Research Topics
| N SafdarSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Educational interventions for prevention of healthcare-associated infection: a systematic reviewNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
Crit Care Med 36:933-40. 2008..Healthcare-associated infections (HCAIs) are associated with considerable morbidity and mortality. Education of healthcare providers is a fundamental measure to prevent HCAI...
Clinical problem-solving. Into the woodsNasia Safdar
Department of Medicine, University of Wisconsin-Madison School of Medicine, Madison, WI 53792, USA
N Engl J Med 356:943-7. 2007- Infections after the use of alemtuzumab in solid organ transplant recipients: a comparative studyNasia Safdar
Department of Medicine, Section Infectious Diseases, University of Wisconsin, Madison, WI 54792, USA
Diagn Microbiol Infect Dis 66:7-15. 2010..76; 95% CI, 1.58-14.28; P = .003). Basiliximab posed a higher risk than alemtuzumab for infection. Disseminated candidal infections were more common in patients receiving alemtuzumab... - Clinical and economic consequences of ventilator-associated pneumonia: a systematic reviewNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Crit Care Med 33:2184-93. 2005..Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critically ill patients. The clinical and economic consequences of VAP are unclear, with a broad range of values reported in the literature.. 
Antimicrobial catheters in the ICU: is the juice worth the squeeze?Nasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, H4 572, Madison, WI 53792, USA
Crit Care 13:148. 2009..A comprehensive economic evaluation is essential to guide informed decision-making regarding the adoption of this technology and its expected benefits in healthcare institutions...- Feasibility and tolerability of probiotics for prevention of antibiotic-associated diarrhoea in hospitalized US military veteransN Safdar
Section of Infectious Diseases, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI, USA
J Clin Pharm Ther 33:663-8. 2008..Probiotics may be efficacious for the prevention of antibiotic-associated diarrhoea. The tolerability and acceptability of probiotics in an elderly US veteran population has not been assessed... - Clinical problem-solving. An unintended consequence--a 79-year-old man with a 5-month history of fatigue and 20-lb (9-kg) weight loss presented to his local physicianNasia Safdar
Department of Medicine, University of Wisconsin School of Medicine, Madison, WI 53792, USA
N Engl J Med 358:1496-501. 2008 - The risk of infection after nasal colonization with Staphylococcus aureusNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
Am J Med 121:310-5. 2008..Some studies have found that colonization with methicillin-resistant S. aureus (MRSA) poses a greater risk of clinical infection than colonization with methicillin-susceptible S. aureus (MSSA). However, the magnitude of risk is unclear... - Polyclonal immunoglobulins and hyperimmune globulins in prevention and management of infectious diseasesJennifer L Hsu
Division of Infectious Disease, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Infect Dis Clin North Am 25:773-88. 2011..The authors review the evidence for the use of immunoglobulin therapy in common adult infectious diseases... - The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and CandidaNasia Safdar
Department of Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, H4/572, Madison, WI 53792, USA
Ann Intern Med 136:834-44. 2002.... - Infected bilomas in liver transplant recipients, incidence, risk factors and implications for preventionAdnan Said
Section of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, USA
Am J Transplant 4:574-82. 2004..T-tube drainage post-transplantation bears reassessment. The protective effect of ursodeoxycholic acid found in this study warrants confirmation in a prospective multicenter, randomized trial... - The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysisNasia Safdar
Section of Infectious Diseases, Department of Internal Medicine, University of Wisconsin Medical School, Madison, WI, USA
Liver Transpl 10:817-27. 2004..Larger multicenter randomized trials in this patient population to assess the effect of SDD in reducing infection and mortality, while assessing the risk of antimicrobial resistance, are needed... - Prevalence, consequences, and solutionsDennis G Maki
Section of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Pharmacotherapy 27:121S-125S. 2007..Education of the patient and the prescriber, as well as antimicrobial stewardship programs, are necessary to avert a global antibiotic resistance catastrophe... - The Wisconsin Upper Respiratory Symptom Survey is responsive, reliable, and validBruce Barrett
Department of Family Medicine, University of Wisconsin Medical School, Madison, 53715, USA
