Scott Sagel

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Airway inflammation in children with cystic fibrosis and healthy children assessed by sputum induction
    S D Sagel
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 164:1425-31. 2001
  2. doi request reprint Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Cyst Fibros 10:31-6. 2011
  3. doi request reprint Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Pediatr Pulmonol 44:402-9. 2009
  4. pmc Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Pediatr 154:183-8. 2009
  5. pmc Update of respiratory tract disease in children with primary ciliary dyskinesia
    Scott D Sagel
    Children s Hospital Colorado, Aurora, CO 80045, USA
    Proc Am Thorac Soc 8:438-43. 2011
  6. pmc Sputum biomarkers of inflammation in cystic fibrosis lung disease
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80218, USA
    Proc Am Thorac Soc 4:406-17. 2007
  7. ncbi request reprint Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80218, USA
    Pediatr Pulmonol 39:224-32. 2005
  8. ncbi request reprint Monitoring inflammation in CF. Cytokines
    Scott D Sagel
    Department of Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, 1056 E 19th Ave, Box B395, Denver, CO 80218, USA
    Clin Rev Allergy Immunol 23:41-57. 2002
  9. ncbi request reprint Noninvasive biomarkers of airway inflammation in cystic fibrosis
    Scott D Sagel
    Departmentof Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, Denver, 80218, USA
    Curr Opin Pulm Med 9:516-21. 2003
  10. pmc Association between pulmonary function and sputum biomarkers in cystic fibrosis
    Nicole Mayer-Hamblett
    Department of Pediatrics, University of Washington, 4800 Sand Point Way N E, Box 5371, Seattle, WA 98105 0371, USA
    Am J Respir Crit Care Med 175:822-8. 2007

