Research Topics
Species | Scott SagelSummaryAffiliation: University of Colorado Country: USA Publications
Research Grants
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Detail Information
Publications
Airway inflammation in children with cystic fibrosis and healthy children assessed by sputum inductionS D Sagel
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Respir Crit Care Med 164:1425-31. 2001..Furthermore, induced sputum samples are similar to spontaneously expectorated samples in describing both inflammation and infection in the CF airway...
Effect of an antioxidant-rich multivitamin supplement in cystic fibrosisScott D Sagel
Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO, USA
J Cyst Fibros 10:31-6. 2011..Despite supplementation with standard multivitamins and pancreatic enzymes, deficiencies of vitamins D and K and antioxidants are common in cystic fibrosis (CF)...- Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosisScott D Sagel
Department of Pediatrics, The Children s Hospital and University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
Pediatr Pulmonol 44:402-9. 2009.... 
Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosisScott D Sagel
Department of Pediatrics, The Children s Hospital and University of Colorado Health Sciences Center, Aurora, CO 80045, USA
J Pediatr 154:183-8. 2009..To assess the effects of Pseudomonas aeruginosa and Staphylococcus aureus infection on lower airway inflammation and clinical status in young children with cystic fibrosis (CF)...- Update of respiratory tract disease in children with primary ciliary dyskinesiaScott D Sagel
Children s Hospital Colorado, Aurora, CO 80045, USA
Proc Am Thorac Soc 8:438-43. 2011..This review concludes with recommendations for clinical endpoints and outcome measures and a prioritized list of treatments to study in PCD clinical trials... - Sputum biomarkers of inflammation in cystic fibrosis lung diseaseScott D Sagel
Department of Pediatrics, The Children s Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80218, USA
Proc Am Thorac Soc 4:406-17. 2007..In the future, pulmonary biomarkers will likely be useful in predicting disease progression, indicating the onset and resolution of a pulmonary exacerbation, and assessing response to current therapies or candidate therapeutics... - Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosisScott D Sagel
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80218, USA
Pediatr Pulmonol 39:224-32. 2005..The observed relationships of MMP-9 with lung function and other measures of airway inflammation suggest that this enzyme may be a useful marker of airway injury and airflow obstruction in persons with CF... - Monitoring inflammation in CF. CytokinesScott D Sagel
Department of Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, 1056 E 19th Ave, Box B395, Denver, CO 80218, USA
Clin Rev Allergy Immunol 23:41-57. 2002..In addition, cytokines may eventually serve as targets for novel anti-inflammatory therapies in CF... - Noninvasive biomarkers of airway inflammation in cystic fibrosisScott D Sagel
Departmentof Pediatrics, Children s Hospital, University of Colorado Health Sciences Center, Denver, 80218, USA
Curr Opin Pulm Med 9:516-21. 2003.... - Association between pulmonary function and sputum biomarkers in cystic fibrosisNicole Mayer-Hamblett
Department of Pediatrics, University of Washington, 4800 Sand Point Way N E, Box 5371, Seattle, WA 98105 0371, USA
Am J Respir Crit Care Med 175:822-8. 2007..Validation of these biomarkers as correlates of disease severity is a key step for their application... - Sputum desmosine during hospital admission for pulmonary exacerbation in cystic fibrosisTheresa A Laguna
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Chest 136:1561-8. 2009.... - Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosisScott D Sagel
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, USA
J Pediatr 141:811-7. 2002.... - Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung diseaseMilene T Saavedra
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Am J Respir Crit Care Med 178:929-38. 2008..Although the standard assessment of pulmonary treatment response is FEV(1), a measure of airflow limitation, the lack of systemic markers to reflect changes in lung inflammation critically limits the testing of proposed therapeutics... - Identifying novel endpoints for cystic fibrosis clinical trialsScott D Sagel