J Clin Epidemiol 58:609-17. 2005..To assess reliability, responsiveness, importance to patients, and convergent validity for the Wisconsin Upper Respiratory Symptom Survey (WURSS-44) and to develop a short-form WURSS... - Effectiveness of preemptive barrier precautions in controlling nosocomial colonization and infection by methicillin-resistant Staphylococcus aureus in a burn unitNasia Safdar
Infectious Diseases, Department of Medicine, University of Wisconsin Medical School and University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
Am J Infect Control 34:476-83. 2006..Use of clean gloves, with or without a gown, bears consideration for all high-risk hospitalized patients to prevent cross transmission of all multiresistant nosocomial pathogens... - Longitudinal trends in antibiotic resistance in US nursing homes, 2000-2004Christopher J Crnich
Section of Infectious Diseases and Department of Medicine, University of Wisconsin Hospital and Medical School, Madison, WI 53792, USA
Infect Control Hosp Epidemiol 28:1006-8. 2007..Significant increases in the number and proportion of infections caused by antibiotic-resistant bacteria were documented over the 5-year study. Further research on antibiotic resistance in nursing homes is urgently needed... - Using benefit harm tradeoffs to estimate sufficiently important difference: the case of the common coldBruce Barrett
Department of Family Medicine, University of Wisconsin Medical School, Madison, WI 53715, USA
Med Decis Making 25:47-55. 2005..Little is known about patient preferences regarding benefits and harms of common cold treatments... - Infected bilomas in liver transplant recipients: clinical features, optimal management, and risk factors for mortalityNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin, Madison, WI, USA
Clin Infect Dis 39:517-25. 2004..Bilomas are most likely to be successfully treated nonsurgically in patients without HAT and without Candida or enterococcus infection... - In vivo pharmacodynamic activity of daptomycinNasia Safdar
Department of Medicine, Section of Infectious Diseases, University of Wisconsin, Madison 53792, USA
Antimicrob Agents Chemother 48:63-8. 2004..The long PAE and potent bactericidal activity make daptomycin an attractive option for the treatment of infections caused by gram-positive bacteria... - Statins are associated with improved outcomes of bloodstream infection in solid-organ transplant recipientsJ Hsu
Section of Infectious Diseases, Department of Medicine, University of Wisconsin, Room H4 572 CSC, 600 Highland Avenue, Madison, WI 53792, USA
Eur J Clin Microbiol Infect Dis 28:1343-51. 2009..In conclusion, appropriate antibiotic therapy and statin use are associated with lower risk of mortality from BSIs in this patient population... - Voriconazole therapeutic drug monitoringJ Smith
University of Wisconsin, Department of Medicine, Madison, WI 53792, USA
Antimicrob Agents Chemother 50:1570-2. 2006..Favorable responses were observed in 10/10 patients with concentrations above 2.05 microg/ml, while disease progressed in 44% (n=18) of patients with concentrations below 2.05 microg/ml... - Rhino-orbital-cerebral zygomycosis in solid organ transplant recipientsHsin Yun Sun
Division of Infectious Diseases, Department of Medicine, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Transplantation 90:85-92. 2010..Rhino-orbital-cerebral disease is a significant manifestation of zygomycosis in solid organ transplant (SOT) recipients. However, its characteristics and outcome are not well addressed... - Comparison of culture screening methods for detection of nasal carriage of methicillin-resistant Staphylococcus aureus: a prospective study comparing 32 methodsNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA
J Clin Microbiol 41:3163-6. 2003..Direct inoculation of swabs onto MSAL(Ox) allows detection of 90% of MRSA carriers... - Pharmacokinetic-pharmacodynamic comparison of amphotericin B (AMB) and two lipid-associated AMB preparations, liposomal AMB and AMB lipid complex, in murine candidiasis modelsD Andes
Department of Medicine, University of Wisconsin, 600 Highland Ave, Room H4 572, Madison, WI 53792, USA
Antimicrob Agents Chemother 50:674-84. 2006..1)... - The role of lactobacillus probiotics in the treatment or prevention of urogenital infections--a systematic reviewC L Abad
Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
J Chemother 21:243-52. 2009..Further research and larger studies on types of lactobacilli strains, dosage of lactobacilli, optimal route and vehicle of administration are needed... - The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for preventionNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, University of Wisconsin Center for Health Sciences, Madison WI, USA
