2005
    ..The purpose of this study was to investigate the receptor requirements for enhanced IL-1beta-induced secretion of nitric oxide (NO) by endothelial cells (ECs) in the presence of fibrinogen...
  2. pmc FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis
    Abha Sahni
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Blood 107:126-31. 2006
    ..These results demonstrate that binding of FGF-2 to fibrin(ogen) mediated by the 5-residue FGF-2-fibrin(ogen) interactive site is required for augmented angiogenesis...
  3. ncbi Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells
    A Sahni
    Department of Medicine, Hematology Oncology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Thromb Haemost 2:1629-36. 2004
    ..We conclude that fibrinogen increases the capacity of FGF-2, but not of VEGF, to up-regulate u-PA, u-PAR, and PAI-1 in endothelial cells and that fibrinogen-bound FGF-2 requires alphaVbeta3 binding to up-regulate endothelial cell u-PA...
  4. ncbi Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3
    Abha Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY, USA
    Blood 104:3635-41. 2004
    ..We conclude that fibrinogen binding of FGF-2 enhances EC proliferation through the coordinated effects of colocalized alpha(v)beta(3) and FGFR1...
  5. ncbi Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form
    Abha Sahni
    Department of Medicine, PO Box 610, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 104:409-14. 2004
    ..We conclude that IL-1beta binds with high affinity to fibrin(ogen) and demonstrates increased activity in the bound form...
  6. ncbi Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2)
    A Sahni
    Hematology Oncology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Thromb Haemost 6:176-83. 2008
    ..Fibrinogen and fibrin bind to FGF-2 and modulate FGF-2 functions. Furthermore, we have shown that extrahepatic epithelial cells are capable of endogenous production of fibrinogen...
  7. ncbi Plasmic degradation modulates activity of fibrinogen-bound fibroblast growth factor-2
    A Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, University Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thromb Haemost 1:1271-7. 2003
    ..The results demonstrate that plasmic degradation of fibrinogen modulates the activity and binding of FGF-2 that involves a site near the carboxyl terminus of the gamma chain...
  8. ncbi FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth
    A Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, University Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thromb Haemost 1:1304-10. 2003
    ..Fibrin may serve as a matrix reservoir for FGF-2 to support cell growth at sites of injury or thrombosis...
  9. doi The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells
    Abha Sahni
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Int J Cancer 125:577-84. 2009
    ..Hence, Fg-beta(15-42) represents a potential molecular target for therapeutic intervention of breast cancer metastasis...
  10. ncbi Potential roles for regulatory oxygenases in rickettsial pathogenesis
    Sanjeev K Sahni
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1063:207-14. 2005
    ....
  11. pmc Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells
    Jeffrey D Alexis
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 104:69-78. 2009
    ....
  12. ncbi Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells
    Min Guo
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Thromb Haemost 92:858-66. 2004
    ..From our findings, we conclude that fibrinogen regulates NF-kappaB activation and expression of inflammatory chemokines in endothelial cells and may be involved in mediating inflammatory processes...
  13. ncbi Identification of a binding site on human FGF-2 for fibrinogen
    Hu Peng
    Department of Medicine, Hematology Oncology Unit, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 103:2114-20. 2004
    ..3 nM and 8.6 nM, respectively, compared with 1.3 nM for wild-type FGF-2. We conclude that these 5 residues define a high-affinity binding site in FGF-2 for fibrinogen...
  14. ncbi Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight
    Alok A Khorana
    James P Wilmot Cancer Center and Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Arterioscler Thromb Vasc Biol 23:2110-5. 2003
    ..Tumors depend on an expanding vasculature, and heparins may affect vessel growth and function. We investigated the effect of heparins differing in Mr on selected endothelial cell properties...
  15. pmc Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins
    Elena Rydkina
    Department of Medicine, Hematology Oncology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Infect Immun 74:5067-74. 2006
    ..Induction of the endothelial COX-2 system and the resultant enhanced release of vasoactive PGs may contribute to the regulation of inflammatory responses and vascular permeability changes during spotted fever rickettsioses...
  16. ncbi Comparative analysis of host-cell signalling mechanisms activated in response to infection with Rickettsia conorii and Rickettsia typhi
    Elena Rydkina
    Hematology Oncology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Med Microbiol 56:896-906. 2007
    ....
  17. pmc Rickettsia rickettsii infection of cultured human endothelial cells induces heme oxygenase 1 expression
    Elena Rydkina
    Hematology Oncology Unit, Vascular Medicine Progam, Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Infect Immun 70:4045-52. 2002
    ..rickettsii infection induces HO-1 expression in host endothelial cells and suggest an important role for this enzyme in cellular response to infection, possibly by serving a protective function against oxidative injury...
  18. pmc UAP56 is an important regulator of protein synthesis and growth in cardiomyocytes
    Abha Sahni
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 393:106-10. 2010
    ..Our data demonstrate that UAP56 is an important regulator of protein synthesis and plays an important role in the regulation of cardiomyocyte growth...