Department of Pediatrics, The Children's Hospital, University of Colorado Health Sciences Center, Denver, Colorado, USA
Adv Pediatr 52:115-27. 2005.... - Update on newborn screening for cystic fibrosisJeffrey S Wagener
University of Colorado Medical School, Department of Pediatrics, Denver, Colorado, USA
Curr Opin Pulm Med 10:500-4. 2004..In this review we discuss the information during the year leading up to this meeting as well as publications since the meeting... - Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutationFrank J Accurso
University of Colorado Denver and Children s Hospital, Aurora, CO 80045, USA
N Engl J Med 363:1991-2003. 2010..VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro... - The clinical course of a Mexican female with cystic fibrosis and the novel genotype S531P/S531PTheresa A Laguna
Department of Pediatrics, University of Colorado School of Medicine and The Children s Hospital, 13123 E 16th Ave, B 395, Aurora, CO 80045, USA
J Cyst Fibros 7:454-6. 2008..This report illustrates the need for better characterization of CFTR mutations in a Hispanic population to aid in clinical care... - Pulmonary exacerbations in cystic fibrosis with negative bacterial culturesEdith T Zemanick
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
Pediatr Pulmonol 45:569-77. 2010..Exacerbations are often associated with characteristic airway bacteria [CF related bacteria (CFRB)]. However, some patients do not have CFRB detected by culture during exacerbations... - A new cystic fibrosis newborn screening algorithm: IRT/IRT1 upward arrow/DNAMarci K Sontag
Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA
J Pediatr 155:618-22. 2009..To evaluate an immunoreactive trypsinogen (IRT) IRT/IRT1 upward arrow/DNA algorithm, aimed at improving sensitivity while decreasing cystic fibrosis (CF) carrier identification... - Reliability of quantitative real-time PCR for bacterial detection in cystic fibrosis airway specimensEdith T Zemanick
Department of Pediatrics, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, United States of America
PLoS ONE 5:e15101. 2010..influenzae from CF airway samples. By reliably quantifying fastidious airway bacteria, qPCR may improve our understanding of polymicrobial CF lung infections, progression of lung disease and ultimately improve antimicrobial treatments... - Bacterial colonization and infection in the CF lungScott D Sagel
Department of Pediatrics, Children's Hospital, University of Colorado Health Sciences Center, Denver, CO, USA
Methods Mol Med 70:433-46. 2002 - Diagnosis of a symptomatic tracheal pouch by means of bronchoscopy after neonatal repair of a tracheoesophageal fistulaJ Brian Kang
Department of Pediatrics, The Children's Hospital and University of Colorado at Denver and Health Sciences Center, Denver, Colo, USA
J Allergy Clin Immunol 120:541-3. 2007 - Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung diseaseGregory S Montgomery
Division of Pediatric Pulmonology, Department of Pediatrics, Indiana University Medical Center, Indianapolis, Indiana, USA
Pediatr Pulmonol 41:383-5. 2006..We report on a patient with severe CF lung disease who experienced clinically significant improvements in exercise tolerance and pulmonary hypertension without changing lung function during sildenafil therapy... - Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosisJ Kirk Harris
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Proc Natl Acad Sci U S A 104:20529-33. 2007..These results show that molecular techniques provide a broader perspective on airway bacteria than do routine clinical cultures and thus can identify targets for further clinical evaluation... - Computed tomography in the evaluation of cystic fibrosis lung diseaseAlan S Brody
Department of Radiology, MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Am J Respir Crit Care Med 172:1246-52. 2005..Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this article is to present the current status of CT scanning in CF... - A pilot study on the safety and efficacy of a novel antioxidant rich formulation in patients with cystic fibrosisKonstantinos A Papas
Yasoo Health, Johnson City, TN, USA
J Cyst Fibros 7:60-7. 2008....
Research Grants
- Noninvasive biomarkers of proteolytic activity in CFScott Sagel; Fiscal Year: 2007..In addition, he will actively participate and train in the Pediatric GCRC, and frequently interact with his sponsor, mentors, and collaborators. ..