Respir Care 50:725-39; discussion 739-41. 2005..Routine surveillance of VAP, to track endemic VAPs and facilitate early detection of outbreaks, is mandatory... - Inflammation at the insertion site is not predictive of catheter-related bloodstream infection with short-term, noncuffed central venous cathetersNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
Crit Care Med 30:2632-5. 2002.... - Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective, randomized trialsNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
Clin Infect Dis 43:474-84. 2006..The use of an anti-infective lock solution warrants consideration for patients who require central access but who are at high risk of BSI, such as patients with malignancy or low-birthweight neonates... - A review of risk factors for catheter-related bloodstream infection caused by percutaneously inserted, noncuffed central venous catheters: implications for preventive strategiesNasia Safdar
Department of Medicine, University of Wisconsin Medical School and University of Wisconsin Hospitals and Clinics, Madison, 53792, USA
Medicine (Baltimore) 81:466-79. 2002.... - From ulcer to infection: an update on clinical practice and adjunctive treatments of diabetic foot ulcersC Abad
Early Intervention Program Clinic, Milwaukee Health Services, Inc, Milwaukee, WI, USA
Curr Infect Dis Rep 14:540-50. 2012..This review summarizes the underlying pathology and classification of diabetic ulcers and focuses on recent advances that have important implications for the use of adjunctive therapy for diabetic foot infections... - Predictors and outcomes of candiduria in renal transplant recipientsN Safdar
Department of Medicine, Section of Infectious Diseases, University of Wisconsin Medical School, Madison, WI, USA
Clin Infect Dis 40:1413-21. 2005..Treatment of asymptomatic candiduria in renal transplant recipients does not appear to result in improved outcome... - Adverse effects of isolation in hospitalised patients: a systematic reviewC Abad
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA
J Hosp Infect 76:97-102. 2010..Large studies examining a number of safety indicators to assess the adverse effects of isolation are needed. Patient education may be an important step to mitigate the adverse psychological effects of isolation and is recommended... - Urokinase lock or flush solution for prevention of bloodstream infections associated with central venous catheters for chemotherapy: a meta-analysis of prospective randomized trialsS Kethireddy
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
J Vasc Access 9:51-7. 2008..We undertook a systematic review to determine the efficacy of urokinase-heparin lock or flush solution compared with heparin alone in preventing IVD-associated BSI... - Blastomycosis in solid organ transplant recipientsG M Gauthier
Department of Internal Medicine, Section of Infectious Diseases, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
Transpl Infect Dis 9:310-7. 2007..In solid organ transplant recipients, the epidemiology, clinical features, and outcomes have not been fully described... - Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a meta-analysisNasia Safdar
Department of Medicine, University of Wisconsin Medical School and University of Wisconsin Hospital and Clinics, Madison, WI 53792-5158, USA
JAMA 288:996-1001. 2002..A randomized trial of adequate power, with multiple distinct strains of E coli O157:H7 represented, is needed to conclusively determine whether antibiotic treatment of E coli O157:H7 enteritis increases the risk of HUS... - The role of the intensive care unit environment in the pathogenesis and prevention of ventilator-associated pneumoniaChristopher J Crnich
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, University of Wisconsin Center for Health Sciences, Madison WI, USA
Respir Care 50:813-36; discussion 836-8. 2005..This review examines strategies to prevent transmission of environmental pathogens to the vulnerable mechanically-ventilated patient... - The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous cathetersNasia Safdar
Section of Infectious Diseases, Department of Medicine, Medical School, University of Wisconsin, Madison, WI 53792, USA
Intensive Care Med 30:62-7. 2004..Strategies achieving successful suppression of cutaneous colonization can substantially reduce the risk of catheter-related BSI with short-term CVCs... - The role of immunoglobulin for the treatment of Clostridium difficile infection: a systematic reviewJohn O'Horo
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
Int J Infect Dis 13:663-7. 2009..difficile infection. Further research is urgently needed to clarify the role of immunoglobulin--intravenous or oral--for the treatment of C. difficile infection... - Prevention of endemic healthcare-associated Clostridium difficile infection: reviewing the evidenceJ Hsu
Section of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