Research Grants

Detail Information

Publications26

  1. ncbi request reprint Airway inflammation in children with cystic fibrosis and healthy children assessed by sputum induction
    S D Sagel
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 164:1425-31. 2001
    ..Furthermore, induced sputum samples are similar to spontaneously expectorated samples in describing both inflammation and infection in the CF airway...
  2. doi request reprint Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Cyst Fibros 10:31-6. 2011
    ..Despite supplementation with standard multivitamins and pancreatic enzymes, deficiencies of vitamins D and K and antioxidants are common in cystic fibrosis (CF)...
  3. doi request reprint Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Pediatr Pulmonol 44:402-9. 2009
    ....
  4. pmc Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Pediatr 154:183-8. 2009
    ..To assess the effects of Pseudomonas aeruginosa and Staphylococcus aureus infection on lower airway inflammation and clinical status in young children with cystic fibrosis (CF)...
  5. pmc Update of respiratory tract disease in children with primary ciliary dyskinesia
    Scott D Sagel
    Children s Hospital Colorado, Aurora, CO 80045, USA
    Proc Am Thorac Soc 8:438-43. 2011
    ..This review concludes with recommendations for clinical endpoints and outcome measures and a prioritized list of treatments to study in PCD clinical trials...
  6. pmc Sputum biomarkers of inflammation in cystic fibrosis lung disease
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80218, USA
    Proc Am Thorac Soc 4:406-17. 2007
    ..In the future, pulmonary biomarkers will likely be useful in predicting disease progression, indicating the onset and resolution of a pulmonary exacerbation, and assessing response to current therapies or candidate therapeutics...
  7. ncbi request reprint Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80218, USA
    Pediatr Pulmonol 39:224-32. 2005
    ..The observed relationships of MMP-9 with lung function and other measures of airway inflammation suggest that this enzyme may be a useful marker of airway injury and airflow obstruction in persons with CF...
  8. ncbi request reprint Monitoring inflammation in CF. Cytokines
    Scott D Sagel
    Department of Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, 1056 E 19th Ave, Box B395, Denver, CO 80218, USA
    Clin Rev Allergy Immunol 23:41-57. 2002
    ..In addition, cytokines may eventually serve as targets for novel anti-inflammatory therapies in CF...
  9. ncbi request reprint Noninvasive biomarkers of airway inflammation in cystic fibrosis
    Scott D Sagel
    Departmentof Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, Denver, 80218, USA
    Curr Opin Pulm Med 9:516-21. 2003
    ....
  10. pmc Association between pulmonary function and sputum biomarkers in cystic fibrosis
    Nicole Mayer-Hamblett
    Department of Pediatrics, University of Washington, 4800 Sand Point Way N E, Box 5371, Seattle, WA 98105 0371, USA
    Am J Respir Crit Care Med 175:822-8. 2007
    ..Validation of these biomarkers as correlates of disease severity is a key step for their application...
  11. pmc Sputum desmosine during hospital admission for pulmonary exacerbation in cystic fibrosis
    Theresa A Laguna
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Chest 136:1561-8. 2009
    ....
  12. ncbi request reprint Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
    J Pediatr 141:811-7. 2002
    ..To validate a sputum induction technique in cystic fibrosis (CF), we examined the relation between airway inflammation and pulmonary function in children with CF by correlating inflammatory indexes in induced sputum with FEV(1)...
  13. pmc Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease
    Milene T Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Respir Crit Care Med 178:929-38. 2008
    ..Although the standard assessment of pulmonary treatment response is FEV(1), a measure of airflow limitation, the lack of systemic markers to reflect changes in lung inflammation critically limits the testing of proposed therapeutics...
  14. ncbi request reprint Identifying novel endpoints for cystic fibrosis clinical trials
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Adv Pediatr 52:115-27. 2005
    ....
  15. ncbi request reprint Update on newborn screening for cystic fibrosis
    Jeffrey S Wagener
    University of Colorado Medical School, Department of Pediatrics, Denver, Colorado, USA
    Curr Opin Pulm Med 10:500-4. 2004
    ..In this review we discuss the information during the year leading up to this meeting as well as publications since the meeting...
  16. pmc Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation
    Frank J Accurso
    University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
    N Engl J Med 363:1991-2003. 2010
    ..VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro...
  17. doi request reprint The clinical course of a Mexican female with cystic fibrosis and the novel genotype S531P/S531P
    Theresa A Laguna
    Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, 13123 E 16th Ave, B 395, Aurora, CO 80045, USA
    J Cyst Fibros 7:454-6. 2008
    ..This report illustrates the need for better characterization of CFTR mutations in a Hispanic population to aid in clinical care...
  18. pmc Pulmonary exacerbations in cystic fibrosis with negative bacterial cultures
    Edith T Zemanick
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pediatr Pulmonol 45:569-77. 2010
    ..Exacerbations are often associated with characteristic airway bacteria [CF related bacteria (CFRB)]. However, some patients do not have CFRB detected by culture during exacerbations...
  19. doi request reprint A new cystic fibrosis newborn screening algorithm: IRT/IRT1 upward arrow/DNA
    Marci K Sontag
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA
    J Pediatr 155:618-22. 2009
    ..To evaluate an immunoreactive trypsinogen (IRT) IRT/IRT1 upward arrow/DNA algorithm, aimed at improving sensitivity while decreasing cystic fibrosis (CF) carrier identification...
  20. pmc Reliability of quantitative real-time PCR for bacterial detection in cystic fibrosis airway specimens
    Edith T Zemanick
    Department of Pediatrics, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 5:e15101. 2010
    ..influenzae from CF airway samples. By reliably quantifying fastidious airway bacteria, qPCR may improve our understanding of polymicrobial CF lung infections, progression of lung disease and ultimately improve antimicrobial treatments...
  21. ncbi request reprint Bacterial colonization and infection in the CF lung
    Scott D Sagel
    Department of Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, Denver, CO, USA
    Methods Mol Med 70:433-46. 2002
  22. ncbi request reprint Diagnosis of a symptomatic tracheal pouch by means of bronchoscopy after neonatal repair of a tracheoesophageal fistula
    J Brian Kang
    Department of Pediatrics, The Children s Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colo, USA
    J Allergy Clin Immunol 120:541-3. 2007
  23. ncbi request reprint Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung disease
    Gregory S Montgomery
    Division of Pediatric Pulmonology, Department of Pediatrics, Indiana University Medical Center, Indianapolis, Indiana, USA
    Pediatr Pulmonol 41:383-5. 2006
    ..We report on a patient with severe CF lung disease who experienced clinically significant improvements in exercise tolerance and pulmonary hypertension without changing lung function during sildenafil therapy...
  24. pmc Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis
    J Kirk Harris
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 104:20529-33. 2007
    ..These results show that molecular techniques provide a broader perspective on airway bacteria than do routine clinical cultures and thus can identify targets for further clinical evaluation...
  25. ncbi request reprint Computed tomography in the evaluation of cystic fibrosis lung disease
    Alan S Brody
    Department of Radiology, MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 172:1246-52. 2005
    ..Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this article is to present the current status of CT scanning in CF...
  26. ncbi request reprint A pilot study on the safety and efficacy of a novel antioxidant rich formulation in patients with cystic fibrosis
    Konstantinos A Papas
    Yasoo Health, Johnson City, TN, USA
    J Cyst Fibros 7:60-7. 2008
    ....

Research Grants5

  1. Noninvasive biomarkers of proteolytic activity in CF
    Scott Sagel; Fiscal Year: 2007
    ..In addition, he will actively participate and train in the Pediatric GCRC, and frequently interact with his sponsor, mentors, and collaborators. ..