Am J Gastroenterol 105:2327-39; quiz 2340. 2010..difficile infection (CDI), interventions to prevent healthcare-associated CDI are essential. We undertook a systematic review of interventions to reduce healthcare-associated CDI... - Meta-analysis: methods for diagnosing intravascular device-related bloodstream infectionNasia Safdar
University of Wisconsin Medical School, Madison, Wisconsin, USA
Ann Intern Med 142:451-66. 2005..The positive predictive value of all tests increased greatly with high pretest clinical probability. Catheters should not be cultured routinely but rather only if IVD-related bloodstream infection is suspected clinically... - Severe Ehrlichia chaffeensis infection in a lung transplant recipient: a review of ehrlichiosis in the immunocompromised patientNasia Safdar
Section of Infectious Diseases, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Emerg Infect Dis 8:320-3. 2002..Of 23 reported cases of ehrlichiosis in immunocompromised patients, organ failure occurred in all patients and 6 (25%) died... - Risk of catheter-related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patientsNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, USA
Chest 128:489-95. 2005..Moreover, PICCs are not advisable in patients with renal failure and impending need for dialysis, in whom preservation of upper-extremity veins is needed for fistula or graft implantation... - Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysisNasia Safdar
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, USA
Lancet Infect Dis 4:519-27. 2004.... - Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysisMaciej Piotr Chlebicki
Section of Infectious Diseases, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA
Crit Care Med 35:595-602. 2007..To assess the efficacy of topical chlorhexidine for prevention of ventilator-associated pneumonia (VAP) in a meta-analysis... - The attributable cost and length of hospital stay because of nosocomial pneumonia in intensive care units in 3 hospitals in Argentina: a prospective, matched analysisVictor D Rosenthal
Department of Infectious Diseases and Hospital of Epidemiology, Bernal Medical Center, Buenos Aires, Argentina
Am J Infect Control 33:157-61. 2005..No information is available on the financial impact of nosocomial pneumonia in Argentina. To calculate the cost of nosocomial pneumonia in intensive care units, a 5-year, matched cohort study was undertaken at 3 hospitals in Argentina... - Quality of care and satisfaction among patients isolated for infection controlNasia Safdar
JAMA 291:420-1; author reply 421-2. 2004 - Device-associated nosocomial infection rates in intensive care units in four Mexican public hospitalsEctor Jaime Ramirez Barba
Public Health Institute, Secretary of Health, Guanajuato,
Am J Infect Control 34:244-7. 2006..8 per 1000 device-days (52/2390); and catheter-associated urinary tract infection rate was 13.4 per 1000 device-days (56/4184). CONCLUSION: Our rates are similar to other hospitals of Latin America and higher than US hospitals... - The effect of process control on the incidence of central venous catheter-associated bloodstream infections and mortality in intensive care units in MexicoFrancisco Higuera
General Hospital, Mexico City, Mexico
Crit Care Med 33:2022-7. 2005..50-0.31; p = .01). CONCLUSION: Implementation of an infection control program utilizing education, process control, and performance feedback was associated with significant reductions in rates of IVD-associated BSI and mortality... - Reduction in nosocomial infection with improved hand hygiene in intensive care units of a tertiary care hospital in ArgentinaVictor D Rosenthal
Section of Infectious Diseases and Hospital Epidemiology, Colegiales Hospital, Buenos Aires, Argentina
Am J Infect Control 33:392-7. 2005..We attempted to enhance compliance with hand hygiene by implementing education, training, and performance feedback. We measured nosocomial infections in parallel... - Bloodstream infection: an ounce of prevention is a ton of workNasia Safdar
Infect Control Hosp Epidemiol 26:511-4. 2005 - Lost in translationNasia Safdar
Infect Control Hosp Epidemiol 27:3-7. 2006 - Effect of education and performance feedback on rates of catheter-associated urinary tract infection in intensive care units in ArgentinaVictor Daniel Rosenthal
Department of Infectious Diseases and Hospital Epidemiology, Colegiales Medical Center, Buenos Aires, Argentina
Infect Control Hosp Epidemiol 25:47-50. 2004..Similar programs may help reduce catheter-associated UTI rates in other Latin American hospitals... - Prevalence-dependent diagnostic accuracy measuresJialiang Li
Department of Statistics and Applied Probability, National University of Singapore, Singapore
Stat Med 26:3258-73. 2007..The methods are illustrated in a meta-analysis of diagnostic tests for intravascular device-related bloodstream infection, where the prevalence may vary widely both within and across populations...